yu Wang

• UNSW Sydney

Aim To investigate the associations of triglyceride‐glucose index (TyG) with anthropometric characteristics, metabolic/endocrine profiles, and pregnancy outcomes in Chinese women with polycystic ovary syndrome (PCOS). Methods This secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial (PCOSAct)...

Microneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch with breathability for wound healing by a multi-step replication method. The microneedle patch consists of a...

The calcineurin B‐like protein (CBL)‐CBL‐interacting protein kinase (CIPK) Ca²⁺ sensors play crucial roles in the plant's response to drought stress. However, there have been few reports on the synergistic regulation of drought stress by CBL‐CIPK and abscisic acid (ABA) core signaling components. In this study, we discovered that ZmCIPK33 positivel...

Avena barbata, a wild oat species within the genus Avena, is a widely used model for studying plant ecological adaptation due to its strong environmental adaptability and disease resistance, serving as a valuable genetic resource for oat improvement. Here, we phased the high‐quality chromosome‐level genome assembly of A. barbata (6.88 Gb, contig N5...

Stomata, which are essential for the exchange of CO 2 and water vapor between plant leaves and the atmosphere, are regulated by a variety of environmental and internal factors. In this study, we identified and characterized two genes, Guard Cell Turgor Maintaining 1 ( GCT1 ) and its closest homolog GCT2 , which encode rapidly accelerated fibrosarco...

Objective Gender is a vital factor for the development and treatment of cardiovascular diseases. This study aimed to evaluate sex-based differences in the prognosis of patients with acute myocardial infarction (AMI). Methods AMI patients who had been registered in the MIMIC III and IV database were enrolled. The primary study endpoint was 1-year a...

To investigate the expression of the transcription factor Yin and Yang 1 (YY1) and the effect of oxidative stress on the upregulation of epidermal growth factor receptor (EGFR) expression in a bronchial epithelial cell line. A bronchial epithelial cell line (BEAS-2B) was stimulated with interleukins (IL-4, IL-13, and IL-17A) to simulate the asthma...

In the presence of interstitial flow (IF), changing both cell densities and the cellular environment results in increased cell motility, which indicates the reliability of microfluidic chips for modeling complex physiological environments.

Biliary atresia (BA) is a rare and severe congenital disorder with a significant challenge for prenatal diagnosis. This study, registered at the Chinese Clinical Trial Registry (ChiCTR2200059705), aimed to develop an intelligent model to aid in the prenatal diagnosis of BA. To develop and evaluate this model, fetuses from 20 hospitals across China...

Glucocorticoids such as dexamethasone have shown promising therapeutic effects in conquering oral ulcers. Challenges in this area are focused on enhancing the localized curative effects and responsive release. Herein, we presented a novel MXene‐integrated responsive hydrogel microneedle delivering dexamethasone to promote the healing of oral ulcera...

A fluorescent/colorimetric dual-mode biosensor was designed using CdTe QDs and CRISPR/Cas for the efficient and ultrasensitive detection of microcystin-leucine-arginine (MC-LR). The biosensor mainly activates the trans-cleavage activity of Cas12a through nucleic acid amplification technology, such as bidirectional rolling circle amplification (B-RC...

The senescence-associated secretory phenotype (SASP) is a key mechanism through which senescent cardiovascular cells contribute to plaque formation, instability, and vascular remodeling. However, the correlation between SASP and acute ischemic stroke (AIS), particularly its immune inflammation characteristics, remains underexplored and requires fur...

Foodborne pathogens, a major cause of foodborne illness due to their high virulence, pose a serious threat to public health. Consequently, identification of foodborne pathogens is essential for the prevention and treatment of foodborne infections. Consequently, there is an immediate need to establish a highly specific and precise approach for the c...

Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation and senescence. Previous studies showed that club cells and club cell secretory proteins (CCSP) have anti‐inflammatory roles, which reduced in COPD. Klotho (KL) decreased in human COPD lung tissue. KL‐deficient mice showed aging phenotypes, such as obvious emphyse...

Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss and the prevention or promotion of cancer. We investigated the causal relationship between weight loss following Roux-en-Y gastric bypass (RYGB) and the incidence of 18 cancers us...

