Yesim Muge Sahin

Verified

Yesim verified their affiliation via an institutional email.

Learn more

Verified

Yesim verified their affiliation via an institutional email.

Learn more

• PhD
• Professor (Associate) at Istanbul Arel University

The fabrication and characterization of bovine hydroxyapatite (BHA) and cerium oxide (CeO2) composites are presented. CeO2 (at varying concentrations 1, 5 and 10wt%) were added to calcinated BHA powder. The resulting mixtures were shaped into green cylindrical samples by powder pressing (350MPa) followed by sintering in air (1000-1300°C for 4h). De...

In the present study for the first time in the literature, novel S-substituted bioactive anthraquinone compound were synthesized with a new, easy and less energetic reaction method (Patent Number: TR2016/19610) from 1-chloro-9,10-dihydrodiagnosisxy-anthraquinone and butyl-3-mercaptopropionate. The resultant structure present remarkable biological p...

In this study, poly (ε-caprolactone) (PCL) and fish sarcoplasmic protein (FSP) (Mw < 200 kDa) composite nanofibers were fabricated by electrospinning technique. Solution properties such as density, viscosity, conductivity and surface tension were studied as a function of FSP content in the solution. The morphology, molecular interaction, degradatio...

Purpose The aim of the study is primarily to ensure the electrical conductivity of the nanocomposite textile surface that is produced. Subsequently, the sensor properties were determined by monitoring the resistance changes under tensile forces. Design/methodology/approach Thermoplastic polyurethane solution was prepared by adding MWCNT and SDS fo...

Microplastics, widely found in aquatic ecosystems, are a rapidly growing environmental issue in the modern world. These tiny plastic particles, smaller than 5 mm, enter natural environments through various human activities. The Ergene River, located in the Thrace region, is a significant waterway in an area with intense industrial and urban activit...

Several therapeutic approaches have been developed to promote bone regeneration, including guided bone regeneration (GBR), where barrier membranes play a crucial role in segregating soft tissue and facilitating bone growth. This study emphasizes the importance of considering specific tissue requirements in the design of materials for tissue regener...

In this study, a new dye, Neurange stain, was developed for histopathological examination of brain tissue using light microscopy. In addition, Neurange dye can be used in routine analyses and microscopic imaging of tissue sections. The synthesis of 1-(4-hydroxyphenylthio)anthracene-9,10-dione (3), a new thio-anthraquinone derivative used in the pre...

Recently, advancements in fabrication technology have brought a new aspect to the field of tissue engineering. By utilizing advanced techniques in 3D manufacturing and biomaterials, scientists have successfully created tissue engineering scaffolds with complex three-dimensional structures and customized chemical compositions that closely mimic the...

Recently, strain sensors have significant areas of usage with their strain, stretching and wearable features for various applications such as personal health monitoring, joint movement detection, robotics, etc. To achieve this, various studies are conducted to optimize the production of MWCNT-based nanocomposites. In the present study, a total of 1...

In bone tissue engineering, scaffold attributes such as pore dimensions and mechanical strength are crucial. This study synthesized polycaprolactone dimethacrylate (PCLDMA) from polycaprolactone (PCL), incorporating epichlorohydrin (Epi-PCL) and methacryloyl chloride (Meth-Cl). PCLDMA was blended with polylactic acid (p-PLA) to 3D-print bone scaffo...

Polymeric barrier membranes are used in periodontal applications to prevent fibroblastic cell migration into the cavities of bone tissue and to properly guide the proliferation of tissues. In this study, the fabrication, characterization, bioactivity, and in vitro biological properties of polyvinyl alcohol-based nanofibrous membranes containing nan...

The effects grain size on transport and retention of plastics in sediments are controversial issue. Four beaches were selected on the Bodrum Peninsula (SW Türkiye) for this study. Twenty-four samples with poorly to well sorted, sandy gravel, gravel, or gravelly sand were collected from the top five cm of the sampling quadrant's four corners and cen...

Background: Introducing three-dimensional (3D) printing has opened new visions in the orthodontic field. This research evaluates three-dimensionally produced orthodontic retainers and their future possible uses. For this purpose, in vitro tests were performed for these groups, including bond strength, failure analysis, discoloration, and biodegrad...

Elektromanyetik koruma amaçlı toz üretim teknikleri olarak gaz atomizasyon tekniği ve kimyasal çöktürme yöntemi, soljel yöntemi vs. örnek verilebilir. Gaz atomizasyon tekniğinde metal bazlı toz üretimi olurken, hidroksiapatit (HA) gibi doğal kaynaklardan seramik tozu üretimi kimyasal çöktürme yöntemi ile sağlanmaktadır. Bu çalışmada atık madde olan...

Wound is defined as the cessation of the structural and functional function of living tissue as a result of the deterioration of the entire skin for various reasons. Wound treatment started with the history of humanity. The main purpose of wound treatment; It is to restore the deteriorated skin structure and functional properties by providing tissu...

