Young-Choon Lee

Dong-A University · Department of Medicinal Biotechnology

Modern vehicles equip dashcams that primarily collect visual evidence for traffic accidents. However, most of the video data collected by dashcams that is not related to traffic accidents is discarded without any use. In this paper, we present a use case for dashcam videos that aims to improve driving safety. By analyzing the real-time videos captu...

In this study, the effects of 3,5,7,3ʹ,4ʹ-pentamethoxyflavone (KP1), a major bioactive ingredient isolated from the Kaempferia parviflora rhizomes, on a neurite outgrowth in Neuro2a cells and its mechanism have been investigated. KP1 increased concentration-dependently the percentage of neurite-bearing cells. KP1 showed a remarkable capability to e...

In the United Arab Emirates, housing establishments offer citizens opportunities to apply for housing loans or grants. The eligibility for a loan or grant depends on the citizen's income. Those with incomes below a predetermined threshold can apply for grants, while those with higher incomes are eligible for loans. Along with proof of income, other...

To address the critical need for enhancing Quality of Service (QoS) monitoring in the logistics service delivery domain, this paper introduces a blockchain-based QoS monitoring framework that aims to automate service delivery and dispute resolution processes. Traditional QoS monitoring solutions rely heavily on human judgment and intervention, whic...

The emergence of fog computing has significantly enhanced real-time data processing by bringing computation resources closer to data sources. This adoption is very beneficial in the healthcare sector, where abundant time-sensitive processing tasks exist. Although such adoption is very promising, there is a challenge with the limited computational c...

In this study we observed that human GD1c/GT1a/GQ1b synthase (hST8Sia V) is particularly expressed in human glioblastoma cells. To address the mechanism regulating human glioblastoma-specific gene expression of the hST8Sia V, after the transcription start site (TSS) was identified by the 5’-rapid amplification of cDNA end with total RNA from human...

In this study, we have firstly elucidated that serum starvation augmented the levels of human GD3 synthase (hST8Sia I) gene and ganglioside GD3 expression as well as bone morphogenic protein-2 and osteocalcin expression during MG-63 cell differentiation using RT-PCR, qPCR, Western blot and immunofluorescence microscopy. To evaluate upregulation of...

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and is still one of the global health burdens. The occurrence of various cases and multidrug resistance confirm that TB has not been completely conquered. For these reasons, the present research has been conducted to explore TB vaccine and drug candidate possibility using Mtb-secreted...

In this study we observed that human GD1c/GT1a/GQ1b synthase (hST8Sia V) is particularly expressed in human glioblastoma cells. To address the mechanism regulating human glioblastoma-specific gene expression of the hST8Sia V, after the transcription start site (TSS) was identified by the 5’-rapid amplification of cDNA end with total RNA from human...

As a critical factor in ensuring the growth of the electronic auction (e-auction) domain, the privacy and security of the participants (sellers and buyers) must always be guaranteed. Traditionally, auction data, including participant details, are stored in a third party (auctioneer) database. This leads to a high risk of a single point of failure i...

Background In this study, we observed that in human colon carcinoma HCT116 cells mRNA level of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was decreased by curcumin. FACS analysis using the α2,6-sialyl-specific lectin (SNA) also showed a noticeable decrease in binding to SNA by curcumin.Objective To investigate the mechanism for curc...

Edge computing has been getting a momentum with ever-increasing data at the edge of the network. In particular, huge amounts of video data and their real-time processing requirements have been increasingly hindering the traditional cloud computing approach due to high bandwidth consumption and high latency. Edge computing in essence aims to overcom...

Blockchain, a type of distributed ledger technology, has revolutionized the digital economy such as cryptocurrencies and supply chain management with its transparency, immutability, and decentralization properties. In addition, smart contracts are introduced to the blockchain to provide programmability removing third parties for administration. Alt...

The usage of blockchain technology has been significantly expanded with smart contracts and blockchain oracles . While smart contracts enables to automate the execution of an agreement between untrusted parties, oracles provide smart contracts with data external to a given blockchain, i.e., off-chain data. However, the validity and accuracy of su...

The vulnerability of smartphones to cyberattacks has been a severe concern to users arising from the integrity of installed applications (\textit{apps}). Although applications are to provide legitimate and diversified on-the-go services, harmful and dangerous ones have also uncovered the feasible way to penetrate smartphones for malicious behaviors...

A blockchain is a form of distributed ledger technology where transactions as data state changes are permanently recorded securely and transparently without the need for third parties. Besides, introducing smart contracts to the blockchain has added programmability, revolutionizing the software ecosystem toward decentralized applications (DApps). A...

Human N-acetylgalactosamine-α2,6-sialyltransferase (hST6GalNAc I) is the major enzyme involved in the biosynthesis of sialyl-Tn antigen (sTn), which is known to be expressed in more than 80% of human carcinomas and correlated with poor prognosis in cancer patients. Athough high expression of hST6GalNAc I is associated with augmented proliferation,...

