
Ying-Fei YangNational Taiwan University | NTU · Department of Bio-Environmental Systems Engineering
Ying-Fei Yang
Doctor of Bioenvironmental Systems Engineering
About
40
Publications
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Publications
Publications (40)
Background
The emergence and progression of highly divergent SARS-CoV-2 variants have posed increased risks to global public health, triggering the significant impacts on countermeasures since 2020. However, in addition to vaccination, the effectiveness of non-pharmaceutical interventions, such as social distancing, masking, or hand washing, on dif...
Background
This study aimed to assess the impact of the COVID-19 pandemic on the disease burden of Taiwan’s notifiable infectious diseases (NIDs). We compared disease burdens between the pandemic and pre-pandemic year of 2020 (with non-pharmaceutical interventions (NPIs)) and 2010 (without NPIs), respectively, to understand the overall pandemic imp...
The COVID-19 pandemic necessitated an urgent global response in vaccine deployment, achieving over 70.6% global vaccination coverage with at least one dose. This study focuses on Taiwan’s vaccine administration and adverse event reporting, set against a global backdrop. Using data from Taiwan’s Vaccine Adverse Event Reporting System (VAERS) and glo...
Objectives
The disability-adjusted life years (DALYs) of COVID-19 have been applied as a time-based measurement to estimate years of life lost due to premature mortality or healthy life lost in different countries. Limited information was found for DALYs among different variants of concern (VOC).
Methods
Disease severities based on categories of a...
Plastic pollution is a global environmental crisis that threatens marine ecosystems and human health. This study provides a comprehensive analysis of the current state of plastic pollution in oceans worldwide. We examined data on global plastic production, annual estimates of plastic emissions to oceans from different countries, surface plastic mas...
COVID-19 pandemic has caused widespread panic and fear among the global population. As such, repurposing drugs are being used as viable therapeutic options due to the limited effective treatments for Long COVID symptoms. Ivermectin is one of the emerging repurposed drugs that has been shown effective to have antiviral effects in clinical trials. In...
Background:
The novel coronavirus disease 2019 (COVID-19) has affected a large number of countries. Informing the public and decision makers of the COVID-19's economic burdens is essential for understanding the real pandemic impact.
Methods:
COVID-19 premature mortality and disability impact in Taiwan was analyzed using the Taiwan National Infec...
The Wells-Riley model invokes human physiological and engineering parameters to successfully treat airborne transmission of infectious diseases. Applications of this model would have high potentiality on evaluating policy actions and interventions intended to improve public safety efforts on preventing the spread of COVID-19 in an enclosed space. H...
Symptom treatments for Coronavirus disease 2019 (COVID-19) infection and Long COVID are one of the most critical issues of the pandemic era. In light of the lack of standardized medications for treating COVID-19 symptoms, traditional Chinese medicine (TCM) has emerged as a potentially viable strategy based on numerous studies and clinical manifesta...
A sharp increase of migrant workers has raised concerns for TB epidemics, yet optimal TB control strategies remain unclear in Taiwan regions. This study assessed intervention efforts on reducing tuberculosis (TB) infection among migrant workers. We performed large-scale data analyses and used it to develop control-based migrant worker-associated su...
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predic...
Titanium dioxide (TiO 2) nanoparticles (NPs) are employed as an ultraviolet filter in sunscreen products because of their high ultraviolet absorptivity. However, sunscreen sprays may pose health risks due to the toxicity of inhaled TiO 2 NPs. Therefore, we estimated the potential human health risk posed by inhaled TiO 2 NPs emitted from sunscreen s...
Norovirus (NoV) is one of the most ubiquitous factors contributing to acute gastroenteritis that causes widespread outbreaks in travel industry, military, or healthcare facilities. NoV could lead to serious symptoms and result in severe societal costs worldwide. Surprisingly, there has been no available licensed vaccines, albeit there are ongoing p...
The pervasive contamination of microplastics (MPs) in freshwater ecosystems is of emerging concern. Mechanistic link between exposure and effect on assessing health risk of freshwater fish posed by environmental MPs, however, is more limited. Our study filled this gap by developing a toxicokinetic/toxicodynamic (TK/TD)-based risk assessment framewo...
Microplastics (MPs) pollution in the ocean is an area of growing concern. Marine fauna subject to MPs exposure from various environmental sources are most likely to have detrimental effects on their immune system. However, studies of potential risks of MPs on marine ecosystems in light of environmental concentrations are largely limited. To this en...
Nervous necrosis virus (NNV) infection in susceptible grouper larvae has been reported to cause high mortalities, leading to great economic losses in aquaculture industry. Although the effects of NNV vaccines on grouper have been broadly investigated, vaccination strategies have not been fully established. To this end, we introduced the parsimoniou...
Objectives
To assess the potential epidemiological impact and cost-effectiveness of shorter antibiotic regimens in high tuberculosis (TB) burden regions of Taiwan.
