Yoshiyuki Mori

• The University of Tokyo

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare autosomal dominant disorder characterized by congenital skeletal malformation and progressive heterotopic ossification. In the oral and maxillofacial region, deformity of the temporomandibular joint is a common feature of FOP, as well as restricted mouth opening derived from heterotop...

In cases of multiple missing teeth with severe jaw deformity, dental implant pretreatments such as bone grafts are generally performed after orthognathic surgery. Bone grafting to the maxillary sinus floor at the same time as Le Fort I osteotomy has previously been reported; however, few of these studies were conducted in Asia-Pacific. Furthermore,...

Background: Postoperative pneumonia is a major cause of postoperative mortality after esophagectomy. Preoperative oral hygiene care is reportedly effective to prevent pulmonary complications after esophagectomy. Methods: Since April 2012, we have included preoperative oral hygiene in the standard perioperative care regimen for esophagectomy and hav...

Maxillary distraction is increasingly used for the correction of severe maxillary retrusion in patients with cleft lip and palate. However, control of the maxillary movement is difficult, and the need to wear visible distractors for a long period of time causes psychosocial problems. A two-stage surgical approach consisting of maxillary distraction...

In East Asia, a square face is considered unattractive, and mandibular contouring surgery is commonly used to give a smooth contour to the lower jaw. Mandibular contouring surgery occasionally involves not only osteotomy of the mandibular angle but also resection of the masseter muscle via an intraoral approach. This type of mandibular contouring s...

Background Surgical complications occur frequently after radical esophagectomy and one of its most serious complications is postoperative pneumonia. Preoperative or postoperative bacteriological assessment may be useful in predicting, preventing, and managing postoperative pneumonia. Methods One hundred and five consecutive patients undergoing any...

Background Early detection of oral squamous cell carcinomas (OSCCs) is urgently needed to improve the prognosis and quality of life (QOL) of patients. Oral leukoplakias (OLs), known as the most common premalignant lesions in the oral cavity, often precede OSCCs. Especially, OLs with dysplasia are known to have a high risk of malignant transformatio...

Acromegaly is caused by growth hormone excess owing to a pituitary adenoma after completion of growth and tends to lead to mandibular prognathism. In this paper, two patients with mandibular prognathism caused by acromegaly and treated by surgical-orthodontic treatment are reported. The first case was a 36-year-old male who was referred to our hosp...

In this study, the mutual fusion of chondrocyte pellets was promoted in order to produce large-sized tissue-engineered cartilage with a three-dimensional (3D) shape. Five pellets of human auricular chondrocytes were first prepared, which were then incubated in an agarose mold. After 3 weeks of culture in matrix production-promoting medium under 5.7...

Short lingual osteotomy is a useful method for the performance of sagittal split ramus osteotomy involving interference between the proximal and distal bone fragments when lateral differences exist in the setback distance. However, this procedure occasionally results in abnormal fracture and nerve injury; expert surgical skill is thus required. We...

Non-Hodgkin's lymphoma is associated with a potential risk of multiple primary carcinoma. Immune suppression related to this disease or the treatment applied has been suggested to cause multiple primary carcinoma. Therefore, appropriate follow-up and management are essential. We report a case of mucoepidermoid carcinoma of the minor salivary g...

Intraoral vertical ramus osteotomy (IVRO) is used widely to correct mandibular prognathism. However, several disadvantages of this procedure have been reported, such as condylar luxation and bony interference at the osteotomy site. The aim of this study was to survey the incidence of complications (condylar luxation and bony interference) based on...

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare life threatening severe cutaneous adverse reactions, primarily caused by drugs and infection. Most of the cases of SJS are predominantly drug related. Drugs including antibacterial sulfonamides, non-steroidal anti-inflammatory drugs (NSAIDs) and anti-epileptic drugs have b...

Odontogenic infection in immunocompromised patients tends to extend systemically beyond the oral cavity. Our case report presents a patient with sepsis due to a Streptococcus constellatus (S. constellatus) odontogenic infection in a 64-year-old-immunocompromised woman with Cogan's syndrome. She had been suffering from chronic mandibular osteomyelit...

Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA To identify novel methylation-silenced genes in oral squamous cell carcinomas (OSCCs), we took a combined approach of methylated DNA immunoprecipitation (MeDIP)-CpG island (CGI) microarray analysis and expression microarray analysis after treatment with a demethylating agent. Me...

