Yi-Tien Chen

Yi-Tien Chen
Taipei Medical University | TMU · School of Food Safety

PhD

About

14
Publications
1,694
Reads
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230
Citations
Citations since 2016
9 Research Items
147 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
Additional affiliations
September 2017 - present
Taipei Medical University
Position
  • Professor (Assistant)
October 2014 - September 2017
National Cheng Kung University
Position
  • PostDoc Position
February 2012 - August 2014
Florida State University
Position
  • PostDoc Position
Education
August 2007 - December 2012
Florida State University
Field of study
  • Food and Nutrition Sciences
September 2001 - June 2004
Tunghai University
Field of study
  • Animal Science and Biotechnology
September 1997 - December 2001
Tunghai University
Field of study
  • Animal Science and Biotechnology

Publications

Publications (14)
Article
Fish is classified as one of the major allergenic foods. However, a reliable assay for detecting the presence of fish protein is not available. In this study, a sandwich enzyme-linked immunosorbent assay (sELISA) was developed using polyclonal antibodies raised against a 36 kDa thermal-stable fish muscle protein. The sELISA was able to detect both...
Article
Pangasius catfish, primarily tra (Pangasius hypophthalmus) and basa (Pangasius bocourti), are farm-raised catfish imported from Asia and have become a common substitute for domestic catfish, grouper, and other high-valued fish in restaurant-served dishes in the United States. This article reports on the development of a monoclonal antibody-based sa...
Article
Four IgG (subclass IgG1) class monoclonal antibodies (MAbs) strongly reactive to Asian farm-raised Pangasius catfish, tra (Pangasius hypophthalmus) and basa (Pangasius bocourti), have been developed. These MAbs were raised by immunizing an animal with thermal-stable crude sarcoplasmic protein extract of cooked tra. The MAbs were selected by screeni...
Article
Full-text available
Receptor for advanced glycation endproducts (RAGE) is an Ig superfamily cell surface receptor that interacts with a diverse array of ligands associated with inflammatory responses. In this study, we provide evidence demonstrating that RAGE is involved in inflammatory responses in the intestines. We showed that RAGE is expressed in intestinal epithe...
Article
SIRPalpha and SIRPbeta1, the two major isoforms of the signal regulatory protein (SIRP) family, are co-expressed in human leukocytes but mediate distinct extracellular binding interactions and divergent cell signaling responses. Previous studies have demonstrated that binding of SIRPalpha with CD47, another important cell surface molecule, through...
Article
Fish tropomyosin is a latest identified fish allergen without full understanding of its biochemical characteristics from the perspective of food allergen. Accordingly, the objective of this study was to investigate the effects of species, muscle location, food processing, and refrigerated storage on fish tropomyosin and compare with main fish aller...
Article
Full-text available
Anemia and dyslipidemia often occurs in premenopausal women. This study investigated the association between dietary patterns and anemia among dyslipidemic women in Taiwan. This study recruited 22,631 dyslipidemic women aged 20–45 years between 2001 and 2015. The dietary assessment was collected by a validated food frequency questionnaire. The bioc...
Article
The 36 kDa antigenic protein of a fish-specific monoclonal antibody (mAb), 8F5, previously developed to detect fish in foodstuffs to protect fish allergic individuals, was characterized to establish its identity and to identify the fish-specific epitope. We hypothesized that this antigenic protein is tropomyosin based on its thermal stability and m...
Article
Full-text available
This study developed and characterized anti-fish monoclonal antibodies (mAbs) capable of detecting fish, a major allergenic food, in processed food products to protect fish sensitized individuals. Of the three mAbs raised against crude protein extract of cooked fish muscle, mAb 8F5 exhibited a positive reaction to all 50 common food fish species te...
Article
Hyperglycemia induces low-grade systemic inflammation and immune dysregulation, leading to overstated reactions to immune stimuli and diabetes-related organ damage. Tissue inflammation is characterized by leukocyte infiltration, and T cells play crucial roles in directing leukocyte-mediated inflammatory responses. The aim of the study was to invest...
Article
Full-text available
Scope : Oligonol has been shown to moderate mitochondrial biogenesis, protein synthesis and protein degradation in diabetic mice in our previous study. We therefore hypothesized that oligonol alleviated sarcopenia by regulating pathways involved in protein turnover and mitochondrial quality. Methods and results : The 32‐wk.‐old senescence‐accelera...
Article
Full-text available
Skeletal muscle, a highly metabolic tissue, is particularly vulnerable to increased levels of saturated free fatty acids (FFAs). The role of autophagy in saturated FFAs-induced cellular senescence and insulin resistance in skeletal muscle remains unclear. Therefore, the present study was aimed to explore autophagic flux in cellular senescence and i...
Article
Full-text available
Myostatin is a negative regulator of myogenesis and has been suggested to be an important factor in the development of muscle wasting during viral infection. The objective of this study was to characterize the main regulatory element of the grouper myostatin promoter and to study changes in promoter activity due to viral stimulation. In vitro and i...

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Projects

Project (1)
Project
I further apply the immunology principle and develop antigens with biotechnology. With negative regulation of growth factor, we can greatly increase speed of growth. The technique is applied to negatively-regulated melanin factor and the negative-growth factor of adipocyte which improve the quality of meat products. The technology has been transferred to many domestic and foreign companies and adapted to functional feed products.