Yuping Wu

Yuping Wu

About

90
Publications
13,841
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1,356
Citations
Citations since 2017
43 Research Items
945 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200

Publications

Publications (90)
Article
Quantifying demographic parameters and patterns of social dynamics is fundamental to understanding the population ecology of group-living animals and carries considerable conservation implications. In the Pearl River Delta (PRD) region, one of the world’s largest, most urbanised and industrialised estuarine systems located on the southeast coast of...
Article
The bans on bisphenol A (BPA) have facilitated the widespread use of BPA alternatives and shifted environmental contamination profiles of bisphenols (BPs). However, the continued reports of toxicities of emerging BPA alternatives have raised questions about whether the shifting profiles are contributed to mitigate BPs-mediated endocrine-disruption...
Article
Although many studies have documented the wide occurrence of polybrominated diphenyl ethers (PBDEs) in cetaceans, little evidence exists regarding the detrimental effects of PBDE exposure on calf death rates for free-ranging cetaceans. This study analyzed life-history-associated PBDE bioaccumulation patterns in 128 stranding Indo-Pacific humpback d...
Article
Full-text available
Reserve planning based on the investigation of the core habitat distribution of wild cetaceans is a powerful conservation strategy for protecting target species. However, studies on core habitats and their variations at the large-scale distribution of cetaceans are limited. In this study, we conducted a seven years (2015-2021) boat-based field obse...
Article
Per- and polyfluoroalkyl substances (PFASs) levels in Indo-Pacific finless porpoises (Neophocaena phocaenoides) in the Pearl River Estuary (PRE), near the most economically developed region in China, have not been characterized. We measured the hepatic concentrations of twelve PFASs, including nine perfluoroalkyl carboxylic acids (PFCAs) and three...
Article
Phthalate esters (PAEs) are ubiquitous environmental contaminants, arising growing public concern. Nevertheless, information on the exposure and risks of PAEs in wildlife remains limited. Here, we conducted the first investigation of the occurrences, spatiotemporal trends, and potential risks of twelve metabolites of PAEs (mPAEs) in 74 humpback dol...
Article
Marine mammals often accumulate high levels of environmental contaminants, even those that are globally regulated regarding usage, raising concerns about their health status. Here, we conducted the first investigation of tissue distribution, spatiotemporal trends, and potential risks of six organotin compounds (OTs) in Indo-Pacific humpback dolphin...
Article
Full-text available
Bisphenol analogues (BPs) are ubiquitous pollutants to marine organisms as endocrine disruptive chemicals. However, the residue contamination and the trophic transfer of BPs in the apex predator nearshore dolphins are poorly studied. Here, we measured the concentrations of six BPs, including bisphenol A (BPA), bisphenol AF (BPAF), bisphenol B (BPB)...
Article
With the dramatic increase in anthropogenic threats to the Pearl River Estuary (PRE), the population size of the Indo-Pacific humpback dolphins (Sousa chinensis) has significantly decreased over the past decade. To understand the impact and potential risks of intense human activities on these dolphins, factors related to the mortality of humpback d...
Article
Accurate diet estimation of marine mammals is fundamental to investigate their ecological roles in marine habitats, but it remains a pervasive challenge to researchers due to the constraints associated with conventional methods based on stomach contents or feces analysis, which are imprecise, limited to last meal and often biased. Quantitative fatt...
Article
The placental transfer and congener composition of organic contaminants (OCs) in Indo-Pacific humpback dolphins have been little studied. In the present study, 16 polycyclic aromatic hydrocarbons (PAHs), 18 organochlorine pesticides (OCPs), and 28 polychlorinated biphenyl (PCB) congeners were analyzed in muscle, lung, liver, kidney, and blubber tis...
Article
Polychlorinated biphenyls (PCBs), as a type of legacy persistent organic pollutants, pose significant health threats to wildlife. However, long-term residue changes and profiles of PCBs in cetaceans have not been extensively studied in the Pearl River Estuary (PRE), an important marine mammal area in China. Here, the body burdens, spatiotemporal tr...
Article
While polychlorinated biphenyl (PCB)-related risks have been reported at the cellular, organ, and individual levels in some marine mammals, studies quantifying the PCB-associated population-level effects are limited. Here, we combined chemical analysis and individual-based model simulation to investigate the impact of PCBs on the Indo-Pacific humpb...
Article
The Pearl River Delta (PRD) region on the southeast coast of China has long been known as a highly productive fishing ground. Since the late 1980s, fishing pressure in the PRD has been intense, which warrants concerns of potential fishery-related impacts on the food resources and foraging ecology of apex marine predators in this region, such as the...