Background Asthma exacerbation significantly contribute to disease mortality and result in heightened health care expenditures. This study was aimed at gaining important new insights into the heterogeneity of epithelial and immune cells and elucidating key regulatory genes involved in the pathogenesis of asthma exacerbation. Methods Functional enr...

Aim Sympathetic overactivation may lead to severe ventricular arrhythmias (VAs) post‐myocardial infarction (MI). The superior cervical ganglion (SCG) is an extracardiac sympathetic ganglion which regulates cardiac autonomic tone. We aimed to investigate the characteristics and functional significance of SCG on neuro‐cardiac communication post‐MI....

Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HA...

Extracellular vesicles (EVs), as a crucial marker of liquid biopsy, are important for early diagnosis and prognostic assessment of cancer. However, the cumbersome sample purification process and the false-positives results...

Recent research highlights the critical roles played by exosomal surface proteins in diagnostic biomarkers for distinguishing various cancers. Consequently, comprehensive detection of exosomal surface proteins is essential to the cancer...

Spin-polarized edge states in two-dimensional materials hold promise for spintronics and quantum computing applications. Constructing stable edge states by tailoring two-dimensional semiconductor materials with bulk-boundary correspondence is a feasible approach. Recently layered NiI2 is suggested as a two-dimensional type-II multiferroic semicondu...

A novel detection technique is introduced that offers sensitive and reliable ochratoxin A (OTA) detection. The method leverages the etching of gold nanorods (AuNRs) stabilized by hexadecyl trimethyl ammonium bromide (CTAB) using the oxidized form of 3,3′,5,5′-tetramethyl benzidine sulfate (TMB²⁺), creating a susceptible multicolor visual detection...

Purpose Diabetes is a risk factor for bone fractures. However, the association between insulin resistance and the risk of fracture has not been well studied. In the present study, we explored the association of the triglyceride glucose index as a measure of insulin resistance with the risk of vertebral fracture in older adults. Methods A total of...

A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow tract (OFT) and atrioventricular canal (AVC) cushions through a process known as endothelial-to-mesenchymal transition (EndMT). Aberrant EndMT is a primary cause of congenital valvular malformations. Manic Fringe (MFNG) has been...

Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, and nerve engineering. In particular, immense efforts have been dedicated to developing electrical microneedles, which demonstrate unique features in terms of controllable drug release, real‐time monito...

Background Despite statins and other medications central to atherosclerotic cardiovascular disease (ASCVD) secondary prevention, stable coronary artery disease (SCAD) patients remain at significant cardiovascular risk, partly due to residual inflammation risk (RIR). This study aims to assess if adding Guanxinning to standard ASCVD therapy further m...

Messenger RNA (mRNA) has demonstrated immense potential in disease therapeutic applications. The current direction is focused on imparting mRNA with competitive synthetic functions and delicate carrier systems. Here, inspired by the collaborative regulation of growth factors by the cellular microenvironment, we present novel transition metal carbid...

Bacterial infected wounds bring an economic burden to the worldwide medical care field. A variety of bioactives‐integrated hydrogel patches are developed in response to this challenge. Here, the melanin hydrogel inverse opal microneedle patches (MNs) with antioxidant and visual color sensing abilities for the management of bacterial infected wounds...

Altered redox homeostasis has long been observed in cancer cells, which can be exploited for therapeutic benefits. However, reactive oxygen species (ROS) pleiotropy coupling with reductive adaptation in cancer cells poses a formidable challenge for redox dyshomeostasis‐based cancer therapy. Herein, a AuPd alloying nanozyme‐glutathione (GSH) biosynt...

MAX phases, a unique class of layered ternary compounds, along with their two-dimensional derivatives, MXenes, have drawn considerable attention in many fields. Notably, their one-dimensional (1D) counterpart exhibits more distinct properties and enhanced assemblability for broader applications. We propose a conformal synthetic route for 1D-MAX pha...

Pulmonary arterial hypertension (PAH) is a progressive and rapidly fatal disease with an intricate etiology. Identifying biomarkers for early PAH lesions based on the exploration of subtle biological processes is significant for timely diagnosis and treatment. In the present study, nine distinct cell populations identified based on gene expression...