We used a piece of costal cartilage as a cartilaginous strut to correct the upturned nasal tip in patients with bilateral cleft lip. The grafted cartilage provides more definition of the tip and improves the obtuse nasolabial angle. Neither the septal cartilage nor the ear cartilage has enough strength to shape the tip. This method of correction ha...

Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recur-rence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young female (25 years old) with pleomorphic adenoma of the parotid gland which showed multiple recurrences through facial to cervical regions...

Previous reports suggest that the most common location of the odontomas are in the maxilla. Among the ectopic odontoma, the nasal ectopic odontomas are rare, and are usually asymptomatic. Here, we present a rare case of an ectopic complex odontoma in the lower nasal turbinate causing nasal obstruction and bleeding, which was removed surgically. A 3...

A patient who had a primary undifferentiated high-grade pleomorphic sarcoma/malignant fibrous histiocytoma that apparently arose in the mandible, but showed uncertain differentiation on histopathological examination, is described. Our regimen, a combination of pre- and postoperative chemotherapy and surgical resection, produced a good outcome.

Recently, there have been remarkable advances in regenerative medicine, and almost all disorders of the oral and maxillofacial region could be research targets of regenerative medicine. Meanwhile, treatment in this region has been well established using biomaterials, prostheses, and microsurgery. Therefore, to surpass such a conventional approach a...

A patient who had a primary undifferentiated high‐grade pleomorphic sarcoma/malignant fibrous histiocytoma that apparently arose in the mandible, but showed uncertain differentiation on histopathological examination, is described. Our regimen, a combination of pre‐ and postoperative chemotherapy and surgical resection, produced a good outcome.

Odontogenic myxoma is a benign odontogenic tumor with locally aggressive behavior, and is relatively rare in the oral cavity. There are currently no clear surgical management guidelines for odontogenic myxoma, and a variety of approaches may be used. This study evaluated the literature concerning the surgical management of odontogenic myxoma, and r...

We report herein on use of a percutaneous zygomatic arch osteotomy that is simple, safe, and less invasive than conventional methods on patients in whom protrusion deformity of the zygoma following facial fracture surgery. Even though osteotomy is performed percutaneously, this technique entails a lower risk of facial nerve damage compared with oth...

To produce a large-sized regenerative joint by the conjugation of small elements combining artificial bone with tissue engineering cartilage, we made small beta tricalcium phosphate (β-TCP)-hexagonal columns (each side: 2 mm, height: 1 cm) as a substitution of subchondral bone, and attempted to achieve mutual bonding of those columns. A large numbe...

Rapid and efficient animal models are needed for evaluating the effectiveness of many new candidate bone regenerative materials. We developed an in vivo model screening for calvarial bone regeneration in lipopolysaccharide (LPS)-treated mice, in which materials were overlaid on the periosteum of the calvaria in a 20 min surgery and results were det...

To establish a large regenerative cartilage without any scaffolds, we cultured chondrocytes on NIsopropylacrylamide (NIPPAM)-coated dishes with 3 × 3 mm2 grids, producing many cell sheets. We then attempted to have the cell sheets form into pellets, which we term cartilage elements, and have the cartilage elements fuse with each other. Finally, we...

Patients infected with the human immunodeficiency virus (HIV) are at risk of developing malignancies and have an increased susceptibility to infection. HIV-associated Burkitt lymphoma (BL) is relatively rare in developed countries, but remains prevalent in developing counties and is sometimes compounded by the fact that patients may be unaware that...

Craniofacial surgery occasionally results in sores and necrosis of the facial skin because of pressure from surgical instruments. During surgical treatment of mandibular condylar process fractures, the main mandibular fragment is routinely retracted downward using a wire to achieve a satisfactory anatomic reduction. This procedure may injure the fa...

Extensive squamous cell carcinoma involving the skin of the upper lip, nasal ala, and cheek is relatively rare. Although numerous reconstruction techniques for the midface including lip, nose, and cheek have been described in the literature, reconstruction of large defects in this area continues to be challenging, as it is difficult to obtain satis...