Article
Microplastic pollution is a growing concern worldwide. Despite numerous studies showing the occurrence of microplastics in low-trophic level aquatic organisms, microplastic ingestion and contamination in cetaceans, especially those from Asian waters, has been rarely recorded. Here, we investigated stomach microplastic pollution in twelve Indo-Pacif...
Article
• The estuaries within the Pearl River Delta are sites for large‐scale urban development and offshore construction. These projects have conservation stakeholders calling for more protection for the Indo‐Pacific humpback dolphins whose habitat overlaps with current and proposed construction sites. • Efforts to improve impact assessments are hindered...
Article
We examined spatiotemporal trends of diet compositions and their relationship with pollutant accumulation levels in 46 weaning Indo-Pacific humpback dolphins (n = 46) from 2004 to 2017 in the Pearl River Estuary (PRE) based on blubber fatty acid signatures using quantitative fatty acid signature analysis in R (QFASAR). Fifty-one potential prey spec...
Article
Full-text available
The author would like to correct the formula in the publication of the original article.
Article
There is little information about the residue levels and congener composition of organic contaminants (OCs) in cetaceans. In the present study, we investigated the polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in the blubber, blood, brain and testes of Indo-Pacific humpback dolphins (...
Article
Full-text available
Age composition is an important population parameter for understanding and managing endangered species. There are very few studies involving cetaceans in estimating the age of individuals in the wild. In this study, we rigorously quantified the body color pattern of 37 stranded Indo-Pacific humpback dolphins (Sousa chinensis) of the Pearl River Est...
Article
Full-text available
Evaluation of fish nutritional content information could provide essential guidance for seafood consumption and human health protection. This study investigated the lipid contents, fatty acid compositions, and nutritional qualities of 22 commercially important marine fish species from the Pearl River Estuary (PRE), South China Sea. All the analyzed...
Article
Cetaceans and humans shared the same route of exposure to many anthropogenic contaminants via fish consumption. To assess the health risks associated with heavy metal levels in fishes from the Pearl River Estuary (PRE) and the seasonal dynamics, 13 fish species (n = 675) consumed by the Indo-Pacific humpback dolphins (Sousa chinensis) and humans we...
Article
Full-text available
Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as “Vulnerable” on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we sequenced and assembled a draf...
Article
Twelve persistent organic pollutants (POPs) were measured in 11 tissue samples from a pregnant sperm whale stranded on the Huizhou coast of the South China Sea, China, in March 2017. POPs were found to be more concentrated in the irrigated tissues such as placenta, ovary, mammary gland, and liver than the less irrigated tissues such as epidermis. H...
Article
1. The finless porpoise (genus Neophocaena) is susceptible to fishery‐caused mortality, and its numbers are thought to be in decline across its entire range. However, population demographics have rarely been quantified for this genus, with a few exceptions of the narrow‐ridged form (Neophocaena asiaeorientalis) in waters off Japan, Korea, and in th...
Article
Sixteen per- and polyfluoroalkyl substances (PFASs) were measured in liver (n = 52) and kidney (n = 18) tissues of Indo-Pacific humpback dolphins (Sousa chinensis) stranded in the Pearl River Estuary (PRE) of China between 2004 and 2016. The average concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and most of other...
Article
As long-lived apex predators in the Pearl River Estuary (PRE) of China, Indo-Pacific humpback dolphins (Sousa chinensis) are particularly vulnerable to anthropogenic impact and may undergo considerable ecological trait changes. The variability of traits, however, is often difficult to trace back in nature. Here, we analyzed stable isotope ratios of...
Article
A high prevalence of infectious diseases (mostly lungworms) is found in finless porpoises (genus Neophocaena) in the coastal waters of China, which is one of the most dichlorodiphenyltrichloroethane (DDT)-polluted areas worldwide, while its association with contaminant exposure remains undetermined. To address this gap, we investigated blubber leve...
Article
We investigated the levels and trends of the 16 USEPA priority PAHs in the blubber of 37 Indo-Pacific humpback dolphins sampled during the period 2012–2017 from the Pearl River Estuary (PRE), China. Σ 16 PAHs concentrations (17.6–6080 ng g−1 wet weight) were at median level compared to dolphin species worldwide. Humpback dolphins affiliated with the h...
Article
Trace element accumulation in the epidermis of cetaceans has been less studied. This study explored the feasibility of using epidermis as a surrogate tissue to evaluate internal contaminant burdens in Indo-Pacific humpback dolphin (Sousa chinensis). Eleven trace elements were analyzed in the epidermis, muscle and liver tissues from 46 individuals o...
