Yuichi Kaji

• University Hospital Medical Information Network

Right-linear finite path overlapping TRS are shown to effectively preserve recognizability. The class of right-linear finite path overlapping TRS properly includes the class of linear generalized semi-monadic TRS and the class of inverse left-linear growing TRS, which are known to effectively preserve recognizability.

We developed an injector with a tip that matches the shape of the ciliary sulcus (Ciliary Sulcus Pad Injector) and is used in ciliary sulcus suture fixation of intraocular lenses. The injector is inserted through the corneal incisions and slid along the posterior surface of the iris to the opposite side. When the tip of injector is fitted in the ci...

We herein report the case of a patient who developed peripheral neuropathy of the bilateral lower legs that later became complicated with isolated oculomotor nerve disorder and was finally diagnosed as systemic lupus erythematosus (SLE). Based on the findings for oculomotor nerve paralysis and contrast-enhanced magnetic resonance imaging findings f...

Purpose: To determine the relationship of the anatomic position of tissue surrounding the ciliary sulcus using ultrasound biomicroscopy (UBM) for measurement of ciliary sulcus parameters and the surrounding tissue after intracapsular cataract extraction (ICCE) and determine the correct suture site for intraocular lens (IOL) suture fixation. Setti...

The role-based access control (RBAC) framework is a mechanism that describes the access control principle. As a common interaction, an organization provides a service to a user who owns a certain role that was issued by a different organization. Such trans-organizational RBAC is common in face-toface communication but not in a computer network beca...

Purpose: In vivo and in situ visualization of biomolecules without pretreatment will be important for diagnosis and treatment of ocular disorders in the future. Recently, multiphoton microscopy, based on the nonlinear interactions between molecules and photons, has been applied to reveal the localizations of various molecules in tissues. We aimed...

This study proposes an electronic voting (e-voting) system based on the Bitcoin protocol and blind sig-natures. Various cryptographic schemes have been studied to realize secure and efficient e-voting systems, but these systems are hardly used in practical voting. One of the technical reasons for this unfortunate situation is that many e-voting syste...

Despite growing demand for truly naïve imaging, label-free observation of cilium-related structure remains challenging, and validation of the pertinent molecules is correspondingly difficult. In this study, in retinas and cultured cells, we distinctively visualized Rootletin filaments in rootlets in the second harmonic generation (SHG) channel, int...

A fingerprinting function for hash-based Winternitz one-time signature is proposed. A hash-based one-time signature is a light-weight and quantum-immune alternative to digital signature schemes that typically make use of number theoretic problems. The Winternitz scheme, which is one of the most promising hash-based one-time signatures, realizes the...

Improvement of Winternitz One Time Signature

Nonlinear spectroscopic imaging enable us to obtain molecular information of cells and tissues without staining and molecular tagging. In the present study, we developed multimodal and multiphoton microscopic systems and performed label-free imaging of a rat eye tissue with molecular specificity through linear and nonlinear optical processes. We ob...

Absorbable polyethylene glycol-based synthetic sealant (PEG sealant) polymerizes under xenon illumination and forms a clear, flexible, and firmly adherent hydrogel. The intraocular biocompatibility of PEG sealant and efficacy for closing retinal breaks were evaluated. In an in vitro study, retinal detachment with a tear was created in porcine eyecu...

The role-based access control (RBAC) is a natural and versatile model of the access control principle. In the real world, it is common that an organization provides a service to a user who owns a certain role that was issued by a different organization. However, such a trans-organizational RBAC is not common in a computer network because it is diff...

A random-walk model is investigated and utilized to analyze the performance of a coding scheme that aims to extend the lifetime of flash memory. Flash memory is widely used in various products today, but the cells that constitute flash memory wear out as they experience many operations. This issue can be mitigated by employing a clever coding schem...

The role-based access control (RBAC) is a natural and versatile model of the access control principle. In the real world, an organization commonly provides a service to a user who owns a certain role that was issued by a different organization. However, such a trans-organizational RBAC is not common in a computer network because it is difficult to...