The aim of this study was to examine the bone regenerative process from fibular periosteum in rats. Twenty male Wistar rats were divided into two groups: a periosteum preservation (PP) group (n=15) and a periosteum removal (PR) group. In the PP group, the fibula was totally removed, but the periosteum and blood supply were preserved. In the PR grou...

A 2-day-old girl was diagnosed with an oral epignathus teratoma and an uncommon combination of orofacial malformations including cleft palate; tongue, mandible, cranial base, cervical vertebrae, lower lip, and pituitary gland duplications; and fistula of the glabella and lower lip. Computed tomography revealed that the mass within the nasal cavity...

To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to create the integral videography...

We have analysed bony defects of the hard palate in patients with submucous cleft palate to find out whether velopharyngeal insufficiency (VPI) is dependent on the extent of these defects. We evaluated the maxillofacial structures associated with cleft palate by 3-dimensional computed tomography (CT) in 23 children diagnosed with submucous cleft pa...

Greater progress has been made in the clinical application of cartilage regenerative medicine, compared with that of other organs. A typical example of cartilage regenerative medicine is autologous chondrocyte implantation, in which chondrocytes isolated from the patient's cartilage are cultured and injected into the cartilage defects in a liquid-...

How the pluripotency of stem cells is maintained and the role of transcription factors in this maintenance remain major questions. In the present study, in order to clarify the mechanism underlying the pluripotency of stem cells for the advancement of regenerative medicine, we examined the effect of forced Nanog expression in mesenchymal cells, wit...

Steady and useful culture for chondrocytes is essential for cartilage regenerative medicine. However, in conventional plate culture, the chondrocytes become dedifferentiated and lose their ability to make cartilage matrices. Three-dimensional culture mimicking the physiological environment in native chondrocytes is useful to maintain the chondrocyt...

The efficiency of substance exchange may be decreased when the thickness and volume of such a tissue-engineered cartilage that is composed of cultured cells and porous scaffold increase. Moreover, during the transport of this construct with complicated shapes, excessive and focal mechanical loading may cause deformation. The establishment of incuba...

Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome or Basal Cell Nevus Syndrome (BCNS), is an autosomal dominant disorder characterized by developmental defects, including palmar or plantar pits, bifid ribs, or calcification of the falx cerebri, and tumorigenesis, such as basal cell carcinoma (BCC), medulloblastoma, or kera...

Henoch–Schönlein purpura (HSP) is a disease that involves palpable purpura on the skin, joint pain, and gastrointestinal problems. An acute bacterial infection is one of the causes of HSP. Odontogenic infectious diseases have also been implicated in causing HSP. However, there are only a few reports describing the correlation between HSP and odonto...

Oblique facial cleft is an extremely rare disorder, accounting for only 0.24% of facial clefts. Even after initial surgery, depressions of the eyeball and facial surface are formed due to bone defects of the maxilla and orbital floor, and since performing bone reconstruction during infancy and early childhood is difficult, pronounced deformity tend...

To determine whether the periosteum influences mandibular head regeneration after condylectomy in rats. male Wistar rats, the periosteum of part of the mandibular head was preserved or removed and the mandibular head was excised up to a section of the neck of the mandible. Radiological and histological findings were evaluated 0, 1, 2, 3, 4, 6, and...

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by postnatal heterotopic ossification (HO). When HO affects the masticatory muscles, mouth opening becomes restricted. This paper presents the changes in facial morphology and occlusion of a patient with FOP who was followed from the age of 8 to age 21. At the initial exami...

The patient presented with a large mandibular body and acceptable occlusion in the molar region with no lateral crossbite. After presurgical orthodontic treatment, mandibular body ostectomy was performed in the missing second premolar region. To avoid nerve injury, we considered removal of the lateral cortical plate around the mental foramen and te...

The performance of the scaffolds holds a key to the realization of tissue engineering/regenerative medicine in clinical settings. We have focused on the vital role of the dimensional compatibility of the scaffolds. By controlling the three-dimensional (3D) shape of the scaffolds, we have significantly improved the performance of the artificial bone...

Objective To compare the accuracy of three-dimensional computed tomography (3D-CT) and panoramic radiography in the evaluation of mandibular hypoplasia in patients with hemifacial microsomia (HFM). Design Retrospective study of imaging data. Setting Images selected from the archives of the University of Tokyo Hospital. Subjects Twenty patients w...

