Yongxia Zhou

University of Southern California | USC · Department of Radiology

New book available Jan. 2023: https://ethicspress.com/products/integrative-imaging-in-neuroplasticity-wisdom-and-neuropsychiatry

"...In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivit...

"...In this book, we report on the significant differences of multiple biomarkers from the ADNI database including neuroimaging, clinical assessments and multiomic biospecimen/genetic data in MCI and early probable AD (pAD), and elucidate the interconnections among different metrics at various domains. Classification results with high accuracies (0...

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New book project, abstracts and manuscripts are welcomed. Special Discount of publication fee from the editor!

Neuroimaging techniques that can help elucidate and characterize the nature and mechanism of tissue injury and disease progression in neurodegenerative disease are of particular importance given its their roles in seeking successful preventive and therapeutic treatments. Studying large-scale samples with various disease mechanisms using multi-param...

New Editing Book Launched. Abstracts and chapters submission are welcomed!

Intechopen Book Chapter Invitation

“Function and Metabolism of Aging: Neuroimaging Evaluation and Improvement” Book Chapter Invitation

Invitation for Book Chapters

The aim of this book is intended to provide a whole picture of new fMRI imaging methodological developments from principles to applications, to both beginners and experts in biomedical imaging and healthcare.

The aim of this book is intended to provide a whole picture of new fMRI imaging methodological developments from principles to applications, to both beginners and experts in biomedical imaging and healthcare.

Please refer to article for details by Yongxia Zhou, “Abnormal Structural and Functional Hypothalamic Connectivity in Mild Traumatic Brain Injury,” Journal of Magnetic Resonance Imaging, 45(4):1105-1112, 2017.

PET/MRI scanner gained popularity due to some advantages including intrinsic between-modality image registration, better interpretation of underlying co-existing pathophysiological events, and most importantly, less patient discomfort [19]. The article by Zhou [2] had evaluated the most up-to-date PET/MRI scanner performance with multiple functiona...

I'm a medical imaging scientist, specialized in MRI neuroimaging and neurosciences applications. I had completed my Ph.D from University of Southern California in Biomedical imaging (2004) and had been trained and worked as neuroimaging scientists in several prestigious institutes including Columbia University, New York University and University of...

Voxel-wise mapping of cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) can provide insight into regional metabolic and hemodynamic processes. A gradient-echo sampling of free induction decay (GESFIDE) imaging module was integrated into the post-labeling delay control module of an acceleration...

Specific objective of this article is to quantify the neuropathological tau depositions in brain regions and to investigate primary age-related tau pathology and associations with amyloid and glucose-metabolism, neurocognitive tests and MRI metrics. Prelim- inary results demonstrated higher temporal deposition especially in the hippocampus and the...

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P53 deletion has been identified as one of the few factors that defined high risk and poor prognosis in MM. It has been reported p53 deletion is associated with resistance to chemotherapy and organ infiltrations of MM. However, p53 deletion in the migration and dissemination of MM cells has not been totally elucidated. In this research, first, we i...

Specific objective of this project is to quantify the neuropathological tau depositions in brain regions and to investigate primary age-related tau pathology and associations with amyloid and glucose-metabolism, neurocognitive tests and MRI metrics. Preliminary results demonstrated higher temporal deposition especially in the hippocampus and the in...

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Although it is challenging to visualize the temporal spreading of the tau pathology, significant correlations between amyloid-beta (Aß) plaques and tau tangles in cortical regions, as well as correlations between tau and neuropathological tests indicate the intertwining and cascade of the neurodegeneration process including Aß, tau and clinical sym...

Purpose: To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with po...

Purpose: To investigate whether there is imaging evidence of hypothalamic injury in patients with mild traumatic brain injury (MTBI), which is a major public health problem due to the high prevalence and difficulty in diagnosis and treatment. Materials and methods: Twenty-four patients (mean age 34.2, range, 18-56 years) with symptomatic MTBI an...

Voxel-wise mapping of cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) can provide insight into regional metabolic and hemodynamic processes. A gradient-echo sampling of free induction decay (GESFIDE) imaging module was integrated into the post-labeling delay control module of an acceleration...

Both age and smoking promote endothelial dysfunction and impair vascular reactivity. Here, we tested this hypothesis by quantifying new cardiovascular magnetic resonance (CMR)-based biomarkers in smokers and nonsmokers. Study population: young non-smokers (YNS: N = 45, mean age = 30.2 ± 0.7 years), young smokers (YS: N = 39 mean age 32.1 ± 0.7 year...

