
Yohan FarouzRoche · Pharma Research and Early Development (pRED)
Yohan Farouz
Ph.D.
About
9
Publications
24,139
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426
Citations
Introduction
PhD student in cardiac tissue engineering at ENS/HEGP
Additional affiliations
September 2011 - September 2015
September 2011 - September 2015
Education
October 2009 - September 2010
September 2006 - September 2010
Ecole Polytechnique ParisTech
Field of study
- Biology, Materials Science
September 2004 - June 2006
Lycée Janson de Sailly
Field of study
- Mathematics, Physics, Chemistry
Publications
Publications (9)
A novel hybrid phage carrying genes from prokaryotic M13 phage and eukaryotic adeno-associated viruses can be used as a tissue engineering material with gene delivery functions. The filamentous shape of the resulting hybrid phage easily forms nanofibrous matrices, which can support cellular growth in tissue culture conditions and deliver the target...
Tissue engineering aims at recapitulating permissive conditions that enable cells to collaborate and form functional tissues. Applications range from human tissue modeling for diagnostic purposes to therapeutic solutions in regenerative medicine and surgery. Across this spectrum, human stem cells are the active ingredient, expandable virtually inde...
Soft hydrogels such as alginate are ideal substrates for building muscle in vitro because they have structural and mechanical properties close to the in vivo extracellular matrix (ECM) network. However, hydrogels are generally not amenable to protein adhesion and patterning. Moreover, muscle structures and their underlying ECM are highly anisotropi...
Retinal cells within neurovascular units generate the blood-retinal barrier (BRB) to regulate the local retinal microenvironment and to limit access to inflammatory cells. Breakdown of the endothelial junctional complexes in the BRB negatively affects neuronal signaling and ultimately causes vision loss. As new therapeutics are being developed eith...
Cell therapy is a promising strategy to help regenerate the damaged heart. Recent studies have placed a lot of hopes in embryonic stem cells and our lab had previously found a way to differentiate them into cardiac progenitors, cells that can only differentiate into cardiomyocyte, endothelial cells or smooth muscle cells. This early commitment decr...
To get approval for initiating a stem cell clinical trial is becoming increasingly difficult because of the stringency of regulatory guidelines. The first section of this chapter presents an outline of the major issues which should be kept in mind by investigators from the very early onset of the program so as to frame it in such a way that it may...
Background
Cardiac-committed cells and biomimetic scaffolds independently improve the therapeutic efficacy of stem cells. This study tested the long-term effects of their combination.
Methods and Results
Eighty immune-deficient rats underwent permanent coronary artery ligation. Five to 7 weeks thereafter, those with an echocardiographically-measur...
Aim:
There is now compelling evidence that cells committed to a cardiac lineage are most effective for improving the function of infarcted hearts. This has been confirmed by our pre-clinical studies entailing transplantation of human embryonic stem cell (hESC)-derived cardiac progenitors in rat and non-human primate models of myocardial infarction...
Type: Review
Language: French.
Original title: Réparer les coeurs brisés et les vaisseaux abîmés