Yuriy M. Sirenko

Shupyk National Healthcare University of Ukraine · Chair of Carduology

Genetic diagnostic testing of 325 pulmonary arterial hypertension (PAH) patients using a PAH specific gene panel including 18 known PAH genes revealed mutations in 23 %. Further PAH candidate genes were sequenced in the remaining patients exposing two SMAD5 variants, which were clinically and functionally characterized. We first recorded familial c...

The aim – to compare pulmonary function test (PFT) results and diffusion capacity of the lungs for carbon monoxide (DLCO) in patients with various forms of pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension (CTEPH) and healthy individuals; to establish correlations between PFT, DLCO and parameters used to stratify...

Guidelines evaluate and summarize available evidence with the aim of as sisting health professionals in proposing the best diagnostic or therapeut ic approach for an individual patient with a given condition. Guidelines are intended for use by health professionals and the European Society of Cardiology (ESC) makes its guidelines freely available.

Spironolactone is a drug that plays an important role in the treatment of various diseases, especially in the field of cardiology and endocrinology. First synthesized in 1957, spironolactone gained widespread recognition due to its unique ability to block the action of aldosterone, a hormone that plays an important role in the pathogenesis of many...

Any military actions on the territory of any country can significantly influence on the quality of medical care. Especially, it could reflect on patients with rare diseases requiring expensive treatment. In this article there were analyzed the work of the specialized pulmonary hypertension (PH) center during the period of Russia’s military invasion...

Актуальність. Використання фіксованих комбінацій антигіпертензивних препаратів може поліпшити контроль АТ та зменшити ускладнення і збільшити тривалість життя. ­Метою нашого дослідження було проаналізувати ефективність фіксованих, вільних та нетрадиційних комбінацій антигіпертензивних препаратів у лікуванні пацієнтів із АГ. Матеріали та методи. Обс...

Артеріальна гіпертензія (АГ) залишається найбільш поширеним неінфекційним захворюванням у наш час. Незважаючи на обнадійливе поліпшення показників контролю, артеріальний тиск (АТ) у світі загалом продовжує зростати (можливо, тому що люди живуть довше і не вмирають від захворювань у молодому віці). У результаті ми спостерігаємо велику кількість нови...

Актуальність. Підходи до лікування артеріальної гіпертензії (АГ) часто відрізняються на стаціонарному й догоспітальному етапах, однак призначення препаратів сімейним лікарем в Україні досліджували мало. Мета: оцінити ефективність антигіпертензивної терапії генеричними формами найбільш популярних у світі антигіпертензивних засобів — раміприлу, s-амл...

Measuring blood pressure (BP) and investigating arterial hemodynamics are essential in understanding cardiovascular disease and assessing cardiovascular risk. Several methods are used to measure BP in the doctor's office, at home, or over 24 h under ambulatory conditions. Similarly, several noninvasive methods have been introduced for assessing art...

Background. Idiopathic pulmonary arterial hypertension (IPAH) is a severe disease that affects the vessels of the pulmonary circulation and leads to right ventricular failure and death of patients. Indicators of hemodynamics and oxygen transport play central role in the progression and development of the disease. Objective: to evaluate indicators o...

BACKGROUND Sildenafil, approved for pulmonary arterial hypertension (PAH), has a recommended adult dose of 20 mg TID, with a previously approved 5-mg TID dose by the US Food and Drug Administration. Safety concerns arose because of common off-label use of higher doses, particularly after pediatric data linked higher doses to increased mortality. To...

Objective Aim. Determining the long-term efficacy and safety of RDN the results of a 10-year follow-up Design and method We selected 1146 patients with resistant arterial hypertension (RAH) who received 3 or more antihypertensive drugs. 16 patients were selected for renal artery denervation. RDN was performed in 8 patients (0.70%). 8 patients refu...

Objective Resistant arterial hypertension (RAH) contributes to high mortality worldwide. Aim of the study: to assess 7-year follow-up survival and development of a composite end point (CEP) in patients with RAH. Design and method The analysis includes 50 patients with RAH who were discharged from hospital. After 7 years discharge from the hospital...

Objective In some studies, there was well established a statin influence on arterial stiffness. It was suggested statins could decrease the blood pressure too. Pulse wave velocity (PWV), a gold standard for arterial stiffness measurement, depends on blood pressure (BP). The aim of study was to evaluate the influence of statins on PWV changes in dep...

