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Publications (229)
Background
Understanding the genetic causes for variability in chromatin accessibility can shed light on the molecular mechanisms through which genetic variants may affect complex traits. Thousands of ATAC-seq samples have been collected that hold information about chromatin accessibility across diverse cell types and contexts, but most of these ar...
Objective
Our study aimed to examine the association between delay discounting (DD) and body mass index (BMI) in individuals with hypertension. Additionally, we sought to explore and compare the potential mediating effects of self-efficacy, physical activity and sedentary behavior in this association.
Methods
A cross-sectional survey was conducted...
Background
Improving health-related quality of life (HRQoL) among hypertensive individuals has emerged as a significant public health issue. However, current research has ignored the individual heterogeneity of perceived social support (PSS) among hypertensive patients. The potential mechanism of delay discounting (DD), living alone, and PSS on HRQ...
Chinese rural women aged 35–64 years are encouraged to complete breast cancer screening (BCS) free of charge. However, it is challenging to reach a satisfying BCS uptake rate. In this study, rural women’s preferences and preferences heterogeneity were measured for the development of strategies to enhance participation in BCS.
A cross-sectional surv...
Purpose: Breast cancer has been a serious health problem all around the world. Early detection is undoubtedly effective in combating severe public health problems in developing countries. Meanwhile, primary care physicians play an important role in implementation of screening programs. The objective of our study was to evaluate the determinates of...
Background
Breast cancer has been a serious health problem all around the world. Early detection is undoubtedly effective in combating severe public health problems in developing countries. Meanwhile, primary care physicians play an important role in implementation of screening programs. The objective of our study was to evaluate the determinates o...
Currently, the copolymer of dopamine (DA) and pyrrole (PY) via chemical and electrochemical oxidation usually requires additional oxidants, and lacks flexibility in regulating the size and morphology, thereby limiting the broad applications of DA‐PY copolymer in biomedicine. Herein, the semiquinone radicals produced by the self‐oxidation of DA is i...
Polydopamine (PDA) as a melanin-like biomimetic material with excellent biocompatibility, full spectrum light absorption capacity and antioxidation property has been extensively applied in the biomedical field. Based on the high reactivity of dopamine (DA), exploiting new strategies to fabricate novel PDA-based nano-biomaterials with controllable s...
Yixin Xie Ji Xu Hui Jin- [...]
Dongtao Ge
Recently, the near-infrared-II (NIR-II, 1000–1350 nm) region has been extensively applied in deep-tissue photothermal therapy (PTT) on account of it having stronger tissue penetration and a higher maximum permissible exposure (MPE) than the near-infrared-I (NIR-I, 650–950 nm) region. In this study, we developed a rapid and convenient in situ polyme...
Background
This study aimed to explore the levels of anxiety and depression in a sample of home-quarantined college students to identify the risk factors for psychological distress during the COVID-19 lockdown.
Methods
A total of 1156 college students studying in Jiangsu, China, participated from August 5 to August 14. A structured questionnaire w...
The high concentration Cl- in wastewater will cause adverse effects on production and environment. The existing chlorine-containing wastewater treatment processes are difficult to meet the requirements of wastewater application objects,...
Y Zeolite plays an irreplaceable role in many important applications due to its unique physicochemical properties, which has attracted extensive attention from researchers. Response surface methodology (RSM) was used to optimize the process parameters for the hydrothermal synthesis of Y zeolite using kaolin activated by microwave heating. The best...
Aim: The first inhibitor targeting myoferlin (MYOF), WJ460, bears poor metabolic stability and water solubility. Therefore, this study aimed to improve the druglike properties of WJ460. Materials & methods: The authors synthesized an array of 1,5-diaryl-1,2,4-triazole analogs and appraised the binding activities with MYOF and their antiproliferativ...
Yilong Guo Ren Wei Yuan He- [...]
Wei Guo
Background
Abdominal aortic aneurysms have a high mortality rate. While surgery is the preferred treatment method, the biological repair of abdominal aortic aneurysms is being increasingly studied. We performed cellular and animal experiments to investigate the simultaneous function and mechanism of fibroblast growth factor 18 and integrin β1 in th...
Background
High screening coverage can effectively reduce the mortality in breast and cervical cancer. Further research on extending the coverage of breast and cervical cancer screening in China is required. This study explored factors influencing women's “two-cancer” screening service utilization using an ecological approach.
Methods
Data were ob...
Large scale genetic association studies have identified many trait-associated variants and understanding the role of these variants in the downstream regulation of gene-expressions can uncover important mediating biological mechanisms. Here we propose ARCHIE, a summary statistic based sparse canonical correlation analysis method to identify sets of...