Biologically uncommon d-β-aspartic acid (d-β-Asp) residues have been reported to accumulate in organs affected by age-related disorders. In the present study, we investigated the localization of d-β-Asp-containing proteins in cases of pterygium, one of the most prominent age-related ocular conditions. Immunohistochemical localization of d-β-Asp-con...

This paper proposes a novel coding scheme which can extend the lifespan of flash memory. Flash memory has a number of advantages against conventional storage devices, but it must be noted that the flash cells which constitute a flash memory accommodate, not a small, but limited number of operations only. A flash code provides a clever way to repres...

We applied our multimodal nonlinear spectral imaging microscope to the measurement of rat cornea. We successfully obtained multiple nonlinear signals of coherent anti‐Stokes Raman scattering (CARS), third‐order sum frequency generation (TSFG), and second harmonic generation (SHG). Depending on the nonlinear optical processes, the cornea tissue was...

In the framework of floating codes, a block of flash cells stores data in the form of binary numbers. The fundamental approach in constructing a coding scheme is by assigning cells to bits. However, the way to assign cells to bits is not simple, as the frequency of changes of the value of the bits is not known. This makes it difficult to partition...

The role-based access control (RBAC) is a natural and versatile model of the access control principle. In the real world, it is common that an organization provides a service to a user who owns a certain role that was issued by a different organization. However, such a trans-organizational RBAC is not common in a computer network because it is diff...

Novel flash codes with small average write deficiency are proposed. A flash code is a coding scheme for avoiding the wearing of cells in flash memory. One approach to develop flash codes with large parameters is to make use of slices which are small groups of cells. Preliminary study shows that using small slices brings several favorable characteri...

Flash codes are used to decode and encode digital information in flash memory. The performance of a flash code is normally evaluated using the write deficiency metric which corresponds to the gap between the theoretical maximum writes in a flash device, against the actual number of writes in using the specific flash code. This study proposes a new...

Objective: IgG4-related disease (IgG4-RD) is characterized by IgG4-positive plasmacytic infiltration and fibrosis in various organs. Orbital involvement in IgG4-RD includes lacrimal glands, extra-ocular muscles, trigeminal nerve and other parts of the orbit. Immunohistochemical staining is used to diagnose IgG4-RD in patients with orbital inflamma...

The sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases that helps regulate the lifespan of diverse organisms. The human genome encodes seven different sirtuins (SIRT1-7), which share a common catalytic core domain but possess distinct N- and C-terminal extensions. Dysfunction of some si...

Corneal dystrophies are genetic disorders resulting in progressive corneal clouding due to the deposition of amyloid fibrils derived from keratoepithelin, also called transforming growth factor β-induced protein (TGFBI). The formation of amyloid fibrils is often accelerated by surfactants such as sodium dodecyl sulfate (SDS). Most eye drops contain...

With slice-based flash code, the smaller the size slice the more flexible it is to distribute cells among the bits and leave less unused levels. However, smaller size slices comes with a small overhead and it some cases worsen its efficiency. To get around this issue, this paper introduces a new technique called resizable- cluster method. This tech...

A new flash code is proposed in this paper. This flash code has two modes of encoding: one extending the binary-indexed flash code which has been proposed by the authors, and the other using a simple mapping. It is shown that the proposed flash code has O(kq\log k + n) worst-case write deficiency, but competes very well with existing flash codes in...

The expected write deficiency of the index-less indexed flash codes (ILIFC) is studied. ILIFC is a coding scheme for flash memory, and consists of two stages with different coding techniques. This study investigates the write deficiency of the first stage of ILIFC, and shows that omitting the second stage of ILIFC can be a practical option for real...

Phacoemulsification is most popular surgical method of cataract surgery. During operation, crystalline lens is fragmented and aspirated before insertion of the artificial lens being into intraocular. Here the fragments of crystalline lens are scattered in the posterior chamber and might impinge onto the endothelial surface of the cornea. This is a...

Gelatinous drop-like corneal dystrophy (GDLD), also known as familial subepithelial corneal amyloidosis, is an autosomal recessive disorder that causes progressive corneal opacity due to accumulation of amyloid fibrils in the corneal stroma. Genetic analyses have revealed that a mutation in membrane component chromosome 1 surface marker 1 gene is r...