Background The cardio-ankle vascular index (CAVI) measure of arterial stiffness is associated with prevalent cardiovascular risk factors, while its predictive value for cardiovascular events remains to be established. The aim was to determine associations of CAVI with cardiovascular morbimortality (primary outcome) and all-cause mortality (secondar...

fixed combinations of antihypertensive medications can improve blood pressure (BP) control, reduce complications and increase life expectancy. The objective of our study was to analyze the efficiency of fixed, free and not traditional combinations of antihypertensive medications in the management of patients with arterial hypertension. 396 patients...

For a long time, the problem of the formation of diastolic dysfunction (DD) of the left ventricle (LV) in patients with arterial hypertension (AH) remained insufficiently studied. It was demonstrated that the formation of LV DD is largely related to the increase in stiffness of this heart chamber. We decided to evaluate the extent to which increase...

Background: Pulmonary arterial hypertension (PAH) is a rare complication of hepatic diseases with portal hypertension that, however, has a significant influence on prognosis. We present a mini-review of how to diagnose and treat it based on a clinical case. Case Presentation: In early childhood, a patient had portal hypertension associated with cav...

In this article there was presented a clinical case of the chronic thromboembolic pulmonary hypertension (CTEPH) in the patient with small arteries damage. The thromb visualization was done by the lung perfusion multispiral computer tomography. The general positions of the definition, the diagnosis and treatment of the CTEPH were elucidated too. It...

Background: pulmonary arterial hypertension (PAH) is a rare complication of hepatic diseases with portal hypertension that, however, has a significant influence on prognosis. We present a mini-review of how to diagnose and treat it based on a clinical case. Case Presentation: in early childhood, a patient had portal hypertension associated with cav...

Метою цього дослідження була оцінка артеріальної жорсткості, яка змінилася після додавання статинів до фіксованої комбінованої антигіпертензивної терапії в пацієнтів з резистентною артеріальною гіпертензією. Матеріали та методи. Включено 99 хворих на помірну й тяжку артеріальну гіпертензію без цукрового діабету. Ці пацієнти були розподілені на 2 гр...

The aim – to determine the long-term efficacy and safety of renal denervation (RDN) at 10-year follow-up.Materials and methods. We selected 1146 patients with resistant arterial hypertension (RAH) who received 3 or more antihypertensive drugs. 16 patients were selected for renal artery denervation. RDN was performed in 8 patients (0.70 %). 8 patien...

The aim – the COVID-19 pandemic influenced seriously on people life in all of the world, including patients with such hard-chronic diseases like pulmonary hypertensions. The aim of our study was to evaluate the COVID-19 morbidity and its influence on mortality during the first 13 pandemic months in patients with pulmonary arterial hypertension (PAH...

Poor adherence to treatment is one of the reasons for not reaching the target levelof blood pressure and the consequences in the form of the development of cardiovascularcomplications.Aim – to analysis adherence to treatment of patients with resistant arterial hypertensionby various methods and to determine ways to overcome non-adherence to treatme...

Background. Resistant hypertension is defined as failure to achieve the target blood pressure (BP), despite treatment with at least three antihypertensive drugs that include a diuretic, and is associated with a poor prognosis. This is caused by organ damage from long-term exposure to high blood pressure, and is also linked to diabetes mellitus, chr...

Aim: The objective of this study was the evaluation of the arterial stiffness, which changed after adding statins to the guidelines recommended dual or triple fixed combination antihypertensive therapy in patients with moderate to severe arterial hypertension. Materials and methods: It was included 99 patients in total being diagnosed with moder...

Objective To assess the influence of various external factors and stress due to a large-scale military invasion on the daily blood pressure (BP) profile in the population of patients with arterial hypertension (AH) in Ukraine. Design and method This was a retrospective analysis of examined patients who underwent ABPM in the last 5 years. We condit...

Objective Diabetes mellitus (DM) remains one of the most important cardiovascular risk factors significantly worsening the prognosis in patients with hypertension and dyslipidemia. The leading role among drugs for the treatment of such patients is played by statins with their powerful influence on the development and progression of atherosclerosis...

Objective Aim of this study was to assess the impact of not achievement of the target blood pressure levels on the presence of the diastolic heart failure in patient with resistant hypertension (RH). Design and method The study included patients with arterial hypertension who received 3 and more AH drugs and had BP > 140/90 mm Hg and were admitted...

