Yulia Loktionova

Orlov State University · Research & Development Center of Biomedical Photonics

The paper is devoted to the study of perfusion and amplitude-frequency spectra of laser Doppler flowmetry (LDF) signals in patients with diabetes mellitus (DM) in different skin areas of the upper and lower extremities using a distributed system of wear-able LDF analysers. LDF measurements were performed in the areas of the fingers, toes, wrists an...

The paper reports the results of blood microcirculation studies in microgravity using portable laser analyzer LAZMA PF. Two cosmonauts (C-1 and C-2) performed pre-launch and inflight (9 days) 8-minute sessions with the use of 2 portable flowmeters symmetrically attached to the temporal skin, palmer sides of distal phalanxes III, forearm superficie...

Performing yoga exercises in addition to basic training helps athletes to improve their results. At the same time, yoga exercises, including Hatha yoga, which involves controlling one’s breathing, are integrated into the training process. This work is devoted to study the influence of breathing exercises, with the decrease and increase in the minut...

The aim of this work was to study the regulation of insulin production by synucleins. In addition, we aimed to evaluate the possible efect of 1267 nm light irradiation, which leads to singlet oxygen production, on insulin production in the animal organism. the present work showed that knockout of genes encoding synuclein proteins is associated with...

Currently, there is a surge of interest in wearable diagnostic devices with the possibility of daily monitoring of the functional state of the human body, for example, microcirculatory-tissue systems. The first such development is the «LAZMA PF» analyzer ((LAZMA Ltd, Russia; in EU/UK this device is produced by Aston Medical Technology Ltd., UK as «...

The work is devoted to the study of the effect of complete hyper- and hypoventilation breathing on the parameters of the blood flow microcirculation. Volunteers achieved hypo- and hyperventilation modes by performing full breathing. The correlations found between parameters of gas analysis and blood microcirculation may indicate the peculiarities o...

The paper is aimed at comparing blood microcirculation parameters of conditionally healthy volunteers and patients undergoing rehabilitation after COVID-19 to identify possible blood flow dysregulation that may result from the disease. A system of wearable laser Doppler monitors was used to conduct the study. The study demonstrated an increase in o...

This paper presents clinical results of wireless portable dynamic light scattering sensors that implement laser Doppler flowmetry signal processing. It has been verified that the technology can detect microvascular changes associated with diabetes and ageing in volunteers. Studies were conducted primarily on wrist skin. Wavelet continuous spectrum...

Summary Introduction. Yoga breathing exercises make it possible to change the minute ventilation (MV) within a wide range, reaching states of hyper-and hypoventilation with corresponding shifts in gas exchange. In this work, the interrelations between external respiration, parameters of gas metabolism and the skin microcirculation were evaluated. M...

The present work is focused on the study of changes in microcirculation parameters in patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry (LDF) devices. The microcirculatory system is known to play a key role in the pathogenesis of COVID-19, and its disorders manifest themselves long after the patient has recovered. In...

Modern photonics methods are considered in relation to solving a number of diagnostic problems in practical medicine. The basic principles of the application of optical noninvasive diagnostic methods are described and examples are given: laser Doppler flowmetry, digital diaphanoscopy, Raman spectroscopy, spectrophotometry, time-resolved fluorescenc...

In this study, we assessed the possibility of using portable laser Doppler flowmeters for determiningthe state of the blood microcirculatory system in upper and lower limbs of diabetic patients during the treat-ment course with intravenous α-lipoic acid infusions. A series of experimental studies were conducted in acohort of ten inpatients with a c...

The rising interest in the development of new wearable electronic devices for mobile healthcare can be exemplified by great opportunities for the development of new methods for broader use of blood perfusion monitoring for the purposes of precision medicine. A fine analysis of capillary blood flow structure and its rhythmic oscillations in the time...

Objective This work aims to study the functional state of resistive skin microvessels in patients with newly diagnosed arterial hypertension (AH), using portable laser Doppler flowmetry (LDF) devices. Materials and methods The study included 89 men aged 30 to 60 years (44.4 ± 8.5) who had no known medical complaints, subjectively considered themse...

This paper presents the first results of the study of changes in microcirculatory-tissue systems functioning under space flight conditions.

The possibility of using the laser Doppler flowmetry (LDF) method for the diagnosis of masked hypertension is considered. Significant trends in changes in parameters between groups of volunteers were identified. This indicates the possibility of using the LDF method to make decisions about the further follow-up of patients for the presence of a hid...

Advances in the development of ultra-compact semiconductor lasers have opened up new possibilities for the development of wearable devices implementing biophotonic technologies, such as laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS). This work is aimed to evaluate the correlation between diagnostic parameters simultaneously regist...

Introduction. Yoga breathing exercises improve the ability to significantly reduce the respiratory rate. A decrease of the minute respiration volume results in compensatory reactions of the microcirculatory bed caused by changes in the gas composition. The reaction of the regulatory mechanisms of the microvascular bed can be evaluated by the optica...

In this study, we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusi...

This study is devoted to the trials of wearable diagnostic system that implements the laser Doppler flowmetry technique to analyse the blood microcirculation. We do preliminary test with involvement of limited group of healthy volunteers of different age and in patients with type 2 diabetes. During the series of measurements, the microcirculation p...

The problem of diabetes mellitus (DM) has attracted scientists of different specialities, as its prevalence is increasing worldwide and assumes the character of a pandemic. The use of optical non-invasive diagnostic methods is a promising direction for the early determination of the presence and severity of diabetic complications. This work is aime...

Early diagnostics of microcirculation complications is an important area for biomedical photonics application. The blood perfusion measurements are capable of identification of particular markers for diagnostics of many pathological conditions of blood microcirculation in the skin. In this work, we apply the laser Doppler Flowmetry method with the...

In this work, we applied a wearable distributed laser measuring system for the study of regional changes in blood microcirculation in healthy volunteers of different age and diabetic patients. It was found that age-related changes in blood microcirculation can be characterized by increased perfusion level in the fingers and decreased amplitudes of...

Laser Doppler flowmetry (LDF) was used for detection of age-related changes in the blood microcirculation. TheLDF signal was simultaneously recorded from the 3rd fingers’ pads of both hands. Amplitudes of the blood flowoscillations and wavelet coherence of the signals were used for the data analysis. A statistical difference in thesynchronisation o...

A novel non-invasive, wearable VCSEL-based system for multipoint in − vivo measurements of blood perfusion was introduced. The system operates on the basis of the laser Doppler flowmetry (LDF) method and allows for microcirculation studies. The sensors developed were used to analyse the skin blood flow synchronization in homologous regions of the c...