Yunbing Wang

Sichuan University | SCU · College of Biomedical Engineering

3D biomass‐derived carbon (3D‐BC) materials are widely developed for various electrochemical sensors due to their structural diversity and high electrical conductivity, and are gradually experiencing their most prosperous moment. A timely and comprehensive review of structure‐strategy‐property will greatly broaden this research field. In this paper...

Biodegradable occluders, which can efficiently eliminate the complications caused by permanent foreign implants, are considered to be the next-generation devices for the interventional treatment of congenital heart disease. However, the controllability of the deployment process of degradable occluders remains a challenge. In this work, a near-infra...

Polymer complex multilayers (PCMs) can be engineered into various structures with tunable properties via layer-by-layer (LBL) assembly driven by noncovalent forces. Due to their ease of preparation, capability of integrating multiple functional components, and excellent substrate compliance, biocompatible PCMs as coating materials or individual ent...

In recent years, bioprosthetic heart valves (BHVs) prepared by cross-linking porcine or bovine pericardium with glutaraldehyde (Glut) have received widespread attention due to their excellent hemocompatibility and hydrodynamic properties. However, the failure of BHVs induced by thrombosis and difficulty in endothelialization still exists in clinica...

Drug-eluting stents (DESs) implantation is an effective method to tackle in-stent restenosis (ISR), which has been considered as an efficient treatment for coronary atherosclerosis. Although fruitful results have been achieved in treating coronary artery diseases (CAD), concern has arisen regarding the long-term safety and efficacy of DESs, primari...

Chronic refractory wounds have become a severe threat to public health and are characterized by repeated bacterial infections, persistent hypoxia, abnormal immune regulation, and obstruction of angiogenesis. However, current treatment strategies usually perform only one or two therapeutic functions and cannot satisfy the dynamic and complex demands...

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes endless pain and poor quality of life in patients. Usage of a lubricant combined with anti-inflammatory therapy is considered a reasonable and effective approach for the treatment of RA. Herein, inspired by glycopeptides, a peptide-decorated hyaluronic acid was synth...

Bacterial infections pose a significant threat to human health and a heavy burden on the global healthcare system. Antibiotics are the primary treatment, but they can lead to bacterial resistance and adverse side effects. Two-dimensional (2D) nanomaterials such as graphene, MoS2, and MXene have emerged as novel antibacterial agents due to their pot...

Mitral regurgitation (MR) was the most common heart valve disease. Surgical repair with artificial chordal replacement had become one of the standard treatments for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) was currently the most commonly used artificial chordae material due to its unique physicochemical and biocompatible prope...

Drug-eluting stent implantation suppresses the proliferation of vascular endothelial cells and smooth muscle cells and thus intimal hyperplasia. However, drug-eluting stent remains limited by delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here, we show a drug-free coating formulation functional...

Anti-inflammation and anti-coagulation are the primary requirements for cardiovascular stents and also the widely accepted trajectory for multi-functional modification. In this work, we proposed an extracellular matrix (ECM)-mimetic coating for cardiovascular stents with the amplified functionalization of recombinant humanized collagen type III (rh...

Long-term blood-contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual-functional surface engineering strategy for CVCs by organic integration of endothelium-mimicking and fibrino...

Intervertebral disc degeneration (IDD) progresses due to local inflammatory response, gradually unbalanced anabolic/catabolic activity, and progressive functional impairment within the nucleus pulposus. Antagomir-21, a cholesterol-modified miRNA-21 inhibitor, has potential extracellular matrix (ECM) regenerative ability, but its application for IDD...

The culprits of atherosclerosis are endothelial damage, local disorders of lipid metabolism and progressive inflammation. Early atherosclerosis is typically difficult to diagnose in time due to the lack of obvious symptoms, thus missing the best period of treatment. In this work, we designed a π‐conjugated polymer (PMeTPP‐MBT) based on 3,6‐bis(4‐me...

Heart failure (HF) affects 60 million people worldwide and has developed into a global public health problem surpassing cancer and urgently needs to be solved. According to the etiological spectrum, HF due to myocardial infarction (MI) has become the dominant cause of morbidity and mortality. Possible treatments include pharmacology, medical device...

Heart valve replacement has become an optimal choice for the treatment of severe heart valve disease. At present, most commercial bioprosthetic heart valves (BHVs) are made from porcine pericardium or bovine pericardium treated with glutaraldehyde. Nevertheless, due to the toxicity of residual aldehyde groups left after glutaraldehyde cross-linking...

Intramyocardial injection of hydrogels possesses great potential in the minimally invasive treatment of myocardial infarction (MI), but the current injectable hydrogels lack conductivity, long-term angiogenesis inductive ability, and reactive oxygen species (ROS)-scavenging ability, which are essential for myocardium repair. In this study, lignosul...