A paradigm transition in cancer treatment gradually moved from "one drug-one target" toward "multi-target selective drugs design", because different drugs simultaneously inhibit tumor progression differently. The underlying mechanism has encountered significant challenges, such as encapsulating chemotherapies into a nanosized particulate system, ad...

In this study, our aim was to determine the effect of the polymer matrix on the drug delivery system; active-drug-loaded xanthan-gum (XaG)-based ZnO nanoparticles were synthesized under the ultrasonic irritation method. We characterized the structure using UV–Vis, SEM–EDX, FTIR and XRD techniques. The morphology of the nanoparticles has been carrie...

Objective Chemotherapeutic drugs, such as cisplatin (CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis (NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by CP. Methods In this study...

Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent,...

It is aimed to produce wound dressing from natural resources with electrospinning, which is a nanotechnological method for the rapid healing of wounds of diabetic patients. In this study, polyvinyl alcohol (PVA), which is very useful for electrospinning method in terms of its properties such as being easily soluble in water, easy spinning, and form...

Chitosan, a biocompatible and biodegradable polymer, has attracted the interest of scientists in recent years due to its antibacterial, antimicrobial and antifungal effects. In this study, the usage of chitosan nanoparticles (CNP) as a drug delivery system is investigated. In this study, the effect of chitosan / cross-linker ratio and pH parameters...

This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For this aim, 56 rats were divided into seven groups, balancing their body weights (BW). The study...

Catal's reagent is characterized by spectroscopic methods such as fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), ultraviolet (UV)–visible spectrophotometry. Effects of different solvents such as methanol and ethanol on absorption spectrum of 1-(Dodecylthio)anthracene-9,10-dion...

Treatment due to bone injuries is required as a result of accidents and injuries. Many different methods are used to fix bone fractures in the health field. These; methods such as using plaster, external stabilization, using plates and screws. However, these methods are not suitable for every bone fracture. Hard tissue adhesives are needed when the...

The wound is defined as the structure and functional function of the living tissue stopping as a result of the disruption of the skin for various reasons. Wound therapy started with human history. The main purpose in wound treatment; It is to restore the damaged skin structure and functional features by providing tissue repair as soon as possible....

Treatment due to bone injuries is required as a result of accidents and injuries. Many different methods are used to fix bone fractures in the health field. These; methods such as using plaster, external stabilization, using plates and screws. However, these methods are not suitable for every bone fracture. Hard tissue adhesives are needed when the...

The wound is defined as the structure and functional function of the living tissue stopping as a result of the disruption of the skin for various reasons. Wound therapy started with human history. The main purpose in wound treatment; It is to restore the damaged skin structure and functional features by providing tissue repair as soon as possible....

In this study, a novel reagent was developed for sensitive detection of iron (II) sulfate, spectrophotometrically. A novel thio-anthraquinone derivative, 1-(Dodecylthio)anthracene-9,10-dione (3), was synthesized from the chemical reaction of 1-Chloroanthraquinone (1) and 1-Dodecanethiol (2) by an original reaction method and was used in the prepara...

Ceramides are structural components of the stratum corneum that regulate cell proliferation and differentiation. The study of the effect of the cream containing dexpanthenol and ceramide on the proliferation processes and regeneration of burn wounds in rats. Experimental rats with III-A degree thermal burn were treated separately with the following...

In this study, polyethylene glycol/guar gum @ silver nanoparticles (PEG/GG@AgNPs) were synthesized by using simple sonication method. The nanoparticles were characterized using Fourier-transform infrared spectroscopy (FTIR) and scanning transmission electron microscopy (STEM). The swelling behaviors of nanoparticles were studied in different pHs (5...

The use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In this study, the characterization and performance of electrospun Achillea lycaonica-loaded (0.125, 0.250 and 0.500, wt%) poly(lactic acid) (PLA) (8%, w...

In this study, α-TCP and β-TCP were successfully produced via a mechanochemical method from aragonite structures, Clinocardium ciliatum seashells, at 850 °C, 1000 °C, and 1200 °C sintering temperatures. The characterization of the obtained materials was carried out via FT-IR, SEM/EDX, BET, XRD, ICP-OES analysis. Samples were soaked for 21 days in s...

As biomaterials, nanofiber bicomposite mats have been fabricated as a versatile approach to tailor rheology and imparting the aimed functionalities to biomaterials. Nonwoven wound dressings have been produced from natural sources by a nanotechnological method, for the rapid recovery of wounds of especially diabetic patients. The emergence of nanote...

Regeneration and repair of injured or diseased heart valves remains a clinical problem. Tissue engineering provides a promising treatment approach to facilitate heart valve repair and regeneration. Approaching three-dimensional biomimetic scaffolds for natural heart valve tissues provide benefit for the successful in vitro development of tissue eng...

It is aimed to produce wound dressing from natural sources by electrospinning which is a nanotechnological method for the rapid recovery of the wounds of diabetes patients. In this study, polyvinyl alcohol (PVA), which is very useful for electrospinning method, has been used for its easy dissolution in water, its ability to spin easily and to form...

