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Introduction
Skills and Expertise
Publications
Publications (145)
The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics, but they are poorly understood owing to the challenges of performing experiments and realizing ab initio calculations. Here, we report the first shock Hugoniot dat...
Rosavin, a phenylpropanoid glycoside, is the specific index component and one of the main active components of Rhodiola rosea. Currently, there are few studies describing the antiaging effect of rosavin, and most of them are mainly based on in vitro antioxidant research. Our study aimed to investigate the antiaging activities and mechanisms of rosa...
Modifications at the harmine (HAM) 9‐N position demonstrated effective antitumor activity in previous studies. However, the difficult preparation, low yield and poor stability of derivatives limited their applications. A partial activity priming was carried out by converting the 9‐position substituted propargyl group of HAM to propynyl group. Molec...
In an experiment performed on the Shenguang-III prototype laser facility, collective Thomson scattering (TS) is used to study the spatial growth of stimulated Brillouin scattering (SBS) in a gas-filled Hohlraum by detecting the SBS-driven ion acoustic wave. High-quality time-resolved SBS and TS spectra are obtained simultaneously in the experiment,...
The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility. Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering (SBS), collective behaviors are excited to enhance the octad SBS. In particular, when two-color/...
Rat sarcoma (RAS), as a frequently mutated oncogene, has been studied as an attractive target for treating RAS-driven cancers for over four decades. However, it is until the recent success of kirsten-RAS (KRAS)G12C inhibitor that RAS gets rid of the title "undruggable". It is worth noting that the therapeutic effect of KRASG12C inhibitors on differ...
Magnolol (M), a hydroquinone containing an allyl side chain, is one of the major active components of Houpoea officinalis for antioxidation and anti-aging. To enhance the antioxidant activity of magnolol, the different sites of magnolol were structurally modified in this experiment, and a total of 12 magnolol derivatives were obtained. Based on the...
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily conserved protein kinase and the most studied member of the Dual-specificity tyrosine-regulated kinase (DYRK) family. It has been shown that it participates in the development of plenty of diseases, and both the low or high expression of DYRK1A protein could...
Polygonati Rhizoma is the dried rhizome of Polygonatum kingianum coll.et hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua, and has a long history of medication. Raw Polygonati Rhizoma (RPR) numbs the tongue and stings the throat, while prepared Polygonati Rhizoma (PPR) can remove the numbness of the tongue, and at the same time enhan...
Ethnopharmacological relevance
As a commonly used traditional Chinese herbal medicine, Erodii Herba Geranii Herba (Geranium wilfordii Maxim., Geranium carolinianum L. and Erodium stephanianum Willd.), which was known as Laoguancao (Chinese:老鹳草), has high medicinal value. It has been used to dispel rheumatism, dredge the meridians, activate blood ci...
Objective: To explore the anti-aging effects of chlorogenic acid (CGA) and the underlying mechanisms based on a Caenorhabditis elegans (C. elegans) model. Methods: The anti-aging activity of CGA was studied based on the body length, exercise behavior, lipofuscin content, antioxidative stress ability, swallowing frequency, body-bending frequency, an...
Herein, we report a novel Cu2(OH)3 F/CQDs-BiVO4 composite photo-Fenton-like system, which used BiVO4 and Cu2(OH)3F as electron donor and acceptor, respectively, and achieved efficient electron transfer between them through the electron bridging effect of Carbon quantum dots (CQDs). The material exhibited excellent ciprofloxacin (CIP) removal effici...
Oxidative stress disrupts the homeostasis of the redox state in cells and induces apoptosis. Prolonged oxidative stress can impair the normal function of cells, tissues, and organs and lead to the development of several diseases. H-2 was synthesized by derivatising N-Alkylamides (NAAs) from Anacyclus pyrethrum (L.) DC, which is commonly used in the...
Both autophagy and apoptosis are mechanisms that maintain homeostasis in cells and that play essential roles in viral infections. Previous studies have demonstrated that autophagy and apoptosis pathways occurred with complex relationships in virus-infected cells. However, the regulation between these two processes in Pseudorabies virus (PRV) infect...
Objectives
Haploid germ cell-specific nuclear protein kinase (Haspin) is a serine/threonine kinase as an atypical kinase, which is structurally distinct from conventional protein kinases.