Valvular heart disease is a major threat to human health and transcatheter heart valve replacement (THVR) has emerge as the primary treatment option for severe heart valve disease. Bioprosthetic heart valves (BHVs) with superior hemodynamic performance and compressibility have become the first choice for THVR, and more BHVs have been requested for...

Tissue injury is a common clinical problem, which may cause great burden on patients' life. It is important to develop functional scaffolds to promote tissue repair and regeneration. Due to their unique composition and structure, microneedles have attracted extensive attention in various tissues regeneration, including skin wound, corneal injury, m...

With the intensification of the aging population and the development of transcatheter heart valve replacement technology (THVR), clinical demand for bioprosthetic valves is increasing rapidly. However, commercial bioprosthetic heart valves (BHVs), mainly manufactured from glutaraldehyde cross-linked porcine or bovine pericardium, generally undergo...

Transcatheter heart valve replacement (THVR) is a novel treatment modality for severe heart valves diseases and has become the main method for the treatment of heart valve diseases in recent years. However, the lifespan of the commercial glutaraldehyde cross-linked bioprosthetic heart valves (BHVs) used in THVR can only serve for 10-15 years, and t...

It remains challenging to cure chronic diabetic wounds due to its' harsh microenvironment and poor tissue regeneration ability. At present, bacteria elimination, inflammatory response suppression and angiogenesis orderly render an important paradigm for chronic diabetic wound treatment. Herein, smart-responsive multifunctional hydrogels were develo...

Almost all commercial (BHVs) are crosslinked with glutaraldehyde; however, issues such as immune responses, calcification, delayed endothelialization, and especially severe thrombosis threaten the service lifespan of BHVs.

Atherosclerosis, as a life‐threatening cardiovascular disease with chronic inflammation and abnormal lipid enrichment, is often difficult to treat timely due to the lack of obvious symptoms. In this work, a theranostic nanoplatform is constructed for the noninvasive in vivo diagnosis, plaque‐formation inhibition and the lesion reversal of atheroscl...

With the advancement of minimally invasive interventional therapy, biological heart valves (BHVs) have been extensively used in clinics. However, BHVs are generally prone to degeneration within 10-15 years after implantation due to defects including cytotoxicity, immune response, calcification and thrombosis, which are closely related to glutaralde...

Commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated from the pericardium have become the most popular choice for treating heart valve diseases. Nevertheless, thrombosis, inflammation and calcification might lead to structural valve degeneration (SVD), which limited the durability of BHVs. Herein, to improve th...

Degradable heart occluders are a promising replacement for currently clinically used non-degradable ones without concerns about the complications caused by the persistent residue of a foreign implant. However, the inherent mechanical properties of degradable occluders are poor and decline with material degradation, leading to a preference for a lon...

Cardiovascular Biomaterials and Devices In article number 2201971, Yunbing Wang and co‐workers provide an overview of the challenges and research frontiers of innovative biomaterials and devices for the treatment of cardiovascular diseases, and their future development directions are discussed. With the development and improved performance of new c...

Thrombosis and stenosis remain two of the most prevalent complications of vascular implants. The most effective strategy in clinics to inhibit stenosis is based on the eluting of anti-hyperplasia drugs such as sirolimus and everolimus while it also has been known to hinder vascular healing and regeneration. Selectively inhibiting intimal hyperplasi...

The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart‐responsive hydrogels are three‐dimensional network structures formed by cross‐linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate...

Current treatments including drug therapy, medical device implantation, and organ transplantation have considerable shortcomings for myocardial infarction (MI), such as high invasiveness, the scarce number of donor organs, easy thrombosis, immune rejection, and poor therapeutic effects. Therefore, the development of new solutions to repair infarcte...

Bioprosthetic heart valves (BHVs) have been widely used due to the revolutionary transcatheter aortic valve replacement (TAVR) techniques but suffer from a limited lifespan. Previous modification methods of BHVs mainly rely on glutaraldehyde precrosslinking and subsequent modification. In this study, we have engineered a Poly-2-Hydroxyethyl methacr...

Magnesium and its alloys have been widely studied as absorbable coronary stent materials. However, the rapid corrosion rate in the intravascular environment inhibits the application of magnesium-based stents. In order to endow magnesium-based stent with appropriate degradation rate and biocompatibility, a hydrophobic layer was constructed by in-sit...

In traditional blood-contacting medical devices, infection and thrombosis are easily formed on the surface of the materials. In addition, inflammation is also a clinical complication that cannot be ignored. More importantly, there is a mutually promoting relationship between the inflammatory response and the infection as well as thrombosis. In this...

