Yusuf Deeni

Yusuf Deeni
The Federal University Dutse · Department of Microbiology and Biotechnology

BSc, MSc, PhD

About

99
Publications
65,847
Reads
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1,005
Citations
Citations since 2017
23 Research Items
452 Citations
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2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
Introduction
Yusuf Deeni currently works at the Department of Microbiology and Biotechnology, Faculty of Science, Federal University Dutse, Nigeria. Yusuf does research in Molecular Biology and Biomedicine with focused interest in Cancer, Microbiology (Medical and Environmental), Biotechnology and Bioinformatics. Their current project is translational research at 'Targeting EGFR family and NRF2 to overcome chemoresistance in ovarian and breast cancer models.'
Additional affiliations
January 2014 - present
Abertay University
Position
  • Senior Lecturer & Director Research Degrees
January 2013 - present
Abertay University
Position
  • Group Leader & Director of Studies
January 2006 - September 2007
Ninewells Hospital
Position
  • Group Leader
Education
September 1993 - November 1997
University of Dundee
Field of study
  • Molecular Biology (Molecular Pharmacology & Toxicology)
September 1987 - June 1989
Bayero University, Kano
Field of study
  • Biology (Microbiology)
September 1978 - June 1981
Savannah State University
Field of study
  • Biology

Publications

Publications (99)
Article
Full-text available
COVID-19 mortality rate has not been formally assessed in Nigeria. Thus, we aimed to address this gap and identify associated mortality risk factors during the first and second waves in Nigeria. This was a retrospective analysis of national surveillance data from all 37 States in Nigeria between February 27, 2020, and April 3, 2021. The outcome var...
Article
Full-text available
Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell’s response to oxidative and electrophilic stress and is a transcription factor regulating the expression of a collection of anti-oxidative and cytoprotective genes. Human epidermal growth factor receptor 4 (HER4/erbB4) regulates growth and differentiation in many...
Article
Full-text available
Background of Study: Many virulence determinants contribute to the pathogenicity of Gram negative bacteria, like Escherichia coli, which is the most common cause of many infections worldwide such as urinary tract infection (UTI), profuse diarrhoea and septicaemia. Aim: To determine the genotypic characteristics of adhesin-producing E. coli isolates...
Article
We are investigating characteristics associated with oil degradation amongst bacteria isolated from clean and hydrocarbon contaminated soils from Nigeria and the UK.Our focus has been to identify bacteria expressing surfactants following isolation on Pseudomonas selective (PSA-CFC) and non-selective nutrient media and investigate the nature of surf...
Article
Full-text available
Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions represents a major goal to control their potentially harmful effects. Here, we adopted a novel strategy of trapping carbonyls present in e-cigarette emissions by adding polyphenols in e-liquid formulations. Our work showed that the addition of gallic acid, hydrox...
Article
Full-text available
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and general physiology models. However, emerging data has uncovered novel functionality of this tra...
Conference Paper
Full-text available
Mosquito breeding sites were grouped into two different study zones (A and B) on the basis of human related activities taking place in and around the breeding sites. An. gambiae larvae collected from ecologically contrasting breeding sites were reared to adults in the laboratory. Adults from the F1 progeny were assayed for resistance against 4% DDT...
Conference Paper
Full-text available
Vector resistance to insecticides is a major challenge in the crusade towards effective malaria control. The issue of tolerance of An. gambiae to commonly used insecticides that were hitherto active against the An. gambiae population has necessitate further effort towards recognizing the biological factors in the insects that facilitates the resist...
Article
Full-text available
Glutathione (GSH) is widely distributed among all living organisms and associated with diverse functions that include maintaining redox homeostasis and detoxification of xenobiotic compounds. The level of GSH within the cell varies with stress often involving changes in GSH content, which is consumed in reactions that protect the cell leading to fo...
Article
Bacterial bio-surfactants have a wide range of biological functions and biotechnological applications. Previous analyses had suggested a limit to their reduction of aqueous liquid surface tensions (γMin), and here we confirm this in an analysis of 25 Pseudomonas spp. strains isolated from soil which produce high-strength surfactants that reduce sur...
Conference Paper
Ataxia telangiectasia and Rad3 related (ATR) kinase, a master regulator of the DNA damage response pathway (DDRP), is activated by single stranded DNA damage to phosphorylate Chk1 and initiate signal transduction cascades that result in cell cycle arrest (checkpoints) and/or apoptosis. A central player in this pathway is the p53 effector protein, w...
Article
Full-text available
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and progression. NRF2 and HERs confer cancers with resistance to several therapeutic agents. Nevertheless...
Article
Full-text available