Recent research has highlighted the potential of Codonopsis Radix to modulate the immune system, making it a promising candidate for treating chronic inflammatory and cardiovascular diseases, tumors, and aging. However, because of the complex immune activities of its various components, a comprehensive understanding of Codonopsis Radix immune-regul...

Objective Artificial intelligence (AI) could help medical practitioners in analyzing radiological images to determine the presence and site of bowel obstruction. This retrospective diagnostic study proposed a series of deep learning (DL) models for diagnosing bowel obstruction on abdominal radiograph. Methods A total of 2082 upright plain abdomina...

Engineered hydrogel patches have shown promising therapeutic effects in the treatment of myocardial infarction (MI), especially anisotropic patches that mimic the characteristics of native myocardium have attracted widespread attention. However, it remains a great challenge to develop cardiac patches with long‐range and orderly electrical conductio...

Harvesting energy from the water − solid interface through natural water evaporation provides a promising approach for generating sustainable electricity to power self-powered electronics. Advancing the bio-based hydrovoltaic materials enhances sustainability, with wood as a viable candidate due to the inherent hydrophilic and charged properties. H...

Microneedles are demonstrated as an effective strategy for chronic wound treatment. Great endeavors are devoted to developing microneedles with natural compositions and potent functions to promote therapeutic effects for wound healing. Herein, a novel graphene oxide‐integrated methacrylated fish gelatin (GO‐FGelMA) microneedle patch encapsulated wi...

Objective: This research was conducted to investigate the monitoring values of routine echocardiography (ECG) and two-dimensional speckle tracking imaging (2D-STI) in cardiotoxicity caused by the treatment of breast carcinoma with anthracyclines (ANTH). Methods: 100 patients with breast carcinoma were selected and enrolled into normal group (n=53 c...

Background: The senescence-associated secretory phenotype (SASP) is a key mechanism through which senescent cardiovascular cells contribute to plaque formation, instability, and vascular remodeling. However, the correlation between SASP and acute ischemic stroke (AIS), particularly its immune inflammation characteristics, remains underexplored and...

Introduction The management of nutritional risk has garnered significant attention in individuals diagnosed with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) due to the high prevalence of malnutrition and its correlation with unfavorable outcomes. While numerous rating scales exist to assist in assessment for both clinical a...

Objective This study aimed to develop and validate several artificial intelligence (AI) models to identify acute myocardial infarction (AMI) patients at an increased risk of acute kidney injury (AKI) during hospitalization. Methods Included were patients diagnosed with AMI from the Medical Information Mart for Intensive Care (MIMIC) III and IV dat...

Objective This study aimed to evaluate the effects of microRNA-650 (miR-650) on melanoma metastasis and reveal the regulatory relationship between miR-650 and the inhibitor of growth family member 4 (ING4). Methods miR-650 expression was determined in human melanoma WM115 and A-375 cells. WM115 cells were transfected with miR-650 mimic or mimic co...

Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest and have been developed for treating oral diseases. In this review, we present up‐to‐date research on hydrogels for the ma...

The cell wall is the first barrier against external adversity and plays roles in maintaining normal physiological functions of fungi. Previously, we reported a nucleosome assembly protein, MoNap1, in Magnaporthe oryzae that plays a role in cell wall integrity (CWI), stress response, and pathogenicity. Moreover, MoNap1 negatively regulates the expre...

Microneedles have demonstrated value in targeted treatment of dermatosis. Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects. Here, we present innovative shell–core microneedles with light-pH dual responsiveness for spatiotemporal sequential release of multiple Chinese herb drugs to tr...

BACKGROUND Cellular communication among different types of vascular cells is indispensable for maintaining vascular homeostasis and preventing atherosclerosis. However, the biological mechanism involved in cellular communication among these cells and whether this biological mechanism can be used to treat atherosclerosis remain unknown. We hypothesi...

Hydrogels hold great promise in the field of flexible electronics. Attempts in this area tend to the microstructure design of hydrogels, giving them specific adhesion and multi‐sensing functions. Here, a novel phase separation‐derived anisotropic adhesive structural color hydrogel film is presented for visually flexible electronics. The hydrogel fi...

Background Collagen (COL) genes, play a key role in tumor invasion and metastasis, are involved in tumor extracellular matrix (ECM)-receptor interactions and focal adhesion pathways. However, studies focusing on the diagnostic value of the COL4 family in stomach adenocarcinoma (STAD) are currently lacking. Methods The TCGA database was employed to...