To compare cerebrovascular reactivity (CVR) quantified with pseudo-continuous arterial spin labeling (pCASL) and blood oxygen level dependent (BOLD) fMRI techniques. Sixteen healthy volunteers (age: 37.8±14.3years; 6 women and 10 men; education attainment: 17±2.1years) were recruited and completed a 5% CO2 gas-mixture breathing paradigm at 3T field...

To quantify and investigate the interactions between multimodal MRI/positron emission tomography (PET) imaging metrics in elderly patients with early Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy controls. Thirteen early AD, 17 MCI patients, and 14 age-matched healthy aging controls from the Alzheimer's Disease Neuroimaging...

A recently introduced integrated scanner combining simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET/MRI) acquisition presents a unique set of opportunities for neuroimaging research and dementia in particular [1]. Among these, the intrinsic co-registration of the images has the potential to reduce errors in...

This study employed graph theory and machine learning analysis of multiparametric MRI data to improve characterization and prediction in autism spectrum disorders (ASD). Data from 127 children with ASD (13.5±6.0 years) and 153 age- and gender-matched typically developing children (14.5±5.7 years) were selected from the multi-center Functional Conne...

To examine thalamic and cortical injuries using fractional amplitude of low-frequency fluctuations (fALFFs) and functional connectivity MRI (fcMRI) based on resting state (RS) and task-related fMRI in patients with mild traumatic brain injury (MTBI). Twenty-seven patients and 27 age-matched controls were recruited. The 3 Tesla fMRI at RS and finger...

Objectives The aim of this study was to examine the self-rated competencies and perceived roles of medical geneticists, genetic counselors, and psychiatrists in the communication of genetic risk for psychiatric disorders to patients and families at an increased risk for schizophrenia, bipolar disorder or major depressive disorder, and their perspec...

Traumatic brain injury (TBI) is a problem of growing public health interest with high incidence. After injury, patients are at risk for several long-term sequelae that encompass a wide array of physical and behavioral symptoms. Since conventional imaging modalities are limited in their ability to assess axonal injury or functional network connectiv...

Purpose: To investigate longitudinal changes in global and regional brain volume in patients 1 year after mild traumatic brain injury (MTBI) and to correlate such changes with clinical and neurocognitive metrics. Materials and methods: This institutional review board-approved study was HIPAA compliant. Twenty-eight patients with MTBI (with 19 fo...

Background and purpose: CC is extensively involved in MS with interhemispheric dysfunction. The purpose of this study was to determine whether interhemispheric correlation is altered in MS by use of a recently developed RS-fMRI homotopy technique and whether these homotopic changes correlate with CC pathology. Materials and methods: Twenty-four...

Background. Brain lesions are common in neuromyelitis optica spectrum disorder (NMOsd) and may resemble lesions of multiple sclerosis (MS). Objectives. To describe the imaging characteristics of supratentorial lesions in NMOsd on ultrahigh-field (7 T) MRI with special attention to vessel-lesion relationship. Methods. Ten NMOsd patients, all women a...

Background Small-world network consists of networks with local specialization and global integration. Our objective is to detect small-world properties alteration based on cortical thickness in mild cognitive impairment (MCI) including stables and converters, and early Alzheimer’s disease (AD) compared to controls. Methods MRI scans of 13 controls...

Purpose: To investigate the integrity of the default-mode network (DMN) by using independent component analysis (ICA) methods in patients shortly after mild traumatic brain injury (MTBI) and healthy control subjects, and to correlate DMN connectivity changes with neurocognitive tests and clinical symptoms. Materials and methods: This study was a...

PURPOSE To document longitudinal changes in brain iron using quantitative measures of magnetic field correlation (MFC) in patients with mild traumatic brain injury (MTBI) compared to a control cohort and to correlate changes in MFC to neuropsychiatric measures. METHOD AND MATERIALS 24 patients with MTBI were prospectively enrolled and 12 matched h...

PURPOSE Previous study of traumatic brain injury (TBI) showed decreased level of hypocretin or orexin, a neuropeptide that is produced in the hypothalamus and has been discovered to be associated with sleep disorder. The purpose of this study was to investigate whether there is imaging evidence of hypothalamic injury in patients with mild TBI (MTBI...

