Yu-Feng Luo

Hohai University

To prepare the emulsifier-modified bitumen for scrap semi-rigid base layer of material recovered depth study, emulsified asphalt was chosen as the research object, starting from an improved method for the performance of modified asphalt emulsion as an observation point. It analyzed the influence of different emulsifiers on asphalt performance under...

Introduction Myostatin (MSTN) negatively regulates skeletal muscle development. However, its function in reproductive performance and visceral organs has not been thoroughly investigated. Previously, we prepared a MSTN and fibroblast growth factor 5 (FGF5) double-knockout sheep, which was a MSTN and FGF5 dual-gene biallelic homozygous (MF −/− ) mut...

Mutations in the well-known Myostatin ( MSTN ) produce a "double-muscle" phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at different loci of the MSTN often produce a variety of different phenotypes. In the current study, we increased the del...

Improving livestock and poultry growth rates and increasing meat production are urgently needed worldwide. Previously, we produced a myostatin (MSTN) and fibroblast growth factor 5 (FGF5) double-knockout (MF-/-) sheep by CRISPR Cas9 system to improve meat production, and also wool production. Both MF-/- sheep and the F1 generation (MF+/-) sheep sho...

Semi-rigid base materials are used in all pavement grades and are shown to have excellent stability. Furthermore, semi-rigid bases are known for their stiffness and strong frost resistance. However, these semi-rigid base materials are starting to require significant levels of maintenance and repair due to wear and tear. Maintenance is performed pri...

Introduction: Toll-like receptor 4 (TLR4) identifies Gram-negative bacteria or their products and plays a crucial role in host defense against invading pathogens. In the intestine, TLR4 recognizes bacterial ligands and interacts with the immune system. Although TLR4 signaling is a vital component of the innate immune system, the influence of TLR4...

Cardiovascular disease is the result of complicated pathophysiological processes in the tissues that make up the blood vessels and heart. Heat shock protein 90 (HSP90) can interact with 10% of the proteome and is the most widely studied molecular chaperone in recent years. HSP90 is extensively involved in the regulation of protein folding and intra...

Here, we present DeepBIO, the first-of-its-kind automated and interpretable deep-learning platform for biological sequence functional analysis. DeepBIO is a one-stop-shop web service that enables researchers to develop a new deep-learning architecture to answer any biological question. Specifically, given any biological sequence data, DeepBIO suppo...

With aging, the progressive loss of skeletal muscle will have negative effect on multiple physiological parameters, such as exercise, respiration, thermoregulation, and metabolic homeostasis. Accumulating evidence reveals that oxidative stress and inflammation are the main pathological characteristics of skeletal muscle during aging. Here, we focus...

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects humans and animals which make coronavirus disease 2019 (COVID-19) a grievous epidemic worldwide which broke out in 2020. According to data analysis of the other coronavirus family, for instance severe acute respiratory syndrome SARS coronavirus (SARS-CoV), can provide...

There are three main types of cancer in the female reproductive system, specifically ovarian cancer (OVCA), endometrial cancer (EC), and cervical cancer (CC). They are common malignant tumors in women worldwide, with high morbidity and mortality. In recent years, androgen receptors (ARs) have been found to be closely related to the occurrence, prog...

Angiogenesis is involved in physiological and pathological processes in the body. Tumor angiogenesis is a key factor associated with tumor growth, progression, and metastasis. Therefore, there is great interest in developing antiangiogenic strategies. Hypoxia is the basic initiating factor of tumor angiogenesis, which leads to the increase of vascu...

The continuous pollution of waste plastics to the ecological environment has attracted global attention. Using waste plastics in road construction can save energy, reduce pollution, and improve the high-temperature performance of asphalt mixtures. It will be the development trend of road materials in the future, but there have been few in-depth stu...

Semi-rigid basement materials had high strength and good integrity therefore it extensively used on pavements of all grades. However, it had serious and widespread early damages, so the treatment of waste semi-rigid subgrade was about to become an important subject in reconstruction. A large amount of semi-rigid base was milled and not fully utiliz...

MSTN and FGF5 gene knockout sheep generated by the CRISPR/Cas9 system exhibit the ‘double-muscle’ phenotype, and increased density and length of hairs, providing valuable new breeding material. In a previous study, we obtained MSTN and FGF5 double-knockout sheep of significant breeding value. In this study, we carried out a 90-day feeding study in...

The formation mechanism of residual stress field (RSF) and the coupling mechanisms of RSFs after single-pass ultrasonic surface rolling process (USRP) are revealed. Based on simulation, the transient evolution and steady distribution of compressive RSF are analyzed, and the influences of process parameters (i.e., the movement distance of the ball i...

The authors analyzed the junior high school physical education academic proficiency examination system in Shandong province, and concluded that the junior high school physical education academic proficiency examination system currently effective in Shandong province had the following 5 major problems: counting physical education scores into midterm...

