Yolocuauhtli Salazar

• PH.D. Biomedical Engineering
• Electrical and Electronic Department at Tecnologico Nacional de Mexico

Background: This work presents a mechanistic nonlinear model, formulated as a system of first-order Ordinary Differential Equations, to investigate the dynamics of Chronic Lymphocytic Leukemia (CLL) under combined chemoimmunotherapy using CAR-T cells and chlorambucil. Methods: Leveraging nonlinear dynamical systems theory and a model-based design a...

This work presents a mechanistic nonlinear model to explore the dynamics of Chronic Lymphocytic Leukemia (CLL) under combined chemoimmunotherapy with CAR-T cells and chlorambucil. The model, formulated by a set of three first-order Ordinary Differential Equations (ODEs), captures the short- and long-term effects of both therapies on the leukemia ce...

This paper presents results concerning mechanistic modeling to describe the dynamics and interactions between biomass growth, glucose consumption and ethanol production in batch culture fermentation by Kluyveromyces marxianus (K. marxianus). The mathematical model was formulated based on the biological assumptions underlying each variable and is gi...

Cancer with all its more than 200 variants continues to be a major health problem around the world with nearly 10 million deaths recorded in 2020, and leukemia accounted for more than 300,000 cases according to the Global Cancer Observatory. Although new treatment strategies are currently being developed in several ongoing clinical trials, the high...

The authors wish to make the following corrections to this paper [...]

Predictive models may be considered a tool to ensure food quality as they provide insights that support decision making on the design of processes, such as fermentation. Objective: To formulate a mathematical model that describes the growth of lactic acid bacteria (LAB) in batch fermentation. Methodology: Based on real-life experimental data from e...

In this paper, we explore the application of Chimeric Antigen Receptor (CAR) T cell therapy for the treatment of Acute Lymphocytic Leukaemia (ALL) by means of in silico experimentation, mathematical modelling through first-order Ordinary Differential Equations and nonlinear systems theory. By combining the latter with systems biology on cancer evol...

Background Vertical jump height is widely used in health care and sports fields to assess muscle strength and power from lower limb muscle groups. Different approaches have been proposed for vertical jump height measurement. Some commonly used approaches need no sensor at all; however, these methods tend to overestimate the height reached by the su...

BACKGROUND Vertical jump height is widely used in health care and sports fields to assess muscle strength and power from lower limb muscle groups. Different approaches have been proposed for vertical jump height measurement. Some commonly used approaches need no sensor at all; however, these methods tend to overestimate the height reached by the su...

La presente investigación tuvo como objetivo determinar la variación entre los resultados de la evaluación docente aplicada en el formato en línea y su aplicación enel aula de manera grupal y supervisada, el objetivo principal del trabajo consiste en comparar los resultados del Cuestionario de Evaluación Docente para docentes y estudiantes del Sist...

Clinical evaluation of the patellar reflex is one of the most frequent diagnostic methods used by physicians and medical specialists. However, this test is usually elicited and diagnosed manually. In this work, we develop a device specifically designed to induce the patellar reflex and measure the angle and angular velocity of the leg during the co...

Mathematical models may allow us to improve our knowledge on tumor evolution and to better comprehend the dynamics between cancer, the immune system and the application of treatments such as chemotherapy and immunotherapy in both short and long term. In this paper, we solve the tumor clearance problem for a six-dimensional mathematical model that d...

The clinical evaluation of muscular strength and stretching reflex are one of the most important neurological data to evaluate patients. Our system measure and capture variables generated by the patellar reflex with a non-invasive way and absolute control in the tapping force on the tendon. The digital saving data process is performed by a PC or No...

Monitoring of post-transplant heart rejection is currently based on endomyocardial biopsy analysis. This study aimed to assess the effects of heart graft rejection on myocardial electrical impedance. Twenty-nine cardiac transplant patients and 9 controls underwent measurement of myocardial electrical impedance using a specifically designed amplifyi...

We measured the myocardial electrical impedance with a custom system using an intracavitary catheter. We calculated the impedance differences between the measurement in the right ventricle with the tip of the catheter in contact with the myocardial wall, and the measurement in the right atrium with the catheter in a floating position. Our study inc...

Our objective is to evaluate whether it is possible to characterize the passive electrical properties of myocardial tissue in contact with the electrocatheters used in arrhythmia diagnosis or radio frequency ablation techniques. To characterize the tissue, we propose the use of electrical impedance spectroscopy to measure the impedance between the...

Electrical properties of myocardial tissue are anisotropic due to the complex structure of the myocardial fiber orientation and the distribution of gap junctions. For this reason, measured myocardial impedance may differ depending on the current distribution and direction with respect to myocardial fiber orientation and, consequently, according to...

A system for detection of cardiac graft rejection based in the temperature, ECG and electrical impedance is described. The temperature is measured with two sensors to obtain the absolute temperature and the differential between two points inside the heart. A standard ECG lead and an intracavitary electrogram are also recorded. The electrical impeda...

We are interested in the use of electrical impedance spectroscopy for on-line in-situ monitorization of the state of the myocardium tissue using a transcatheter method. In this study we evaluate a new 3 electrode measurement method (3EM) in comparison with the standard two electrode method (2EM). We analyze the effect of the tip distance to the myo...