Objective ASE guidelines for the diagnostics of the left ventricle (LV) of diastolic dysfunction in 2016 suggested using the method of non-invasive assessment of central blood pressure (CBP) and the augmentation index (Aix) in order to obtain more detailed information in patients with arterial hypertension (AH). Routine determination of CBP does no...

Актуальність. Атеросклеротичне ураження сонних артерій є важливим фактором ризику серцево-судинних захворювань. Останнім часом все більше доказів того, що артеріальна гіпертензія (АГ) зустрічається в поєднанні з гіпергомоцистеїнемією (ГГЦ) і може бути виявлена одночасно з бляшками в сонних артеріях, що впливає на прогноз подальших серцево-судинних...

Актуальність. Прихильність до лікування факторів ризику (антигіпертензивної, ліпідознижуючої та антитромботичної терапії, лікування діабету) не тільки запобігає прогресуванню захворювання, але й зменшує смертність від серцево-судинних причин. У цій статті ми проаналізували результати всеукраїнського дослідження думки пацієнта, проведеного методом і...

The aim – to identify patients with true resistant arterial hypertension and to assess patients’ adherence to treatment on the background of a fixed combination of antihypertensive drugs.Materials and methods. 1146 patients with resistant hypertension were included in the study. Men and women over the age of 18 were included, provided that the aver...

Arterial hypertension (AH) is expected to contribute to approximately 13% of all deaths worldwide in the coming years. Objective — to perform retrospective analysis of the factors of the adverse course of the disease in patients with hypertension who were treated in a specialized department for secondary and pulmonary hypertension of the «NSC M. D....

The aim – to assess the arterial stiffness changes in patients with arterial hypertension (AH) and obstructive sleep apnea (OSA) and possibilities of its correction by continuous positive airway pressure (CPAP)-therapy.Materials and methods. 185 patients with mild and moderate AH (49.8±0.8 years old) were enrolled in the study and divided into grou...

Abstarct Aim This study aims to evaluate the left ventricle (LV) systolic and diastolic function in patients with idiopathic pulmonary arterial hypertension (IPAH) and its correlation with systemic arterial stiffness assessed by cardio-ankle vascular index (CAVI). Patient and methods We included 37 patients with IPAH and 20 healthy people matched...

In recent years, the method of determining the Cardio-Ankle Vascular Index (CAVI) has been introduced into clinical practice, which can be used to determine changes in the stiffness of the large arteries regardless of changes in blood pressure (BP). Aim. To compare the effect of 12-month angiotensin II receptor blocker (ARB) therapy with olmesartan...

Auteurs : the PRECISION investigators

Актуальність. Неконтрольований артеріальний тиск (АТ), особливо на фоні стресу, пов’язаний із чотириразовим збільшенням ризику розвитку серцево-судинних подій порівняно з пацієнтами з артеріальною гіпертензією (АГ), які досягли цільового рівня АТ. Стрес-індукована АГ — це гостре, транзиторне та лабільне підвищення АТ під впливом психосоціальних фак...

Background Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess th...

Hypertension is a key cardiovascular disease risk factor leading to premature mortality worldwide. The purpose of the May Measurement Month (MMM) campaign in Ukraine is to improve awareness of hypertension at the individual and population level. Adults (≥18 years) were screened at sites in Ukraine. Data from the MMM17 (19 sites), MMM18 (1 site), an...

The aim – determination of the relationship between arterial hypertension (AH) and hyperhomocysteinemia (H-Hcy) with the presence of atherosclerotic plaques in the carotid arteries.Materials and methods. Our research was carried out within the framework of the study HIPSTER in Ukraine. The study included 40 patients with I and II degrees of hyperte...

Background. Uncontrolled blood pressure (BP), especially in the context of stress, is associated with a fourfold increase in the risk of developing cardiovascular events compared to patients with hypertension who have reached the target BP level. Aim: to evaluate the mechanisms of the influence of stress on the development of hypertension, types of...

https://doi.org/10.1093/eurheartj/ehac237

The Pulmonary Vascular Research Institute (PVRI) GoDeep meta‐registry is a collaboration of pulmonary hypertension (PH) reference centers across the globe. Objectives: Merging worldwide PH data in a central meta‐registry to allow advanced analysis of the heterogeneity of PH and its groups/subgroups on a worldwide geographical, ethnical and etiologi...

