Yu Chinn Joshua Chey

Yu Chinn Joshua Chey
University of Adelaide

Master of Philosophy
PhD Candidate at The University of Adelaide

About

7
Publications
1,060
Reads
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71
Citations
Citations since 2017
7 Research Items
71 Citations
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20172018201920202021202220230510152025
20172018201920202021202220230510152025
Introduction
Joshua is a molecular biologist and higher degree by research candidate. He is currently undertaking a PhD in medical sciences at the University of Adelaide.
Education
August 2017 - March 2020
University of Adelaide
Field of study
  • Molecular and Biomedical Science
July 2014 - July 2017
University of Adelaide
Field of study
  • Biomedical Science

Publications

Publications (7)
Article
Full-text available
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...
Thesis
Multiple myeloma (MM) is a blood cancer characterised by the uncontrolled proliferation and dissemination of neoplastic plasma cells in the bone marrow (BM). As the BM is physiologically hypoxic, hypoxia may serve as a microenvironmental stimulus that drives MM disease development and progression by promoting a broad range of tumorigenic features l...
Article
Full-text available
Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. In this study, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE, along with a selection marker. We tested these constructs (with selection) in HEK293T, K562, HeLa and mouse embry...
Article
Full-text available
CRISPR gene‐editing technology creates precise and permanent modifications to DNA. It has significantly advanced our ability to generate animal disease models for use in biomedical research and also has potential to revolutionize the treatment of genetic disorders. Duchenne muscular dystrophy (DMD) is a monogenic muscle‐wasting disease that could p...
Preprint
Full-text available
Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. Currently, the delivery of PE components to mammalian cell lines requires multiple plasmid vectors. To overcome this limitation, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE,...
Article
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...
Article
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The Factor Inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...

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