PURPOSE To demonstrate imaging evidence of functional connectivity and structural changes of the thalamus in patients with mild traumatic brain injury (MTBI) using resting state fMRI (RS-fMRI), diffusional kurtosis imaging (DKI), as well as morphological shape analysis. METHOD AND MATERIALS 25 clinically diagnosed MTBI patients (GCS, 13~15; age,...

To explore the neural correlates of the thalamus by using resting-state functional magnetic resonance (MR) imaging and to investigate whether thalamic resting-state networks (RSNs) are disrupted in patients with mild traumatic brain injury (MTBI). This HIPAA-compliant study was approved by the institutional review board, and written informed consen...

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. There...

Brain imaging studies of early Alzheimer's disease (AD) have shown decreased metabolism predominantly in the posterior cingulate cortex (PCC), medial temporal lobe, and inferior parietal lobe. This study investigated functional connectivity between these regions, as well as connectivity between these regions and the whole brain. Functional magnetic...

Recently a smooth temporal activation model was introduced to include temporal a priori information for the spatiotemporal localization of EEG sources. The temporal and spatial smoothing constraints improved accuracy of reconstruction in noisy data, but the spatial resolution was relatively poor. We have investigated a novel approach where in addit...

A multicomponent model reflecting the temporal characteristics of micro- and macrovasculature hemodynamic responses was used to fit the time-course of voxels in functional MRI (fMRI). The number of relevant components, the latency of the first component, the time-separation among the components, their relative amplitude and possible interpretation...

The influence of conductivity tensor on the forward solution of electroencephalography was assessed in 2-D head models of a human subject. The conductivity tensors of different regions of the head were estimated from magnetic resonance-diffusion tensor images by linearly mapping the mean trace values to the published conductivity values. The anisot...

A multi-componet model reflecting the temporal characteristics of micro- and macro-vasculature hemodynamic responses was used to fit the time-course of voxels in functional MRI (fMRI). The number of relevant components, the latency of the first component, the time-separation among the components, their relative amplitude and possible interpretation...

The temporal resolution of functional MRI (fMRI) is limited by the shape of the haemodynamic response function (hrf) and the vascular architecture underlying the activated regions. Typically, the temporal resolution of fMRI is on the order of 1 s. We have developed a new data processing approach to extract temporal information on a pixel-by-pixel b...

We have investigated electroencephalography (EEG) distributed source imaging with a realistic finite-element (FE) head model. The performance of different FE imaging methods was evaluated and compared in two- (2-D) and three-dimensional (3-D) simulation studies. The results demonstrate the feasibility of EEG distributed source imaging with FE head...

We have investigated electroencephalography (EEG) distributed source imaging with a realistic finite-element (FE) head model. The performance of different FE imaging methods was evaluated and compared in two-(2-D) and three-dimensional (3-D) simulation studies. The results demonstrate the feasibility of EEG distributed source imaging with FE head m...

The influence of conductivity tensor on the forward solution of electroencephalography (EEG) was assessed in the 2D head models of a human subject. The conductivity tensors of the different regions of the head were estimated from the diffusion tensor images by scaling the mean trace values to the published conductivity values. The anisotropic condu...

There are a variety of research applications that require reconstruction of objects from unorganized points. In our implementation, we accomplish this task in two steps: first by connecting points to contours and then contours to objects. We focus on the first step in this paper. We present a Voxel-coding algorithm which assembles unorganized point...

Skeletonization promises to become a powerful tool for compact shape description, path planning and other applications. However, current techniques can seldom efficiently process real, complicated 3D data sets, such as MRI and CT data of human organs. In this paper, we present an efficient voxel coding-based algorithm for the skeletonization of 3D...

Cortical sulci are convoluted regions between cortical folds deeply embedded in the surface of the brain. Because of their significant characteristics, their functional separation of distinct brain regions, and their natural topological partition of anatomy, sulci serve as a basis for structural analysis of the brain. Current sulcal modeling techni...

We propose an algorithm for generating 18-connected skeletons and centerlines of 3D binary volume data sets. With of an approximate minimum distance field, we express skeletons as a set of clusters with a set of local maximum paths (LMpaths). Each cluster consists of geometrically adjacent voxels with the same local maximum value. Distinct clusters...

PURPOSE/AIM To demonstrate the potential of several novel quantitative MRI approaches in detecting thalamic injury that is not seen on conventional imaging and to investigate its crutial role in post concussive syndrome (PCS) in patients with mild traumatic brain injury (MTBI). CONTENT ORGANIZATION We will demonstrate MTBI patients with no initial...