Yun-Ho Lin

Yun-Ho Lin
Taipei Medical University | TMU · Department of Pathology

About

75
Publications
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1,214
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Publications

Publications (75)
Article
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We recently reported that the periodontopathic bacteria Porphyromonas gingivalis (P. gingivalis) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from Polygonum multiflorum Thunb., 2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside (THSG...
Article
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Porphyromonas gingivalis, a periodontal pathogen, has been proposed to cause blood vessel injury leading to cerebrovascular diseases such as stroke. Brain endothelial cells compose the blood-brain barrier that protects homeostasis of the central nervous system. However, whether P. gingivalis causes the death of endothelial cells and the underlying...
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The main aim of this study is to develop a one-stage method to combine platelet-rich fibrin (PRF) and autologous cartilage autografts for porcine articular cartilage repair. The porcine chondrocytes were treated with different concentrations of PRF-conditioned media and were evaluated for their cell viability and extracellular glycosaminoglycan (GA...
Article
Background Aldo‐keto reductase family 1 member B10 (AKR1B10) is an enzyme implicated in physiological xenobiotic detoxification and also in pathological carcinogenesis. Overexpression of AKR1B10 has been reported in oral squamous cell carcinoma (OSCC), but its correlation with clinical prognosis is controversial. The aim of this study was to invest...
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Background: Insufficient cell numbers still present a challenge for articular cartilage repair. Converting heterotopic auricular chondrocytes by extracellular matrix may be the solution. Hypothesis: Specific extracellular matrix may convert the phenotype of auricular chondrocytes toward articular cartilage for repair. Study design: Controlled...
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The microstructural, in vitro and in vivo properties of the microwave-synthesized samples were investigated using the optical microscope, scanning electron microscope, X-ray diffraction, differential scanning calorimeter, contact angle goniometer, cell cytotoxicity assay and chick chorioallantoic membrane (CAM) model in the study. When the calcium...
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Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbit meniscocytes were cultured wi...
Article
The design of a homogeneous sample plate to solve the sweet heating spot issues is the key step to expand the applicability in surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). Here, large-scale and highly oriented Langmuir-Blodgett (LB) films of uniform-shaped silver nanocrystals have been fabricated as a highly efficient...
Article
In this study, different concentrations of Ag were added to Ti-27.5Nb (wt.%) alloy and the microstructural characteristics were analyzed by optical microscope, electron microscope and X-ray diffraction. Moreover, the cell cytotoxicity assay and antibacterial test were performed according to the ISO 10993-5 and JIS Z2801:2010 specifications, respect...
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Dietary fatty acid patterns have been linked to the prevalence of certain cancers, however in oral carcinoma is limited. Thus, we investigated the chemopreventive effects of various dietary n-6 and n-3 fatty acids in a 9,10-dimethyl-1,2-benz[a]-anthracene (DMBA)- and betel quid extract (BQE) -induced hamster oral cancer model. Thirty 6-week-old adu...
Article
Chronic rhinosinusitis (CRS) has raised attentions both in many countries due to its high relapsing rate and the resistance of certain treatments especially antibiotics application on both acute and chronic bacterial rhinosinusitis. The aim of this research is stressing on developing an effective alternative treatment for treating CRS and reducing...
Article
Purpose: To examine early bone tissue healing in dental implants incorporating StemBios cell therapy. Materials and methods: SLAffinity samples were examined by scanning electron microscopy and atomic force microscopy. The clinical trial comprised 11 patients, who each received a dental implant in the mandible. Only one of these 11 patients rece...
Article
Objective To present a rare case of serous degeneration of bone marrow which resembles primary spinal tumor or bony metastasis to spine. Summary of background dataSerous degeneration of bone marrow or gelatinous marrow transformation is a rare disease characterized by focal marrow hypoplasia, fat atrophy, and accumulation of extracellular mucopolys...
