Yuliia Moskalenko

• Doctor of Philosophy
• Medical Doctor at Sumy State University

The p53 protein participates in many cellular processes, including DNA repair, cell cycle control, autophagy, apoptosis, and senescence. Мutation in the TP53 gene is a factor of unfavorable prognosis. Loss of tumor suppressor function causes resistance to drug therapy, metastasis, and disease progression. However, breast cancer is a heterogeneous d...

Introduction. An essential role in the formation and development of non-small cell lung cancer (NSCLC) is played by systemic inflammation, which indirectly affects neoangiogenesis, proliferation, disease recurrence, and tumor spreading and can modulate the response to medication therapy. Clinical monitoring of inflammatory markers may help predict...

Background. The effectiveness of targeted therapy in patients with HER2+ breast cancer largely depends on the tumor microenvironment. Regulatory T-lymphocytes (FOXP3+) negatively regulate immune responses and are mostly considered a factor of unfavorable prognosis. Breast cancer is a heterogeneous disease with unique biological properties for each...

GLUT1 is an essential glucose transporter, the expression of which increases in tumor cells, especially under conditions of hypoxia, and correlates with their active proliferation. This study aimed to investigate the relationship between GLUT1 expression and biological parameters and to evaluate the potential impact on survival in patients with rad...

Background. Lung cancer continues to be a significant health concern globally. Due to the heterogeneity of the disease, using innovative strategies for effective management and treatment of patients is extremely important. Purpose – to characterize the mutational profile of a group of non-small cell lung cancer (NSCLC) patients utilizing a next-gen...

Background. The association between body mass index and prognosis in patients with HER2-positive metastatic breast cancer (mBC) is unclear. Purpose – the first purpose of our study was to determine whether BMI is an independent prognostic factor for progression-free survival (PFS) and overall survival (OS) in HER2-positive mBC patients. The second...

Недрібноклітинний рак легень (НДКРЛ) є одною з провідних причин смертності в онкології. Упровадження в клінічну практику таргетної терапії та імунотерапії дозволило досягти суттєвого прогресу в поліпшенні результатів лікування хворих на НДКРЛ. Вибір стратегії лікування ґрунтується на результатах мультигенного тестування НДКРЛ з оцінкою відповідного...

Lung cancer is the leading cause of death from cancer in Ukraine and worldwide. The impact on the tumor microenviron-ment is the most promising direction for lung cancer therapy. Tumor-associated macrophages of type M2 have the most powerful immunosuppressive properties. A new potential way of influencing M2 macrophages is the signaling protein and...

The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer...

Introduction: Thyroid cancer (TC) demonstrates steady growth in incidence worldwide and remains an urgent problem in oncology. The detection of sentinel lymph nodes (SLN) with a selective dye and further histological examination in selecting the proper (personalized) surgical strategy and the volume of surgical intervention for clinically undeterm...

Introduction. Thyroglossal duct cysts (TGDCs) can be diagnosed at any age. They are most common in women aged 30–40. Cysts can become malignant in 1% of patients. As a result, a very rare tumor – TGDC carcinoma ¬– develops. Some oncologists believe it is sufficient to perform surgery using the Sistrunk procedure. Other scientists insist on performi...

Introduction. Anaplastic thyroid cancer is an aggressive disease with meager patient survival. The tumors are often unresectable and insensitive to standard treatment methods (chemotherapy and radioiodine therapy). In recent years, much attention has been paid to new therapeutic strategies, mainly targeted therapy. The purpose of our study was to s...

Biopsy of sentinel lymphatics has reliably entered the guidelines for diagnosing and treating many malignant neoplasms, but the situation in patients with thyroid cancer remains debatable.Objective. The purpose of the work is the search, bibliometric analysis, and generalization of scientific literature data to study the prognostic value and featur...

Introduction: Patients with lung cancer receive treatment according to National Cancer Comprehensive Network (NCCN) standards. However, disease recurrence is reported in about 30% of patients during the first five years. Our study aimed to establish independent predictors of lung cancer recurrence. Material and methods: 104 patients with definit...

The scientific monograph presents the theoretical and practical aspects of the development of modern scientific research. General questions of economics and enterprise management, regional economics, marketing, technical sciences, technology of food and light industry, and so on are considered. The publication is intended for scientists, educators,...

Introduction. Thyroid cancer ranks ninth in the structure of malignant neoplasms. Since the 1980s, most countries in the world have seen a rapid increase in the incidence rate and a relatively stable or even decreasing mortality rate. The objective of our study was to analyze the thyroid cancer morbidity and mortality trends in the Sumy region duri...

Introduction. Prediction of lung cancer recurrence is one of the most urgent problems of modern oncology. Scientists are trying to find independent predictors that will help intensify, personalize the patient's treatment, and prevent the disease relapse on time. The study aimed to find indicators of inflammation that could be independent predictors...

Introduction. Treatment of patients with thyroid cancer (TС) with clinically undetected metastases to regional lymph nodes remains an unsolved problem of modern oncology. The search for reliable diagnostic methods, which underlie the decision to perform an adequate lymphadenectomy for TC, is one of the priorities of oncosurgery. The aim of the res...

Ectopic calcification or pathological biomineralization correlates with morbidity and mortality from cardiovascular diseases. Aortas with atherosclerotic lesions and biomineralization were selected for the study. Thirty samples of mineralized abdominal aortas (group M) were examined by histology. Depending on the calcifications size, samples were s...

According to GLOBOCAN 2.2 data a million of new cases of lung cancer and 1.8 million of deaths from this pathology were registered in the world in 2020. Every tenth patient with suspected malignancy was diagnosed with lung cancer, and death of every fifth of them was caused by it. Aim. To analyze the trend of the spreading of lung cancer among the...

