Yusuke Tsuno

Yusuke Tsuno
Kanazawa University | Kindai

Ph.D. in Medicine, Univ. Tokyo

About

15
Publications
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257
Citations

Publications

Publications (15)
Article
The suprachiasmatic nucleus (SCN), the central circadian pacemaker in mammals, is a network structure composed of multiple types of γ-aminobutyric acid (GABA)-ergic neurons and glial cells. However, the roles of GABA-mediated signaling in the SCN network remain controversial. Here, we report noticeable impairment of the circadian rhythm in mice wit...
Article
In mammals, olfactory sensation depends on inhalation, which controls activation of sensory neurons and temporal patterning of central activity. Odor representations by mitral and tufted (MT) cells, the main output from the olfactory bulb (OB), reflect sensory input as well as excitation and inhibition from OB circuits, which may change as sniff fr...
Article
Medial entorhinal cortex is the gateway between cortex and hippocampus, and plays a critical role for spatial coding as represented by grid cell activity. In the medial entorhinal cortex, inhibitory circuits are robust, and the presence of h-current leads to rebound potentials and rebound spiking in in vitro experiments. It has been hypothesized th...
Article
Full-text available
The suprachiasmatic nucleus (SCN), the central circadian clock in mammals, is a neural network consisting of various types of GABAergic neurons, which can be differentiated by the co-expression of specific peptides such as vasoactive intestinal peptide (VIP) and arginine vasopressin (AVP). VIP has been considered as a critical factor for the circad...
Preprint
Full-text available
In mammals olfactory sensation depends on inhalation, which controls activation of sensory neurons and temporal patterning of central activity. Odor representations by mitral and tufted (MT) cells, the main output from the olfactory bulb (OB), reflect sensory input as well as excitation and inhibition from OB circuits, which may change as sniff fre...
Article
Unlabelled: Serotonergic neurons in the brainstem raphe nuclei densely innervate the olfactory bulb (OB), where they can modulate the initial representation and processing of olfactory information. Serotonergic modulation of sensory responses among defined OB cell types is poorly characterized in vivo Here, we used cell-type-specific expression of...
Article
Medial entorhinal cortex Layer-II stellate cells (mEC-LII-SCs) primarily interact via inhibitory interneurons. This suggests the presence of alternative mechanisms other than excitatory synaptic inputs for triggering action potentials (APs) in stellate cells during spatial navigation. Our intracellular recordings show that the hyperpolarization-act...
Conference Paper
Medial Entorhinal Cortex Layer-II stellate cells (mEC-LII-SCs) primarily interact via inhibitory interneurons. This suggests the presence of alternative mechanisms to excitation for triggering action potentials (APs) in stellate cells during spatial navigation. Our intracellular recordings show that the hyperpolarization-activated cation current (I...
Article
Extensive in vitro data and modeling studies suggest that intrinsic properties of medial entorhinal cortex (MEC) neurons contribute to the spiking behavior of functional cell types of MEC neurons such as grid cells recorded in behaving animals. It remains unclear, however, how intrinsic properties of MEC neurons influence cellular dynamics in intac...
Article
Full-text available
The acquisition of sensory information during behavior shapes the neural representation, central processing, and perception of external stimuli. In mammals, a sniff represents the basic unit of odor sampling, yet how sniffing shapes odor representations remains poorly understood. Perhaps the earliest hypothesis of the role of sniffing in olfaction...
Article
Full-text available
The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular mechanisms in EC that can be modulated through choli...
Article
Odorant receptor maps in the glomerular layer of the mammalian olfactory bulb are organized into zones and domains. This organization is functionally related to specific odor-induced behavioral responses. Mitral and tufted cells associated with a glomerulus (an odorant receptor channel) extend long lateral dendrites that form dendrodendritic synaps...
Article
Changes in behavioral state are accompanied by coordinated changes in the information processing mode in the hippocampus and neocortex of the brain. We review here the recent progress in the knowledge of behavioral state-dependent changes in the information processing mode in the central olfactory system. Olfactory cortex shows state-dependent gati...
Article
Full-text available
Behavioral states regulate how information is processed in local neuronal circuits. Here, we asked whether dendrodendritic synaptic interactions in the olfactory bulb vary with brain and behavioral states. To examine the state-dependent change of the dendrodendritic synaptic transmission, we monitored changes in field potential responses in the olf...

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