Yong-Ming Lu

Anhui University · School of Life Sciences

Age-associated increase in intestinal permeability is known to relate with gut microbiota dysbiosis and loss of epithelial tissue integrity. To improve healthy aging and prevent age-associated chronic disabilities, the protective potential of polysaccharides from Oudemansiella raphanipes (ORP-1) against age-associated intestinal epithelial barrier...

Armillariella tabescens is a traditional Chinese medicinal and edible fungus which holds importance for treatment of gastrointestinal disorders. This study was aimed to evaluate the effect of methanol extract of A. tabescens (AME) in dextran sulfate sodium (DSS) induced ulcerative colitis (UC). The results showed that AME significantly attenuated U...

Tartary buckwheat is a popular natural grain commonly used as a functional food in various countries. This study aimed to prepare buckwheat dietary fiber with improved biological activity using liquid fermentation of Aspergillus niger and to elucidate its physicochemical properties and related mechanisms. Compared with unfermented buckwheat dietary...

Intestinal dysbiosis is one of the major causes of the occurrence of metabolic syndromes, such as obesity, diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Polysaccharide-based microbial therapeutic strategies have excellent potential in the treatment of metabolic syndromes, but the underlying regulatory mechanisms remain el...

The objectives of this study were (1) to prepare Armillariella tabescens mycelia polysaccharides (PAT) with remarkably growth inhibitory effect on typical food-borne pathogenic bacteria using a green and efficient polyamide method and (2) to explore the antibacterial mechanism of PAT for use as a natural antibacterial agent. The sugar and uronic ac...

Tea polysaccharides have gained great attention but acid-assisted extraction was scarcely studied. Herein, an acid-extracted tea polysaccharide TP-1 was isolated. TP-1 contained glucose and galactose in a molar ratio of 4.33:1.00, and the molecular weight was 9.47 × 10³ Da. The backbone is comprised of 1,4-α-Glcp, 1,6-α-Glcp, and 1,4-β-Galp, with b...

In our continuous exploration for bioactive polysaccharides, a novel polysaccharide FMP-2 was isolated and purified from the fruiting bodies of Morchella esculenta by alkali-assisted extraction. FMP-2 had an average molecular weight of 1.09 × 10⁶ Da and contained mannose, glucuronic acid, glucose, galactose, and arabinose in a molar ratio of 4.10:0...

Fungi play an important role in dying wastewater treatment. In this work, the mycelia of Lactarius deliciosus exhibited an excellent capacity in decolorizing coomassie brilliant blue (CBB). The results demonstrated that the mycelia could treat CBB with high concentrations over a broad range of pH and temperature. The decolorization rate of 99.19% a...

Sarcodon aspratus, a popular edible fungus for its tasty flavour and can be used as a dietary supplement for its functional substances. Our study is conducted to evaluate the protective effect of Sarcodon aspratus polysaccharides (SAFP) on oxidative stress damage and pulmonary fibrosis (PF), and further explore the signaling pathways in vitro and i...

In this study, the immunoenhancement effect of crude polysaccharides (HLP) from the fruiting bodies of Helvella leucopus were investigated on immunosuppressive mice model induced by cyclophosphamide (CTX). Monosaccharide composition analysis indicated that HLP was composed of mannose, rhamnose and glucose with ratio of 8.51:1:1.87. HLP treatment co...

5-Fluorouracil (5-Fu) is an effective anticarcinogenic agent, however, continuous use of 5-Fu may cause severe side effects. The goal of this study was to investigate the effectiveness of Sarcodon aspratus polysaccharides (SATP) in alleviating 5-Fu-induced toxicity in Lewis tumor-bearing mice. Lewis tumor-bearing mice were treated with saline, SATP...

Diabetic nephropathy (DN), a complication of diabetes mellitus, has been the leading cause of death in people with chronic kidney disease. This study was conducted to examine the potential health benefits of Cordyceps cicadae polysaccharides (CCP) on kidney injury and renal interstitial fibrosis that occur in DN rats. First, a DN model was establis...