This study was carried out in 2015 to assess the level of resistance of sibling species of Anopheles gambiae complex the principal malaria vector from Bichi in Kano state to three classes of insecticides; (DDT, Permethrin and Bendiocarb) approved by World Health Organization (WHO) for vector control with the aim of obtaining baseline susceptibility...
Article
Full-text available
Background: In Nigeria, decline in the sensitivity of Plasmodium falciparum to Artemisinin Combination Therapy (ACT) has prompted the unofficial use of chloroquine (CQ) for self-medication. This study was designed to determine the prevalence and distribution of CQ resistant/susceptible alleles of CQ resistance transporter (Pfcrt) and P. falciparum...
Article
Full-text available
Abstract—this study was carried out to assess the level of susceptibility or resistance of sibling species of Anopheles gambiae complex from Auyo in Jigawa state between 2013 and 2014 to three classes of insecticides approved by World Health Organization (WHO) for vector control. A. gambiae larvae collected from ecologically contrasting breeding si...
Article
Full-text available
Although bacterial cellulose synthase (bcs) operons are widespread within the Proteobacteria phylum, subunits required for the partial-acetylation of the polymer appear to be restricted to a few γ-group soil, plant-associated and phytopathogenic pseudomonads, including Pseudomonas fluorescens SBW25 and several Pseudomonas syringae pathovars. Howeve...
Chapter
Biosurfactants which reduce the surface or interfacial tension of liquids and act as emulsifiers, foaming and dispersing agents with low toxicity, are increasingly finding applications in biotechnology and driving the search for novel compounds for further exploitation. Potential biosurfactants sourced from bacteria are often selected first by qual...
Article
Full-text available
Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to uncontrolled receptor activation and signaling. A combination of HER2 targeting monoclonal antibodies shows greater anticancer e...
Conference Paper
Full-text available
Ovarian cancer is the most lethal gynaecological malignancy with very little achievement recorded on 5 year overall survival in the last couple decades. Despite the availability of several treatment options, the anticancer effectiveness of these options has been limited by lack of outstanding target specificity and/or the capacity to identify and f...
Conference Paper
Full-text available
Malaria being the most important endemic protozoan disease in the tropics in terms of morbidity and mortality has attracted a continuous effort by researchers for it's control and prevention. Malaria vector control programs in Africa rely heavily on the use of pesticides for insecticide treated nets (ITN) and long lasting insecticides treated nets...
Conference Paper
Ovarian cancer is the most lethal gynaecological malignancy with very little achievement recorded on 5 year overall survival in the past few decades, in spite the availability of several treatment options. The anticancer effectiveness of these treatment options has been constrained by lack of outstanding target specificity, adverse side effects, th...
Conference Paper
Reactive oxygen species (ROS) exacerbate oxidative stress (OS) on cells and impact cell fate, including proliferation. Research has highlighted the role of the trans-acting regulator NRF2, which drives the transcription of genes associated with redox homeostasis. We propose that ROS manipulation could control proliferation depending on cell line an...
Article
Full-text available
Sorghum is the fifth most important cereal worldwide and is a major source of agricultural residues in tropical regions. Bioconversion of whole sorghum crop residues comprising stalks, leaves, peduncles and panicles to ethanol has great potential for improving ethanol yield per sorghum crop cultivated, and for sustainable biofuel production. Effect...
Article
A study was conducted to evaluate the influence of sewage sludge on biodegradation of engine oil in contaminated soil. Soil samples were collected from a mechanics workshop in Sokoto metropolis. The Soil samples were taken to the laboratory for isolation of engine oil degrading bacteria. About 1 g of soil sample was used to inoculate 9 ml of trypti...
Article
Full-text available
NF-E2 related factor-2 (NRF2) is an essential transcription factor for multiple genes encoding antioxidants and detoxification enzymes. NRF2 is implicated in promoting cancer therapeutic resistance by its detoxification function and crosstalk with proproliferative pathways. However, the exact mechanism of this intricate connectivity between NRF2 an...
Article
Full-text available
Monitoring of insecticide resistance is indispensable to acquire comparable baseline data on insecticide resistance. Hence, there is need to understand its past and present status. An investigation was carried out on the insecticide resistance to Anopheles spp. mosquitoes in Nigeria which is on the increase and spreads across Africa. Various method...
Conference Paper
Anopheles gambiae (An. gambiae) is the principal malaria vector in Africa, where vector control measures involve the use of insecticides. The development of insecticides resistance mitigates these approaches. Glutathione (GSH) is widely distributed among all living organisms and is associated with detoxification pathways, especially the Glutathione...
Article
Full-text available
Experimental evolution studies are used to investigate bacterial adaptive radiation in simple microcosms. In the case of the Wrinkly Spreader, a class of biofilm-forming adaptive mutants of Pseudomonas fluorescens SBW25, the current paradigm is that they are only evolutionarily successful in static microcosms where they out-compete other lineages f...
