Ying Yuen Wan

Ying Yuen Wan
City University of Hong Kong | CityU · Department of Applied Social Studies

About

208
Publications
15,421
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
14,672
Citations
Citations since 2017
50 Research Items
5650 Citations
201720182019202020212022202302004006008001,000
201720182019202020212022202302004006008001,000
201720182019202020212022202302004006008001,000
201720182019202020212022202302004006008001,000

Publications

Publications (208)
Article
Full-text available
Cerium dioxide (CeO 2 , ceria) has long been regarded as one of the key materials in modern catalysis, both as a support and as a catalyst itself. Apart from its well-established use (three-way catalysts and diesel engines), CeO 2 has been widely used as a cocatalyst/catalyst in energy conversion and storage applications. The importance stems from...
Article
Full-text available
Chitosan-cysteine (CH-CY) conjugate with an optimal content of thiol groups was synthesized and combined with amino-functionalized mesoporous bioglass (ABG) nanoparticles (NPs) with radially-porous architecture to build multi-crosslinked ABG/CH-CY composite hydrogels. Besides the network formed by self-crosslinking of thiol groups in CY-derived sid...
Article
Full-text available
Traditional approaches for transition-metal catalyzed oxidative cross-coupling reactions rely on sp2-hybridized starting materials, such as aryl halides, and more specifically, homogeneous catalysts. We report a heterogeneous Pd-catalyzed radical relay method for the conversion of a heteroarene C(sp3)–H bond into ethers. Pd nanoparticles are suppor...
Article
Full-text available
Mesoporous bioactive glass (BG) nanoparticles (NPs) with a high specific surface area were prepared. The surfaces of BG NPs were further modified using an amino-containing compound or synthesized precursors to produce three kinds of amino-functionalized bioactive glass (ABG) NPs via devised synthetic routes. The achieved ABG NPs possessed various s...
Article
Full-text available
Pd catalysts are widely used in alkynol semi-hydrogenation. However, due to the existence of scaling relationships of adsorption energies between the key adsorbed species, the increase in conversion is frequently accompanied by side reactions, thereby reducing the selectivity to alkenols. We report that the simultaneous increase in alkenol selectiv...
Article
Full-text available
An emulsification method was developed for fabricating core-shell microspheres with a thick shell layer. Kartogenin (KGN) and platelet-derived growth factor BB (PDGF-BB) were respectively loaded into the core portion and the shell layer of the microspheres with high loading efficiency. The optimally built microspheres were combined with chitosan (C...
Article
Single chemotherapy often causes severe adverse effects and chemoresistance which limits therapeutic efficacy. Recently, combination of chemotherapy with photothermal therapy (PTT) have received broad attention for synergistic treatment of osteosarcoma, ultimately resulting in the enhancement of therapeutic efficacy of anticancer drugs. In this stu...
Article
Thiolated hyaluronic acid(THA) conjugates were synthesized and the selected THA was combined with silk fibroin(SF) and bioactive glass nanoparticles to build a novel type of composite hydrogel with dual-network structure. The optimally achieved gels showed greatly enhanced strength and stiffness compared to the gels built from either THA or SF whil...
Article
The shuttle effect caused by soluble lithium polysulfides (LiPSs) deteriorates multiphase transformation reaction kinetics of sulfur species, and gives rise to an unserviceable lithium-sulfur (Li-S) battery. Catalysis, as a process optimization approach, offers an option to eliminate the intrinsic issues. However, exploring and understanding the ro...
Article
Germanium phosphide (GeP), a new member of phosphorus-based 2D materials, is a semiconductor with indirect and narrowed band gap, which theoretically would have great potential to serve as near-infrared (NIR) photothermal agent (PTA) with high photothermal conversion efficiency (PTCE). However, the photothermal conversion performance and biomedical...
Article
Simple encapsulation of 3 nm gold nanoparticles in ordered mesoporous carbon with large pores of 17 nm and thick pore walls of 16 nm was achieved by a metal-ligand coordination assisted-self-assembly approach. Polystyrene-block-polyethylene-oxide (PS-b-PEO) diblock copolymer with a large molecular weight of the PS chain and mercaptopropyltrimethoxy...
Article
Full-text available
The shuttling of soluble lithium polysulfides between the electrodes leads to serious capacity fading and excess use of electrolyte, which severely bottlenecks practical use of Li‐S batteries. Here, selective catalysis is proposed as a fundamental remedy for the consecutive solid‐liquid‐solid sulfur redox reactions. The proof‐of‐concept Indium (In)...