To promote clinical application of cartilage tissue engineering, we should establish a serum-free chondrocyte growth medium. The serum-free medium would increase the cell numbers by more than 20-fold within one week, which proliferation ability almost matches that of serum-based one. For that, we examined the combinations of growth factors and the...

The differential diagnosis of embryonal rhabdomyosarcoma (RMS), pleomorphic sarcoma, and leiomyosarcoma remains a challenge because of their overlapping histological presentations, with serious implications on the choice of treatment. We report a rare case of a tumor confined to the tongue in a 22-year-old woman. Clinical, histological, and immunoh...

Artificial bones are useful for tissue augmentation in patients with facial deformities or defects. Custom-made artificial bones, produced by mirroring the bone structure on the healthy side using computer-aided design, have been used. This method is simple, but has limited ability to recreate detailed structures. The authors have invented a new me...

The branching patterns of the external carotid artery vary among individuals, and consideration of the proximity of nerves is important during catheter insertion in superselective intra-arterial infusion via the superficial temporal artery. We aimed to evaluate the anatomy of the external carotid artery and its surrounding nerves for safe and accur...

In the oral and maxillofacial region, conditions such as bone fracture, trauma-induced bone or cartilage defects, and tumor or birth defects are common, and it is necessary to elucidate the molecular mechanisms that control the differentiation of cells to establish new treatment strategies for these conditions. Therefore, numerous studies have inve...

Reiter's syndrome, also known as reactive arthritis, is composed of the triad of arthritis, urethritis, and conjunctivitis. We herein report the rare case of a male patient with Reiter's syndrome and trismus caused by intravesical BCG immunotherapy. The patient experienced pain of the temporomandibular joint following immunotherapy, and it persiste...

When tooth ankylosis occurs in growing children, the ankylosed tooth fails to erupt and gradually positions itself below the occlusal plane. This causes functional and esthetic problems, and orthodontic treatment is often impossible. To clarify this problem, we developed a new treatment protocol for the movement of ankylosed teeth. This consists of...

The aim of this study was to examine the effect of cyclooxygenase (COX)-2 on bone repair after craniofacial fracture in mice. A 4-mm fracture was created in the parietal bone of 8-week-old male COX-2 wild-type (COX-2(+/+)) and knockout (COX-2(-/-)) mice. Ribonucleic acid was extracted from the fractured bone and analysed. For morphological and hist...

This study assessed the clinical efficacy and acceptability of trehalose solution for oral dryness caused by dental treatment. The efficacy of trehalose on oral dryness under drying conditions was assessed by measuring the surface area of the fungiform papillae and the moisture content of the tongue in seven healthy volunteers. Based on the data fr...

Hepatocellular carcinoma (HCC) is a common neoplasm worldwide, with more than half of the tumors associated with regional metastasis. Extrahepatic metastasis is also common, and the most frequently affected sites are the lungs, abdominal lymph nodes, diaphragm, and bone. However, HCC metastasis to the mandible is rare, with approximately 50 cases r...

Our study aimed to develop an intelligent wound dressing containing elements that promote wound healing. Unlike conventional dressings, this is a gel-type dressing that contains basic factors required by cells in a complex of alkaline-treated collagen and atelocollagen. Full-thickness 8-mm skin defects were made with a DermaPunch® in the left and r...

When reconstructing hard tissue using an autologous bone graft, it is necessary to harvest more bone than the defect area in order to achieve the proper shape. Harvesting of large amounts of bone is highly invasive, and, as a result, it is desirable to minimize the amount of bone harvesting. In the present study, surgery was simulated using a three...

Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disease characterized by renal phosphate wasting and hypophosphatemia. Recently, it was reported that tumors associated with TIO produce fibroblast growth factor (FGF) 23, identified as the last member of the FGF family and of which excessive action causes several hypophosphatemic d...

There are various techniques for palatoplasty, but no studies of postoperative osteogenesis at the palatal fissure. In the cranial and maxillofacial region it is thought to develop from the periosteum, so palatoplasty with mucoperiosteal flaps may encourage new bone to form at the fissure. We evaluated the status of osteogenesis in the hard palate...

