Yonatan Greenstein

Rutgers New Jersey Medical School | UMDNJ · Division of Pulmonary and Critical Care Medicine

Background: SARS-CoV-2 infection potentiates thromboinflammation contributing to poor outcomes in COVID-19. In non-critically ill patients hospitalized for COVID-19, therapeutic-dose heparin improves clinical outcomes. We hypothesized therapeutic-dose heparin impacts thromboinflammatory biomarkers in patients hospitalized for COVID-19 infection. Me...

Purpose: Intraosseous (IO) catheters allow healthcare workers to rapidly administer fluids and medications to critically ill patients when intravenous access is inadequate or unable to be obtained. An improperly placed IO catheter can lead to delays in care, as well as serious complications such as limb necrosis. Methods: In this single-center, pro...

Importance: Platelet activation is a potential therapeutic target in patients with COVID-19. Objective: To evaluate the effect of P2Y12 inhibition among critically ill patients hospitalized for COVID-19. Design, setting, and participants: This international, open-label, adaptive platform, 1:1 randomized clinical trial included critically ill (...

The use of point-of-care ultrasonography in the intensive care unit has been rapidly advancing over the past 20 years. This review will provide a broad overview of the discipline spanning lung ultrasonography to advanced critical care echocardiography. It will highlight new research that questions the utility of the inferior vena cava for determini...

Importance Platelets represent a potential therapeutic target for improved clinical outcomes in patients with COVID-19. Objective To evaluate the benefits and risks of adding a P2Y12 inhibitor to anticoagulant therapy among non–critically ill patients hospitalized for COVID-19. Design, Setting, and Participants An open-label, bayesian, adaptive r...

Background: Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19. Methods: In an open-label, adaptive, multiplatform, randomized clinical trial, critically...

All aspects of medical education were affected by the Novel Coronavirus Infectious Disease-19 (COVID-19) pandemic. Several challenges were experienced by trainees and programs alike due to the economic repercussions of the pandemic, how social distancing affected the delivery of medical education, testing and interviewing, how the surge of patients...

Purpose of review: This article summarizes the utility and evidence supporting the use of ultrasound exams in the intensive care unit. Recent findings: Point-of-care ultrasonography (POCUS) is widely used by intensivists managing critically ill patients whereby they can accurately and rapidly assess for many pathologies such as pneumothorax, pul...

I read with interest the study by Tang and colleagues, published March 27, 2020, entitled “Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease patients with coagulopathy.” Unfortunately, this retrospective study came to conclusions that are inaccurate with the information provided. The authors use of the wor...

Primary cardiac angiosarcoma is a rare disease with a dismal prognosis. We report a case of a 50-year-old man who presented with haemoptysis, cough and worsening dyspnoea. An intracardiac mass was visualised on echocardiogram. He was treated for diffuse alveolar haemorrhage and acute respiratory distress syndrome but died from refractory hypoxaemic...

The assessment of left ventricular diastolic function is an important element of advanced critical care echocardiography. Standard methods of evaluating diastolic function that are routinely performed on an elective basis in the cardiology echocardiography laboratory may be difficult to apply in the critical care unit. In this article, we review me...

Background: Flexible bronchoscopy (FB) in intubated patients on mechanical ventilation increases airway resistance. During FB, two ventilatory strategies are possible: maintaining tidal volume (VT) while maintaining baseline CO2 or allowing reduction of VT. The former strategy carries risk of hyperinflation due to expiratory flow limitation with F...

Background: Widespread use of critical care ultrasonography (CCUS) for the management of patients in the ICU requires an effective training program. The effectiveness of national and regional CCUS training courses is not known. This study describes a national-level, simulation-based, 3-day CCUS training program and evaluates its effectiveness. Me...

Objective: Current guidelines recommend the use of intraosseous access when IV access is not readily attainable. The pediatric literature reports an excellent safety profile, whereas only small prospective studies exist in the adult literature. We report a case of vasopressor extravasation and threatened limb perfusion related to intraosseous acce...

SESSION TITLE: Education and Simulation SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM PURPOSE: Widespread use of critical care ultrasound (CCUS) for the management of patients in the intensive care unit requires an effective training program. Experiential training and mentoring, while e...

Goal-directed echocardiography (GDE) is used to answer specific clinical questions that provide invaluable information to physicians managing a hemodynamically unstable patient. We studied perception and ability of house staff previously trained in GDE to accurately diagnose common causes of cardiac arrest during simulated advanced cardiac life sup...

SESSION TITLE: Critical Care Student/Resident Case Report Posters II SESSION TYPE: Medical Student/Resident Case Report PRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PM INTRODUCTION: Hemophagocytic lymphohistiocystosis (HLH), a syndrome of pathologic immune system activation, results in a severe systemic inflammatory response. Rare in...

SESSION TITLE: Critical Care Case Report Posters III SESSION TYPE: Affiliate Case Report Poster PRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PM INTRODUCTION: The 2010 guidelines for advanced cardiac life support recommend intraosseous (IO) access if intravenous (IV) access is not readily attainable.¹ We report a case of vasopressor e...

Critical Care PostersSESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PMPURPOSE: Goal-directed echocardiography (GDE) is used to answer specific clinical questions which can provide invaluable and timely information to the critical care physician. Studies that assess competency are lacking. We...

Chest compressions (CCs) are a critical part of cardiopulmonary resuscitation. We studied the presence and duration of adequate CCs performed by medical housestaff, and correlated our findings with gender and body mass index. Fifty-eight first-postgraduate-year medical housestaff performed CCs on a computerized patient simulator equipped with a cal...

PURPOSE:Chest compressions (CC) are a critical part of cardiopulmonary resuscitation. CC require strength, endurance, and proper technique. We examined whether gender and/or body mass index (BMI) were determinants of medical housestaff ability to perform adequate CC and the length of time during which housestaff can maintain adequate CC. METHODS:Co...