Article
In this study, novel bioactive glass flakes (BGFs) (45S5 composition), obtained by compression in the liquid phase in a stirred media mill, are combined with chitosan (CS) to develop composite membranes via solvent casting for guided bone regeneration (GBR). The incorporation of BGFs endows CS membranes with superior bioactivity as evidenced by rap...
Article
Full-text available
Background: Chemotherapeutic drugs used for tumor treatments often show limited efficiency due to their short lifetime, nonspecific delivery, and slow or insufficient intracellular drug release, and also, they can cause severe system or organ toxicity. The development of chemotherapeutic nanomedicines with high efficacy and satisfactory safety sti...
Article
Image-guided chemo-photothermal therapy based on near-infrared (NIR) theranostic agents has found promising applications in treating tumors. In this multimodal treatment, it is of critical importance to image real-time distribution of photothermal agents in vivo and to monitor therapeutic outcomes for implementing personalized treatment. In this st...
Article
Full-text available
The shuttling of soluble lithium polysulfides (LiPSs) is one of the main bottlenecks to the practical use of Li–S batteries. It is reported that in situ synthesized ultrasmall vanadium nitride nanoparticles dispersed on porous nitrogen‐doped graphene (denoted VN@NG) as a catalytic interlayer solves this problem. The ultrasmall size of VN particles...
Article
Amino-functionalized mesoporous silica nanoparticles with radially porous architecture were optimally synthesized, and they were used together with silk fibroin and chitosan to produce a type of covalently crosslinked composite hydrogel using genipin as a crosslinker. The optimally achieved composite gels were found to be thermo-responsive at physi...
Preprint
Full-text available
The shuttling of soluble lithium polysulfides between the electrodes leads to serious capacity fading and excess use of electrolyte, which severely bottlenecks practical use of Li-S batteries. Here selective catalysis is proposed as a fundamental remedy for the consecutive solid-liquid-solid sulfur redox reactions. The proof-of-concept In 2 O 3 cat...
Article
Full-text available
Supported gold nanoparticles are emerging catalysts for heterogeneous catalytic reactions, including selective hydrogenation. The traditionally used supports such as silica do not favor the heterolytic dissociation of hydrogen on the surface of gold, thus limiting its hydrogenation activity. Here we use gold catalyst particles partially embedded in...
Article
AuPd nanoalloys with tunable Pd concentrations have been synthesized and used as model catalysts. They have been directly imaged by high-angle annular dark-field scanning transmission electron microscopy and investigated by thorough analyses of their extended X-ray absorption fine structure, X-ray absorption near-edge structure, X-ray diffraction a...
Article
The shuttling of soluble lithium polysulfides (LiPSs) intermediates bottlenecks practical uses of lithium-sulfur (Li-S) batteries. A commercial organometallic salt, nickel chloride dimethoxyethane adduct (NiDME), is introduced as the homogenous catalyst dissolved in the electrolyte to suppress the shuttle effect. A very small amount of catalyst (on...
Article
Full-text available
Alginate-poloxamer (ALG-POL) copolymer with optimal POL content was synthesized, and it was combined with silk fibroin (SF) for building ALG-POL/SF dual network hydrogels. Hyaluronic acid(HA)/chitosan-poly(dioxanone)(CH-PDO) complex nanoparticles (NPs) with optimized composition and high encapsulation efficiency were employed as a vehicle for loadi...
Article
Full-text available
Thermosensitive alginate–poloxamer (ALG–POL) copolymer with an optimal POL content was synthesized, and it was used to combine with silk fibroin (SF) for building ALG–POL/SF hydrogels with dual network structure. Mesoporous bioactive glass (BG) nanoparticles (NPs) with a high level of mesoporosity and large pore size were prepared and they were emp...
Article
Poloxamer was grafted onto alginate and the optimally synthesized alginate-poloxamer (ALG-POL) copolymer was combined with silk fibroin (SF) to produce thermosensitive ALG-POL/SF hydrogels with covalently and physically crosslinked networks. The formulated ALG-POL/SF gels were found to be injectable with sol-gel transitions near physiological tempe...
Article
Layered osteochondral composite scaffolds are considered as a promising strategy for the treatment of osteochondral defects. However, the insufficient osseous support and integration of the subchondral bone layer frequently result in the failure of osteochondral repair. Therefore, it is essentially important to explore new subchondral bone construc...
Article
The incomplete removal of bone tumors leads to increased local recurrence and poor prognosis. To prevent ostoperative tumor recurrence and simultaneously repair surgery‐caused bone defects, there is a need of great significance to develop implantable biomaterials possessing both cancer cell‐killing ability and excellent bioactivity. In this work, a...