We measured velocity distributions in the anterior chamber of porcine eyes under simulated cataract surgery using stereoscopic particle image velocimetry (stereo-PIV). The surface of the cornea was detected based on the images of laser-induced fluorescent light emitted from fluorescent dye solution introduced in a posterior chamber. A coaxial phaco...

To visualize irrigation fluid flow and calculate its velocity distribution in the anterior chamber during phacoemulsification by particle image velocimetry. Porcine eyes were fixed in a glass chamber filled with balanced salt solution. An ultrasound handpiece was fixed to the glass chamber, and its tip was inserted into the anterior chamber through...

Monochrome two-dimensional barcodes are rapidly becoming a de-facto standard for distributing digital data through printed medium because of their small cost and portability. Increasing the data density of these barcodes improves the flexibility and effectiveness of existing applications of barcodes, and has the potential to create novel means for...

Role-Based Access Control (RBAC) is a powerful and versatile access control system for large-scale access control management within an organization. Most studies so far consider RBAC models that have a single consistent access control policy, which implicitly confine an RBAC system to one organization. However, many real-world requirements of acces...

Role-Based Access Control (RBAC) is a powerful and versatile access control system for large-scale access control management within an organization. Most studies so far consider RBAC models that have a single consistent access control policy, which implicitly confine an RBAC system to one organization. However, many real-world requirements of acces...

The expected write deficiency of the index-less indexed flash codes (ILIFC) is studied, and a technique is developed to improve the write deficiency of ILIFC. ILIFC is a coding scheme for flash memory, and consists of two stages with different coding techniques. This study first clarify the average write deficiency of the first stage of ILIFC, and...

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measu...

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measu...

Homochirality is essential for life. L-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, d-amino acids, which are enantiomers of L-amino acids, were recently detected in various living organisms in the form of free D-amino acids and D-amino acid residues in pepti...

UV-B irradiation is one of the risk factors in age-related diseases. We have reported that biologically uncommon D-β-Asp residues accumulate in proteins from sun-exposed elderly human skin. A previous study also reported that carboxymethyl lysine (CML; one of the advanced glycation end products (AGEs)) which is produced by the oxidation of glucose...

Klebsiella pneumoniae endophthalmitis is rare and despite immediate management, visual outcome is generally poor. We report a case of endogenous K. pneumoniae endophthalmitis that was treated successfully. An 80-year-old woman with a liver abscess was diagnosed at an early stage with endogenous K. pneumoniae endophthalmitis. She underwent par plana...

Mutations in keratoepithelin are associated with blinding ocular diseases, including lattice corneal dystrophy type 1 and granular corneal dystrophy type 2. These diseases are characterized by deposits of amyloid fibrils and/or granular non-amyloid aggregates in the cornea. Removing the deposits in the cornea is important for treatment. Previously,...

Velocity distribution in the anterior chamber of porcine eyes under a simulated cataract surgery has been measured by using stereoscopic PIV. Surface location of the cornea was determined based on the images of laser-induced fluorescent light emitted from the fluorescent dye solution introduced in a posterior chamber. Cataract surgery was performed...

112 Carbohydrates are indispensable nutrients for life. However, due to the presence of a carbonyl group, reducing sugars such as glucose react non-enzymatically with amino groups on proteins in glycation (or Maillard) reactions. This reaction is divided into early and advanced phase reactions: the former covers the reaction progression up to the A...

107 Age-related macular degeneration has become a leading cause of blindness in most developed countries worldwide. In the early phase of the disease, abnormal, yellow-colored material called "drusen" appears between the retinal pigment epithelial cells and Bruch's membrane. Immunohistochemical studies have confirmed that drusen contain D-amino aci...

Anti-oxidant activities of adrenergic β-blockers are proposed in various organs. The aim of the present study was to investigate the effect of carteolol hydrochloride, an adrenergic β-blocker, on the production of reactive oxygen species (ROS) and the viable cell number after ultraviolet irradiation of cultured lens epithelial cells (LECs). Culture...