Conference Paper
Abstract Anopheles gambiae (An. gambiae) is the principal malaria vector in Africa, where vector control measures involve the use of insecticides. The development of insecticides resistance mitigates these approaches. Glutathione (GSH) is widely distributed among all living organisms, and is associated with detoxification pathways, especially the...
Article
Full-text available
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of the antioxidant response (AR) pathway and functions as a transcription factor for basal and oxidative stress-induced expression of a battery of detoxification enzymes and cytoprotective genes. Recent evidence has also demonstrated a role of NRF2 in driving resistance of num...
Data
Advances in technology are rapidly improving the range of available biotechnological tools and applications. Interfacial opportunities, such as those combining biomedical improvements with aspects of engineering, computing and innovative biomaterials are at the forefront of these enhancements. Personalised and predictive screening, pre-disease and...
Article
For improved production of ethanol from whole sorghum residues, physico-chemical compositions and fermentation characteristics of the substrates are important factors to consider. In the present study, Nigerian sorghum cultivars SSV2, KSV8 and KSV3 were grown under rain-fed conditions without chemical fertilization in Kano state, Nigeria. On harves...
Article
Full-text available
Efficient starch saccharification is an essential step towards achieving improved ethanol yields by fermentation. Sorghum grains are important starch sources for bioconversion to ethanol. In the present study, disease degraded (spoilt) husked grains from Nigerian sorghum cultivars were obtained from field sites and subjected to bioprocessing to eth...
Article
Full-text available
Advances in technology are rapidly improving the range of available biotechnological tools and applications. Interfacial opportunities, such as those combining biomedical improvements with aspects of engineering, computing and innovative biomaterials are at the forefront of these enhancements. Personalised and predictive screening, pre-disease and...
Article
Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet phys- iological requirements and from exogenous sources. While endogenous ROS are considered as important signalling molecules, high uncontrollable ROS are detrimental. It is unclear how cells can achieve a bal- ance between maintaining physiological re...
Article
Full-text available
We present CoSMoS as a way of structuring thinking on how to reuse parts of an existing model and simulation in a new model and its implementation. CoSMoS provides a lens through which to consider, post-implementation, the assumptions made during the design and implementation of a software simulation of physical interactions in the formation of vas...
Article
Full-text available
Unlabelled: Bacteria produce a variety of biosurfactants capable of significantly reducing liquid (aqueous) surface tension (γ) with a range of biological roles and biotechnological uses. To determine the lowest achievable surface tension (γMin ), we tested a diverse collection of Pseudomonas-like isolates from contaminated soil and activated slud...
Conference Paper
Cancer arises from aberrant cell functioning, conferring cancerous cells with increased proliferation and growth, resistance to pre-programmed cell death and the capacity to migrate and metastasise. Cell functioning is governed in part by molecular signaling pathway networks with complex topologies, including feedback loops and crosstalk. As our un...
Article
Investigating the role of glutathione and glutathione biosynthetic enzymes in the adaptation of Anopheles gambiae to insecticides Habibu Usman Abdu, , Andrew Spiers, Yusuf Deeni Show more DOI: 10.1016/j.jbiotec.2014.07.310 Get rights and content Glutathione (GSH) plays a central role in the detoxification of xenobiotics. The GSH biosynthetic gene γ...
Conference Paper
Proliferation is coupled metabolic competence and environmental circumstance of a cell. Reactive oxygen species (ROS) are modulators of intracellular signalling that govern cellular proliferation. High uncontrollable ROS lead to mutation and acceleration of disease, ageing, or death. Anticancer radio/chemotherapy depends on ROS to induce cytotoxici...
Article
Advances in technology are rapidly improving the range of available biotechnological tools and applications. Interfacial opportunities, such as those combining biomedical improvements with aspects of engineering, computing and innovative biomaterials are at the forefront of these enhancements. Personalised and predictive screening, pre-disease and...
Article
Full-text available
Cytochrome P450s, including CYP6M2 gene, are involved in the detoxification of permethrin. Some of these genes are regulated by CnCC/Keap 1 and Spineless/Tango in Drosophila melanogaster. This mechanism is yet to be identified in Anopheles gambiae. Thus we examine whether there is differential regulation of CYP6M2 gene between insecticide susceptib...
Article
Full-text available
Cytochrome P450s including CYP6M2 have been demonstrated to be involved in the metabolism of insecticides, typically through up regulation in resistant individuals. The difference in gene expression levels seen in insecticide resistant mosquitoes may result from sequence differences in the 5’ upstream region of CYP6M2 including those in the promote...
Article
Full-text available
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single drug therapy. Reprogramming of the RTK network leading to alteration in RTK co-expression in res...