In a social system, the self-interest of agents can be detrimental to the collective good, sometimes leading to social dilemmas. To resolve such a conflict, a central designer may intervene by either redesigning the system or incentivizing the agents to change their behaviors. To be effective, the designer must anticipate how the agents react to th...

The mainlobe jamming suppression technique is one of the key techniques of radar electronic counter- countermeasure (ECCM). In the view of multistatic radar, the interference signals received with different view angles would be highly coherent, on the contrary, the target echoes would be independent due to the radar cross section (RCS) of target wo...

Alfalfa is the most extensively cultivated forage legume worldwide, and salinity constitutes the main environmental scourge limiting its growth and productivity. To unravel the potential molecular mechanism involved in salt tolerance in alfalfa, we accomplished a combined analysis of parallel reaction monitoring-based proteomic technique and target...

In this study, the volumetric compression of jadeite (NaAlSi2O6) melt at high pressures was determined by three-dimensional volume imaging using the synchrotron-based X-ray microtomography technique in a rotation-anvil device. Combined with the sample mass, measured using a high-precision analytical balance prior to the high-pressure experiment, th...

This paper investigates the influence of non-uniform corrosion in the transversal direction of the steel reinforcement on the cracking propagation of the concrete cover. An analytical model is proposed for the prediction of the corrosion-induced cracking performance. Both the thick cylinder theory of the concrete and the effect of transversal non-u...

Preparation of aluminosilicate ferrierite (FER) zeolite nanosheets with controllable thickness in the presence of a sole organic ammonium is attractive, but still challenging. In this report, with the employment of N,N-diethyl-cis-2,6-dimethylpiperidinium (DMP) as both a structure directing agent and crystal growth inhibitor, aluminosilicate FER ze...

Dual antifouling and antibacterial polysulfone(PSf)/polyethersulfone(PES) hybrid membranes were developed by the synergy of capsaicin-mimic N-(5-methyl acrylamide-2,3,4 hydroxy benzyl) acrylamide (AMTHBA) and vinyl triethylene (b-methoxy ethoxy) silane (VTMES). First, AMTHBA as a natural antimicrobial agent was incorporated into a casting solution...

The evolution of interfaces for underwater gas jets is the main morphological manifestation of two-phase unstable interaction. The high-speed transient photographic recording and image post-processing methods are used to obtain the interfacial change in a submerged gaseous jet at different stages after its ejection from the Laval nozzle exit. The r...

A high-performance multi-resonance plasmonic sensor with double-layer metallic grooves is theoretically constructed by introducing a polymethyl methacrylate groove with a numerical simulation method. Multiple resonance wavelengths can be generated at the oblique incidence, and the number and feature of resonant mode for sensing detection is differe...

As pedestrian dead-reckoning (PDR), based on foot-mounted inertial sensors, suffers from accumulated error in velocity and heading, an improved heuristic drift elimination (iHDE) with a zero-velocity update (ZUPT) algorithm was proposed for simultaneously reducing the error in heading and velocity in complex paths, i.e., with pathways oriented at 4...

This study aimed to show the α-L-Hexaguluroic acid hexasodium salt (G6) protective effect against UVA-induced photoaging of human keratinocyte cells. We found that G6 localized to the mitochondria and improved mitochondrial functions. G6 increased respiratory chain complex activities, which led to increased cellular ATP content and NAD+/NADH ratio....

Hydroxyl terminated polybutadiene (HTPB) coating is widely used in a solid rocket motor, but an aging phenomenon exists during long-term storage, which causes irreversible damage to the performance of this HTPB coating. In order to study the effect of aging on the dynamic mechanical properties of the HTPB coating, the thermally-accelerated aging te...

Larix olgensis Henry is an important afforestation species in northeastern China because of its fast juvenile growth, high-quality timber, and significant economic and ecological values. The selection of appropriate reference genes is necessary for the normalization of gene expression determination during quantitative real-time polymerase chain rea...

Accumulating evidence highlights the link between gut microbiota and depression. As an antidepressant herbal drug in clinic, Chaihu-Shu-Gan-San (CSGS) has also been used in China for the treatment of various gastrointestinal disorders. Therefore, we hypothesize that the gut microbiota might be involved in the effect of CSGS. Here, we investigated t...

The existing coating systems used for the preparation of super-hydrophobic surfaces are facing new challenges because the use of organic solvents and long-carbon-chain organic fluorine monomers is banned. In this article, the authors have proven that by using inductively coupled plasma-enhanced chemical vapor deposition (PECVD) with argon (Ar), whi...

Testosterone (T) is essential for muscle fiber formation and growth. However, the specific mechanism by which T regulates skeletal muscle development in chicken embryos remains unclear. In this study, the role of T in myoblast proliferation both in vivo and in vitro was investigated. Results showed that the T administration significantly increased...