Sarcodon aspratus, a popular edible fungus that has commonly been used as a functional food in China and other Asian countries. This study is conducted to examine the potential health benefits of SATP, the polysaccharides isolated from the fruit body of S. aspratus, on obesity and related metabolism disorders. C57BL/6J mice were fed with high-fat d...

The mushroom polysaccharides are important substances with variety of functions, especially to the human body's immunomodulation effects. In this work, a polysaccharide fraction (LDP-1) was extracted and purified from the fruiting bodies of a rare wild Lactarius deliciosus. LDP-1 with molecular weight of 9.8 × 10⁵ Da showed an obvious immunological...

A novel heteroglycan TLH-G was successfully isolated from Tricholoma lobayense cultivated in south China. TLH-G was composed of five monosaccharides, namely, mannose, rhamnose, glucuronic acid, glucose and galactose, and consisted of →1)-β-D-Glcp-(6→ and →1)-α-D-Galp-(6→ motifs. TLH-G had excellent scavenging activities towards 2, 2-diphenyl-1-picr...

Fine particulate matter (PM2.5) exposure could cause many acute and chronic respiratory diseases. In this study the protective effects of polysaccharide from Morchella esculenta (FMP-1) and its derivatives against PM2.5-induced inflammation were evaluated. By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protecti...

Polysaccharides from Morchella esculenta are known to possess diverse bioactivities, while anti-melanogenesis effect has been barely addressed. Herein, the anti-melanogenesis activity of a heteropolysaccharide from M. esculenta (FMP-1) was investigated in vitro and in vivo. FMP-1 had no significant cytotoxic effect on B16F10 melanoma cells as well...

Oxidative stress is considered to involve cell death in severe pulmonary diseases like idiopathic pulmonary fibrosis (IPF). Polysaccharide FMP-1 from Morchella esculenta can exert significant antioxidant activity. However, its effects on alveolar epithelial cells remain unperceived. Herein, the effects of FMP-1 against H2O2-induced oxidative damage...

A new polysaccharide fraction (CCPP-1) was obtained from Craterellus cornucopioides. CCPP-1 had an average molecular weight of 9.2 × 105 Da, which was mainly composed of mannose, glucose, xylose, arabinose, fructose in molar ratio of 0.7:0.05:0.18:1:0.05. Results of structural characterization revealed that the dominant linkage types of CCPP-1 were...

This study aimed to investigate the structural features, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta (FMP-1). FMP-1 had an average molecular weight of 4.7 × 10³ Da and consisted of mannose, glucose and galactose. By methylation and NMR analysis, the backbone of FMP-1 was dedu...

To inform rational therapeutics to alleviate many senescence-related diseases in terms of the pathogenic pathways, we investigated the protective mechanisms of TLH-3 against premature senescence in tert-butyl hydroperoxide (t-BHP)-induced human embryonic lung fibroblast (HELF) cells model and d-galactose-induced premature aging mice model. We demon...

Nowadays it is still of great demand to find a feasible, inexpensive and green material for industrial enzyme immobilization for wastewater treatment. In this work, horseradish peroxidase (HRP) was successfully immobilized on glutaraldehyde activated carbon nanospheres. Compared with free HRP, the immobilized one showed better tolerance of temperat...

Tricholoma lobayense is a nutritious mushroom with great health benefits. Three polysaccharides with purity higher than 99% were successfully extracted from Tricholoma lobayense. The molecular weights of TLH-1, TLH-2 and TLH-3 were determined to be 8.43 × 10⁵，5.36 × 10⁵ and 4.53 × 10³ Da, respectively. The backbones of TLH-1 and TLH-2 were mainly c...

Malachite green (MG), a recalcitrant, carcinogenic, and mutagenic triphenylmethane dye, was decolorized and detoxified using crude manganese peroxidase (MnP) prepared from the white rot fungus Irpex lacteus F17. In this study, the key factors (pH, temperature, MG, Mn2+, H2O2, MnP) in these processes were investigated. Under optimal conditions, 96 %...