Article
Thiolated chitosan (CS-NAC) was synthesized and the selected CS-NAC was used together with silk fibroin (SF) to produce dual network CS-NAC/SF hydrogels. The CS-NAC/SF solutions with formulated compositions were able to form hydrogels at physiological temperature and pH. Rheological measurements showed that elastic modulus of some CS-NAC/SF gels co...
Article
Full-text available
Local administration of platelet-derived growth factor-BB (PGDF-BB) and bone morphogenetic protein-2 (BMP-2) in a sequential release manner could substantially promote bone healing. To achieve this goal, a delivery system that could sustain the release of PGDF-BB and BMP-2 by way of temporal separation was developed. One type of PGDF-BB-encapsulate...
Article
Full-text available
Chitosan(CH)-poly(dioxanone) (CH-PDO) copolymers containing varied amounts of PDO and having free amino groups at their CH backbone were synthesized using a group protection method. The selected CH-PDO with soluble characteristics in aqueous media was used together with hyaluronic acid (HA) to prepare HA/CH-PDO polyelectrolyte complex nanoparticles...
Article
A self‐assembly approach has been developed for the immobilization of nitrogen‐modified gold nanoparticles in an ordered mesoporous carbon matrix with large pores. Self‐assembly of the polystyrene‐block‐poly(4‐vinylpyridine) (PS‐b‐P4VP) diblock copolymer template coordinated with gold ions and a low‐polymerized phenolic resin leads to a face‐center...
Article
The requirement for the favorable therapeutics against ulcerative colitis (UC) is that anti-inflammatory drugs can be specifically internalized by macrophages and subsequently be on-demand released to suppress inflammation. Herein, we developed a type of multi-bioresponsive anti-inflammatory drug (curcumin, CUR)-loaded nanoparticles (NPs) that were...
Article
Full-text available
Copper-containing bioactive glass nanoparticles (Cu-BG NPs) with designed compositions and sizes were synthesized and incorporated into chitosan (CH)/silk fibroin (SF)/glycerophosphate (GP) composites to prepare injectable hydrogels for cell-free bone repair. The resulting Cu-BG/CH/SF/GP gels were found to exhibit well-defined injectability and to...
Article
Full-text available
Understanding the catalytic mechanism of bimetallic nanocatalysts remains challenging. Here, we adopt an adsorbate mediated thermal reduction approach to yield monodispersed AuPd catalysts with continuous change of the Pd-Au coordination numbers embedded in a mesoporous carbonaceous matrix. The structure of nanoalloys is well-defined, allowing for...
Article
Full-text available
Chemo-photothermal combination therapy could achieve synergistically enhanced efficiency against tumors. Nanocarriers with good safety and high efficiency for chemo- photothermal therapy are pressingly needed. A new type of hydroxyethyl starch (HES) based on nanoparticles (NPs) loaded with doxorubicin (DOX) and indocyanine green (ICG) was, thus, de...
Article
In this current study, a novel multilayer porous composite scaffold was fabricated with chitosan (CS), silk fibrin (SF) and nano‐hydroxyapatite (n‐HA). Scanning electron microscope (SEM) was utilized to detect the characteristics of the composed scaffold. Rat bone marrow stromal cells (rBMSC) were loaded onto the CS/SF/n‐HA scaffold and cultured in...
Article
This study proposes ordered mesoporous carbon nanosphere-supported gold catalysts to eliminate the diffusion limitation inside the long channels of bulk mesoporous materials. The nanospherical catalysts have a spherical morphology with a diameter of approximately 90 nm, uniform pore sizes of 2.5 nm, and high surface areas of approximately 600 m ² /...
Article
Full-text available
Chitosan(CH)-polylactide(PLA) copolymers containing varied PLA percentages were synthesized using a group-protection method and one of them with solubility in water-based solvents was used to prepare CH-PLA/hyaluronic acid (HA) complex microspheres for the delivery of transforming growth factor-β1 (TGF-β1). An emulsification processing method was d...
Article
Full-text available
Chitosan (CH), silk fibroin (SF), and hydroxyapatite (HA) were used to prepare CH/SF/HA composites and the resulting composites were electrospun into nanofibrous membrane units with gradient compositional and structural features. The optimal membrane unit was used together with CH/HA and CH/SF composites to fabricate a type of three-layer scaffold...
Article
Bioactive glass scaffolds (BGS) of 45S5 composition exhibit desired bioactivity, osteogenesis and angiogenesis potential, being promising biomaterials for bone repair/regeneration. Natural polymer based coatings, e.g., gelatin coating, are effective to enhance the mechanical properties of BGS. However, the presence of a coating may reduce the bioac...