Cadmium (Cd) is present in many soils and, when entering the food chain, represents a major health threat to humans. Reducing Cd accumulation in plants is complicated by the fact that most known Cd transporters also operate in the transport of essential nutrients such as Zn, Fe, Mn, or Cu. This work summarizes the current knowledge of mechanisms me...

Electric vehicles (EVs) are flexible demand-side response resources in a power distribution system. Reasonable and orderly control of charging/discharging processes of aggregated EVs can improve their coordination and interaction with the distribution system and ensure its efficient and stable operation. Aiming at the problem that the fluctuation o...

AlGaN/GaN lateral Schottky barrier diodes (SBDs) with three different anode geometries (stripe, circular, and the conventional plane one) and different rows of anode trenches are fabricated and electrically characterized to study the influence of anode trench geometries. The SBDs with anode trenches exhibit the lower on-state resistance (RON) than...

The effects of the package materials on the hot workability and stress-strain characteristics of high-Nb TiAl alloy with a nominal composition of Ti-46Al-8Nb (in at.%) were systematically studied via “sandwich structure” hot compression. TiAl sheet fabrication was conducted by hot pack rolling, and the microstructural characteristics and deformatio...

The design and synthesis of solid sorbents for effective carbon dioxide adsorption are essential for practical applications regarding carbon emissions. Herein, we report the synthesis of composite materials consisting of amine-functionalized imidazolium-type poly(ionic liquid) (PIL) and metal organic frameworks (MOFs) through complexation of amino...

Cancer cells have been characterized with alkaline intracellular pH (pHi) values (≥7.2) to enable cancer proliferation, migration, and progression. The aim of the present study was to explore the concentration-dependent effects of Andrographolide, an active diterpenoid compound of herb Andrographis paniculata, on Na+/H+ exchanger isoform 1 (NHE1),...

Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large n...

Organic–inorganic halide perovskites are promising photovoltaic materials with excellent optoelectronic properties. However, the extreme structural instability hinders their wide application as well as the microstructure characterization using high energy beams such as transmission electron microscopy (TEM). Here, taking BA2FAPb2I7 and BA2MAPb2I7 a...

Composed of multi-strand parallel high-strength wires or steel strands, the stayed cables have been widely used recently in stayed bridges or suspension bridges owing to their light weight and high bearing capacity, especially the steel strands. Meanwhile, chloride-induced corrosion of steel strands is one of the most considerable factors for the d...

All-wood biocomposites were prepared with an efficient method. The ionic liquid of 1-butyl-3-methylimidazolium chloride (BMIMCl) was used to impregnate manchurian ash (MA) before hot-pressing, and the all-wood biocomposites were prepared by controllable dissolving and regenerating the cellulose in MA. The Fourier transform infrared analysis suggest...

Biodegradation of contaminants is extremely complicated due to unpredictable microbial behaviors. Monitoring of microbial biodegradation drives us to determine (1) the amounts of specific degrading microbes, (2) the abundance, and (3) expression level of relevant functional genes. To this endeavor, the cultivation independent polymerase chain react...

Massive efforts to build walking aid platforms for the disabled have been made in line with the needs of the aging society. One of the core technologies that make up these platforms is a realization of the skin-like electronic patch, which is capable of sensing electromyogram (EMG) and delivering feedback information to the soft, lightweight, and w...

Emergent contamination warning systems are critical to ensure drinking water supply security. After detecting the existence of contaminants, identifying the types of contaminants is conducive to taking remediation measures. An online classification method for contaminants, which explored abnormal fluctuation information and the correlation between...

In recent years, the red turpentine beetle (RTB) (Dendroctonus valens LeConte) has invaded the northern regions of China. Due to the short invasion time, the outbreak of tree mortality corresponded to a low level of damage. Important information about tree mortality, provided by remote sensing at both single-tree and forest stand scale, is needed i...

Stretchable nano-fibers have attracted dramatic attention for the utility in wearable and flexible electronics. In the present case, Ag nanowires (AgNWs)-intertwined thermoplastic polyurethanes (TPU) unwoven nano-membrane is fabricated by an electrospinning method and dip coating technique. Then a strain sensor with a spring-like configuration is f...

The process of ion implantation often involves vacancy generation and migration. The vacancy generation and migration near a monocrystalline silicon surface during three kinds of energetic Si35 cluster ion implantations were investigated by molecular dynamics simulations in the present work. The patterns of vacancy generation and migration, as well...

Unmanned aerial vehicles using light detection and ranging (UAV LiDAR) with high spatial resolution have shown great potential in forest applications because they can capture vertical structures of forests. Individual tree segmentation is the foundation of many forest research works and applications. The tradition fixed bandwidth mean shift has bee...