Through electrostatic and H-bonding interaction, polyelectrolyte could be self-assembled onto the medical devices via layer-by-layer (LBL) method. However, the built-in instability of LBL coating has seriously limited its further application. The polyphenols were incorporated into the polyelectrolyte coating, which provided various synergistic forc...

Heart failure (HF) is an irreversible disease characterized by the reducing capacity of blood supply as a consequence of cardiomyocyte death and deteriorated fibrosis. There is a lack of effective treatment for heart failure other than a heart transplant, and thus significant resources have been dedicated to developing functional materials for card...

Antibiotic resistance has become one of the greatest health threats in the world. In this study, a charge-dispersed dimerization strategy is described for the antimicrobial peptide (AMP) mimics via a tunable cationic charge to improve the selectivity between prokaryotic microbes and eukaryotic cells. This strategy is demonstrated with a series of c...

Atherosclerosis, which is triggered by endothelial damage, progressive local inflammation and excessive lipid accumulation, is one of the most common cardiovascular diseases in recent years. Drug delivery systems have shown great potential for the accurate diagnosis and effective treatment of early atherosclerosis, but are accompanied by disadvanta...

In the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant d...

Cardiovascular implants made from heterogeneous tissues (HT) often clinically face premature failures such as thrombosis, inflammation, and calcification. Herein, we report a hydrogel-tissue composite exhibiting inflammation instructive release of multiple components towards preventing coagulation, promoting endothelial growth, and modulating react...

Cardiovascular diseases (CVDs) have become the leading causes of death worldwide. The increasing burden of cardiovascular diseases has become a major public health problem and how to carry out efficient and reliable treatment of cardiovascular diseases has become an urgent global problem to be solved. Recently, implantable biomaterials and devices,...

Bioprosthetic heart valves (BHVs) are widely used in clinic, but they still have problems of calcification, thrombogenicity, and cytotoxicity. The reported techniques based on glutaraldehyde (Glut) crosslinking have difficulty in solving these problems simultaneously. In this study, we grafted Glut-crosslinked porcine pericardium (GA) with hyaluron...

Bioprosthetic heart valves (BHVs) have been used widely due to the development of transcatheter heart valve replacement technology. However, glutaraldehyde crosslinked pericardium (GA), which is widely used as a leaflet material for BHVs, still has disadvantages, including cytotoxicity, thrombosis, and calcification, which lead to the dysfunction a...

The introduction of drug-eluting stents (DESs) have yield a significant reduction in the incidence of re-stenosis, however, challenges remain including incomplete healing of the endothelium, inflammatory response and thrombogenesis at the site of vascular wall injury. Here, we developed a novel stent with polyphenol-polyamine surface combining the...

Blood-contacting devices, including vascular stents, catheters and extracorporeal membrane oxygenation (ECMO), often lead to complications such as thrombosis, inflammation and infections, resulting in implantation failure and adverse events in clinical applications. In this study, a facile and universal antifouling coating with superhydrophobic pro...

Bioprosthetic heart valve thrombosis (BHVT) is no longer considered a rare clinical entity in recent years and could cause valve motion abnormalities, which requires reoperation. Currently reported modifications of bioprosthetic heart valves (BHVs) mainly focused on improving the anti-calcification property. However, it was hard to improve their an...

As the prevalence of diabetes increases year by year and the aging population continues to intensify in the world, chronic wounds such as diabetic foot ulcers and pressure ulcers have become serious problems that threaten people's health, and have brought an enormous burden to the world healthcare system. Conventional clinical treatment of chronic...

So far, cloaking materials with platelet membranes have been widely studied, mainly focused on covering nanosized materials but rarely forwarded to dressing large-scale materials. Herein, a platelet-membrane coating (PMC) constructed on the surface of a macroscopic device is reported, driven by the spontaneous fusion of platelet-membrane vesicles (...

Magnesium (Mg) and its alloys have been intensively studied to develop the next generation of bone implants recently, but their clinical application is restricted by rapid degradation and unsatisfied osteogenic effect in vivo. A bioactive chemical conversion Mg-phenolic networks complex coating (eEGCG) was stepwise incorporated by epigallocatechin-...

Challenges in cranial defect reconstruction after craniotomy arise from insufficient osteogenesis and biofilm infection, which requires novel biomaterials. Herein, we propose a mussel-inspired bioactive poly(styrene-butadiene-styrene) (SBS) as a promising cranioplasty material. The catechol-modified quaternized chitosan (QCSC) was employed in the b...

Mass detection of glucose, which is required in many applications, remains challenging. The commercial enzyme-based glucose test strips cannot be reused, and current non-enzymatic glucose sensors exhibit a narrow range of detection and slow glucose oxidation kinetics. Herein, controlled etching of Prussian blue analogue (PBA) nanocubes at the verti...

