Yori Yuliandra

Universitas Andalas | ANDA · Faculty of Pharmacy

Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to antibacterial resistance including deactivation of antibacterial agents by bacterial enzymes. Enzymatic drug modification confers resistance to β-lactams, aminoglycosides, chloramphenicol, macrolides,...

Abstract Aim: To improve the solubility and antibacterial activity of trimethoprim (TMP) by preparing its multicomponent crystals with malic acid (MA). Methods: Multicomponent crystals of TMP-MA were prepared by solvent co-evaporation. The solid-state properties were characterised by powder X-ray diffraction (PXRD), differential thermal analysis (D...

The use of chemotherapeutic agents in the management of cancer is often followed by a range of toxicities to various organ systems. A retrospective study on the hematologic toxicities of chemotherapy in lung cancer patients has been carried out. The study was conducted by a cross-sectional method from medical records of four-year data in 2010–2014...

Ibuprofen is classified as a BCS class II drug which has low solubility and high permeability. We conducted the formation of the cocrystalline phase of ibuprofen with coformer nicotinamide to increase its solubility. The purpose of this study was to characterize the solid state of cocrystalline phase of ibuprofen-nicotinamide, determine the solubil...

Objectives: Pseudomonas aeruginosa is an opportunistic pathogen that has an innate resistance to some antibiotics. This bacterium is one of the mostcommon causes of nosocomial infections that include surgical wound infections, burns, and urinary tract infections. The bacteria have been reportedlyresistant to many antibiotics and have developed mult...

Fenofibric acid is a poorly water‐soluble drug with high permeability; thus, it is classified as a Biopharmaceutical Classification System (BCS) class II. This study aimed to prepare a eutectic mixture of fenofibric acid with syringic acid as a coformer to improve its solubility, dissolution rate, and antihyperlipidemic activity. The solvent co‐eva...

Famotidine is a potent histamine 2 antagonist used in the treatment of gastric acid overproduction. Famotidine belongs to Class IV in Biopharmaceutics Classification System (BCS) which has low solubility and membrane permeability. The purpose of this study was to compare the solubility and dissolution profile of solid dispersions (SDs) of famotidin...

Scopoletin is a coumarin derivative known for its antioxidant capacity. The present study was undertaken to investigate the blood pressure lowering effect of scopoletin in multiple models of hypertensive rats. To obtain animal models of hypertension, a number of 18 Wistar-Kyoto male rats were divided into two groups receiving a combination of oral...

Objective: The aims of this study were to investigate the comparative pharmacodynamics effect of methylprednisolone (MP) innovator, MP branded generic, and MP generic products to the serum concentration of annexin A1 (AnxA1).Methods: It was conducted by two-way crossover design in male rabbits. AnxA1 was measured at 0, 0.5, 1, 2, 3, 5, 7, and 9 h a...

Objective: To study the liver toxicity of Cassytha filiformis L. extract and its reversibility in mice. Methods: A total of 108 male mice were used to investigate the hepatotoxicity of Cassytha filiformis extract (CFE) and the reversibility of its toxicity to the liver. Seventy-two mice were treated with CFE orally for 7 consecutive days. A half of...

Objective: The aims of this study were to investigate the comparative pharmacodynamics effect of methylprednisolone (MP) innovator, MP branded generic, and MP generic products to the serum concentration of annexin A1 (AnxA1).Methods: It was conducted by two-way crossover design in male rabbits. AnxA1 was measured at 0, 0.5, 1, 2, 3, 5, 7, and 9 h a...

The effect of ethanolic extract of Eleutherine americana Merr. on the blood pressure and heart rate has been investigated. A number of 25 Sprague-Dawley male rats were induced with prednisone 1.5 mg/kg in combination with saline solution 2.5% for 14 days to obtain hypertension model. The rats were anesthetized and prepared for the recording of bloo...

Tujuan dari penelitian ini adalah untuk mengkaji karakteristik sosiodemografi pasien HIV/AIDS dan mengevaluasi penggunaan obat antiretroviral pada pasien tersebut. Penelitian ini bersifat deskriptif-evaluatif dengan metode kuantitatif dan kualitatif dengan menggunakan data retrospektif pada tahun 2015 di RSUP Dr. M. Djamil Padang. Data diperoleh da...

Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative st...