Article
Nerve conduits containing aligned fibrous fillers with gradiently distributed signal molecules are essential for long-gap nerve repair. This study was to develop an approach for establishing nerve growth factor (NGF) gradients onto the aligned chitosan-polylactide (CH-PLA) fibers. CH-PLA containing 37 wt% of PLA was spun into fibers using a wet-spi...
Article
Chitosan/silk fibroin/glycerophosphate gels were loaded with nerve growth factor (NGF) and further processed into multi-tubule fillers. NGF was loaded into the fillers in such a way so that a NGF gradient was established longitudinally along the filler length. A type of poly(lactide-co-glycolide)(PLGA)/chitosan(CH) porous conduit was fabricated usi...
Article
Full-text available
Oral drug delivery has been considered as a promising strategy for ulcerative colitis (UC) therapy. Here, an emulsion solvent evaporation technique was employed to prepare non-porous curcumin (CUR)-loaded polymeric nanoparticles (NPs) and porous CUR-loaded polymeric NPs in the absence or presence of ammonium bicarbonate. The resultant CUR-loaded NP...
Article
A coordination-assisted pyrolysis procedure was adopted to encapsulate palladium (Pd) nanoparticles in a mesoporous carbonaceous matrix. X-ray diffraction and transmission electron microscopy measurements revealed that approximately 2.5-nm nanoparticles were highly dispersed inside the well-ordered porous framework. High resolution TEM and temperat...
Article
In this study, we propose gold-intercalated ordered mesoporous carbon nanosphere catalysts in which gold nanoparticles are reduced by high-temperature carbonization of the carbonaceous matrix to catalyze the selective hydrogenation of aromatic nitro compounds. A spherical morphology of particles with size approximately 90 nm and ordered mesoporous...
Article
Simultaneously controlling the size of Au nanoparticles and immobilizing their location to specific active sites while hindering migration and sintering at elevated temperatures is a current challenge within materials chemistry. Typical methods require the use of protecting agents to control the properties of Au nanoparticles and therefore it is di...
Article
Some poly(p-dioxanone) (PDO) homopolymers were first synthesized and the selected PDO was conjugated onto chitosan using a group-protecting method to produce chitosan-poly(p-dioxanone) (CH-PDO) copolymers with various PDO percentages changing from around 30 to 60wt%. The CH-PDO with the PDO content of around 42wt% was used to blend with prescribed...
Article
The interactions between nanoparticles and cells or tissues are frequently mediated by different biomolecules adsorbed onto the surface of nanoparticles. In this study, several methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) copolymers with various mPEG/PCL ratios were synthesized and used to produce three types of mPEG-PCL nanopartic...
Article
Full-text available
Chitosan/nano-hydroxyapatite (HA) composites were first prepared and then used together with chitosan and silk fibroin (SF) to produce a type of four-layer porous scaffold that is potentially applicable for articular cartilage repair. The bottom layer of the scaffold was built with the chitosan/HA composite and the other three layers of the scaffol...
Article
Dextran-polylactide (Dex-PLA) copolymers were synthesized and the selected Dex-PLA with water-soluble characteristics was used together with chitosan and glycerophosphate (GP) to produce injectable chitosan/Dex-PLA/GP hydrogels. Some chitosan/Dex-PLA/GP solutions with designated compositions were able to form into hydrogel in a temperature range be...
Article
Mesoporous C and N codoped anatase nanocrystal–carbon composites have been synthesized by chelation-assisted coassembly of urea, TiCl4, resols, and triblock copolymer. The composite catalysts have biphasic constituents in the pore walls of amorphous carbon and C,N-codoped anatase nanoparticles (≈4.0 nm) that are “glued” together; the composite cata...
Article
Chitosan-poly(p-dioxanone) (CH-PDO) copolymers with various poly(p-dioxanone) (PDO) percentages changing from around 20 to 70 wt% were synthesized. The selected CH-PDO with the PDO content of around 45 wt% was blended with prescribed amounts of silk fibroin (SF) to build porous conduits that are potentially suitable for the applications in long-gap...
Article
Gold nanoparticles approximately 3 nm in diameter free of protecting agent were loaded onto less-interacting, self-assembling mesoporous carbon using a two-step carbonization method. The catalyst exhibits TOF value of 478 and 31.2 h-1 at 25 and 0 °C, comparable to, and much higher than an 8.9 nm gold-supported nanocatalyst, respectively, for the wa...
Article
In this study, heterogeneous palladium catalysts supported on ordered mesoporous cobalt oxide-carbon nanocomposites were applied to the water-mediated Suzuki coupling reaction of chlorobenzene and phenylboronic acid and exhibited a high yield of biphenyl (49%) under mild reaction conditions free of phase-transfer agents and ligands. Product yields...
