Yi Dai

Yi Dai
Fudan University

About

38
Publications
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881
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Publications

Publications (38)
Article
Full-text available
Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence has linked impaired mitochondrial quality control with RGCs degeneration, while parkin, an E3 ubiquitin ligase, has proved to be protective and promotes mitophagy in RGCs a...
Article
Full-text available
The ophthalmoscopic beta zone of parapapillary atrophy has recently been proposed to divide into a gamma zone and a (new) beta zone based on OCT imaging. The present study was undertaken to compare the microstructural characteristics of parapapillary gamma and beta zones and their influencing factors between primary open angle glaucoma (POAG) and p...
Article
Purpose This study aimed to investigate the effect of nimodipine on peripapillary and macular capillary vessel density (VD) in patients with normal-tension glaucoma (NTG) using optical coherence tomography angiography (OCTA). Methods Sixty mg nimodipine was administered to 20 enrolled NTG patients for 3 months. Patients were treated with glaucoma...
Article
Glutamate excitotoxicity may contribute to the death of retinal ganglion cell (RGC) in glaucoma and other retinal diseases such as ischemia. Deubiquitinating enzyme (DUB) inhibitors are emerging as attractive targets for pharmacological intervention in neurodegenerative diseases. However, the role of PR-619, the broad spectrum DUB inhibitor, on RGC...
Article
To investigate the microvasculature in subzones of parapapillary atrophy (PPA) and their associated factors in healthy myopic eyes using optical coherence tomography (OCT) angiography. The cross-sectional study included 55 healthy myopic eyes with PPA. The superficial radial peripapillary capillary (RPC) and choroidal microvascular densities were d...
Article
Full-text available
Background Horizontal eye movements have been proposed to induce biomechanical stress and strain on optic nerve head. Since strabismus may lead to sustained adduction or abduction, we investigate the effects of long lasting unilateral horizontal strabismus on the morphology of optic disc. Methods The observational cross-sectional study included pa...
Article
Purpose: To investigate the morphological features of parapapillary beta zone and gamma zone and their associated factors in eyes with chronic primary angle-closure glaucoma (CACG). Methods: The observational cross-sectional study included 65 CACG eyes and 65 non-myopic control eyes. On enhanced depth imaging of optical coherent tomography image...
Chapter
Glaucoma is a group of eye conditions which result in characteristic damage to the optic nerve. The pathogenesis and management of primary angle closure glaucoma are different from that of primary open-angle glaucoma. The main types of secondary glaucoma and their underlying causes, treatment principles, and medication options are discussed in this...
Chapter
Glaucoma physicians frequently face dilemmas generated by atypical or complicated cases and must answer questions such as “yes or no,” “treat or wait,” “medication or surgery,” and “switch or add.” There are no gold standard answers to these questions. Treatment decisions are usually based on comprehensive evaluation of the type and stage of the di...
Chapter
Glaucoma is a group of diseases that require long-term and even life-long treatment. Each ophthalmologist should master the art of glaucoma medical therapy based on scientific understanding of the etiology of glaucoma and the pharmacological mechanisms of anti-glaucoma medications.
Book
This book provides comprehensive information on current medications for glaucoma. From anatomy and physiology of glaucoma related ocular structure to the current mechanism theories and evaluation techniques of glaucoma, our understanding of glaucoma has been considerably improved in the last three decades. A large number of medications have been de...
Article
Full-text available
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases. Optic Atrophy Type 1 (OPA1), a mitochondrial fusion protein, has recently been suggested to be a mitophagic factor. Our previous...
Article
Full-text available
Purpose To compare various biometric parameters between fellow eyes of acute primary angle closure (glaucoma) [APAC(G)] and fellow eyes of chronic primary angle closure (glaucoma) [CPAC(G)]. Methods Ultrasound biomicroscopy examinations were performed on 47 patients with unilateral APAC(G) and 41 patients with asymmetric CPAC(G) before laser perip...
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Article
Full-text available
Glaucoma is a leading cause of irreversible blindness and characterized by progressive damage of retinal ganglion cells (RGCs). Growing evidences have linked impaired mitophagy with neurodegenerative diseases, while the E3 ubiquitin ligase parkin may play a key role. However, the pathophysiological relationship between parkin and glaucoma remains l...
Article
Full-text available
Purpose To investigate the role of parkin in regulating mitochondrial homeostasis of retinal ganglion cells (RGCs) under glutamate excitotoxicity. Methods Rat RGCs were purified from dissociated retinal tissue with a modified two-step panning protocol. Cultured RGCs were transfected with parkin using an adenovirus system. The distribution and morp...
Article
Full-text available
Primary angle-closure glaucoma (PACG) is a common cause of blindness. Angle closure is a fundamental pathologic process in PAGC. With the development of imaging devices for the anterior segment of the eye, a better understanding of the pathogenesis of angle closure has been reached. Aside from pupillary block and plateau iris, multiple-mechanisms a...