Ji Xu Yuan He Yanan Sun- [...]
Dongtao Ge
Conductive polypyrrole (PPy) has excellent biocompatibility and structural stability. It is an ideal electroactive biomaterial that can apply exogenous electrical stimulation to promote osteoblast differentiation. However, PPy is a kind of bio-inert material, which does not have osteoinductive capacity. Therefore, we have introduced a kind of bioac...
Yilong Guo Ren Wei Yuan He- [...]
Wei Guo
Background: Abdominal aortic aneurysms have a high mortality rate. While surgery is the preferred treatment method, the biological repair of abdominal aortic aneurysms is being increasingly studied. We performed cellular and animal experiments to investigate the simultaneous function and mechanism of fibroblast growth factor 18 and integrin β1 in t...
Background
Promoting cervical cancer screening (CCS) is undoubtedly effective in combating severe public health problems in developing countries, but there are challenges to its implementation. Understanding the factors influencing primary care physicians' intentions to provide CCSs to rural women is crucial for the future implementation of screeni...
In this study, 11 metabolites of PAEs (mPAEs) and 6 metabolites of OPs (mOPs) were determined in urine samples and amniotic fluid samples collected from participants living in e-waste dismantling sites and a reference area in Southern China. Results showed e-waste dismantling activities contributed to human exposure to PAEs and OPs. The health risk...
Background
It was reported that the incidence of breast cancer (BC) was the highest among cancers worldwide. The breast cancer screening (BCS) program is regarded as an effective preventive measure. However, rural women's willingness to participate in the BCS program is relatively low. To provide measures to prevent BC, it is necessary for the gove...
REY zeolites play an irreplaceable role in the high-tech field due to their unique internal structure and chemical properties, which have received extensive attention from domestic and foreign scholars. In this study, kaolin, which is cheap and good in quality, is used as the basic raw material, and the effect of various factors on the synthesis of...
Neonicotinoids (NEOs) have become the most widely used insecticides in the world. However, information on the NEO concentrations in tap water based on nationwide surveys is limited in China. In this study, the levels of six NEOs were measured in tap water samples collected from 38 cities in China. Across all sampling locations, the overall frequenc...
Aortic dissection (AD) is one of the most fatal cardiovascular emergency. At the anatomical level, AD occurs due to the formation of intimal tears. However, the molecular mechanism underlying this phenomenon remains unknown. Angiotensin II (Ang II) is a important effector in the development of cardiovascular disease that acts through binding to ang...
The synthesis of zeolite has more than 100 years of history, its special physicochemical properties make it widely used as adsorbents, ion exchange materials, excellent performance catalysts and other applications in environmental protection, petrochemical, petroleum refining and other fields. However, the synthesis process of zeolite is not comple...
Large scale genetic association studies have identified many trait-associated variants and understanding the role of these variants in downstream regulation of gene-expressions can uncover important mediating biological mechanisms. In this study, we propose Aggregative tRans assoCiation to detect pHenotype specIfic gEne-sets (ARCHIE), as a method t...
Perfluoroalkyl sulfonates (PFSAs), perfluoroalkyl carboxylates (PFCAs), and emerging alternatives and precursors of these compounds were determined in tissues of finless porpoise (Neophocaena asiaeorientalis sunameri) collected from East China Sea in 2009-2010 and 2018-2019. The median hepatic concentrations of emerging poly- and perfluoroalkyl sub...
Long non-coding RNA (lncRNA) genes have well-established and important impacts on molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a major challenge to identify the subset with disease or trait relevance. To systematically characterize these lncRNA genes, we used Genotype Tissue Expression (GTEx) project v...
Purpose:
Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customized targeted panels commonly used in clinical practice.
Materials and methods:
TMB spectra of 295...
As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored. In the present study, we provided the first functional evidence that MYOF promoted the cell in...
Background:
The global outbreak of the coronavirus disease 2019 (COVID-19) has emerged as a major public health threat. This study aimed to analyze the influencing factors of international students' intention to wear a mask based on the theory of planned behavior (TPB). The findings are important because they provide pertinent information in desig...
Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (TEFF)-driving transcription factors (TFs), the transcriptional coordination of TEFF biology remains poorly understood. We developed an in vivo T cell CRISPR screening platform and identified a key m...
Conducting polymer coatings and patterns are the most important forms of these materials for many practical applications, but a simple and efficient approach to these forms remains challenging. Herein, we report a universal oxidant-intermediated surface polymerization (OISP) for the fabrication of conducting polymer coatings and patterns on various...
