Yu-Kang Tu

Yu-Kang Tu
National Taiwan University | NTU · Graduate Institute of Epidemiology and Preventive Medicine

DDS, MSc, PhD

About

452
Publications
63,578
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
10,305
Citations
Citations since 2016
272 Research Items
7976 Citations
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
Additional affiliations
August 2017 - present
National Taiwan University
Position
  • Manager
August 2016 - present
National Taiwan University
Position
  • Professor
August 2012 - July 2016
National Taiwan University
Position
  • Professor (Associate)
Education
November 2002 - April 2006
University of Leeds
Field of study
  • Statistical Epidemiology
September 2000 - September 2001
University College London
Field of study
  • Periodontology
September 1986 - June 1992
National Taiwan University
Field of study
  • Dentistry

Publications

Publications (452)
Article
Full-text available
Background There is a lack of consensus on the optimal serum valproic acid (VPA) concentration for maintenance therapy in bipolar disorder (BD). We aimed to investigate the association between serum VPA levels and risk of mood episode recurrence. Methods We enrolled patients with BD from multiple medical institutions in Taiwan between January 1, 2...
Article
Full-text available
Background Acute mania is a psychiatric emergency requiring rapid management. However, randomised controlled trials (RCTs) have shown considerable individual differences in treatment effects on manic symptoms with antimanic drugs. Methods We searched the MEDLINE, CENTRAL, EMBASE, PsycINFO, and ClinicalTrials.gov to identify RCTs without language r...
Article
The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials...
Article
Objective To integrate all evidence derived from randomized controlled trials (RCTs) of both pharmacological and nonpharmacological augmentation interventions for clozapine-resistant schizophrenia (CRS). Methods Six major electronic databases were systematically searched for RCTs published until July 10, 2021. The primary outcome was change in ove...
Article
Objectives: To assess the reporting and methodological quality of split-mouth trials (SMTs) in oral implantology published during the past ten years, and to investigate whether there was any improvement over time. Materials and methods: We searched PubMed for SMTs in oral implantology published during 2011-20. We used CONSORT 2010, its extension...
Article
Full-text available
Objectives: To assess the cardiovascular and renal efficacy and safety of sodium-glucose cotransporter-2 (SGLT2) inhibitors in patients without diabetes. Methods: We searched PubMed, MEDLINE, Embase and Cochrane Library for publications up to 17 August 2022. Certainty of evidence was assessed using the Grading of Recommendations, Assessment, Dev...
Article
Hintergrund und zielsetzung: Vergleich der Wirksamkeit und Sicherheit von Biologika zur Behandlung mittelschwerer bis schwerer Plaque-Psoriasis im Kindes- und Jugendalter, soweit diese von der US Food and Drug Administration (FDA) und der European Medicines Agency (EMA) zugelassen sind. Patienten und methodik: Die Datenbanken MEDLINE, Embase und Co...
Article
Full-text available
Capecitabine‐induced hand‐foot syndrome is common in clinical practice. There are many regimens used to prevent hand‐foot syndrome. However, the most effective preventive regimen has not yet been identified. Thus, we conducted a network meta‐analysis to investigate the best preventive regimen for hand‐foot syndrome. The PRISMA‐NMA guidelines were u...
Article
Background and objectives: To compare the efficacy and safety of biologic treatments for moderate-to-severe pediatric psoriasis approved by the US Food and Drug Administration and European Medicines Agency. Patients and methods: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials for relevant randomized controlled trials (RCTs) w...
Article
Full-text available
Background: A total esophagectomy with gastric tube reconstruction is the mainstream procedure for esophageal cancer. Colon interposition and free jejunal flap for esophageal reconstruction are the alternative choices when the gastric tube is not available. However, to date, a solution for the high anastomosis leakage rates among these three types...
Preprint
Full-text available
Objective: The aim of this study is to review the reasons reported within rehabilitative ultrasound imaging (RUSI) research for using percent change, and to conduct Monte Carlo simulations to evaluate the statistical assumptions, statistical power, reliability, and type 1 error rate regarding this practice. Design: Systematic review with Monte Car...