Article
Full-text available
Background The parapapillary gamma zone has recently been defined as the parapapillary region free of Bruch’s membrane. Although it has been reported the presence of defects in peripapillary gamma zone, hitherto undescribed is the herniation of the retinal nerve fiver layer tissue into the peripapillary gamma zone defect with the resulting localize...
Article
Purpose: To investigate the difference between two-dimensionally measured disc diameters (DDs) based on fundus images and three-dimensionally measured DDs based on enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: The DDs were three-dimensionally measured on EDI-OCT images of optic nerve heads and two-dimensionally measured...
Article
Purpose: To describe the appearance of the temporal inferior vein submerging into the parapapillary region with characteristics of parapapillary gamma zone and parapapillary beta zone. Methods: Ophthalmoscopy in a 28-year-old man showed a sagittally rotated optic nerve head with marked temporal inferior parapapillary atrophy, in which the tempor...
Article
Purpose: To examine the morphology of the optic nerve head in patients with unilateral peripapillary intrachoroidal cavitations (PICCs). Methods: The hospital-based observational study included patients with unilateral PICCs. Tomographic images of the parapapillary fundus were taken by enhanced depth imaging mode of optical coherent tomography....
Article
To describe the appearance of a defect in the parapapillary region of a highly myopic eye. During a routine ophthalmologic examination, in a 26-year-old man with a visual acuity of 0.80 and a refractive error of -10.25 D, a dehiscence in the parapapillary region was detected. A choroidal vessel appeared to emerge out of the dehiscence : Optical coh...
Article
Full-text available
Thy-1 is a cell surface protein that is expressed during the differentiation of retinal ganglion cells (RGCs). Optic nerve injury induces progressive loss in the number of RGCs expressing Thy-1. The rate of this loss is fastest during the first week after optic nerve injury and slower in subsequent weeks. This study was undertaken to determine whet...
Article
Full-text available
The loss of RGCs expressing Thy-1 after optic nerve injury has an initial phase of rapid decline followed by a longer phase with slower reduction rate. This study used longitudinal retinal imaging of mice expressing cyan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice) to determine how the alpha2-adrenergic agonist brimonidin...
Article
Purpose: To examine the morphologic features of parapapillary atrophy by using enhanced depth imaging optical coherence tomography (EDI-OCT) and color fundus photographs. Methods: The clinical observational comparative study included 80 normal eyes of 46 subjects and 80 eyes of 46 patients with primary open-angle glaucoma. Both groups did not va...
Article
Background: To investigate the association between the position of the central retinal vessel trunk (CRVT) in the optic nerve head and the pattern of remaining visual field and thickness of the retinal nerve fibre layer (RNFL) in end-stage glaucoma. Methods: The clinical observational study included patients with end-stage glaucoma with a remain...
Article
Full-text available
To examine histomorphometrically the parapapillary region in human eyes. The histomorphometric study included 65 human globes (axial length:21-37 mm). On anterior-posterior histological sections, we measured the distance Bruch's membrane end (BME)-optic nerve margin ("Gamma zone"), BME-retinal pigment epithelium (RPE) ("Beta zone"), BME-beginning o...
Article
  To investigate the responses of lateral geniculate nucleus (LGN) astrocytes to experimental glaucoma in monkeys.   Rhesus monkeys (Macaca mulatta).   Unilateral chronic elevation of intraocular pressure (IOP) was induced in six rhesus monkeys by laser photocoagulation of the trabecular meshwork. Four normal monkeys were used as controls. Immunohi...
Article
Full-text available
To investigate how OPA1 expression and distribution are altered by increased nitric oxide (NO) and whether aminoguanidine, a relative selective NO synthase (NOS)-2 inhibitor, can restore OPA1 expression and subsequently increase retinal ganglion cell (RGC) survival in ocular hypertensive rats. Elevated intraocular pressure was induced unilaterally...
Article
Full-text available
To determine whether acute intraocular pressure (IOP) elevation alters dynamin-related protein 1 (Drp1) as well as whether a selective inhibitor of Drp1, mdivi-1, can block apoptotic cell death and subsequently increase retinal ganglion cell (RGC) survival in ischemic mouse retina. C57BL/6 mice received injections of mdivi-1 (50 mg/kg) or vehicle,...
Article
Transgenic Col1a1(r/r) mice develop elevated intraocular pressure (IOP) with an open angle and progressive optic nerve axon loss. The present study was undertaken to evaluate aqueous outflow facility and its age dependence in these mice. Homozygous B6;129S4-Col1a1(tm1Jae) mice and corresponding wild-type Col1a1(+/+) mice from 12 to 56 weeks of age...
Article
The post-injury responses of traumatic optic neuropathy elicit a number of neuronal reactions in the visual system which have not been fully elucidated. This study aimed to investigate the immediate early gene (IEG) expression in the lateral geniculate nucleus (LGN) following unilateral optic nerve (ON) crush in adult rats with or without contralat...

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