Microstereolithography (microSL) technology can fabricate complex, three-dimensional (3D) microstructures, although microSL has difficulty producing macrostructures with micro-scale features. There are potentially many applications where 3D micro-features can benefit the overall function of the macrostructure. One such application involves a medica...

Prior to the emergence of life, it is believed that only L-amino acids were selected for formation of proteins, and that D-amino acids were eliminated on the primitive Earth. Whilst homochirality is essential for life, recently the occurrence of proteins containing D-beta-aspartyl (Asp) residues from various tissues of elderly subjects has been rep...

Transparency is essential for eyes, which serve as cameras. However, decreased transparency caused by accumulation of abnormal proteins is commonly observed especially in elderly people. However, the mechanism of accumulation of abnormal proteins in various ocular diseases is still unclear. In the present study, we investigated the role of D-amino...

It is a well-known theorem by Chomsky and Schützenberger (1963) that every context-free language can be represented as a homomorphic image of the intersection of a Dyck language and a regular language. This paper gives a Chomsky-Schützenberger-type characterization for multiple context-free languages, which are a natural extension of context-free l...

A healthy 64-year-old man presented with a non-tender soft mass in the upper inner quadrant of the anterior left orbit. Magnetic resonance imaging revealed a 14 x 16 x 14-mm homogeneous cystic lesion in the anterior superonasal orbit with a distinct margin. An orbital cyst was suspected, and its surgical removal was planned. During the operation, t...

The purpose of this study was to investigate the influence of overnight orthokeratology on corneal sensation. A prospective study was conducted in 34 eyes of 17 patients undergoing overnight orthokeratology. Their ages ranged from 21 to 33 years (23.5 +/- 3.2 years, mean +/- standard deviation). The logarithm of minimum angle of resolution of uncor...

The number of minimum weight codewords is an important parameter to measure the potential performance of a linear block code. This paper studies the number of minimum weight codewords of simple and full-length array (SFA) LDPC codes. The notion of a cyclic shift closure is introduced, and it is shown that the set of minimum weight codewords of the...

To compare the efficacy and safety of estriol and triamcinolone acetonide suspensions in visualizing the prolapsed vitreous body in the anterior chamber after posterior capsule rupture in animal models. Tsukuba University Institute of Clinical Medicine, Ibaraki, Japan. To evaluate efficacy, triamcinolone acetonide or estriol suspension was injected...

Increased concentration of (1,3)-beta-D-glucan, one of the major components of fungal cell walls, is detected in the serum of systemic fungal infection. In our study, the concentration of (1,3)-beta-D-glucan was measured in the tear fluid of patients with mycotic keratitis. Tear fluid was collected from patients with fungal keratitis (n = 4) and ba...

Long-term duration of lifestyle-related diseases including diabetes induces various ocular diseases. For this reason, the development of lifestyle-related ocular diseases is closely related to the aging process. In the present study, we tried to reveal the molecular mechanism of lifestyle-related ocular diseases, especially diabetic complications o...

The toxicity of conventional formulations of amphotericin B deoxycholate (AmB(DOC)) limits its clinical applications. To reduce the toxicity of AmB(DOC), lipid formulations of amphotericin B (AmB) have been developed and clinically applied. In the present study, we evaluated the ocular toxicity and pharmacokinetics of subconjunctival injection of l...

A secure and efficient scheme to rekey group keys is investigated. A group key is secret information which is owned by all users in a certain group. When a user newly joins the group, and when a user leaves the group, the group key must be updated, or rekeyed, to conform the security. Widely known LKH scheme works efficiently if its internal key-tr...

This study is to investigate new schemes for distributing cryptographic keys in sensor networks. Sharing a key is the very first step to realize secure communication over an untrusted network infrastructure, but commonly used cryptographic techniques cannot be employed for sensor networks due to the restriction of computational resources of sensor...

The efficacy and toxicity of triamcinolone acetonide and other lipid formulae--calcium palmitate, cholesterol and 11-deoxycortisol--in the visualization of the prolapsed vitreous body in the anterior chamber after posterior capsule rupture were investigated in animal models. In porcine eyes, a suspension of calcium palmitate, cholesterol, triamcino...