Grifola frondosa is a popular edible mushroom for its tasty flavour and can be used as a dietary supplement for its functional substances. In this study, an exopolysaccharide (EPS), purified from the submerged culture of G. frondosa, was chemically modified to obtain its carboxymethylated (CM-EPS) and selenising derivatives (Se-EPS). The chemical c...

The solvent-free selective oxidation of alcohols by O2 without any additives has been studied using palladium nanoparticles supported on a titanate nanobelt. The catalysts were prepared by polyol reduction and impregnation with different kinds of supports. They were evaluated in oxidation reactions of benzyl alcohol. The calcined titanate nanobelt...

Polysaccharide TLH-3 from the fruit body of Tricholoma lobayense Heim has shown outstanding antioxidant activity. In order to further explore it, TLH-3 was successfully modified to obtain a sulfated derivative (STLH-3). The chemical characteristics of STLH-3 and TLH-3 were determined by High Performance Liquid Chromatography and Infrared Spectrosco...

Ginkgolide B, one of the important components of Ginkgo biloba extracts, has been revealed to exhibit great potential in therapy of cerebrovascular diseases. However the lack of permeability greatly limited it from further clinical application. Based on the prediction model for blood brain barrier (BBB) permeation, herein a potential brain-targetin...

In order to develop the application of the natural polysaccharide lentinan (LNT) and decrease the side effects of doxorubicin, we successfully synthesized a novel folate-modified maleilated lentinan-doxorubicin (FA-M.LNT-DOX) polymer and used it for tumor-targeted drug delivery. The release efficiency and cytotoxicity of the prodrugs were evaluated...

Our previous studies have revealed that the Tricholoma lobayense polysaccharide TLH-3, which has an IC50 value for scavenging superoxide radicals comparable to that of Vitamin C (VC), could be prepared by hot water extraction and column chromatography. However, this method is tedious and inefficient. In this study, high-pressure homogenization (HPH...

Ceria (CeO2) nanorods with well-defined surface planes can be synthesized and utilized for the hydrogenation of nitroaromatics. The CeO2 nanorods containing a {110} plane can efficiently and selectively catalyse the hydrogenation of nitroaromatics with N2H4 as a reducing agent, while nano-ceria with a {100} or {111} plane shows poor performance for...

In this paper, monodisperse Pd nanocrystals were immobilized on previously reported carbon nanospheres via in situ adsorption and reduction. In this protocol, no excess reductant and capping reagents were necessary, which made the surface of the as-prepared nanocatalysts very clean. Using sodium tetrachloropalladate(II) as the metal precursor yield...

Fe(7)Se(8) polyhedra with high-index facets and Fe(7)Se(8) nanorods can be selectively synthesized by a solvothermal reaction in a mixed solvent of diethylenetriamine (DETA) and deionized water (DIW). It is found that the morphologies of Fe(7)Se(8) nanocrystals can be effectively controlled by adjusting the volume ratio of DETA and DIW. The unusual...

Reaction of [60]fullerene with freshly prepared RCH(2)CH(2)ONa/RCH(2)CH(2)OH (R = H, Me, Et, Ph) in anhydrous toluene in the presence of air unexpectedly afforded fullerene products with a C(60)-fused tetrahydrofuran ring skeleton and an acetal moiety, which could be further transformed into C(60)-fused dihydrofurans, tolyl-substituted C(60)-fused...

A mild and facile process for the preparation of 1,4-fullerenols C(60)ArOH was achieved. The key intermediate 1,2-C(60)Ar(NO(2)) was identified to better understand the reaction mechanism. Further functionalizations including esterification, etherification, and arylation of the synthesized 1,4-C(60)ArOH provided efficient access to versatile fuller...

Amphiphilic methanofullerene 1 exhibits strong tendency to form aggregates in THF-H2O solvent mixtures. Two different aggregation processes induced by either varying the solvent composition or upon standing have been found. Concentration has great influence on the aggregation process. Paralleling to the UV-Vis changes, an unusual solvatochromism ha...