Article
Full-text available
The finless porpoise (genus Neophocaena) is a poorly known cetacean of great conservation concern. Within its range, from western Pacific to northwestern Indian Ocean, there are currently two species recognized (N. asiaeorientalis and N. phocaenoides), thought to be reproductively isolated since last glacial maximum, with the only sympatric overlap...
Article
Full-text available
We assessed the spatio-temporal trends of the concentrations of 11 heavy metals (HMs) in the liver and kidney of Indo-Pacific humpback dolphins (Sousa chinensis) from western Pearl River Estuary (PRE) during 2004-2015. The hepatic levels of Cr, As and Cu in these dolphins were among the highest reported for cetaceans globally, and the levels of Zn,...
Article
To gain the basic knowledge about cetacean conservation, we assessed the polymorphism and expression of the immunologic gene MHC-I (Major Histocompatibility Complex class I) in three cetaceans (Sousa chinensis, Neophocaena phocaenoides, and Stenella attenuata) around the Pearl River Estuary. We first confirmed the expression of MHC-I genes in the t...
Article
Full-text available
Over the past few thousand years, human development and population expansion in southern China have led to local extirpation and population contraction of many terrestrial animals. At what extent this early human-induced environmental change has also affected coastal marine species remains poorly known. We investigated the demographic history of th...
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Full-text available
Infanticide has been observed in several mammalian taxa and studied in considerable detail in carnivores and primates. Although reported previously in cetaceans, known cases are few and their socio-behavioral context remains poorly understood. We report here on three cases of social coercion directed at mother-neonate pairs of Indo-Pacific humpback...
Article
Full-text available
The continuous disposal of persistent organic pollutants (POPs) in South Africa (SA) warrants concern about their detrimental effects on humans and wildlife. We surveyed six dolphin species (n=90) incidentally captured in shark net installations or stranded off the SA east and south coast from 2005 to 2009 to study the POP exposure. Sousa plumbea,...
Article
It has been widely reported that the major histocompatibility complex (MHC) is under balancing selection due to its immune function across terrestrial and aquatic mammals. The comprehensive studies at MHC and other neutral loci could give us a synthetic evaluation about the major force determining genetic diversity of species. Previously, a low lev...
Article
Full-text available
In coastal waters of the Pearl River Delta (PRD) region, the Indo-Pacific humpback dolphin (Sousa chinensis) is thought to number approximately 2500 individuals. Given these figures, the putative PRD population may appear strong enough to resist demographic stochasticity and environmental pressures. However, living in close proximity to the world's...
Article
Full-text available
In coastal waters of the Pearl River Delta (PRD) region, the Indo-Pacific humpback dolphin (Sousa chinensis) is thought to number approximately 2500 individuals. Given these figures, the putative PRD population may appear strong enough to resist demographic stochasticity and environmental pressures. However, living in close proximity to the world's...
Article
Full-text available
As top predators in the Pearl River Estuary (PRE) of China, Indo-Pacific humpback dolphins (Sousa chinensis) are bioindicators for examining regional trends of environmental contaminants in the PRE. We examined samples from stranded S. chinensis in the PRE, collected since 2004, to study the distribution and fate of total mercury (THg), methylmercu...
Article
Full-text available
We used 344 mitochondrial control region (717 bp) sequences from the finless porpoise (genus Neophocaena) from the northwestern Pacific to investigate the extent and manner in which past climatic oscillations may have shaped patterns of genetic diversity for this marine mammal. Both SplitsTree and Analysis of Molecular Variance (AMOVA) revealed the...
Article
Full-text available
Much of the knowledge about the wide-ranging finless porpoise species (Neophocaena phocaenoides) remains limited, as well as its phylogenetic relationship with another taxa (N. asiaeorientalis) in genus Neophocaena. Using 11 microsatellite loci, we first investigated population differentiation of N. phocaenoides within the Pearl River Estuary (PRE)...
Article
Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts across China, and thus to evaluate...
Article
Full-text available
The Indo-Pacific humpback dolphin (Sousa chinensis), a marine mammal species inhabited in the waters of Southeast Asia, South Africa and Australia, has attracted much attention because of the dramatic decline in population size in the past decades, which raises the concern of extinction. So far, this species is poorly characterized at molecular lev...
Article
The marine mammalian Indo-Pacific humpback dolphin, once widely lived in waters of the Indian to western Pacific oceans, has become an endangered species. The individual number of this dolphin has significantly declined in recent decades, which raises the concern of extinction. Direct concentration on laboratorial conservation of the genetic and ce...
Article
The effectiveness of the E2/E6 ratio, the state of viral genome integration and the viral load of human papillomavirus 16 (HPV 16) in predicting the risk of cervical cancer among Chinese women was investigated. Quantitative PCRs for the E2/E6 ratio and the viral load were performed on 85 cervical cancer samples and 55 HPV 16 positive healthy contro...