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Purpose Electrochemical oxidation following sandblasting and acid-etching (SLA) treatment has received interest as a surface modification procedure for titanium (Ti) implants (denoted as an SLAffinity surface); however, little information is available on its impacts on the in vivo performance of SLAffinity-Ti implants. The present study evaluated t...
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Background Minimally invasive surgery is performed using an endoscope and other instruments including the electrosurgical units. However, concerns including surgical smoke, tissue sticking and thermal injury are remaining in electrosurgery. Aims Accordingly, a newly developed electrosurgical electrode coating with hydrogenated Cu-incorporated diamo...
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The purpose of the present study was to examine thermal damage and a sticking problem in the tissue after the use of a minimally invasive electrosurgical device with a nanostructured surface treatment that uses a femtosecond laser pulse (FLP) technique. To safely use an electrosurgical device in clinical surgery, it is important to decrease thermal...
Article
Purpose: The aim of the present study was to examine the osseointegration in low-density bone tissue for SLAffinity-treated implants with StemBios (SB) cell therapy. Materials and methods: The morphologies of SLAffinity-treated surfaces were characterized using scanning electron microscopy. In the animal model, implants were installed in the man...
Article
A man in his 60s with a history of hyperlipidemia, gout, and sleep apnea was seen an incidental finding of a left torus tubarius, blackish, mucosal lesion. He had no nasal obstruction, nasal bleeding, or feeling of aural fullness. Fibroscopic evaluation revealed a black nevus–like lesion over the left torus tubarius, without surface necrosis or sig...
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Background Ginsenosides, the major bioactive compounds in ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. Methods Male Sprague–Dawley rats were randomly divided into...
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Epidemiological studies have indicated that impaired glucose metabolism may increase the risk of squamous cell carcinoma of the head and neck (SCCHN). AMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase (ACC).Thus, we analyzed...
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Primary pituitary gland cancer is extremely rare. The current study presents the case of a patient diagnosed with pituitary cancer three months after completing surgery and post-operative chemoradiotherapy for hypopharyngeal cancer. In this report we discuss 57-year-old patient who presented with diplopia and ptosis four months following the comple...
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Purpose: We aimed to test our primary hypothesis that the effects of methylprednisolone on bone marrow in chickens are age-sensitive and increase with prolonged treatment and our secondary hypothesis that the effects of methylprednisolone on bone marrow can have individual effects. Methods: Sixteen control (group A) and 29 methylprednisolone-tre...
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Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs which co-express melanocytic and smooth muscle markers. Although their distinctive histologic, immunohistochemical, ultrastructural, and genetic features have been clearly demonstrated, their histogenesis and normal counterpart remain la...
Article
The osseointegration of titanium dental implants is essential for successful therapy, and this is strongly affected by the surface chemistry and roughness. In this study, using electrochemical anodization after sand blasting, and acid etching of Ti surface (SLA), SLA specimens with the high wettability of the thick TiO2 layer (SLAffinity) surface w...
Article
In this study, plasma-nitrided austenitic stainless steel was prepared using a microwave system as a function of the nitriding duration. The nitride layers were characterized via scanning electron microscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy, atomic force microscopy and a Vickers micr...
Article
A porous structural oxide film was formed on titanium-niobium alloys (TiNb) by anodic oxidation after cathodic pretreatment. The effects of titanium hydride compounds on the formation of an oxide film and the structural properties of a TiNb matrix were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electro...
Article
Primary squamous cell carcinoma (SCC) of the pelvic retroperitoneum is very rare. We present a primary SCC of the pelvic retroperitoneum, which to our knowledge is the second case described. In this case, a heterogenous mass with irregular cystic echoes located at the left pelvic cavity was examined in a 44-year-old female patient. Final pathologic...
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Autologous chondrocyte implantation has become the current principal procedure for cell-based cartilage repair.1,2 However, the disadvantages of autologous chondrocyte implantation include the necessity to perform two surgical procedures: isolation of the chondrocytes from a tissue sample that has been extracted from the patient, which is time-cons...