Purpose – to investigate the frequency of peripheral arteries damage by determining theankle- brachial index (ABI) in patients with hypertension of 1-3 degrees of the older agecategory (> 55 years) using automatic devices for measuring blood pressure.Material and methods. The object of the study were patients with hypertension olderthan 55 years, 1...

The article analyzes the structure of cardiovascular diseases and mortality from their complications, as well as the effectiveness of their control over the results of studies, in particular, the international study EUROASPIRE V (2019). In order to improve the secondary prevention of cardiovascular disease, it is proposed to introduce into the prac...

The aim – to evaluate the diagnostic possibilities of using the method of speckle-tracking echocardiography (ST-Echo) in patients with idiopathic pulmonary arterial hypertension (IPAH) and to compare the results with a healthy population.Materials and methods. The study included 27 patients with IPAH and 9 people who were in the control group. Both...

Objective — to compare effects of spironolactone and moxonidine as the fourth component of the treatment of resistant hypertension (RT) on the stiffness of the main arteries. Materials and methods. We retrospectively selected 60 patients with resistant hypertension from the database of secondary and pulmonary hypertension, treated on the basis of M...

Objective: The aim of this study was to evaluate the effectiveness of new 2- or 3-component fixed-dose combinations (FDC) with Olmesartan in comparison with general clinical practice antihypertensive treatment. Design and method: 72 physicians were involved in the multicenter open-label study. They included patients with uncontrolled systolic (S...

Objective: Aim of this study was to evaluate dynamics of arterial stiffness using cardio-vascular index (CAVI), of the fixed triple combination of valsartan / amlodipine / hydrochlorothiazide and a double fixed combination of valsartan / amlodipine in the treatment of patients with arterial hypertension II-III degree depends on added statin therap...

In the presence of resistant hypertension, patients have a significantly higher risk of stroke, myocardial infarction, kidney disease, heart failure, and death than patients with elevated blood pressure. Increased arterial stiffness is an important factor in determining cardiovascular risk. Peripheral artery damage is a target organ lesion, and its...

Актуальність. Останнім часом в Україні зріс попит на призначення комбінованої антигіпертензивної терапії на амбулаторному етапі, однак даних щодо частоти використання фіксованих комбінацій раніше наведено не було. Мета дослідження: оцінити реальну практику застосування фіксованих комбінацій на амбулаторному етапі надання медичної допомоги в Україні...

Мета: оцінити антигіпертензивний ефект генеричного препарату телмісартан (Хіпотел виробництва компанії «Кусум Фарм», Україна) як монотерапії або в комбінації із S-амлодипіном (Семлопін виробництва компанії «Кусум Фарм», Україна) у пацієнтів із м’якою та помірною артеріальною гіпертензією (АГ). Матеріали та методи. У дослідження було включено 40 пац...

На сьогодні розроблена ефективна антигіпертензивна терапія, що значно знижує ризик серцево-судинних ускладнень у пацієнтів з артеріальною гіпертензією (АГ). Одним із завдань терапії АГ є забезпечення контролю показників артеріального тиску нижче від цільових рівнів, що сприяє зниженню ризику серцево-судинної захворюваності та смертності. Застосуван...

Актуальність. У літературі обговорюється застосування метаболічної терапії в пацієнтів із кардіологічною патологією, у тому числі вплив такої терапії на функцію ендотелію. Одним із найбільш популярних метаболічних препаратів є мельдоній. Метою нашого дослідження було вивчити вплив мельдонію в пацієнтів з артеріальною гіпертензією (АГ) та ішемічною...

Background. Pulmonary hypertension (PH) is a hemodynamic and pathophysiological condition characteri-zed by an increase in the average pressure in the pulmonary artery > 20 mm Hg and is evaluated according to the data of the right heart catheterization (RHC). In most cases, PH is not an independent disease but is a manifestation of other diseases....

The aim – evaluate the parameters of pulmonary and systemic hemodynamics obtained in patients with various forms of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) in Ukraine.Materials and methods. The study included 195 patients: IPAH was in 68 patients; PAH associated with connective tissue diseases...

Background Right ventricular (RV) function is well-known prognostic factor in patients with pulmonary hypertension (PH). However, situation becomes critical when underfilling of left ventricle (LV) leads to systemic hypoperfusion and scenario worsening. Objective To evaluate the relationship of RV and LV dysfunction in patients with the different...