In recent years, we have witnessed an explosive growth of data. Much of this data is video data generated by security cameras, smartphones, and dash cams. The timely analysis of such data is of great practical importance for many emerging applications, such as real-time facial recognition and object detection. In this study, we address the problem...

Cloud gaming services enable users to enjoy various high-quality computer games without installing them in their devices which may have poor resources. However, it consumes high bandwidth in backbone networks as game videos have to be constantly streamed to client devices, which can be a hindering factor for providing Ultra High Definition (UHD)-qu...

The use of smart contracts for access control has shown to be promising as it ensures integrity and governs access to stored data, thanks to blockchain's immutability. While several recent studies have shown such usage, their applicability to supply chain applications remains limited due to less governance control capability and implementation comp...

Blockchain is a form of distributed ledger technology (DLT) where data is shared among users connected over the internet. Transactions are data state changes on the blockchain that are permanently recorded in a secure and transparent way without the need of a third party. Besides, the introduction of smart contracts to the blockchain has added prog...

In oat ingredients, flavonoids and phenolic acids are known to be the most important phenolic compounds. In phenolic compounds, wide-ranging biological responses, including antioxidative, anti-inflammatory, anti-allergic, and anti-cancer properties, were reported. Avenanthramide C (Avn C), a component of the phenolic compound of oats, has been repo...

Virtual Reality (VR) has shown great potential to revolutionize the market by providing users immersive experiences with freedom of movement. Compared to traditional video streaming, VR is with ultra high-definition and dynamically changes with users' head and eye movements, which poses significant challenges for the realization of such potential....

Virtual Reality (VR) has shown great potential to revolutionize the market by providing users immersive experiences with freedom of movement. Compared to traditional video streaming, VR is with ultra high-definition and dynamically changes with users’ head and eye movements, which poses significant challenges for the realization of such potential....

Inflammation is implicated in various diseases, such as inflammatory bowel disease and cancer. Ascochlorin (ASC) and its derivatives have been shown to modulate inflammatory responses in many previous studies. However, the effects of 4-O-methylascochlorin (MAC), one of the ASC derivatives, on inflammatory responses have yet to be reported. In addit...

In this study, we found that gene expression of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was specifically increased during differentiation of human MG-63 osteoblastic cells by serum starvation (SS). In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin, was observed in serum-starved cells, as demonstr...

Renewable energy, such as wind and photovoltaic electric power has been increasingly integrated into data center power provisioning systems to address its high energy consumption. However, the intermittency and randomness of renewable energy (power supply fluctuation) is detrimental to the reliable operation of sophisticated IT equipment in those s...

Serverless computing has emerged as a new cloud computing execution model that liberates users and application developers from explicitly managing ‘physical’ resources, leaving such a resource management burden to service providers. In this article, we study the problem of resource allocation for multi-tenant serverless computing platforms explicit...

3′-sialyllactose is one of the abundant components in human milk oligosaccharides (HMOs) that protect infants from various viral infections in early stages of immune system development. 3SL is a combination of lactose and sialic acid. Most sialic acids are widely expressed in animal cells and they bind to siglec proteins. In this study, we demonstr...

Public cloud users are educated to practice horizontal scaling at the application level, with the assumption that more processing capacity can be achieved by adding nodes into the server fleet. In reality, however, applications—even those specifically designed to be horizontally scalable—often face unpredictable scalability issues when running at s...

-20pt?>Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium that causes contagious tuberculosis (TB). Recently, Mtb-secreted proteins have been considered virulence factors and candidates for drugs and vaccines. Among these proteins, 6-kDa early secreted antigenic target (ESAT-6) is known to be able to induce component of matrix metalloprotei...

The pervasive use of virtualization techniques in today's datacenters poses challenges in power monitoring since it is not possible to directly measure the power consumption of a virtual entity such as a virtual machine (VM) and a container. In this paper, we present cWatts++, a lightweight virtual power meter that enables the accurate power usage...

Rapid growth in Big Data and Cloud technologies has fueled rising energy demands in large server systems such as data centers, leading to a need for effective power management. In this paper, we investigate the energy consumption characteristics of data-intensive distributed applications in terms of the CPU and memory subsystem. To this end, we dev...

Ethnopharmacological relevance: Plant-specific fungus of natural compound of Ascochyta viciae has traditionally been used in the treatment of sleeping sickness and tumors. The anti-tumor activities of the compounds obtained from Pisum sativum L were evaluated in this study. Aim of the study: In this study, during the prolonged incubation, treatm...

Toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) are known to play important roles in inflammatory diseases such as arteriosclerosis and plaque instability. The purpose of this study was to perform the effect of 4-O-carboxymethylascochlorin (AS-6) on MMP-9 expression in lipopolysaccharide (LPS)-induced murine macrophages and signa...