Article
Full-text available
Background Melasma is a chronic skin condition that adversely impacts quality of life. Although many therapeutic modalities are available there is no single best treatment for melasma. Oral tranexamic acid has been used for the treatment of this condition but its optimal dose is yet to be established. Objectives We used network meta-analysis to de...
Article
The efficacies of various exercise modalities in improving older adults’ sleep quality remain unclear. Therefore, in this study, network meta-analysis was performed by comparing the efficacies of various exercise regimens in improving sleep quality in this age group. Six electronic databases were searched for relevant studies between the date of da...
Article
Full-text available
Until now, no study has directly network meta‐analysed the impact of nasal masks, nasal pillows and oronasal masks on continuous positive airway pressure therapy in patients with obstructive sleep apnea. This study aimed to meta‐analyse the impact of three kinds of nasal interfaces with both network meta‐analysis and pairwise comparison. PubMed, EM...
Article
Importance/background Several diagnostic criteria have been developed to effectively diagnose systemic lupus erythematosus (SLE). Three criteria are most common, namely the American College of Rheumatology (ACR)-1997, the Systemic Lupus International Collaborating Clinics (SLICC)-2012, and the European League Against Rheumatism (EULAR/ACR)-2019. Wh...
Article
Background Modern technological applications, including exergames and virtual technology-assisted rehabilitation (VTAR) programmes, are promising for Parkinson’s disease (PD) rehabilitation. However, evidence regarding their efficacy for rehabilitation is inconclusive. Objectives This network meta-analysis (NMA) investigated the efficacy of exerga...
Article
Aim: In recent decades, the prevalence of amphetamine and methamphetamine use disorders has at least doubled in some regions/countries, with accompanying high risks of drug overdose-associated mortality. Noninvasive brain stimulation (NIBS) methods may be effective treatments. However, the comparative efficacy of the NIBS protocol for amphetamine/...
Article
Background Although numerous studies have examined the development of preterm children born very low birth weight (VLBW, birth body weight < 1500 g), variations of developmental progress within individuals have rarely been explored. The aim of this research was to examine the cognitive and motor trajectories in preterm children born VLBW at early a...
Article
Importance: Negative symptoms have a detrimental impact on functional outcomes and quality of life in people with schizophrenia, and few therapeutic options are considered effective for this symptomatic dimension. Studies have suggested that noninvasive brain stimulation (NIBS) interventions may be effective in treating negative symptoms. However,...
Article
Background: Network meta-analysis computes treatment ranking to assist with clinical decision making, but it is not always clear how reliable the ranking is and how likely the accumulation of new evidence may alter the ranking. Uncertainty and robustness of ranking are two concepts related to the reliability of ranking. However, it is still unclear...
Article
Full-text available
Background: : Current guidelines recommend per-oral endoscopic myotomy (POEM) and laparoscopic Heller's myotomy (LHM) as first-line treatment of idiopathic achalasia, but the optimum choice between different endoscopic and surgical modalities remains inconclusive. We conducted a network meta-analysis to compare the efficacy of 8 treatments for idi...
Article
The optimal serum lithium levels for preventing the recurrence of mood episodes in bipolar disorder are controversial, especially when polarity is considered. The present study aimed to comprehensively examine the dose-response relationship between lithium concentration and risk of recurrence of mood episodes. We conducted a systematic search of ma...
Article
Background While Alzheimer’s dementia (AD) has a prevalence as high as 3-32% and is associated with cognitive dysfunction and the risk of institutionalization, no efficacious and acceptable treatments can modify the course of cognitive decline in AD. Potential benefits of exogenous melatonin on cognition have been divergent across trials. Objectiv...
Article
Full-text available
Background Although the current consensus recommends a standard treatment of high-dose intravenous immunoglobulin with high-dose aspirin to manage Kawasaki disease (KD), the use of different adjunctive therapies remains controversial. The aim of the current network meta-analysis (NMA) was to compare the efficacy and tolerability of different existi...