Background Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are progressive condition with high mortality rate despite modern pharmacotherapy. There is no reliable data concerning influence of Covid-19 infection on PAH and CTEPH morbidity and mortality. Aim To evaluate influence 12-month Covid-19 pand...

The aim assess correlation the arterial stiffness in patients with resistant arterial hypertension (AH) and obstructive sleep apnea (OSA) Design 185 patients with AH were enrolled into the study. They were divided on 2 groups: OSA group – 148 patients were found to have OSA, indicated by at mean AHI of 38.1±2.5 h–1, and control group – 37 patients...

The structure of prescriptions of cardiac drugs by the primary care physicians has remained unknown for a long time. We decided to use the data of the OZIRKA study, which aimed to investigate the effect of Ozalex (rosuvastatin) on lipid and cholesterol levels in patients with lipid metabolism disorders and hypercholesterolemia, and to assess the st...

The aim – to evaluate the therapeutic efficacy and dynamics of arterial stiffness using сardio-ankle vascular index (CAVI), as well as the dynamics of erectile function in men of the generic fixed triple combination of valsartan/amlodipine/hydrochlorothiazide and a double fixed combination of valsartan/amlodipine in the treatment of patients with a...

The aim was to assess the arterial stiffness changes in patients with resistant arterial hypertension (AH) and obstructive sleep apnea (OSA) and possibilities of its correction by continuous positive airway pressure (CPAP)-therapy. Design: In 10 month follow-up study were included 46 patients with RAH, who were divided into groups: 1-st - patients...

Background. Obstructive sleep apnea (OSA), especially severe, is related to fatal and non-fatal cardiovascular events. OSA and arterial hypertension (AH) have significant correlations, and this comorbidity is very common and is associated with an increased risk of cardiovascular diseases. One of the causes is an increased arterial stiffness. Aortic...

Background. Diabetes mellitus (DM) remains one of the most important cardiovascular risk factors significantly worsening the prognosis in patients with hypertension and dyslipidemia. The leading role among drugs for the treatment of such patients belongs to statins with their powerful influence on the development and progression of atherosclerosis...

The lecture discusses the role of thiazide and thiazide-like diuretics, in particular chlorthalidone, in the modern treatment of arterial hypertension. The modern concepts about the mechanism of action of thiazide diuretics and chlorthalidone are presented. Differences in the degree of antihypertensive effect of hydrochlorothiazide and chlorthalido...

Background. Identification of risk factors and preliminary assessment of overall cardiovascular risk in patients with hypertension is the most important task in clinical practice. Most patients, in addition to high blood pressure (BP), have other cardiovascular risk factors that aggravate each other, leading to an increase in overall cardiovascular...

In recent decades, some monogenic forms of arterial hypertension have been identified. They were caused by specific pathways due to rare disruptive mutations in individual genes that determined an early and severe hypertension phenotype. At least 37 genes are known, the disruption of which is clearly accompanied by a dysfunction of the blood pressu...

Objective Glomerular filtration rate (eGFR) drop in patients with resistant hypertension and how different factors can affect on achievement of target blood pressure in patients with resistant hypertension and chronic kidney disease (CKD). To evaluate factors related with achievement of target blood pressure in patients with resistant hypertension...

Objective Aim. Evaluate the therapeutic efficacy of fixed triple combination of valsartan / amlodipine / hydrochlorothiazide compared a double fixed combination of valsartan / amlodipine in patients with arterial hypertension. Design and method The study included 50 patients with moderate and severe arterial hypertension. Patients were divided int...

Objective The aim of our study was to evaluate the prevalence of hyperhomocystinemia in patients with mild to moderate hypertension, to investigate the relationship between hyperhomocystinemia with arterial stiffness. Design and method In the study was included 40 patients with mild and moderate hypertension. Performed measurements of office SBP,...

Objective Previously it was shown that in a large cohort of unselected outpatients there was a strong independent association between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events which may be associated with inflammation. The aim of our analysis was to evaluate whether RDW was independently assoc...

Objective This study is the first attempt to use cardio-ankle vascular index (CAVI) for evaluation of systemic arterial stiffness in patients with idiopathic pulmonary arterial hypertension (IPAH). Design and method 45 patients with IPAH, 32 patients with arterial hypertension (AH), 35 healthy persons adjusted by age were included in study. RHC, E...