Methods
We combined the TB population dynamic model and cost-effectiveness analysis with local data to simulate the disease burdens, effectiveness, and costs of hypothetical 4-month, 2-...
Neonicotinoids (NEOs) are a class of pesticides widely used worldwide. This study analyzed post-cooking residues of NEO pesticides and assessed their potential health risks for preschool children (0–6 years old) by conducting a total diet study (TDS). It involved food sampling, preparation, analysis of pesticide residues, estimation of food consump...
Nano zero-valent iron (nZVI) is one of the most paramount nanoparticles (NPs) applied in environmental remediation, leading to great concerns for the potential impacts on soil ecosystem health. The objective of this study was to link toxicokinetics and consumer–resource dynamics in the Caenorhabditis elegans–Escherichia coli (worm–bacteria) ecosyst...
Susceptibility of hard clams Meretrix lusoria to birnavirus (BV) infections caused by temperature variations, from a mechanistic perspective, has rarely been explored. We used a deterministic susceptible–infectious–mortality (SIM) model to derive temperature‐dependent key epidemiologic parameters based on data sets of viral infections in hard clams...
Background
Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood.
Objective
To develop a probabilistic integrated population-level risk assessment approach for evaluating the contri...
Background
No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.
Objective
The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for t...
Background
The high prevalence of dengue in Taiwan and the consecutive large dengue outbreaks in the period 2014–2015 suggest that current control interventions are suboptimal. Understanding the effect of control effort is crucial to inform future control strategies.
Objectives
We developed a framework to measure season-based health burden risk fr...
Hazard assessment
Dr Travis and co-workers argued that paraquat (PQ) as a risk
factor of inducing Parkinson’s disease (PD) is a hypothesis
and Bnothing^ in the paper proved it. However, it should be
cautiously noted that the risk assessment framework in this
study was constructed by following the procedure in an eminent textbook describing principl...
A novel virus, tilapia lake virus (TiLV), has been identified as a key pathogen responsible for disease outbreak and mass mortality of farmed tilapia. We used a deterministic susceptible‐infectious‐mortality (SIM) model to derive key disease information appraised with published TiLV‐induced cumulative mortality data. The relationship between tilapi...
Exposure to several specific pesticides has led to an increase of Parkinson’s disease (PD) risk. However, it is difficult to quantify the PD population risk related to certain pesticides in regions where environmental exposure data are scarce. Furthermore, the time trend of the prevalence and incidence of PD embedded in the background relationship...
Background
Oseltamivir-resistant mutants with higher drug resistance rates and low trans-mission fitness costs have not accounted for influenza (sub)type viruses. Predicting the impacts of neuraminidase inhibitor therapy on infection rates and transmission of drug-resistant viral strains requires further investigation.
Objectives
The purpose of th...
Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose of this study was to investigate the impacts of chronically pulsed exposure on biodynamics and subcellular partitioning of Cu in freshwater tilapia (Oreochromis mossambicus). Long-term 28-day pulsed Cu exposure experiments were performed to explore su...
Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe⁰) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, ther...
Aqueous Fe concentrations over time for (A) waterborne and (B) food-borne exposure experiments.
Note: Dashed lines indicate the aqueous Fe concentration trend over time.
Soil contamination caused by silver nanoparticles (AgNPs) released from sewage treatment plants (STPs) is of great public concern. Understanding the relationships between the physicochemical properties of AgNPs and their toxicity is critical for environmental and health risk analysis. Here we presented an approach for rapidly screening and assessin...
Waterborne and dietborne exposures of freshwater fish to mercury (Hg) in the forms of inorganic (Hg(II)) and organic (methylmercury or MeHg) affect their growth, development, and reproduction. However, an integrated mechanistic risk model framework to predict the impact of Hg(II)/MeHg on freshwater fish is lacking. Here, we integrated biokinetic, p...
Nanoscale zerovalent iron (nZVI) is widely used with large scale for environmental remediation for in situ or ex situ applications. The potential impact of nZVI on biota at environmentally relevant concentrations needs to be elucidated. In this study, the reproductive toxicities of three irons species: carboxymethyl cellulose (CMC)-stabilized nZVI,...
Phthalate esters are ubiquitous environmental contaminants and numerous organisms are thus exposed to various levels of phthalates in their natural habitat. Considering the critical, but limited, research on human neurobehavioral outcomes in association with phthalates exposure, we used the nematode Caenorhabditis elegans as an in vivo model to eva...
Cinnamomum osmophloeum Kaneh is an indigenous tree species in Taiwan. In this study, phytochemical characteristics and antioxidant activities of the essential oils and key constituents from the leaves of two C. osmophloeum clones were investigated. The two trees possess two chemotypes, which were classified as the cinnamaldehyde type and camphor ty...