Article
The purpose of this study was to investigate the effects of glutamine supplementation on inflammatory responses in chronic ethanol-fed rats. Male Wistar rats weighing about 160 g were divided into five groups. Two groups were fed a normal liquid diet and three groups were fed a glutamine-containing liquid diet. After 1 week, one of the normal liqui...
Article
Polysaccharide-rich Lycium barbarum and Rehmannia glutinosa have been considered to have immune-modulating activity. This study investigated the effects of water extracted Lycium barbarum and Rehmannia glutinosa (HE) on carbon tetrachloride (CCl(4))-induced liver injury in rats. Male Sprague-Dawley rats were randomly divided into: normal diet + per...
Article
Appendiceal intussusception is a rare entity that is difficult to diagnosis before surgery both clinically and radiologically. We report here a case of a 55-year-old woman with a 6-month history of right lower abdominal pain caused by appendiceal intussusception. Laparoscopic appendectomy was performed. Endometriosis foci were identified in the app...
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Curcumin and saikosaponin a, the bioactive phytochemicals of turmeric and Bupleurum, act as antioxidants. This study investigated the effects of supplementation with curcumin and/or saikosaponin a on hepatic lipids and antioxidant status in rats with CCl(4)-induced liver injury. Male Sprague-Dawley rats were randomly divided into control, CCl(4), C...
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Although toxocaral granulomatous hepatitis (TGH) characterized with a dominant-Th2 type immune response is a self-limiting disease, little is known concerning the role of fibrosis-related cytokine transforming growth factor-beta 1 (TGF-beta 1) in pathogenesis of TGH. A detailed histological and quantitatively immunohistochemical analysis of TGF-bet...
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The role of nitric oxide (NO) in granuloma pathology is largely unclear to date. We investigated the role of NO in fibrotic granuloma development in the musculature of mice infected with Toxocara canis from 1 day (dpi) to 8 weeks post-infection (wpi) using the NO synthase (NOS) inhibitors, L-NIL (l-N 6-1-iminoethyl lysine). In infected mice, elevat...
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Because the outcomes and sequelae after different types of brain injury (BI) are variable and difficult to predict, investigations on whether enhanced expressions of BI-associated biomarkers (BIABs), including transforming growth factor beta1 (TGF-beta1), S100B, glial fibrillary acidic protein (GFAP), neurofilament light chain (NF-L), tissue transg...
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The frequency of double primary cancers synchronous-ly found in an individual has been increasing. However, synchronous or asynchronous triple primary cancers have rarely been repor ted. A 69-year-old female received an operation for right breast cancer and sub-sequent chemotherapy in 2001. During the 5-year fol-low-up period, second and third prim...
Article
This investigation attempted to clarify the hypolipidemic effects of non-dialyzed soybean protein hydrolysate (NSPH), which is hydrolyzed by pepsin from soybean acid-precipitated protein (APP), in rats fed a cholesterol-rich diet. Forty Sprague-Dawley rats were divided into four groups as the control group (19.7% casein), the APP group (14.7% casei...
Article
Reported herein is the case of a 35-year-old multipara woman diagnosed (on sonography) with total placenta previa that had ruptured through the myometrium of the uterus, invading the wall of the urinary bladder. In the 32nd week of gestation the patient underwent an emergency cesarean section due to profuse vaginal bleeding. Due to possible intraop...
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Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E(2) (PGE(2)) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of ind...
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Ameloblastic carcinoma, a rare malignant odontogenic tumor, is a highly aggressive tumor with rapid growth and a high potential for distant metastasis. Surgical resection is the most common treatment modality, while there are still controversies about the efficacy of neck dissection, radiotherapy, and chemotherapy. Herein we report a case of amelob...
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We describe here a patient with an unusual presentation--mesenteric calcifying fibrous pseudotumor in association with jejunojejunal intussusception. This 25-year-old woman came to our emergency department with severe abdominal distension and intermittent epigastric cramping pain. She was found to have rebound tenderness and an ill-defined mass pal...