Article
Full-text available
Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent LDL-C lowering agents. However, few head-to-head studies evaluated the efficacy on the lowering in other atherogenic apolipoproteins and safety of PCSK9 inhibitors at different dosages as an add-on statins therapy in hypercholesterolemia patients. Methods: T...
Article
Full-text available
Objectives The risk of dialysis following contrast exposure is unclear. We aimed to examine the overall risk of contrast induced nephropathy and the need of dialysis based on a systematic review with random-effects meta-analysis.Methods We searched the electronic database including PubMed, Medline, Embase, and Cochrane Library from inception to 31...
Article
Full-text available
Previous studies have suggested that the topical mechanistic target of rapamycin (mTOR) inhibitors may be effective in treating facial angiofibromas in patients with tuberous sclerosis complex (TSC). Various concentrations of topical sirolimus for TSC have been tested, but their comparative efficacy and safety remained unclear. To assess the effect...
Article
Full-text available
Purpose: The aim of the present systematic review was to evaluate the effect of different lateral bone augmentation (LBA) procedures on the complete correction of a peri-implant bone dehiscence (BD) or fenestration (BF) from implant placement to implant surgical uncovering. Methods: Electronic (Medline, Scopus, and Cochrane databases) and hand l...
Article
Full-text available
Background Current pharmacologic prophylactic strategies for migraine have exhibited limited efficacy, with response rates as low as 40%–50%. In addition to the limited efficacy, the acceptability of those pharmacologic prophylactic strategies were unacceptable. Although noninvasive brain/nerve stimulation strategies may be effective, the evidence...
Article
Background: Evidence about the association between types of oral anticoagulants and hazards of diabetes complications is limited in patients with atrial fibrillation (AF) and diabetes mellitus (DM). Objective: To compare the hazards of diabetes complications and mortality between patients with AF and DM receiving non-vitamin K antagonist oral an...
Article
Full-text available
We examined the cardiovascular safety, acceptability, and trajectory of the antidepressant effects of psilocybin after single- or two-dose administration. Four major electronic databases were systematically searched. Data were pooled using a multivariate random-effects meta-analysis. Primary outcomes were changes in depressive symptoms. Secondary o...
Article
Objectives To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses. Methods We conducted two cohort studies on: (1) 972 schoolchildren from November 2009 – March 2010 to evaluate pandemic policies and (2) 935 schoolchildren fro...
Article
Full-text available
Background: Researchers have emphasized the importance of examining how different factors affect men's and women's functional status over time. To date, the literature is unclear about whether sex affects the rate of change in disability in middle to older age. Researchers have further emphasized the importance of examining how different factors a...
Article
Full-text available
Purpose: Hyperuricemia is associated with increased cardiovascular risk. Because patients with asymptomatic hyperuricemia (AH) experience no immediate discomfort and there are possible side effects of urate-lowering drugs, treatment for AH is controversial. We aimed to perform a network meta-analysis (NMA) to investigate the effects of different u...
Article
Full-text available
Patients with malignant pleural mesothelioma (MPM) have very poor prognoses, and pemetrexed plus platinum is the standard first-line therapy. However, the second-line therapy for relapsed MPM remains controversial. A comprehensive search was performed to identify randomized controlled trials (RCTs) evaluating various second-line regimens in patient...
Article
Full-text available
Background: Allergic diseases are frequently observed in children with Kawasaki disease (KD). However, the evidence supporting the association between KD and allergies has been conflicting. The objective of the current study is to examine the association between KD and allergic diseases. Methods: We conducted an electronic search using PubMed, Emba...
Article
Study objectives: The aim of this study is to evaluate the relationship between the month of birth (MOB) and the risk of narcolepsy. Methods: We conducted a systematic review of electronic databases, namely PubMed, Embase, and Cochrane CENTRAL, from their inception to September 30, 2021. We also added data on narcolepsy from the National Databas...
