Yu Chinn Joshua CheyUniversity of Adelaide
Yu Chinn Joshua Chey
Master of Philosophy
PhD Candidate at The University of Adelaide
About
7
Publications
1,060
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71
Citations
Citations since 2017
Introduction
Joshua is a molecular biologist and higher degree by research candidate. He is currently undertaking a PhD in medical sciences at the University of Adelaide.
Education
August 2017 - March 2020
July 2014 - July 2017
Publications
Publications (7)
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...
Multiple myeloma (MM) is a blood cancer characterised by the uncontrolled proliferation and dissemination of neoplastic plasma cells in the bone marrow (BM). As the BM is physiologically hypoxic, hypoxia may serve as a microenvironmental stimulus that drives MM disease development and progression by promoting a broad range of tumorigenic features l...
Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. In this study, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE, along with a selection marker. We tested these constructs (with selection) in HEK293T, K562, HeLa and mouse embry...
CRISPR gene‐editing technology creates precise and permanent modifications to DNA. It has significantly advanced our ability to generate animal disease models for use in biomedical research and also has potential to revolutionize the treatment of genetic disorders. Duchenne muscular dystrophy (DMD) is a monogenic muscle‐wasting disease that could p...
Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. Currently, the delivery of PE components to mammalian cell lines requires multiple plasmid vectors. To overcome this limitation, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE,...
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The Factor Inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show h...