Marked nasal deformities, in particular a flattened nasal apex with wide nostrils and a short columella, may develop with facial growth after primary cheiloplasty in patients with cleft lip and palate. This study used auricular cartilage as an augmentation material for the nasal apex to improve the shape of the nose with good results. From July 200...

The most important role of orthodontists in jaw distraction treatments is to follow up on the long-term outcomes as well as the orthodontic treatment itself. In the maxilla/midface advancement in patients with cleft palate or with syndromic cranio-synostosis, the long-term stability of the distraction treatments seems to be good. Stretching scar ti...

Ideally, artificial bones should be dimensionally compatible with deformities, and be biodegradable and osteoconductive; however, there are no artificial bones developed to date that satisfy these requirements. We fabricated novel custom-made artificial bones from alpha-tricalcium phosphate powder using an inkjet printer and implanted them in ten p...

抄録 We describe the very rare case of a 72-year-old woman who had a mass in the floor of the mouth. After admission to our inpatient department, MR imaging suggested that the mass was a tumor of the right sublingual gland. Surgical excision of the sublingual gland tumor was performed with the patient under general anesthesia.The histological diagnos...

抄録 Ameloblastoma is a typical benign odontogenic tumor that occurs in the jaw. Common treatment methods for cystic ameloblastoma include fenestration, in which the cystic cavity is exposed to the oral cavity by resecting a part of the cyst wall along with the mucosa and bone, and the dredging method, in which the tumor is totally resected and the s...

To elucidate the characterizations of chondrocytes originating from auricular cartilage (donors: 10-15 years) and nasoseptal one (20-23 years), we evaluated proliferation or matrix synthesis of both cells cultured under monolayer and collagen type I (COL1) three-dimensional (3D) conditions. Three passages were needed until cell numbers of auricular...

A 23-year-old female with hypoglossia, who had a narrow mandibular dental arch, was treated using the gradual expansion technique. Three lower incisors were missing and the right molar occlusion showed a scissor bite. Her speech was acceptable. Gradual unilateral expansion of the mandibular alveolar bone was performed. Orthodontic tooth alignment w...

Objective: To investigate the effects of transforming growth factor-β1 (TGF-β1) in combination with fibroblast growth factor-2 (FGF-2) and insulin-like growth factor-I (IGF-I), on the properties of chondrocytes after proliferation culture.Materials and Methods: The chondrocytes were obtained from remnant auricular cartilage during microtia operatio...

A 32-year-old woman presented with difficulty in swallowing and swelling of the tongue. A fistula was seen on the dorsum of the tongue. As T2-weighted magnetic resonance imaging showed a high signal intensity lesion with poorly defined margins, a provisional diagnosis of tongue lipoma or angiomyolipoma was made. The lesion was surgically removed in...

This study reports on 15 mandibular reconstructions using the Dumbach Titan Mesh-System and particulate cancellous bone and marrow harvested from bilateral posterior ilia. All cases showed segmental defects. Eleven cases involved patients with malignant tumor. Six patients had received irradiation of 40-50 Gy. Reconstructions were performed immedia...

With regard to the graft materials, cortical bone block, vascularized bone flap and particulate cancellous bone and marrow (PCBM) have been used for the reconstruction of maxillofacial skeleton. Needless to say, the aim of cortical bone block and vascularized bone flap transfer is the transplantation of bony tissue of its own. On the other hand, th...

Necrotising ulcerative stomatitis is a very rapid, destructive disease of the alveolar bone and gingiva. The rapid destruction leads to devastating facial defects and death, if it is not treated promptly. Candida albicans and Pseudomonas aeruginosa are frequent causes of disseminated infections among patients who are immunocompromised. This report...

A large carcinoma ex pleomorphic adenoma (CXPA) with regional lymph node metastasis occurred in the left submandibular gland of a 64-year-old man. Initially, the patient underwent tumor extirpation and ipsilateral radical neck dissection. Histologic examination revealed the malignant component of CXPA was clear cell squamous cell carcinoma (SCC), w...

Prostate cancer frequently metastasises to bones, but rarely metastasises to bones in the head and neck. We describe a patient with prostate cancer in whom the tumour metastasised to the mandibular condyle. The level of prostate-specific antigen, a biomarker for prostate cancer, was extremely high. This report documents the case, with associated pe...