In this paper, we consider consecutive burst transmission with burst loss recovery based on Forward Error Correction (FEC) in which redundant data is transmitted with multiple bursts. We propose two burst generation methods: Out-of Burst Generation (OBG) and In-Burst Generation (IBG). The OBG generates a redundant burst from redundant data, while t...

Biologically uncommon D-beta-aspartic acid (D-beta-Asp) has been detected in proteins from various human tissues in elderly donors. Previous studies have identified D-beta-Asp residues at four different specific sites in alpha-crystallin from aged human lenses and an increased amount of D-beta-Asp residues with age. D-beta-Asp is formed as a result...

Simple and full-length array LDPC codes (SFA-LDPC codes) is a class of LDPC codes which are algebraically constructed from a family of array codes. The minimum weight of SFA-LDPC codes has been investigated in literatures, but exact minimum weight of the code is not known except for some small parameters. In this paper it is shown that the class of...

To evaluate the efficacy of subconjunctival injection of micafungin in the treatment of experimental Candida albicans keratitis in rabbits compared with fluconazole. In 1 eye of 24 New Zealand white rabbits, C. albicans (5 x 10 yeast cells) was inoculated in the corneal stroma. The animals were randomly assigned to 3 groups and received subconjunct...

The interaction of advanced glycation end products (AGEs) with their receptors is hypothesized to be involved in the development of diabetic retinopathy. In the present study, the role of an AGE receptor, RAGE, was investigated in the development of diabetic retinopathy in vivo. C57/BJ6 and RAGE-transgenic mice that carried human RAGE genetic DNA u...

To review changes in the optical quality of the cornea induced by overnight orthokeratology for myopia. Sixty-four eyes of 39 patients who underwent overnight orthokeratology for myopia were prospectively examined. Inclusion criteria were uncorrected visual acuity of 20/20 or better after treatment and a minimum follow-up of 3 months. To quantitati...

An algorithm for encoding low-density parity check (LDPC) codes is investigated. The algorithm computes parity check symbols by solving a set of sparse equations, and the triangular factorization is employed to solve the equations efficiently. It is shown analytically and experimentally that the proposed algorithm is more efficient than the Richard...

The retinal ischemia-reperfusion model is used in the study of transient ischemia-related diseases, such as central retinal artery occlusion, angle-closure glaucoma, and others. There are two methods for experimentally producing an ischemia-reperfusion model in the rat retina: (i) the intraocular pressure is greatly raised by increasing the height...

To investigate the influence of pupil diameter on the relation between induced changes in ocular higher-order wavefront aberrations and changes in contrast sensitivity by conventional laser in situ keratomileusis (LASIK) for myopia. In 215 eyes of 117 patients (age, 33.2 +/- 8.3 years) undergoing LASIK for myopia of -1.25 to -13.5 D (-5.28 +/- 2.55...

An 82-year-old woman with age-related cataract and high myopia had uneventful phacoemulsification and intraocular lens (IOL) implantation. Preoperative visual acuity was 20/60 with -16.00 -3.00 x 70 and axial length was 29.29 mm. An IOL (MA60MA, Alcon) of +5.0 diopters (D) was selected with target refraction of -1.5 D. The next day, visual acuity w...

Diabetic retinopathy, a cause of blindness, is often associated with the upregulation of vascular endothelial growth factor (VEGF) in the retina. Recently, leukocyte adhesion (leukostasis) is claimed for the occlusion of retinal capillary vascularity, which ultimately assists in the progression of diabetic retinopathy. In addition, intercellular ad...

Advanced glycation end products (AGEs) are known to be deposited in the target organ of ageing. In addition, the deposition of AGEs accelerate the process of ageing. We investigated the immunohistochemical localization of AGEs in pinguecula, one of the ocular changes related with ageing process. Surgical specimens of conjunctiva with or without pin...

This study investigates new schemes for distributing cryptographic keys in sensor networks. Sharing a key is the very first step to realize secure communication over an untrusted network infrastructure, but commonly used cryptographic techniques cannot be employed for sensor networks due to the restriction of computational resources of sensor nodes...