Polypyrrole (PPy) is a promising conducting polymer in bone regeneration; however, due to the biological inertia of the PPy surface, it has poor cell affinity and bioactivity. Based on the excellent adhesion capacity, biocompatibility, and bioactivity of polydopamine (PDA), the PDA is used as a functional coating in tissue repair and regeneration....
Objectives:
The goal of this study was to investigate factors favouring the bird-beak configuration after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection.
Methods:
We retrospectively analysed 76 patients with type B aortic dissection who underwent landing zone 1 and 2 TEVAR from December 2015 to January 2018. Preoperativ...
Large scale genetic association studies have identified many trait-associated variants and understanding the role of these variants in downstream regulation of gene-expressions can uncover important mediating biological mechanisms. In this study, we propose Aggregative tRans assoCiation to detect pHenotype specIfic gEne-sets (ARCHIE), as a method t...
Background:
We explored the ability of delta α-fetoprotein (ΔAFP) to detect recurrence in patients with liver cancer treated with hepatectomy.
Methods:
A total of 1,846 patients diagnosed with local liver cancer who underwent hepatectomy at Sun Yat-sen University Cancer Center were enrolled in the present study. Receiver operating characteristic...
Objective:
This study was performed to demonstrate the feasibility and effectiveness of a novel off-the-shelf endograft (G-Branch™; Lifetech Scientific, Shenzhen, China) for the treatment of patients with complex thoracoabdominal/abdominal aortic aneurysms.
Methods:
Three patients (one with a suprarenal abdominal aortic aneurysm and two with tho...
Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs), exhibits complex patterns of tissue-specific effects. Characterization of these patterns may allow us to better understand mechanisms of gene regulation and disease etiology. We develop a constrained matrix factorization model, sn-spMF, to learn patterns...
Micron-sized praseodymium oxide powders are prepared successfully from the praseodymium oxalate in a microwave field at 750 °C for 2 h in the present study. X-ray diffraction (XRD) analysis demonstrates that the presence of cubic structured crystalline Pr6O11 and complete decomposition of the precursor are confirmed by Fourier transform infrared (F...
Purpose
Patients who have survived an acute aortic dissection remain at risk for postdissection thoracoabdominal aortic aneurysms (PD-TAAAs). Fenestrated/branched endovascular repair for PD-TAAA is increasingly used in some high-volume centers, but outcomes are still limited because of the additional challenges compared to atherosclerotic thoracoab...
The chloride salt derived from the rare earth smelting wastewater was effectively dislodged using Friedel’s salt precipitation assisted with ultrasonic enhancement. Various single factors such as the reagent ratio, temperatures, reaction time and agitation speed were determined and investigated systematically. Results showed that the optimal single...
Background: Current variability in methods for tumor mutational burden (TMB) estimation and reporting urges the need for a homogeneous TMB assessment. Here we compared the TMB distributions in different cancer types using two customized targeted panels commonly used in clinical practice.
Methods: TMB spectrum of the 295- and 1021-Gene panels in mul...
Aim: To compare and evaluate the prognostic value of various pretreatment combinations of inflammatory factors in patients with lung cancer (LC). Materials & methods: This study enrolled 1005 patients with LC and categorized into a discovery cohort and a validation cohort. Results: A combination of lymphocyte to C-reactive protein levels (LCR) demo...
Triclosan (TCS) and Triclocarbon (TCC) are chlorinated synthetic antimicrobial agents formaternal urinelated in quantities of consumer products. However, the biomonitoring of direct exposure reflection for fetuses are rare. In this study, we determine the concentrations of TCS and TCC in paired maternal serum, cord serum, maternal urine, and amniot...
The extraction of chloride from wastewater using trioctylamine (TOA) diluted in sulfonated kerosene as the extractant has been investigated. The results showed that the optimal operating conditions of the extraction chloride were ascertained by univariate experiment, and the best removal rate 79.11% was determined. The McCabe–Thiele diagram demonst...
Aim: The role of NK homeobox 2.2 (NKX2.2) in human colorectal cancer (CRC) remains to be unveiled. This study was designed to explore the epigenetic regulation and function of NKX2.2 in human CRC.
Methods: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used to assess the methylation data of NKX2.2 in CRC. Six CRC cel...
An empirical analysis is conducted to evaluate the effect of the geometric parameters of microchannel on the mixing performance at high flow rates. The mixing performance is assessed using I⁻/IO3⁻parallel competition reaction covering the whole flow regime, and measured using segregation index (Xs) covering different lengths of outlet tube (Lout),...