Article
Estimating the degree of isolation or gene flow is central to understanding population dynamics and conservation. In this study, we used both mitochondrial and nuclear markers to investigate the genetic structure of Indo-Pacific humpback dolphins (genus Sousa) in China. Contrary to previous photo-identification and genetic studies, we found no evid...
Data
The Sketch Map of Construction of HLA-DRB1 Promoter Vectors. Only the reporter gene and its 5′ flanking region in which the multiple clonal sites are located, were shown on the sketch. The numbers in the parenthesis following the names of restriction endonuclease (REN) denote the relative positions of the RENs at the vector sequence. The rectangles...
Data
The Sketch Map of Construction of HLA-DRB1 3′UTR and recombinant Vectors. Only the reporter gene and its 5′ flanking region in which the multiple clonal sites are located were shown on the sketch. The numbers in the parenthesis following the names of restriction endonuclease (REN) denote the relative positions of the RENs at the vector sequence. Th...
Data
Neutral test in DRB1 promoter region and 3′ non-coding region with our data. (XLS)
Data
Phylogenetic Analysis for the 3′-UTR and 3′-UTR Downstream Sequences (3′-UTR-DS). Taxon names that designated with UTH plus numbers represent haplotypes containing 3′-UTR or 3′-UTR downstream sequences. UTHx signifies that the haplotype is distinct from the others. The arrow indicated the different position of the UTHx haplotype on the 3′-UTR tree...
Data
Polymorphism in the Core Promoter Region of Partial DRB Alleles from human, chimpanzee, rhesus and marmoset. The numbering is relative to the transcription start site. The cis-element box was encircled with a pane and the core sequence in a cis-element box was marked with underline. (JPG)
Data
The Sketch of the Relative Position of Primers at HLA-DRB1 Gene. The number – represents the primers at certain position, for example, represents the 5 primers designated as H1ASP1R, H21ASP1R, H22ASP1R, H3ASP1R and H4ASP1R which are specific for different sequence lineage. The distance marked in the figure denotes the approximate size of PCR produc...
Data
All primer sequences involved in this paper. (XLS)
Data
Slide Window Analysis for Nucleotide Polymorphisms and Frequency Spectrum Analysis for the Promoter Sequences of HLA-DRB1. A mutation of size i means that is occurs i times in our sample of 52 sequences. The thin line represents the expected frequency spectrum in neutral equilibrium, and the black bars denote the observed values. (JPG)
Article
Full-text available
HLA-DRB1 is the most polymorphic MHC (major histocompatibility complex) class II gene in human, and plays a crucial role in the development and function of the immune system. Extensive polymorphisms exist in the promoter and 3'-UTR of HLA-DRB1, especially a LTR (Long terminal repeat) element in the promoter, which may be involved in the expression...
Article
During a survey of control region (D-loop) sequence variances in 142 cervical cancer (CC) patients and 136 controls, all Chinese women, including both HPV-positive (human papillomavirus) and HPV-negative subjects, we determined that the C150T polymorphism increased the CC risk in a case-control study (OR=3.0, 95% CI=1.8-5.0, P<0.05). HPV-positive i...
Article
Taxonomy within genus Sousa is confused largely due to inconsistencies among external morphology, skull morphology, pigmentation patterns and molecular studies. Here we provide our understanding of the evolution of Sousa chinensis by proposing a phylogeographic history based on mtDNA study. It is proposed that the species originated in eastern Aust...
Article
To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans. The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans. The frequencies of allelic types B/B, haplotype B w...
Article
Human leukocyte antigen (HLA) alleles have been associated with an increased or decreased risk of developing cervical cancer through infection with oncogenic forms of the human papillomavirus (HPV). The aim of this study was to analyze the interactions between HPV and HLA, particularly of the entire HLA and partial non-HLA regions, in invasive cerv...
Article
Full-text available
In this study, the mitochondrial DNA (mtDNA) control region and the mitochondrial cytochrome b gene of stranded Indo-Pacific humpback dolphin (Sousa chinensis) samples from the Pearl River Estuary and Xiamen waters were sequenced and analyzed. The result of mtDNA control region revealed 34 variable sites and four unique haplotypes (named as A, B, C...
Article
The issue about the origin of the Tibeto-Burman speaking ethnic groups (TBs) mostly residing in the Hengduan and Himalayan region in southwest China has been disputed for several decades. Based primarily on historical literatures and archaeologic findings the "Di-Qiang origin" hypothesis was proposed, in which the Tibeto-Burman speakers were though...