Key findings
Functionally, Haspin is involved in important cell cycle progression, particularly in critical mitosis regulating centromeric sister chromatid cohes...
As a glucagon (GCG) receptor (GCGR) and glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) dual agonist, oxyntomodulin (OXM) has been attracting scientific attentions due to its efficacies of suppressing appetite, increasing energy expenditure, and inducing body weight loss in obese humans. Based on the scaffold of native OXM, specific helix-favorin...
Here, we report a simple and efficient strategy for evenly in situ growth of Cu2(OH)3F nanosheets on BiVO4 spheres as a novel photo-Fenton-like catalyst using hydrothermal method. The Cu2(OH)3F/BiVO4 composite catalysts showed great performance for the organic pollutants degradation under visible light irradiation due to the efficient electron tran...
Rehmanniae Radix (RR, the dried tuberous roots of Rehmannia glutinosa (Gaertn.) DC.) is an important traditional Chinese medicine distributed in Henan, Hebei, Inner Mongolia, and Northeast in China. RR is frequently used to treat diabetes mellitus, cardiovascular disease, osteoporosis and aging-related diseases in a class of prescriptions. The olig...
The application of traditional Chinese medicine has a long history in China with unique advantages and functions. With the rapid development of separation and purification technologies, more and more polypeptide compounds with specific biological activity and medicinal value were isolated from natural plants. The plant polypeptides have a lot of bi...
A new method for measuring the time-dependent drive flux at the hohlraum center is proposed as a better alternative to conventional wall-based techniques. The drive flux here is obtained by simultaneous measurement of the reemitted flux and shock velocity from a three-layered "cakelike" sample. With these two independent observables, the influence...
The structural modulation of graphitic carbon nitride (g-C3N4) is regarded as an effective strategy to boost its photocatalytic behavior. Herein, we have synthesized 4,6-dimethyl-2-hydroxypyrimidine-doped and cyano defects co-modified graphitic carbon nitride (HDMP-CD-g-C3N4) using a facile in situ co-condensation method. HDMP-CD-g-C3N4 was employe...
Purpose
Pinocembrin is a dihydroflavonoid, which is widely found in several plant species. Although pinocembrin has good pharmacological activity, it has poor water solubility and low bioavailability. Therefore, we have modified the structure of pinocembrin with a combination of different amino acids to solve this problem. Moreover, the effect of t...
[This corrects the article DOI: 10.2147/DDDT.S330223.].
Gastric cancer (GC) is one of the most common malignancies and has the second highest lethal rate in the world; thus, finding new medicines with high potency and low toxicity is urgent. Cudrania tricuspidata (Carr.) Bur. ex Lavallee (Moraceae) is a traditional medicinal herb that is considered to have antitumour efficacy. We extracted and isolated...
Inhibiting the competitive effect of O2 in copper-based Fenton reagents and improving the photogenerated electron-hole pair separation of g-C3N4 are the focus of current research. In this article, Cu2(OH)3F was successfully synthesized by the hydrothermal method and combined with g-C3N4via a simple mix-load method. The composite catalyst (CFO/CN) e...
In this study, an effective Ni-doped Cu2(OH)3F was synthesized by a simple one-step hydrothermal method to activate H2O2 for degrading organic pollutants in water. The prepared (Cu2-xNix)2(OH)3F showed significant degradation performance for the degradation of RhB and TC. The characterization methods of XRD, XPS, TEM, SEM, FT-IR proved that Ni succ...
Enhancing the effective contact between heterogeneous interfaces and accelerating photo-generated charge separation is the focus of current photocatalysis research. Herein, a novel Z-scheme Cu2(OH)3F/Bi2WO6(CFO/BWO) heterojunctions with intimate hetero-surface contact were successfully synthesized via electronic coupling of the surface hydrogen bon...
Vacancy engineering has been a very active research hotspot in the field of photocatalysis. The electronic and band structure of carbon nitride can be tuned by vacancies. However, the hydrogen production rate of carbon nitride modified only by a single defect was not notable. Therefore, we constructed the nitrogen-oxygen double vacancy modified car...
Harmine is a beta-carboline and harmala alkaloid with extensive bioactivities. However, its toxicity, especially in neural system, is not systematically assessed and the toxic mechanism is not yet clear. Using Caenorhabditis elegans (C. elegans) as a model system, we found that harmine exhibited dosage dependent (0, 5, 10, 20, 40, 80, 160, and 320...