To discuss the autologous serum production for cartilage tissue engineering, we compared three kinds of sera: whole blood-derived serum (WBS), platelet-containing plasma-derived serum (PCS), and plasma-derived serum (PDS), on the growth factor contents and their biological effects on human auricular chondrocytes. EGF, VEGF and PDGF levels were high...

Systemic sclerosis (SSc) is a relatively rare condition characterized by the excessive production and deposition of collagen within tissue. This condition is thought to be immunologically mediated and, in addition to its notorious cutaneous manifestations, often involves multiple organs. A case is presented of systemic sclerosis associated with ext...

Hard tissue reconstruction is very useful for bony defects of the maxillofacial region. Autogenous bone, allogeneic bone, and artificial bone have been used to reconstruct maxillofacial bone; however, the use of autogenous bone involves high surgical invasiveness because of the need to harvest the bone. The use of allogeneic bone is associated with...

A 23-year-old female patient with microglossia and micrognathia was reported with respect to articulation. The case was treated by gradual expansion of the mandibular dental arch followed by double-jaw orthognathic surgery. 1. As before treatment, /t, d, n, r/, sounds were distorted and almost like palatalized articulation; they were made with the...

The reconstruction of the soft palate following resection of a tumour remains a challenge to this day. We recently reconstructed the soft palate by a procedure using the palatal mucoperiosteal flap, with blood supply from the greater palatine vessels. This operative procedure is simple, easy to perform and minimally invasive, and has been used on 2...

Although autologous chondrocyte implantation has already been in clinical use, chondrocyte dedifferentiation is problematic during proliferation culture. We attempted a three-dimensional (3D) collagen gel culture under chondrocyte proliferation with repeated passaging to prevent the chondrocytes dedifferentiation. Human auricular chondrocytes were...

The aim of this study was to examine the effect of cyclooxygenase (COX)-2 on bone response after the placement of implants in the femurs of mice. titanium implants 1.0mm in diameter were placed into the middle of the femurs of 9-week-old male COX-2 wild-type (COX-2(+/+)) and knockout (COX-2(-/-)) mice. For RNA analysis, the mice were killed 0, 1, 2...

A 20-year-old man was referred to our department because of severe pain while eating. Physical examination revealed an erosion and ulcer in the oral cavity. He had been treated for aplastic anemia on an outpatient basis at the Department of Cell Therapy and Transplantation Medicine of our hospital. He had received bone marrow transplants twice. Sub...

A 2-stage procedure combining maxillary advancement by distraction technique with mandibular setback surgery was used to correct jaw deformities in 5 patients with severe maxillary retrusion secondary to cleft lip and palate. First, a Le Fort I maxillary osteotomy was performed. Immediately after maxillary distraction, the distraction device was re...

Objective: To assess the transcriptional regulation of cyclooxygenase-2 by bone morphogenetic protein2 in isolated bone marrow stromal cells obtained from cyclooxygenase-2 wild-type and cyclooxygenase-2defrcient mice.Materials and Methods: Bone marrow stromal cells were cultured for 14 days in the presence of osteogenic medium with or without bone...

Ocular surface reconstruction with autologous oral mucosal epithelium has attracted attention as a novel treatment strategy that avoids allograft rejection. To evaluate the absorption of ultraviolet (UV) A or B irradiation by human oral mucosal epithelium cultured on human amniotic membrane. Human oral mucosal and limbal epithelial cells were co-cu...

Objectives: To assess the effects of platelet-rich plasma on the proliferation of cultured mouse bone marrow stromal cells and on the production of cyclooxygenase-2 and prostaglandin E2 by these cells, and to determine whether the mitogenic activity of platelet-rich plasma is enhanced by combination with a selective cyclooxygenase-2 inhibitorMateri...

Neurosensory disturbance on mental region after sagittal split ramus osteotomy of mandible (SSRO) is one of the most frequent complications. We used Semmes-Weinstein pressure aesthesiometer to evaluate the incidence of postoperative neurosensory disturbance in relation to gender, age, indication for osteotomy, magnitude of mandibular movement and s...

Sox9 is necessary for chondrogenic differentiation both before and after mesenchymal condensations, while Sox5 and Sox6 are necessary only after mesenchymal condensations. However, no individual Sox is sufficient for the process, since none individually induced the differentiation in various cell types, including ES cells, nonchondrogenic immortali...