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Introduction
Skills and Expertise
Publications
Publications (5)
Background
Metformin remains the cornerstone for the treatment of type 2 diabetes mellitus. Although the mechanism in which this drug elicits its therapeutic effects is unknown, studies have shown that solute carrier transporters play an important role in the transport and distribution of metformin. Genetic variation(s) in solute carrier genes have...
Two pharmaceutical solid state co-crystals EFZA and NEF of two non-nucleoside reverse transcriptase inhibitors (efavirenz, EFV and nevirapine, NVP) and a nucleoside reverse transcriptase inhibitor, zidovudine (AZT) were prepared. Currently, these drugs are essential in various front-line HIV treatment regimens due to their potential in the manageme...
Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and compared their capability to enhance pentamidine penetration across blood brain barrier (BBB). Size...
South Africa has the world's largest antiretroviral (ARV) program and despite having stringent upstream medicine's regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The aim of this study was to evaluate and compare the post-market quality of four fixed-dose combination (FDC) generics containing e...