Article
Full-text available
Background: Lactated Ringers reduced mortality more than saline in sepsis patients but increased mortality more than saline in traumatic brain injury patients. Method: This prospective cohort study was conducted in a medical intensive care unit (ICU) in central Taiwan. We applied standard sepsis evaluation protocol and identified heart, lung, liver...
Article
Study objective This updated network meta-analysis aims at exploring whether the concurrent use of midazolam or antiemetics may enhance the efficacy of other pharmacological regimens for delirium prophylaxis in pediatric population after general anesthesia (GA). Design Network meta-analysis (PROSPERO registration: CRD42020179483). Setting Postope...
Article
Full-text available
Plant-based diets, characterized by a higher consumption of plant foods and a lower consumption of animal foods, are associated with a favorable cardiovascular disease (CVD) risk, but evidence regarding the association between plant-based diets and CVD (including coronary heart disease (CHD) and stroke) incidence remain inconclusive. A literature s...
Article
Many studies use dental patient-reported outcomes (dPROs) to evaluate treatments and interventions. However, the consensus on the methodology for combining results of dPROs for meta-analysis has not yet been fully established or widely discussed. The aim of this study is to conduct a scoping review for the methodological issues and difficulties spe...
Article
The comparative efficacy of various approaches of digital cognitive behavioral therapy for insomnia (CBTi) is still unclear. This network meta-analysis explored the comparative efficacy of digital CBTi approaches in adults with insomnia. Four electronic databases were searched from inception to June 27, 2020. Primary outcomes were self-reported tot...
Article
Full-text available
Background Restless legs syndrome (RLS) is common among patients with end stage kidney disease (ESKD) and is associated with poor outcomes. Several recently published studies had focused on pharmacological and nonpharmacological treatments of RLS, but an updated meta-analysis has not been conducted. Methods The study population was adult ESKD pati...
Article
Full-text available
Introduction: The priority of interventions to alleviate cognitive deficits in patients with bipolar disorder (BD) is inconclusive. We systematically evaluate the efficacy of pharmacological or neurostimulation interventions for cognitive function in BD through a network meta-analysis. Methods: The PubMed, PsycINFO, Embase, and Cochrane Library...
Article
Full-text available
Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs has been made, and different efficacies of ALKIs may present across ethnicity. This study aims to...
Article
Background Gender differences in alcohol use have narrowed in Western societies, but that in Asia has been less investigated. By comparing the 2014 and 2018 waves of the national survey in Taiwan, we aimed to examine the gender differences in population trends in past-month alcohol use, binge drinking, and harmful alcohol use. Methods The national...
Article
Full-text available
Vegetarian dietary patterns provide health benefits for cardiovascular health; however, the studies examining the association of vegetarian diets with stroke incidence showed inconsistent findings. We systematically evaluated the risk of incident stroke among vegetarians (diets excluding meat, poultry, fish, and seafood) compared among nonvegetaria...
Article
Background Sialorrhea often happens in patients with neurologic disorders, and botulinum toxin (BoNT) which inhibits acetylcholine activating may be an effective treatment for drooling. This systematic review and meta-analysis of randomized control trials (RCTs) aim to evaluate the efficacy and safety of BoNT in adults and children with sialorrhea...
Article
Introduction : Coronavirus disease 2019 (COVID-19) has had an enormous impact worldwide, and vaccination is believed to be the method that will control the pandemic. Several types of vaccines developed using different platforms have been authorized for emergency use, but vaccine administration has varied based on the country, vaccine supply, safety...
Article
Full-text available
Background Although tinnitus has a prevalence between 20 and 42.8%, the currently recommended management for tinnitus, such as tinnitus support and psychologic therapies, are relatively time-consuming and expensive. Several new pharmacologic treatments designed for tinnitus patients without specific origin had been developed but their efficacy rema...
Article
Full-text available
Aspirin was once believed to reduce the mortality of Kawasaki disease (KD) due to its effect on the thrombotic occlusion of coronary arteries. However, conflicting evidence has been found regarding aspirin treatment and its benefit in patients with acute KD. We compared the efficacy of different aspirin doses in acute KD. A literature search of Pub...
Article
Full-text available
Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-an...