Tumor molecular profiling in patients with non-small cell lung cancer (NSCLC) is used to identify driver mutations, which lead to premature carcinogenesis in more than 80% of adenocarcinoma cases, including epidermal growth factor receptor (EGFR) mutations. Identification of specific somatic aberrations allows to personalize treatment. Personalizat...

Introduction. Before the middle of the 20th century, colorectal cancer (CRC) was a fairly rare disease. A significant increase in the prevalence of this pathology began after this period and was accompanied by a doubling of indicators in each subsequent decade. By 2030, the incidence rate of colorectal cancer is expected to increase by 60% or more...

Gastrointestinal stromal tumors (GIST) are one of the most common mesenchymal tumors that originate from the intestinal cells of Cajal. The most common localization of GIST is the gastrointestinal tract, however, extragastrointestinal forms are sometimes found. Most GISTs are small in size, which most often does not exceed 5 - 8 cm in maximum dimen...

Today, breast cancer occupies a leading position in the structure of morbidity and mortality among women in Ukraineand and throughout the world. Late diagnosis of the disease adversely affects the prognosis. Since this pathology is characterized by a wide range of gene mutations, the relationship between the molecular genetic characteristics of a t...

Lung cancer is one of the main causes of death from malignant neoplasm all around the world. For the purpose of personalized treatment immunohistochemical determination of specific proteins (biomarkers) presence in tissues and biological fluids is needed. Today management of patients with lung cancer is directly associated with determination of gen...

Background & Objective: To study the immunophenotype of prostate cancer (PC) with the presence and absence of intraluminal inclusions (IIn), depending on the grade score. Methods: A total of 30 PC samples with IIn (group E) and 30 PC samples without them (group C) were studied. These groups were divided into 2 subgroups, depending on the grade of...

Lung cancer is one of the major causes of death from malignancies. That is why the article devoted to the issue early diagnosis of lung cancer. The objective of the work is to consider the features and prospects of using the most modern methods of diagnosis of lung cancer. The introduction of the latest technologies is essential for quality screeni...

Peculiarities of differential diagnosis of benign pulmonary tumors and its significance for the surgical tactics choosing

Рідинна біопсія знаходиться під прицілом уваги, завдяки своєму клінічному значенню для персоналізованої медицини. Цей діагностичний метод направлений на виявлен-ня та аналіз таких біомаркерів крові, як цирку-люючі пухлинні клітини (ЦПК), позаклітинна циркулююча пухлинна ДНК (цпДНК), цирку-люючі РНК та екзосоми, які вивільняються з первинних пухлин...

ANALYSIS OF LUNG CANCER INCIDENCE IN WOMEN IN SUMY REGION. Lung cancer (LC) is one of the most important and complex problems of modern oncology in developed countries. Primary LC is the most common malignancy after epithelial skin cancer. Nowadays it is the main cause of death from cancer all over the world. In Sweden, Denmark, Iceland incidence r...

Background: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. Case presentation: We showed a case of multiple primary tumor with metahronic...

The proportion of liposarcoma in the structure of cancer incidence is from 10 to 35% of all mesenchymal tumors. This clinical observation describes an 12-year struggle with myxoid liposarcoma of the left upper arm, during which 17 surgeries were performed due to local recurrences, 17 radiation therapy courses and 5 chemotherapy courses were conduct...

MIXOID LIPOSARCOMA (LITERATURE REVIEW) The incidence of liposarcom has a proportion from 10 to 35 % among all soft tissue sarcomas in the cancer structure. They are often located on the extremities (60 %) and in the retroperitoneal space (10– 20 %). Liposarcoma is one of the most mysterious malignancies, which generates still a lot of questions. T...

The last decade in Sumy region has been marked with extraordinary incidence of malignant tumors of the thyroid gland (TG), which is higher than the nationwide figures. The aim is to analyze the statistics of thyroid cancer incidence in Sumy region during 2004-2014. Research results. According to the National Cancer Registry, during 2004–2014 there...

The results of the study of testes' tissue of 128 immature rats, which get within 60 days drinking water with threshold concentration of salts of copper, zinc, iron, manganese, lead, chromium. It was found that morphological changes of microvasculature was nonspecific and lead to the secondary damage of blood-testis barrier and correlated with chan...

Наведені результати дослідження тканини сім’яників 128 лабораторних щурів, які отримували з питною водою порогові концентрації солей міді, цинку, заліза, марганцю, свинцю, хрому. Встановлено, що морфологічні зміни мікроциркуляторного русла неспецифічні і призводять до вторинного ушкодження гематотестикулярного бар’єра та корелюють із змінами паренх...

Entrance of threshold concentrations of copper, zinc, iron, manganese, lead, chromium into the body of sexually mature male rats leads to secretory malfunction of the testicles, which manifests by a decrease of sperm concentration in the ejaculate, a decrease of percentage of motile gametes, an increase in the proportion of morphologically abnormal...

The paper is devoted to the peculiarities of medical discourse in pathological anatomy as coherent speech and as a linguistic correlate of medical practice taking into account the analysis of its strategies and tactics. The purpose of the paper is to provide a multifaceted analysis of the speech strategies and tactics of pathological anatomy discou...

Entrance of threshold concentrations of copper, zinc, iron, manganese, lead, limp into the body of sexually mature male of rats leads to secretory malfunction of the testicles, which manifests by a decrease of sperm concentration in the ejaculate, a decrease of percentage of motile gametes, an increase in the proportion of morphologically abnormal...