Article
Chitosan-polylactide (CH-PLA) copolymers with various polylactide percentages changing from around 14 to 40 wt% were synthesized. CH-PLAs were then blended with type-II collagen to fabricate layered collagen/CH-PLA scaffolds that are potentially suitable for the applications in articular cartilage repair. Based on combinatorial processing technique...
Article
Full-text available
Based on surface-engineered poly(aminoamie) dendrimers, a novel type of targeted bifunctional nanoconjugate with optimum folic acid was designed to enhance the intracellular delivery of a highly pleiotropic active agent, curcumin.
Article
Full-text available
Purpose: Radiolabeled Arg-Gly-Asp (RGD) and Ala-Thr-Trp-Leu-Pro-Pro-Arg (ATWLPPR) peptide analogs have received interests for their capability to serve as radiopharmaceuticals for imaging integrin αvβ3 and Neuropilin-1 (NRP-1) positive tumors, respectively. In this study, we developed a RGD-ATWLPPR heterodimeric peptide which contained both RGD an...
Article
Collagen, chitosan-polycaprolactone (CH-PCL) copolymer with PCL content of around 40wt% and chondroitin sulfate (CS) were mixed together at various ratios to prepare collagen/CH-PCL/CS composites and the resulting composites were used to build stratified porous scaffolds that are potentially applicable for articular cartilage repair. The ternary co...
Article
A synergy effect by carbon and anatase in the mesoporous C-TiO2 nanocomposites is reported here on the degradation of dye in contaminated water. The as-formed mesoporous C-TiO2 composites have ordered 2D hexagonal mesostructure, high surface area (384 m(2)/g), uniform and large mesopores (4.5 nm), large pore volume (0.31 cm(3)/g), titania nanoparti...
Article
Chitosan was conjugated with folic acid (FA) and the resulting chitosan derivatives with a FA-substitution degree of around 6 % was used to synthesize FA-conjugated chitosan–polylactide (FA–CH–PLA) copolymers to build a drug carrier with active targeting characteristics for the anticancer drug of paclitaxel (PTX). Selected FA–CH–PLAs with various p...
Article
Ordered mesoporous basic MgO–SiO2–C functional nanocomposites have been synthesized via the direct triblock-copolymer self-assembly route. The TG, XRF, EDX, CO2-TPD and titration techniques reveal the MgO content ranges from 1.8–28.5 wt% in the composite with tunable medium to strong strength basic cites. Magnesium oxide thin layers are coated on p...
Article
Chitosan-polycaprolactone (CH-PCL) copolymers with various PCL percentages less than 45wt% were synthesized. Different CH-PCLs were respectively blended with Type-II collagen at prescribed ratios to fabricate a type of layered porous scaffolds with some biomimetic features while using sodium tripolyphosphate as a crosslinker. The compositions of di...
Article
A coordination assisted route is firstly reported here for the synthesis of highly active and stable gold nanoparticles in ordered mesoporous carbon catalysts using triblock copolymer F127 as a structure-directing agent, thiol-containing silane as a coordination agent, HAuCl4 as a gold source and phenolic resin as a carbon source. Upon carbonizatio...
Article
Galactosylated chitosan-hydroxypropyltrimethylammonium (gal-HTCC) was synthesized by galactosylating and quaternizing chitosan to endue chitosan with targeting specificity for potential applications as gene vectors. The composition and physicochemical properties of gal-HTCC were characterized by FT-IR, (1) H NMR, elemental analysis, X-ray diffracti...
Article
The high efficiency of ordered mesoporous carbon-based anatase for the visible light-driven photo-degradation of phenol in water is reported. Adsorption-photocatalysis cycles were used to treat polluted water. Contaminated water containing 200 mg/L phenol can be completely mineralized within 10 cycles, in which each cycle consisted of adsorption fo...
Article
Galactosylated chitosan-polycaprolactone (Gal-CH-PCL) copolymers with a galactosylation degree of around 10% and varied PCL percentages less than 40wt% were synthesized and used to produce nanoparticles for delivering curcumin. Some nanoparticles with encapsulation efficiency of 70% or higher and sizes changing from 100 to 250nm were able to delive...
Article
Integrin α(v)β(3) has been recognized to play an important role in angiogenesis, tumor growth and metastasis. It will be of interest to apply this promising target for tumor imaging and visualization of tumor angiogenesis in vivo. In this study, a novel integrin α(v)β(3) targetting imaging probe, (99m)Tc-HYNIC-E[c(RGDfK)](2), was used to investigat...