Objective: The primary objective of this study was to assess the diagnostic potential of galectin-3 (Gal-3), fractalkine (FKN), interleukin (IL)-6, microRNA(miR)-21, and cardiac troponin I (cTnI) in patients with ischemic cardiomyopathy (ICM). Method: A total of 78 ICM patients (Case group) and 80 healthy volunteers (Control group) admitted to o...

Benefiting from the complex system composed of various constituents, medicament portions, species, and places of origin, traditional Chinese medicine (TCM) possesses numerous customizable and adaptable efficacies in clinical practice guided by its theories. However, these unique features are also present challenges in areas such as quality control,...

Chronic obstructive pulmonary disease (COPD) is often associated with lung squamous cell carcinoma (LUSC), which has the same etiology (smoking, inflammation, oxidative stress, microenvironmental changes, and genetics). Smoking, inflammation, and airway remodeling are the most important and classical mechanisms of COPD comorbidity in LUSC patients....

The aim of this study was to construct a classification model for the automatic diagnosis of pediatric supracondylar humerus fractures using radiomics-based machine learning. We retrospectively collected elbow joint Radiographs of children aged 3 to 14 years and manually delineated regions of interest (ROI) using ITK-SNAP. Radiomics features were e...

Purpose Pericoronary adipose tissue (PCAT) attenuation is a non-invasive biomarker of coronary perivascular inflammation. This study aims to explore the relationship between pericoronary adipose tissue mean attenuation (PCATMA) and volume with the severity of coronary artery stenosis and plaque characteristics. Methods We conducted a retrospective...

The development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances. Current attempts tend to elaborate on the micro/nano‐structure design of the microcarriers to achieve multiple drug delivery and spatiotemporal responsive features. Here, the desired hydrogel microspheres are presented...

Background The purpose of this study was to explore the association between triglycerides (TGs) and the risk of atrial fibrillation (AF) recurrence. Methods and Results Included were adult patients with AF who underwent radiofrequency catheter ablation in the Affiliated Changzhou Second People's Hospital of Nanjing Medical University. The enrolled...

Drought stress has negative effects on crop growth and production. Characterization of transcription factors that regulate the expression of drought‐responsive genes is critical for understanding the transcriptional regulatory networks in response to drought, which facilitates the improvement of crop drought tolerance. Here, we identified an Alfin‐...

Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on neonatal necrotizing enterocolitis (NEC) is not well characterised. This cross-sectional study evaluated the potential effects of pandemic-related measures on NEC morbidity in premature infants in a neonatal ward during the COVID-19 pandemic. Methods This was a retrospect...

Calcium oscillations are induced by different stresses. Calcium‐dependent protein kinases (CDPKs/CPKs) are one major group of the plant calcium decoders that are involved in various processes including drought response. Some CPKs are calcium‐independent. Here, we identified ZmCPK2 as a negative regulator of drought resistance by screening an overex...

Immunity imbalance of T helper 17 (Th17)/regulatory T (Treg) cells is involved in the pathogenesis of Crohn's disease (CD). Complanatuside A (CA), a flavonol glycoside, exerts anti‐inflammatory activities and our study aimed to identify its effect on TNBS‐induced colitis and the possible mechanisms. We found that CA alleviated the symptoms of colit...

Background Emerging evidence indicates carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is involved in the development of atherosclerosis (AS). However, the roles and functions of CEACAM1 in AS remain unknown. Therefore, this study aims to investigate the roles and molecular functions of CEACAM1 in AS. Methods We constructed a d...

Objective This study aimed to evaluate the role of receptor-interacting protein kinase-3 (RIPK3) in the diagnosis, estimation of disease severity, and prognosis of premature infants with necrotising enterocolitis (NEC). Methods RIPK3, lactic acid (LA), and C-reactive protein (CRP) levels were measured in the peripheral blood of 108 premature infan...

Labelling medical images is an arduous and costly task that necessitates clinical expertise and large numbers of qualified images. Insufficient samples can lead to underfitting during training and poor performance of supervised learning models. In this study, we aim to develop a SimCLR-based semi-supervised learning framework to classify colorectal...