Yuriy Nalapko

Lugansk State Medical University · Anesthesiology, Intensive Care and Emergency Medicine

Mitochondria are major organelles that produce energy for cellular metabolism and are vital to proper cell functioning. Metabolic dysregulation is a critical contributing factor to the initiation and development of degenerative and autoimmune diseases, thus is present in cartilage disorders such as osteoarthritis and rheumatoid arthritis. Mitochond...

Type 1 Diabetes Mellitus (T1DM) is an important autoimmune disease characterized by the destruction of insulin-secreting beta cells in pancreatic islets of Langerhans. A deficiency in insulin level results in hyperglycemia in diabetic patients. The management of T1DM requires lifelong daily injections of exogenous insulin to control blood sugar lev...

Cartilage diseases refer to an umbrella of joint disorders, joint injuries and cartilage tumors that are largely characterized by degenerative chondrocyte changes in joints. Osteoarthritis (OA) is the most common form of chronic cartilage diseases, affecting 250 million people and is the fourth leading cause of disability worldwide. The widely used...

Purpose Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed to assess frailty, but few of them can be used in emergency situations. In this setting the clinical frailty scale (CFS) is fre...

Background Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients. Methods We i...

Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score...

Background Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear. Objective To...

Background: The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determ...

Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and 3582 (47%) female patients. The...

Genome of eukaryotic cells contains up to 69% of the transposable elements and repetitive sequences. To a large extent it is a result of billions of years of evolution through which eukaryotes were encountering gazillions of viruses and storing the footprints of those encounters in its genome. This time Mankind deals with a novel virus belonging to...

Genome of eukaryotic cells contains up to 69% of the transposable elements and repetitive sequences. To a large extent it is a result of billions of years of evolution through which eukaryotes were encountering gazillions of viruses and storing the footprints of those encounters in its genome. This time Mankind deals with a novel virus belonging to...

Genome of eukaryotic cells contains up to 69% of the transposable elements and repetitive sequences. To a large extent it is a result of billions of years of evolution through which eukaryotes were encountering gazillions of viruses and storing the footprints of those encounters in its genome. This time Mankind deals with a novel virus belonging to...

Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function that happens over time and from the point of view of modern conventional medicine is considered to be an incurable and irreversible disease. The main risk factors attributing to CKR are diabetes mellitus, hypertension, glomerulonephritis, renal artery stenosis and fa...

Genome of eukaryotic cells contains up to 69% of the transposable elements and repetitive sequences. To a large extent it is a result of billions of years of evolution through which eukaryotes were encountering gazillions of viruses and storing the footprints of those encounters in its genome. This time Mankind deals with a novel virus belonging to...

Purpose Premorbid conditions affect prognosis of acutely-ill aged patients. Several lines of evidence suggest geriatric syndromes need to be assessed but little is known on their relative effect on the 30-day survival after ICU admission. The primary aim of this study was to describe the prevalence of frailty, cognition decline and activity of dail...

Role of cell therapy in regenerative medicine. Qualitative and quantitative analysis of cell therapy's outcomes weas attempted to be done. Discussions on safety and efficacy.

Phosphatidylcholine is a polyunsaturated fatty acid compound and is an essential cell membrane phospholipid. It is important in maintaining normal membrane structure and increase cell protection against external factors. Maintenance of the integrity of the cell membrane is vital as destructive cell membrane results in the release of lowdensity lipo...

Background: Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection...

Background Infections are a leading cause of death in patients with advanced cirrhosis, but there are relatively few data on the epidemiology of infection in intensive care unit (ICU) patients with cirrhosis. AimsWe used data from the Extended Prevalence of Infection in Intensive Care (EPIC) II one-day point-prevalence study to better define the ch...

З метою виявлення рівня глікемії, що є несприятливим фактором перебігу тяжкої поєднаної травми, було обстежено 66 постраждалих, які перебували на лікуванні у відділенні інтенсивної терапії. За допомогою виявлення ініціального рівня глікемії та статистичного аналізу доведено, що рівень глюкози крові понад 8,3 ммоль/л є прогностичним критерієм розвит...

Мета роботи — встановити гемодинамічні профілі постраждалих із тяжкою поєднаною травмою при різних програмах адреноміметичної підтримки. У дослідження включені 84 постра­ждалих із тяжкою поєднаною травмою, які для підтримки гемодинаміки потребували проведення адреноміметичної корекції. Залежно від адреноміметичного препарату, що використовувався (д...

В статье проведен анализ применения метода интрагастральной pH-метрии в клинической практике и его диагностических возможностей. Отмечены преимущества и недостатки на примере интрагастральной pH-метрии. Освещены диагностические задачи метода, а также представлена информация об основных современных приборах для pH-метрии. Авторы предлагают перспекти...

To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and...

A.G.Salmanov, V.F.Marievskiy, Yu.I.Nalapko. Analysis of etiology and antimicrobial resistance of the main nosocomial pathogens isolated from the surgical department. Key words: nosocomial infections, etiology, epidemiology, antimicrobial resistance. Nosocomial infections are very important cause of morbidity and mortality in all developed countrie...

A.G.Salmanov, V.F.Marievskiy, S.I.Doan, Yu.I.Nalapko, O.M.Ruban. Antibacterial resistance of basic agents of nosocomial purulent inflammatory infexctions in surgical departments. Key words: hospital department, infections, antibacterial resistance. The investigation of leading agents of purulent inflammatory infections in the departments of surger...

V.F.Marievskiy. A.G.Salmanov, S.I.Doan, O.I.Polischuk, Yu.I.Nalapko. Analysis of ethiological structure of agents of purulent inflammatory infections in surgical departments of Ukraine in 2008. Kyiv, Lugansk, Ukraine. Key words: hospital infections, microorganisms, structure. The investigation of structure of agents of purulent inflammatory infect...