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The three purgative Cheng-Chi-Tang decoctions (CCTDs) including Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT), and Tiao-Wei-Chen-Chi-Tang (TWCCT) are used for treating gastrointestinal disorders, including liver diseases in traditional Chinese medicine. However, the underlying mechanisms as liver disease remedies are far from fully clarified....
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This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride (CCl4)-induced liver injury. Male Sprague-Dawley rats (n = 8-12 per group) were divided into the control, CCl4, CCl4 + silymarin (0.35%...
Article
Alveolar soft-part sarcoma (ASPS) is rare. We present a case of a 30-year-old woman with a 6-month history of a palpable mass in her left thigh. MRI showed an 8-cm mass and a satellite nodule at the left gluteus muscle. The main tumor exhibited an isointense signal on T1-weighted images and high-signal-intensity areas with low-signal-intensity scan...
Article
We report a case of gastrointestinal stromal tumor (GIST) of the prostate in a 75-year-old man with dysuria and urinary retention. Digital rectal examination revealed a markedly enlarged prostate. The serum level of prostate-specific antigen was 0.2 ng/dL. Imaging studies showed an expanded prostate, measuring 6.7 x 5.6 x 5.5 cm, with heterogeneity...
Article
Acute p.o. administration of absolute ethanol (10 ml/kg) to fasted mice would produce extensive renal failure. Pretreatment with p.o. administration of propolis ethanol extract (PEE) could prevent such renal failure effectively and dose dependently. This renal protective effect of PEE may be contributed, at least in part, to its antioxidative activ...
Article
The small intestine is the initial organ which Toxocara canis larvae invade. Information on intestinal pathological changes associated with transforming growth factor-beta1 (TGF-beta1) and secretory granules (SG) in Paneth cells (PCs) caused by T. canis is unclear. Mice orally inoculated with 250 T. canis infective eggs were evaluated by pathologic...
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Giant cell tumor of the tendon sheath with medullary extension in the foot has rarely been reported before. We report a 28-year-old man who had a painless swollen lesion over the proximal pha- lanx of the second toe of the left foot for several years. Conventional radiographs showed a lobulated lucency in the bone marrow of the proximal phalanx sur...
Article
A 58-year-old asymptomatic man was scheduled to undergo FDG PET for whole-body cancer screening. Intense, focally linear F-18 FDG uptake was found in the lower buttock. A malignant tumor in the rectum was suspected. However, physical examinations and a rectocolonscopic study were negative. MRI showing an anorectat fistula provided a morphologic dia...
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Ocular injury to ICR mice from embryonated eggs of Toxocara canis, which had been maintained in 2% formalin for 14 months at 4°C, was evaluated by microscopic and pathologic assessments at 1, 2, 3, 5, 7, 28, 56, 84, 112, 140, 168, 196, 294 and 469 days post infection (DPI). On each date, three infected mice and two age-matched uninfected control mi...
Article
Milium-like syringoma is a variant of syringoma first described in 1987. Only few cases have been reported in the literature. It may be misleading clinically, and its histogenesis has not been clarified. We present a case of periorbital milium-like syringoma, with studies on the histopathologic, histochemical, and immunohistochemical features. Hist...
Article
The study objective of this research is in order to investigate the hepatoprotective and therapeutic effects of propolis ethanol extract (PEE) on acute econazole-induced liver injury. Positive control of various concentrations of PEE on liver function and the dose-response relationship of liver injury induced by various doses of econazole were firs...
Article
Cryptococcosis is not uncommon. Potential interpretation pitfalls should be kept in mind when fluorodeoxyglucose (FDG) positron emission tomography (PET) is used for differentiating pulmonary nodules and for discriminating infection from malignancy, especially in areas where the prevalence of granulomatous infection is high and in immunocompromised...
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Infectivity and pathogenicity to mice of embryonated eggs of Toxocara canis, that had been maintained in 2% formalin for 14 months at 4 degrees C, were evaluated by immunological and pathological assessment at 1, 4, 8, 12, 16, 20, 24, 28, 42 and 67 weeks post-infection (WPI). On each date, three infected mice and two age-matched uninfected mice wer...