Corneal endothelial cell loss is a change that occurs with age, but its mechanism is still unclear. We postulated that interaction between advanced glycation end product(AGE) and its receptors is implicated in the corneal endothelial cell loss with age. We investigated the expression of AGE receptors: receptors for AGE(RAGE) and galectin-3 in bovin...

Laser iridotomy often causes bullous keratopathy; however, the mechanism is unclear. We investigated whether changes in aqueous humor hydrodynamics after laser iridotomy have any role in corneal endothelial cell loss. Porcine corneal endothelial cells were plated onto glass slides. Following 1 or 3 hours for adhesion, the endothelial cells were exp...

To report a patient with a significant amount of ocular coma-like aberration that was caused by the tilting of an intraocular lens (IOL) who was treated successfully by IOL repositioning surgical procedure. Interventional case report. At the Department of Ophthalmology, University of Tsukuba, a 52-year-old man complained of unclear and distorted vi...

To evaluate ultraviolet (UV) A and B transmittance by human limbal epithelial cells cultured on human amniotic membranes. Human limbal epithelial cells were taken from the limbus of donor corneas and were cultured on human amniotic membranes with inactivated 3T3 fibroblasts for 2 to 4 weeks. Then, the cultured cells were examined histologically. Ne...

To evaluate the clinical usefulness of 11-deoxycortisol, a precursor of cortisol in steroid metabolism, in visualizing the vitreous body in the anterior chamber after posterior capsule rupture during cataract surgery. Department of Ophthalmology, Tsukuba University Hospital, Ibaraki, Japan. Eight eyes had anterior vitrectomy during cataract surgery...

There have been no reports of the topical application of micafungin to the eye. The aim of this study was to evaluate the safety of topical instillation of 0.1% micafungin ophthalmic solution in rabbit eyes. In New Zealand white rabbits (n = 6), 50 microL of 0.1% micafungin solution was topically instilled to 1 eye, and 50 microL of sterile saline...

Fourier harmonic analysis can decompose videokeratography data into spherical power, regular astigmatism, and irregular astigmatism (asymmetry and higher-order irregularity). The aim of this study was to evaluate whether determination of cylinder power by Fourier analysis facilitates measurements of visual acuity and refraction in eyes after penetr...

The complete subtree (CS) method is widely accepted for the broadcast encryption. A new method for assigning keys in the CS method is proposed in this paper. The essential idea behind the proposed method is to use two trapdoor permutations. Using the trapdoor information, the key management center computes and assigns a key to each terminal so that...

The complete subtree (CS) method is one of the most well-known broadcast encryptions which do not enforce the receivers to keep "online." This paper is to reduce the size of secret information which must be stored in a terminal of the method. In the original CS method. the size of the secret information increases as the number of terminals increase...

Major problems in the management of keratomycosis stem from the difficulty of its diagnosis and limited choice of antifungal agents. In the present paper we propose a new method of detecting (1,3)-beta-D-glucan, one of the major components of fungal cell wall, in tears from an animal model of keratomycosis. In addition, we investigated the efficacy...

To investigate long-term changes in the cornea after ionizing irradiation in rabbits. Mature albino rabbits (n = 4) were unilaterally irradiated with 20 Gy of x-rays. The contralateral eye served as a control. The rabbits were examined with slit-lamp biomicroscopy for 5 years. The eyes were then enucleated for histopathologic examinations with ligh...

Purpose: Major problems in the management of keratomycosis stem from the difficulty of its diagnosis and limited choice of antifungal agents. In the present paper we propose a new method of detecting (1,3)-β-d-glucan, one of the major components of fungal cell wall, in tears from an animal model of keratomycosis. In addition, we investigated the ef...

To develop a new technique to visualize vitreous body prolapsed in the anterior chamber using 11-deoxycortisol. Experimental study. An animal model of posterior capsule rupture was developed to investigate the usefulness of 11-deoxycortisol, a precursor of cortisol without steroid activity. After the intentional creation of posterior capsule ruptur...