Yuri KarpenkoZaporozhye State Medical University | ZSMU · Inorganic Chemistry
Yuri Karpenko
PhD in Chemistry
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25
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Introduction
Publications
Publications (25)
1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are of both
theoretical and practical interest. This class has been known for about 100 years, and in recent
decades 1,2,4-triazoles have become one of the most attractive objects of research in the chemistry
of heterocyclic compounds due to their unique properties. Recentl...
1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are of both theoretical and practical interest. This class has been known for about 100 years, and in recent decades 1,2,4-triazoles have become one of the most attractive objects of research in the chemistry of heterocyclic compounds due to their unique properties. Recentl...
Due to the study of the toxicity of 1,2,4-triazole derivatives by non-experimental methods using GUSAR
and TEST models, it was found that the test compounds could be classified as low-toxic substances.
The compound is an organic salt that exists in the crystal as a solvate with one molecule of methanol and two
molecules of water. When studying the...
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishing patterns “structure – biological activity”. The...
From ancient times the people used different poisons as a treatment for diseases of different genesis. To date, almost nothing has changed. One of the main conditions for the development of a new drug is its low toxicity. Literature analysis has shown that 1,2,4-triazole-3-thione derivatives are low-toxic compounds and exhibit a wide range of pharm...
At the present stage of development of medical chemistry, many basic synthetic approaches to the synthesis of 1,3,4-oxadiazole structures are known, which are focused mainly on the principles of combinatorial chemistry with a wide range of biological activity.
The aim of the work was searching, systematizing, and generalizing literature sources fo...
2020.-Т. 13, №1(32) Оригінальні дослідження Оriginal research Молекулярний докінг і біодоступність S-алкіл похідних 5-(3-флуорофеніл)-, 5-(5-бромофуран-2-іл)-та 5-(((3-(піридин-4-іл)-1H-1,2,4-тріазол-5-іл)тіо)метил)-4-метил-4H-1,2,4-тріазолів in silico методами Запорізький державний медичний університет, Україна A-концепція та дизайн дослідження; B...
A combination of two rings of 1,2,4-triazole with the formation of new hybrids, bis-1,2,4-triazoles, with various functional groups and
pharmacophores may comprise a promising class of the biologically active compounds. Alkaline phosphatases belong to a broad family
of enzymes, ectonucleotidases, which are responsible for the dephosphorylation of n...
It is considered that necessity of developing safe medications is one of the most important issues of pharmaceutical industry and bioorganic chemistry. Searching for new biologically active substances is linked, primarily, with existence of negative side effects. The second reason for continuation of the research is appearance of the new, resistant...
One of the important problems of medical and organic chemistry is the creation of new highly active and safe medical substances. Justification of the search is also conditioned by the presence in some cases of undesirable side effects in the existing drugs and the acquisition of the resistance of microorganisms to them. Not only substances of natur...
The synthesis of new hybrides 1,3,4-oxadiazol-2-thione with acridine 9(10H)-one is carried out. Their structure is confirmed by LC-MS, IR-,¹H and¹³C NMR-spectroscopy. The thione-thiol equilibrium was investigated in eight solvents with different relative permittivity with the help of UV-spectroscopy and quantum chemistry methods using DFT/B3LYP and...
The combination in one molecule of two pharmacophore fragments, the acridine
and azole heterocycle linked by a methylene bridge, can lead to the formation of
compounds exhibiting a wide range of biological activity. The pharmacological aspect of
such heterocyclic systems is of particular interest, so far as π-electron-deficient
heterocycles, includ...
SYNTHESIS AND TRANSFORMATION OF
10-((5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)METHYL)-2R-ACRIDIN-9(10H)-ONES
Ліпофільність - це фізико-хімічна властивість, що має вирішальне значення в біоорганічній, фармацевтичній та медичній хімії.
З проаналізованих літературних джерел, було встановлено тісний взаємозв’язок між адсорбційними властивостями сполуки та зростанням показників її біологічної дії. Встановлено, що затримка сполуки в рідинній та тонкошарової хро...
Дослідження стосується синтезу гідразидів 2-(2R-9-оксоакридин-10(9H)-іл)етанових кислот, які завдяки своїй реакційній здатності широко використовуються для синтезу різних азотовмісних гетероциклічних систем, таких як 1,3,4-оксадіазол, 1,2,4-тріазол та 1,3,4-тіадіазол. N-заміщені гідразиди 2-(2R-9-оксоакридин-10(9Н)-іл)етанових кислот знаходять своє...
The synthesis and research of acute toxicity of new 1,3,4-oxadiazole-2-thione hybrids with acridine-9(10H)-one are given in the work. By means of heterocyclization reaction of the appropriate 2-(2R-9-oxoacridine-10(9H)-yl)acetohydrazides under the action of a carbon disulfide, a system was synthesized with isolated heterocycles which is coupled by...
Lipophilicities of the s-derivatives of 10-((5-mercapto-1,3,4-oxadiazol-2-yl)methyl)-2R-acridine-9(10H)-ones have been studied by various chromatographic methods and the results were compared with those obtained from the distribution method in binary n-octanol/water system. The linear relationships between the chromatographic parameters (t R , R M...
At the present stage of development of organic chemistry there are a lot of basic synthetic approaches to synthesis of 1,3,4-oksadiazole derivatives with a wide spectrum of biological activity. The heterocyclic systems which contain 1,3,4-oksadiazole nucleus have a rich synthetic history and they are characterized by a wide range of methods of synt...
Стаття є оглядом проблеми пошуку нових біологічно активних речовин. Як перспективний клас сполук розглянуто похідні N-заміщених акридин-9-ону й 2,5-заміщених 1,3,4-оксадіазолів, відзначені їхні фармакологічні властивості. Похідні N-заміщеного акридин-9-ону, а саме акридинооцтова кислота і її гідразид за рахунок високої ліпофільності, плоского трици...
Using the computer program PASS (Prediction Activitity Spectra for Substances) was created the combinatorial library of bioregulators in order to determine the direction of research of bioactive substances on the basis of the structures of 5,8-dioksoquinoline and furan (1-8), quinoline and triazole (9-12).
Materials and results. It is established t...