Background
N-Alkylamides (NAAs), derived from Anacyclus pyrethrum (L.) DC, have potential anti-tumor effects. To explore the molecular mechanism and chemo-preventive capacity of NAAs, we synthesized an NAA (H-10) and evaluated whether it could inhibit the proliferation of B16, HepG2, HeLa, and HCT116 cancer cells in 2D culture.
Methods
To evaluate...
Background:
Peganum harmala L. is a medicinal herb extensively used in traditional Chinese medicine (TCM). So far, relevant reports on the toxicity of Peganum harmala L. seeds (PHS) are hardly available. Especially, we still know little about the in vivo mechanism for PHS toxicity. This study aims to evaluate the toxicity effects of PHS in Caenorh...
Huntington's disease (HD) is a relentlessly progressive neurodegenerative disease featured by the over-expanded polyglutamine (polyQ)-induced protein aggregation. Using Caenorhabditis elegans (C. elegans) as a model system, we show that water soluble polysaccharide extracted from the herb Peganum harmala L. (PS1) not only reduces polyQ aggregation...
The problem of an aging society is becoming increasingly acute. Diseases related to aging also come with it. There are some diseases that people can’t treat fundamentally. Therefore, people try to find a natural ingredient from natural medicine to treat these diseases and improve the quality of life of the elderly. With the screening of a large num...
Fufang Xueshuantong (FXST), a Chinese patent medicine, is composed of Panax notoginseng, Salviae miltiorrhizae, Astragali Radix and Radix Scrophulariae and has been found to prevent diabetic retinopathy. Yes-associated protein (YAP) participates in the pathophysiology of retinal disease and promotes endothelial cell proliferation and angiogenesis....
Background:
Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encodes LET-60, in Caenorhabditis elegans regulates vulval development. While the loss of let-60 function leads to failure of vulva fo...
Ethnopharmacological relevance:
Radix trichosanthis (RT) is a popular plant in China to treat diabetes.
Aim of the study:
The aim of this study is to investigate the therapeutic effect of different extracts of RT and explore the underlying mechanism.
Methods:
Ethyl acetate extracts of radix trichosanthis (ERT), methanol extracts of radix trich...
The root of Anacyclus pyrethrum (L.) Lag., Asteraceae, is very widely used for treating various diseases in Traditional Uygur Medicine, particularly in the treatment of vitiligo. However, there have been few studies on the quality standards of A. pyrethrum in China. A. pyrethrum contains abundant N-alkylamides, which are considered to be the princi...
Objective
The severity of angina pectoris has been recognized. It is believed that Chinese herbal injections have an outstanding clinical effect on this condition. This network meta-analysis was devised to investigate the comparative efficacy of eight Chinese herbal injections (Ciwujia injection, Dazhuhongjingtan injection, Huangqi injection, Shenf...
Diabetic retinopathy (DR) is a severe complication of diabetes, which seriously affects the life quality of patients. Because of the damage caused by DR, there is an urgent need to develop effective drugs. Folic acid, a water-soluble vitamin, is one of the vitamin B complexes. Folic acid is widely found in the meat and vegetables. In the clinic, lo...
Structure is a crucial factor to decide the selectivity and sensitivity of chemosensors. In this work, a diacylhydrazone 2a and its congeneric derivatives 2b-2d were synthesized and their applications for Al³⁺ detection were investigated. Except 2d, all the other compounds exhibit notable turn-on fluorescence toward Al³⁺ over 15 other metal ions an...
The aim of this research is to investigate the therapeutic effect of GGQL decoction on cardiac dysfunction and elucidate the pharmacological mechanisms. db/db mice were divided into DB group or GGQL group, and WT mice were used as control. All mice were accessed by echocardiography. And the total RNA of LV tissue samples was sequenced, then differe...
A rapid, convenient and effective identification method of alkaloids was established and an attempt on isolating and analyzing
the alkaloids in Aconitum pendulum Busch was conducted successfully. In this article, four high-content components including deoxyaconitine, benzoylaconine,
aconine and neoline were isolated by using column chromatography....