Bioprosthetic heart valves (BHVs), mostly fabricated from glutaraldehyde crosslinked porcine or bovine pericardium, have been increasingly used in clinic with the application of transcatheter aortic valve replacement surgery. However, several drawbacks of glutaraldehyde crosslinked BHVs including poor cytocompatibility, thrombosis and calcification...

The anti-biofouling properties have important applications in the medical field. In this study, cross-linked networks were prepared by photopolymerizing two synthetic macromonomers, including fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(l-lactide) prepolymers (3-PLLA-F) and poly(ε-caprolactone) prepolymers (2-PCL-F), with N-...

Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the long-term function of cardiovascular materials. Here, we proposed a self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted of thrombin-responsive nanogels with anticoagulant and anti-inflammatory...

Due to the avascular characteristic of articular cartilage, its self-repair capacity is limited. When cartilage is damaged or forms osteoarthritis, clinical treatment is necessary. However, conventional treatments, including joint replacement, microfracture, cell and drug therapies, have certain limits. Lately, the exosomes derived from mesenchymal...

The progression of intervertebral disc degeneration (IDD) is characterized by an initial chronic local inflammatory response and ultimately leads to unbalanced anabolic/catabolic activity within the nucleus pulposus (NP). Injectable inflammation-responsive hydrogels have great potential in treating IDD through on-demand local drug delivery. Here, w...

Chronic diabetic wounds are lack of angiogenesis and susceptible to bacterial infections due to their high sugar microenvironment, making them difficult to heal. Here, a conductive and intrinsically antibacterial hydrogel with pH responsiveness has been developed. This hydrogel has good mechanical properties, self-healing ability and biocompatibili...

Titanium (Ti) and its alloys are the most commonly used materials for bone implants. However, implant failure often happens due to bacterial infection. Developing antibacterial coatings on Ti implants is an effective strategy. Dopamine and tannic acid were cross-linked to form coating on Ti through Michael addition and Schiff base reaction. In addi...

Drug-eluting stents (DESs) placement remarkably reduces the over-proliferation of smooth muscle cells (SMCs) and thus neointimal hyperplasia. However, the pharmacological agent also slows down the re-endothelization, delays injury vascular healing and increases the risk of in-stent restenosis (ISR). Here, inspired by mussel foot proteins (Mfps), a...

With the development of diagnostic techniques, the incidence of bioprosthetic heart valve thrombosis (BHVT) is found to be seriously underestimated. Developing bioprosthetic heart valves (BHVs) that have good hemocompatibility without sacrificing other properties such as hydrodynamics and durability will be an effective strategy to alleviate BHVT....

As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fingerprints from two independent nanostructured matrixes through machine learning for highly sensitive detection and high throughput analysis, w...

For biomedical magnesium alloys, in addition to the optimization of bulk materials, surface coatings that can synergistically support improved corrosion protection and biocompatibility have also attracted special interest. In this chapter, chemical conversion coatings, constructed with the incorporation of tannic and gallic acids or their derivates...

The development of responsive antibacterial implants is of high significance for the treatment of implant-associated infections. In this study, a self-adaptive antibacterial Ti-based implant with pH-sensitive coating was flexibly designed and constructed, with the dual functions of antibacterial and promoted osseointegration. The pH-sensitive antib...

A large number of blood contacting implantable devices are used worldwide annually. Acellular matrix (AM), as one of the blood-contacting materials, has achieved a great success, since it remains the structures, components and certain functions of extracellular matrix. However, AM often fails during the period of service owing to non-ideal anticoag...

The extensive use of antibiotics causes drug resistance, which slows the healing process in wound infections and this calls for an urgent response to the development of novel therapeutic approaches. However, it is challenging to develop materials with intrinsic and effective antibacterial properties for enhanced wound healing. Here, a highly effici...

Bioprosthetic heart valves (BHVs) are widely used to treat valvular disease. Almost all commercial BHVs are treated with glutaraldehyde (Glut). However, Glut-treated BHVs still have problems such as cytotoxicity, thrombosis, and calcification. This study focused on enhancing the performance of BHVs by cross-linking porcine pericardium (PP) with sod...

Magnesium alloy (Mg alloy) has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability. However, whether and how the Mg alloy induces inflammation in endothelial cells remains unclear. In the present work, we investigated the activation of Yes-associated protein (YAP)...

Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris. Atherogenesis is associated with the upregulation of CD47, a key antiphagocytic molecule that is known to render malignant cells resistant to programmed ce...

Inhibition of vascular smooth muscle cells (VSMCs) proliferation without dysregulating endothelial cells (ECs) may provide an ideal therapy for in-stent restenosis. Due to its anti-proliferation effect on VSMCs and pro-endothelium effect, arsenic trioxide (ATO) has been used in a drug-eluting stent in a recent clinical trial. However, the underlyin...