Yu-Jie Huang

National Taiwan University | NTU · Department of Electrical Engineering

Microfluidic pump is an essential component in lab-on-chip applications. It is of importance to develop an active microfluidic pump with low-power and low-cost characteristics for portable and miniaturized diagnostic systems. Taking advantages of CMOS technologies, in this work, we report a low-power microfluidic pump based on travelling-wave elect...

Multi-modal sensing system is essential in healthcare and internet-of-things (IoT) [1]. Making the sensor systems small, low power and cost effective is the ultimate goal to fulfill the growing needs. To achieve this requirement, we present a single-device-dual-sensor by transforming a conventional dual-gate ion sensitive field-effect transistor (D...

With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography ([Formula: see text]) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS sepa...

A batteryless remotely-controlled locomotive IC utilizing electrolytic bubbles as propelling force is realized in 0.35 μm CMOS technology. Without any external components, such as magnets and on-board coils, the bare IC is wirelessly powered and controlled by a 10 MHz ASK modulated signal with RS232 control commands to execute movement in four movi...

This paper presents a highly-integrated DNA detection SoC, where several kinds of cantilever DNA sensors, a readout circuit, an MCU, voltage regulators, and a wireless transceiver, are integrated monolithically in a 0.35 μm CMOS Bio-MEMS process. The cantilever-based biosensors with embedded piezoresistors aim to transduce DNA hybridization into re...

As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semico...

A drug-delivery chip and a method of fabricating the same are provided. The drug-delivery chip has a main body having at least one drug receiving space individually formed with an opening for storing drugs therein; a thin film for sealing up the at least one drug receiving space; a first conductive wire connecting to one end of the thin film; a sec...

In this work, a fully integrated DNA detection system-on-a-chip (SoC) was implemented by 0.35 μm commercialized standard CMOS process for label-free and real-time detection of Hepatitis B virus (HBV) DNA. The chip implementation was achieved in the Taiwan Semiconductor Manufacturing Company's (TSMC) 0.35 μm CMOS process. The implemented chip size w...

A highly adaptive multi-sensor SoC comprising four on-chip sensors and a smart wireless acquisition system is first realized in standard CMOS process. To intelligently process different types (C/R/I/V) of sensor signals, a linear (R2 = 0.999) and reconfigurable sensor readout is proposed. A two-input energy harvesting interface with conversion effi...

A fully integrated humidity sensor chip was designed, implemented, and tested. Utilizing the micro-stamping technology, the pseudo-3D sensor system-on-chip (SSoC) architecture can be implemented by stacking sensing materials directly on the top of a CMOS-fabricated chip. The fabricated sensor system-on-chip (2.28 mm × 2.48 mm) integrated a humidity...

An implantable system-on-a-chip (SoC) integrating controller/actuation circuitry and 8 individually addressable drug reservoirs is proposed for on-demand drug delivery. It is implemented by standard 0.35-μm CMOS technology and post-IC processing. The post-IC processing includes deposition of metallic membranes (200Å Pt/3000Å Ti/200Å Pt) to cap the...

Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to com...

Based on the improvements of the fabrication technologies, the dimension of the device has decreased to tens of nanometer. This scale approaches to most bio-molecules, such as DNAs and proteins. Therefore, the nano-scale device has become an important connection between semiconductor technologies and biomedical applications. However, few of previou...

A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated fo...

This paper presents a novel CMOS wireless temperature sensor design in order to improve the sensitivity and linearity of our previous work on such devices. Based on the principle of CMOS double zero temperature coefficient (DZTC) points, a combined device is first created at the chip level with two voltage references, one current reference, and one...

Cardiovascular disease remains the main cause of death, and great efforts are spent on the design of ECG (electrocardiogram) body sensors these years. Essential components such as analog frontend and wireless transceivers have been integrated on a compact IC with micro-Watt power consumption. To provide timely warning against the fatal vascular sig...

A highly-integrated DNA detection SoC, which includes DNA sensors, readout circuit, MCU, and OOK TX/RX, is implemented in a 0.35�Ù m CMOS Bio-MEMS process. For low DNA concentration, an oscillator-based self-calibrated readout circuit with high sensitivity (2kHz/�Ë�º is proposed to convert small resistance variation of the piezoresistive cantilever...

Recently, micro- and nano-technologies have enabled rapid progress in biomedical applications. Although in vitro analytical and diagnostic tools have been the focus of such technologies, in vivo therapeutic and sensing applications have received significant attention in the past few years. Novel implantable drug delivery devices, which can precisel...