Yuri Natochin

Yuri Natochin
Russian Academy of Sciences | RAS · I.M. Sechenov Institute Of Evolutionary Physiology And Biochemistry Of The Russian Academy

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35
Publications
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309
Citations

Publications

Publications (35)
Article
Full-text available
Aim. The study of ion- and osmoregulating renal functions in patients with type 2 diabetes mellitus (T2DM) for individual predictive assessment of renal response to exenatide treatment. Materials and methods. In total, 41 patients with T2DM were included in the study (12 males, 29 females). Compensated and subcompensated heart failure was observed...
Article
The results of joint studies and approaches to solve difficult problems of pathogenesis and treatment of patients in the departments of nephrology and pulmonology were analyzed. The studies have been done over 40 years in common by workers of Pediatric University and Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy...
Article
The aim of the present study was an investigation of mechanisms mediating selective effect of vasotocin analogues on water, sodium, and potassium excretion. We tested vasotocin analogues: Mpa(1)-vasotocin (dAVT), Mpa(1)-Arg(4)-vasotocin (dAAVT) and Mpa(1)-DArg(8)-vasotocin (dDAVT). The effects on water, sodium, and potassium transport were evaluate...
Article
The aim of the present study was to clarify the mechanisms mediating the effect of a glucagon-like peptide-1 (GLP-1) mimetic on solute-free water excretion in rats. GLP-1 mimetic (exenatide, 0.05-5.0 nmol/kg, i.m.) alone and with a V2 -antagonist (15 nmol/kg, i.p.) or vasopressin (0.01 nmol/kg, i.m.) was injected into control and water-loaded (wate...
Article
Vasopressin and nonmammalian hormone vasotocin are known to increase the water permeability of mammalian collecting ducts, frog skin and the urinary bladder. Neurohypophysial nonapeptides have also been shown to interfere with the regulation of renal ion transport. The subject of this study was a search for vasopressin and vasotocin analogues with...
Article
Full-text available
Prebiotic peptide formation under aqueous conditions in the presence of metal ions is one of the plausible triggers of the emergence of life. The salt-induced peptide formation reaction has been suggested as being prebiotically relevant and was examined for the formation of peptides in NaCl solutions. In previous work we have argued that the first...
Article
1-Deamino-arginine vasotocin (1dAVT) induced diuresis and a considerable increase in urinary sodium excretion in female Wistar rats. Sodium fractional excretion rose up to 19.3 ± 1.1%. An increase in urine flow rate after 1dAVT (0.5 nmol/kg body-weight [bw]) injection was accompanied by a significant rise of the solute-free water reabsorption. The...
Article
Injections of furosemide at a dose of 0.3 μmol per 100 g body weight or 1-deamino-arginine-vasotocin (1dAVT) at a dose of 0.05 nmol per 100 g body weight induced nearly equal increase in urinary sodium excretion: up to 406 ±20 and 405±23 μmol/2 h, respectively. Increase in urinary sodium excretion after injection of 1d-AVT was followed by enhanceme...
Article
Experiments on healthy rats showed that increased diuresis induced by administration of water, polyethylene glycol 400, furosemide, or 1-desamino-arginine-vasotocin is associated with increased protein excretion by the kidneys. The results can be explained by enhanced filtration of plasma proteins in glomeruli during polyuria of various geneses.
Article
Children with acute pyelonephritis develop polyuria and have reduced maximum urinary concentration capacity. We studied whether these abnormalities are associated with altered urinary excretion of the water channel aquaporin-2 (AQP2) in the renal collecting duct. AQP2 is the main target for antidiuretic action of arginine vasopressin (AVP), and the...
Article
The experiments conducted in vitro on isolated ileum segments (with introduced AVT) and bladders (as test objects) of frogs Rana temporaria L. indicate the absorption of cyclic nonapeptide - AVT in frog's ileum with retaining its high physiologic activity.
Article
Renal function was studied in 62 children with primary nocturnal enuresis (PNE) and in 20 healthy children aged 6-15 years. During the night, children with PNE exhibited an increase in diuresis, free water reabsorption and solute excretion (including sodium and magnesium) in comparison to controls. Intranasal administration of Adiuretin-SD (10.5-24...
Article
Twenty children with primary nocturnal enuresis and 20 healthy children of the same age and sex were studied. Natural urination was used for the 24-h urine collection. It was found that urine osmolality and free water reabsorption during the night did not differ statistically significantly between the enuretic children and the healthy. The increase...
Article
1. The application of 1 mM CdCl2 to the outside surface of frog skin causes a large increase in the potential difference (PD) across the skin and in the short-circuit current (SCC); the subsequent addition of selected dithiocarbamate chelating agents (which by themselves have no effect on PD or SCC) restored both electrical parameters to values clo...
Article
Experiments were carried out on the cockroach Nauphoeta cinerea and larvae of cabbage moth Mamestra brassicae. A significant decrease of body mass was observed 24 h after the application of dichlorophos, lindane, or Decis, amounting to 6.8% in the cockroach and 26.8% in the caterpillars. -after Journal
Article
Full-text available
In the blood serum of the bream, stress condition due to captivation decreases the osmolality and sodium level resulting in the increase of the volume of muscle cells. During anadromous migration, return of the pink salmon from river to the sea is accompanied by the increase in osmolality and sodium level in the blood serum, as well as by the decre...
Article
Full-text available
The kidney is an organ of complex structure and function, a fact that is increasingly revealed as our investigations proceed. We have witnessed a progression from recognition of a single nephron to three types of nephrons, of four main tubular parts (proximal tubule, intermediate tubule, distal tubule, collecting duct) to several subdivisions of th...
Article
Within a few months after denervation of the dog kidney, during its reinnervation, an increased excretion of calcium and copper was observed, whereas the excretion of zinc, magnesium, sodium, potassium and chloride ions was the same as in the opposite intact kidney. Addition of copper or zinc ions to the outside frog skin was shown to increase the...
Chapter
This chapter reviews that the early forms of vertebrates have developed the principle of structural, functional, and chemical organization of the nephron, and have assured possible changes in the cell activity of the nephron under the influence of humoral or nervous stimulation. During evolution the renal structure has become more sophisticated, ne...
Article
On addition to the solution on the side of the outer surface of the frog skin of ethacrynic acid (0·063-1·0 mg/ml) or mersalyl (0·2-1·0 mg/ml) as in the case of furosemide, the potential difference rises for 1-2 min by tens of millivolts with unchanged or increased short circuit current. This is apparently due to the block of the chloride channels...
Article
A similarity was found in the stages of development of the osmoregulatory function of the kidney in the phylogenesis of vertebrates, in the ontogenesis of mammals, and in the clinical picture of the recovery period after acute renal insufficiency. A study of the excretion of ions (Na, K, Ca, Mg, Cl, SO4, PO4) by the kidney of representatives of all...

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