Background In a previous study, the cardio-ankle vascular index (CAVI) was increased significantly in idiopathic pulmonary arterial hypertension (IPAH) patients compared to the healthy group and did not much differ from one in systemic hypertensives. In this study the relations between survival and CAVI was evaluated in patients with IPAH. Patient...

Increased arterial stiffness is an important determinant of cardiovascular risk. Elevated total homocysteine (HC) levels appeared to be an independent risk factor for cardiovascular disease (CVD). To date, clinical studies on the relationship between HC and pulse wave velocity (PWV) assessment have shown conflicting results. Aim. To estimate the p...

Methods: We conducted a 17-question electronic survey among ECs. Results: Overall, 52 ECs from 20 European and three non-European countries participated, providing hypertension service for a median of 1500 hypertensive patients per center per year. Eighty-five percent of the ECs reported a shutdown lasting for 9 weeks (range 0-16). The number of pa...

The aim – to present to the medical community the functioning algorithm of the heart team concept in the diagnosis and surgical treatment of chronic thromboembolic pulmonary hypertension (CTEPH) in Ukraine. The concept of the CTEPH team implies a multi-disciplinary approach to the diagnosis and, consequently, surgical treatment of CTEPH with the pa...

Objective This study is the first attempt to use cardio-ankle vascular index (CAVI) for the evaluation of systemic arterial stiffness in patients with IPAH. Methods 112 patients were included in the study: group 1 – 45 patients with new diagnosed IPAH, group 2 – 32 patients with arterial hypertension, control group – 35 healthy persons adjusted by...

Background. In Ukraine, the number of statin prescriptions in recent years remains relatively low. A large-scale Ukrainian study OZIRKA would disprove some of the myths and demonstrate that long-term therapy with one of the most effective statins — rosuvastatin — in moderate and high doses is safe and effective in a large cohort of patients during...

This paper presents clinical case of pulmonary hypertension associated with left heart diseases (PH-LHD) in 63 year old woman with heart failure and preserved ejection fraction (HFpEF). The history of disease (arterial hypertension, atrial fibrillation, diabetes mellitus, acute pulmonary embolism, obesity, chronic obstructive lung disease) and resu...

Целью нашего исследования было оценить влияние блокаторов рецепторов к ангиотензину II (АТ II) — олмесартана, азилсартана и телмисартана при приеме их в утренние или вечерние часы на показатели артериального давления (АД) при суточном мониторировании. Материалы и методы. В исследование было включено 126 пациентов с мягкой и умеренной артериальной г...

В данной статье описывается клинический случай легочной гипертензии, ассоциированной с заболеванием левых отделов сердца (ЛГ-ЛОС), на фоне сердечной недостаточности с сохраненной фракцией выброса (СНсФВ) у женщины в возрасте 63 лет. История болезни (артериальная гипертензия, фибрилляция предсердий, сахарный диабет, тромбоэмболия легочных артерий, о...

This article is clinical presentation of pulmonary hypertension case, associated with rare lung disease – lymphangioleiomyomatosis. There are elucidated: diagnostic criteria of this disease, its prevalence, pathogenesis, including mechanisms of pulmonary hypertension development, clinical presentations and methods of treatment. Authors concluded so...

Сердечно-сосудистые заболевания остаются наиболее распространенными неинфекционными заболеваниями не только в Украине, но и во всем мире, однако наши представления о них накапливаются с каждым днем, появляются новые схемы лечения. Именно поэтому в последнее время мы наблюдаем обновления значительного массива кардиологических рекомендаций. Одной из...

on behalf of the VASOTENS Registry Study Group Objective: In this analysis of the telehealth-based Vascular health ASsessment Of The hypertENSive patients Registry, we checked how 24-h central and peripheral hemodynamics compare with hypertension-mediated organ damage (HMOD). Methods: In 646 hypertensive patients (mean age 52 AE 16 years, 54% males...

В данной статье приведен клинический случай легочной гипертензии (ЛГ), ассоциированной с редким заболеванием легких — лимфангиолейомиоматозом. Освещаются такие вопросы относительно данного заболевания: критерии диагностики, распространенность, основные пути патогенеза, в том числе механизмы развития ЛГ, клинические проявления, методы лечения. Делаю...

The aim – critical review of our own experience, its compliance with current recommendations and data from international registries, as also assessment of pulmonary and systemic hemodynamics obtained in patients with pulmonary arterial hypertension (PAH) in Ukraine. Materials and methods. 220 procedures of the right heart and pulmonary artery cathe...