Background:
Crude radix Aconitum kusnezoffii (RAK) has great toxicity. Traditional Chinese medicine practice proved that processing may decrease its toxicity. In our previous study, we had established a new method of RAK processing (Paozhi). However, the mechanism is yet not perfect.
Objective:
To explore the related mechanism of processing thro...
Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly inhibit cathepsin K activity, a h...
Piglets infected with the highly pathogenic PRRSV (HP-PRRSV) HuN4 strain develop severe thymus atrophy. However, the attenuated strain HuN4-F112 does not lead to lesions in organs. Here, we have characterized the thymic lesions in piglets infected with attenuated strains of HP-PRRSV HuN4 isolated at different passages in the attenuation process to...
Previously, we demonstrated that the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) HuN4 strain causes obvious thymic atrophy and thymocytes apoptosis in infected piglets after birth, which is more severe than that induced by classical PRRSV. In this study, we investigated apoptosis and autophagy in the thymus of p...
To prevent a future influenza A virus subtype pandemic outbreak, developing a broad-spectrum vaccine would be highly beneficial. The ion channel protein M2 is highly conserved in a diverse number of influenza A virus subtypes. This distinguishing characteristic makes M2 an attractive vaccine target for a broadly protective vaccine. We expressed a f...
Exposure to air pollution has long been known to trigger cardiovascular events, primarily through activation of local and systemic inflammatory pathways that affect the vasculature. Detrimental effects of air pollution exposure on heart failure and cardiac remodeling have also been described in human populations. Recent studies in both human subjec...
Calculus bovis have been widely used in Chinese herbology for the treatment of hyperpyrexia, convulsions, and epilepsy. Nowadays, due to the limited source and high market price, the substitutes, artificial and in vitro cultured Calculus bovis, are getting more and more commonly used. The adulteration phenomenon is serious. Therefore, it is crucial...
Enterohemorrhagic Escherichia coli (EHEC) strains cause serious gastrointestinal disease, which can lead to potentially life-threatening systemic complications such as hemolytic uremic syndrome. Although the ehx gene is established as a major virulence factor of EHEC, the role of this gene in colonization and biofilm formation remains to be elucida...
Streptococcus suis is a serious threat to swine industry and public health. In this work, a total of 62 S. suis isolates recovered from infected and healthy pigs from four provinces in northern China were classified by multilocus sequence typing into nine sequence types (STs), including six novel ones, namely, ST417, ST418, ST419, ST420, ST421, and...
Bio-oil produced from prolysis process of biomass cannot be directly used for transportation fuels, because of the poor quality. Catalytic hydrogenation is then used to upgrade bio-oil to engine-grade fuel. However, external H2 addition may not be cost effective to obtain high quality of oil. In this work, the feasibility of in situ hydrogen genera...
The Cre-loxP recombination system has been used to promote DNA recombination both in vitro and in vivo. For in vivo delivery, Cre expression is commonly achieved through the use of tissue/cell type-specific promoters, viral infection, or drug inducible transcription and protein translocation to promote targeted DNA excision. The development of cell...
Catalytic performance of palladium supported on activated carbons and mesoporous aluminosilicate Al-SBA-15 were investigated at 300 °C under 8 MPa H2 for hydrotreating of bio-oil model compounds, including phenol, anisole, and furfural. With Pd/C catalysts, phenol, anisole, and furfural have been mainly hydrogenated into cyclohexanol, 1-methoxycycl...
This paper focuses on the shift control strategy and the related experiments for dry dual clutch transmissions (DCT). The gearshift processes, upshifts and downshifts, have been analyzed by model simulation. The control strategies for both the torque phase and the inertia phase of both clutches are proposed during the shift process respectively. Th...
Porcine reproductive and respiratory syndrome (PRRS) is an immunosuppressive disease that is characterized by respiratory distress and poor growth in piglets and by severe reproductive failure in sows. PRRS was first recognized in the 1990s in Europe and the United States. In 2006, highly pathogenic (HP)-PRRS caused enormous economic losses in Chin...
Background:
Mesaconitine is the main active component of genus aconitum plants that are widely used in clinics in China. However, little has been known about the metabolic pathway of mesaconitine.
Objective:
To explore the metabolites and propose the pathway of mesaconitine.
Materials and methods:
In the present study, mesaconitine (4 mg kg(-1...