Ekstraksi dan analisis KLT dari ekstrak rebung Schizostachyum brachycladum Kurz (Kurz), serta uji aktivitas antihiperurisemia pada mencit putih jantan telah dilakukan. Proses ekstraksi dilakukan dengan cara maserasi. Penentuan golongan senyawa dilakukan dengan berbagai reagen warna pada plat KLT. Pengukuran kadar asam urat dilakukan pada hari ke-8...

Thin-layer chromatography (TLC) analysis of bamboo shoot extract (Schizostachyum brachycladum) and its antihyperuricemic activity evaluation on male mice have been conducted. The extraction was processed by the maceration method, while the determination of the compound was carried out by using various color reagents of TLC plate. To evaluate the an...

Blood sugar lowering effect of Cassytha filiformis fractions on alloxan induced diabetic mice has been conducted. A number of 45 male mice with the fasting blood glucose level of ≥126 mg/dL (weighing of 20-30 g and aged of 2-3 months) were divided such where they were treated with Butanol (BuOH), ethyl acetate (EtOAc) and water fractions of Cassyth...

A study on the protection effect of methyl gallate (MG) isolated from Toona sureni leaves against atherosclerosis has been carried out. Rats with high blood cholesterol level were obtained by feeding with high fat diet and inducing propyl thiouracil (PTU). MG was administered orally at the doses of 5, 10, and 20 mg/kg. Histopathologic examination w...

Parents’ adherence in giving antibiotics plays an important role in therapeutic management of pediatric patients with respiratory tract infections and can avoid antibiotic resistance. The aims of this research are to evaluate parents’ adherence in giving antibiotic and factors associated with adherence. This research is conducted involving responde...

To enhance the dissolution rate of ketoprofen, a poorly water-soluble drug, eutectic mixture of ketoprofen with nicotinamide had been prepared by melting technique. The binary phase diagram was constructed to determine the eutectic composition of the binary mixture. The physicochemical properties of this eutectic mixture were investigated by differ...

Sub-chronic toxicity test of the deffated ethanolic extract of Cassytha filiformis L. on the renal function of rat has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and...

Defatted ethanolic extract of Cassytha filiformis exhibits a potential antihypertensive activity based on our previous study. The objective of this study is to evaluate the acute and delayed toxicities of the extract. Determination of LD 50 and delayed toxicity were conducted on 90 mice (divided into 6 groups of 15 mice each) at doses of 25, 50, 10...

An in vivo study of the activity of scopoletin isolated from noni fruit (Morinda citrifolia L.) on the level of interleukin-4 (IL-4) in type I hypersensitive male Swiss-Webster mice has been carried out. Scopoletin was isolated from dried noni powder by soxhletation method using dichloromethane, separated by column chromatography using silica gel a...

The hypotensive effectiveness of defatted crude ethanolic extract, ethyl acetate and butanolic fractions of Cassytha filiformis L. have been compared on anesthesized prednisone-saline-induced (PN) and Prednisone-saline-LNAME -induced (PNL) hypertensive rats. Extract/fractions were given at the dose of 5 mg/kg each while a group treated by 100 µmol/...

A comparative study of the hypotensive activity of defatted crude ethanolic extract of Cassytha filliformis L. and its ethyl acetate and butanolic fractions has been carried out on the anaesthetized hypertensive-induced rats. An amount of 30 Sprague-Dawley rats were divided into two subdivisions: prednisone-saline-induced (PN) and prednisone-saline...

The aim of this study was to know the water fraction effect of Salam Leaves (Syzygium polyanthum Wight.Walp) on rats, which would be focused on the effect in lowering uric acid levels in blood on male hyperuricemic-diabetic rats. Material use in this research were n- hexane fraction, ethyl acetate fraction and water fraction of the leaves. Hyperuri...

A study of the antihypertensive effect of Cassytha filiformis L. defatted extract on the hypertensive rats has been carried out. The study was conducted on 30 male Sprague-Dawley rats induced by Prednisone-NaCl for 14 days to obtain hypertensive rats. All rats were anesthetized to perform direct blood pressure measurement and divided into control g...

An anti hypertensive effect of Connarus grandis Jack leaves ethanolic extract has been investigated on anesthetized two kidney one clipt (2K1C) Goldblatt hypertensive rats. Four groups of animals were treated with the extract at doses of 10, 20, 40 and 80 mg/kg BW intra peritoneally. These doses were repeated every half an hour. Blood pressure (sys...