Improving effector activity of antigen specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (TEFF)-driving transcription factors (TF), the transcriptional coordination of TEFF biology remains poorly understood. We developed an in vivo T cell CRISPR screening platform and identified a novel...
Neonicotinoids (NEOs) are insecticides that are widely used around the world. Following exposure, NEOs get metabolized in human bodies. The biomarkers to assess human NEOs exposure are not well described due to the lack of information on the metabolites of NEOs (m-NEOs). In this study, five m-NEOs including N-desmethyl-acetamiprid (N-dm-ACE), 5-hyd...
The vapor phase polymerization (VPP) method is a conventional strategy for synthesizing conducting polymers (CPs) on the surfaces of various materials. However, the current VPP method performed on a metal surface usually requires harsh reaction conditions, such as high temperature and low vacuum. In this paper, a polypyrrole (PPy) and vanadium pent...
Objectives:
This study aims to evaluate differences in proximal aorta geometry and identify specific anatomical predictors of type B aortic dissection (TBAD).
Methods:
We evaluated computed tomographic angiograms of controls (n = 185) and patients with acute TBAD (n = 173). Using propensity score matching, we created 2 groups of 127 patients. 3m...
Objective
To investigate the clinical implications of sleep quality, anxiety and depression in patients with advanced lung cancer (LC) and their family caregivers (FCs).
Methods
A total of 98 patients with advanced LC and their FCs (n=98) were recruited from the Oncology Department in Nanfang Hospital. The Pittsburgh Sleep Quality Index (PSQI), co...
Benzophenone (BP)-type ultraviolet (UV) filters are widely used in personal care products. Some of them have been identified as endocrine disrupting chemicals. However, little is known about the occurrence of BP-type UV filters in paired maternal-fetal samples. In this study, we investigated the occurrence of eight BP-type UV filters in paired mate...
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY‐444 ((N4‐((5‐(4‐(benzyloxy)phenyl)‐2‐thiophenyl)methy...
Zinc and iron were separated from the spent pickling solution by extraction with methyl trioctyl ammonium chloride (Aliquat 336). The purpose of the extraction experiment is to determine a variety of parameters (e.g. addition of octanol, contact time, phase ratio, [H⁺] concentration and Aliquat 336 concentration). Under optimal extraction condition...
Purpose
Fenestrated/branched endovascular aneurysm repair is a feasible and effective treatment option for patients with post-dissection thoracoabdominal/abdominal aneurysm. However, this technique is cumbersome when the target vessel originates from the false lumen. We herein report our primary experiences in utilizing a reversed off-the-shelf ili...
With the phase out of perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), the composition profiles of poly- and perfluoroalkyl substance (PFAS) in our living environment are unclear. In this study, 25 PFASs were analyzed in indoor dust samples collected from urban, industrial, and e-waste dismantling areas in China. PFOS alternatives...
Aortic dissection (AD) is a fatal disease that accounts for a large proportion of aortic-related deaths and has an incidence of about 3–4 per 100,000 individuals every year. Recent studies have found that inflammation plays an important role in the development of AD, and that macrophages are the hub of inflammation in the aortic wall. Aortic sample...
Six parabens and their four metabolites were measured in paired maternal serum (MS) and cord serum (CS) samples collected from 95 pregnant women to elucidate placental transfer of this class of compounds. Matched maternal urine (MU) and amniotic fluid (AF) collected from 13 of 95 pregnant women were also analyzed to examine partition of these chemi...
Bisphenol A (BPA) and its alternatives are suspected endocrine disruptors. However, prenatal exposure and transplacental transfer of bisphenols (BPs is still limited. Therefore, BPA and its six alternatives in maternal serum (MS), maternal urine (MU), cord serum (CS), and amniotic fluid (AF) samples collected from 106 maternal-fetal pairs in an e-w...
of main observation and conclusion
Process reinforcement research was carried out in Y‐junction slug flow microreactors under variable conditions, using EHEHPA (2‐ethylhexyl phosphonic acid mono‐2‐ethylhexyl) to extract yttrium(III) from hydrochloric acid solution. The influence of pH and flow rate on the extraction‐reaction efficiency, slug size,...
Aortic dissection (AD) is one of the most lethal cardiovascular diseases. Endothelial cell (EC) dysfunction serves an important role in AD progression. Angiotensin II (Ang II) is a key effector in cardiovascular disease development that acts through binding to angiotensin type 1 receptor (AT1R). Yes-associated protein (YAP) is well-known as a key m...