In a blockchain system, consensus protocol as an incentive and security mechanism, is to ensure the participants to build the block honestly and effectively. There are different consensus protocols for blockchain, like Proof of work (PoW), Proof of Stake (PoS), Proof of Space (PoSpace), Proof of Activities etc. But most of these consensus protocols...

N-glycolylneuraminic acid (Neu5Gc), a generic form of sialic acid, is enzymatically synthesized by cytidine-5′-monophospho-N-acetylneuraminic acid hydroxylase (CMAH). Although expression of pig CMAH gene pcmah encoding CMAH has been reported to be regulated by pathogenic infection and developmental processes, little is known about the mechanisms un...

Natural compound esculentoside B (EsB), (2S,4aR,6aR,6aS,6bR,8aR,9R,10R,11S,12aR,14bS)-11-hydroxy-9-(hydroxymethyl)-2 methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-10-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid with molecular weight of 664.833, isolated from roots of Phytolacca...

A water‐soluble saponin, Esculentoside H (EsH), 3‐O‐(O‐β‐d‐glucopyranosyl‐(1→4)‐β‐d‐xylopyranosyl)‐28‐β‐d‐glucopyranosylphytolaccagenin has been isolated and purified from the root extract of perennial plant Phytolacca esculenta. EsH is known to be an anticancer compound, having a capacity for TNF‐α release. However, the effects of EsH on migration...

Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa , upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells. In this study, on the contrary to this finding, we demonstrated that curcum...

In our previous studies, structurally similar compounds of ascochlorin and ascofuranone exhibited anti‐inflammatory activity. Neural inflammation plays a significant role in the commence and advancement of neurodegenerative diseases. It is not known whether 4‐O‐carboxymethylascochlorin (AS‐6) regulates the initial stage of inflammatory responses at...

Curcumin, a natural polyphenolic compound isolated from the plant Curcuma longa, is known to induce autophagy in various cancer cells, including lung cancer. In the present study, we also confirmed by LC3 immunofluorescence and immunoblotting analyses that curcumin triggers autophagy in the human lung adenocarcinoma A549 cell line. In parallel with...

Curcumin, a natural polyphenolic compound isolated from the plant Curcuma longa, is known to induce autophagy in various cancer cells, including lung cancer. In the present study, we also confirmed by LC3 immunofluorescence and immunoblotting analyses that curcumin triggers autophagy in human lung adenocarcinoma A549 cell line. In parallel with aut...

The disialic acid-containing glycosphingolipid GD3 recruited membrane transglutaminase 2 (TG2) as a signaling molecule for erythroid differentiation in human chronic myelogenous leukemia (CML) K562 cells. The α1-adrenergic receptor (α1-AR)/TG2-mediated signaling pathway regulated GD3 functions, including gene expression and production, to different...

Gangliosides are known to specifically inhibit vascular leukocyte recruitment and consequent interaction with the injured endothelium, the basic inflammatory process. In this study, we have found that the production of nitric oxide (NO), a main regulator of inflammation, is suppressed by GM3 on murine macrophage RAW264.7 cells, when induced by LPS....

The natural fungal compound ascofuranone (5-chloro-3-[(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxo-tetrahydrofuran-2-yl]-3-methyl-octa-2,6-dienyl]-2,4-dihydroxy-6-methyl-benzaldehyde, MW 420.93) (AF) isolated from Ascochyta viciae has been known to promote cell cycle arrest and inhibit invasion of tumor cells. We have previously studied a structurally simila...

The disialoganglioside GD3 has been considered to be involved in tumor progression or suppression in various tumor cells. However, the significance of the biological functions of GD3 in breast cancer cells is still controversial. This prompted us to study the possible relationship(s) between GD3 expression and the metastatic potential of a breast c...

Supplementary figure 1.

Jellyfish species are widely distributed in the world’s oceans, and their population is rapidly increasing. Jellyfish extracts have several biological functions, such as cytotoxic, anti-microbial, and antioxidant activities in cells and organisms. However, the anti-cancer effect of Jellyfish extract has not yet been examined. We used chronic myelog...

Raw data from the western blot for data analyses and densitometry for Fig. 5B for the time dependent manner

Effects of various jellyfish extracts on K562 cells during 1 to 3 days of treatment K562 cells were separately treated with H2O extracts, EtOH extracts, BuOH extracts, EA extracts and hexane extracts for 1 to 3 days and cell viabilities were measured using MTT assay. *** P < 0.0005 vs. medium (untreated).

Raw data from the western blot for Figs. 4A, 4C, 4F, 5A, 5C, 5F, and 6C

Raw data from the western blot for data analyses and densitometry for Fig. 5D for the dose dependent manner