Wound dressings provide quick and cosmetic healing of wounds. Wound dressings have many varieties such as transparent film covers, hydrocolloid covers, polymer foam covers, hydrogels, hydrophilic covers, alginate covers, antibacterial covers, honey covers and biological dressings equivalent to skin structure. The wound is selected according to the...

Resveratrol, which is the main component of the plant extracts used for centuries to treat human diseases in traditional medical science, is a natural phytoalexin found in many different plants, especially grapes. Phytoalexins are antifungal and antimicrobial compounds produced against microbial and physical stimuli. Resveratrol, a natural source o...

Resveratrol, which is the main component of the plant extracts used for centuries to treat human diseases in traditional medical science, is a natural phytoalexin found in many different plants, especially grapes. Phytoalexins are antifungal and antimicrobial compounds produced against microbial and physical stimuli. Resveratrol, a natural source o...

It is aimed to produce wound dressing from natural sources by electrospinning which is a nanotechnological method for the rapid recovery of the wounds of diabetes patients. In this study, polyvinyl alcohol (PVA), which is very useful for electrospinning method, has been used for its easy dissolution in water, its ability to spin easily and to form...

Wound dressings provide quick and cosmetic healing of wounds. Wound dressings have many varieties such as transparent film covers, hydrocolloid covers, polymer foam covers, hydrogels, hydrophilic covers, alginate covers, antibacterial covers, honey covers and biological dressings equivalent to skin structure. The wound is selected according to the...

Regeneration and repair of injured or diseased heart valves remains a clinical problem. Tissue engineering provides a promising treatment approach to facilitate heart valve repair and regeneration. Approaching three-dimensional biomimetic scaffolds for natural heart valve tissues provide benefit for the successful in vitro development of tissue eng...

Indocyanine green (ICG) provides an advantage in the imaging of deep tumors as it can reach deeper location without being absorbed in the upper layers of biological tissues in the wavelengths, which named “therapeutic window” in the tissue engineering. Unfortunately, rapid elimination and short‐term stability in aqueous media limited its use as a f...

Nigella sativa (Nigella) is a natural plant with antimicrobial, antifungal and antioxidant properties which is effective against viruses and fungi. In addition to the thymokinone compound which is the active ingredient of black seed, vitamins A, B, and C have a healing effect on the wound healing with valuable components such as calcium, potassium,...

Resveratrol, which is the main component of the plant extracts used for centuries to treat human diseases in traditional medical science, is a natural phytoalexin found in many different plants, especially grapes. Phytoalexins are antifungal and antimicrobial compounds produced against microbial and physical stimuli. Resveratrol, a natural source o...

Regeneration and repair of injured or diseased heart valves remains a clinical problem. Tissue engineering provides a promising treatment approach to facilitate heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds approaching natural heart valve tissues are useful for successful in vitro development of tissue engineering...

Objective: It is aimed to produce wound dressing from natural sources by electrospinning which is a nanotechnological method for the rapid recovery of the wounds of diabetes patients. Materials and methods: In this study, polyvinyl alcohol (PVA), which is very useful for electrospinning method, has been used for its easy dissolution in water, its...

Bioactivity, which we call biological activation, is defined as the formation of a bond with a special biological reaction that occurs at the material interfaces. High-activity bioceramics react with collagen tissue fibers in the human body to produce HCA (hydroxycarbonaapatite) at the interface. This layer is similar in physical and chemical terms...

Regeneration and repair of injured or diseased heart valves remains a clinical problem. Tissue engineering provides a promising treatment approach to facilitate heart valve repair and regeneration. Approaching three-dimensional biomimetic scaffolds for natural heart valve tissues provide benefit for successful in vitro development of TEHV (tissue e...

A new anthraquinone [1-(2-Aminoethyl)piperazinyl-9,10-dioxo-anthraquinone] derivative was synthesized and characterized by density functional theory (DFT) calculations, experimental and theoretical vibrational spectroscopy and NMR techniques. The most stable molecular structure of the title molecule was determined by DFT B3LYP method with 6-31++G(d...

Hydroxyapatite is a naturally occurring calcium phosphate mineral. The formula is generally written as Ca10(PO 4) 6 (OH) 2 and it crystallizes in the hexagonal crystal system [1]. Epoxidized maleinated castor oil (EMACO) was synthesized by our group earlier [2]. EMACO contains epoxy groups and free carboxyl groups. When EMACO is synthesized freshly...

The present paper aims to overcome the problems related to previous use of autologous grafts using available synthetic grafts. To examine the optimum of the ideal vessel‐like constructs parameters are produced at 230 °C. At this production temperature, the elastic modulus values of the constructs ranges from 56 MPa to 174 MPa. The maximum cell prol...

Saç kılları temel olarak dıştan içe kütikül, korteks ve bazen de medulla olmak üzere üç ayrı tabakadan oluşur ve tamamen keratinleşmiş epitel hücrelerinden meydana gelir. Korteks, saç kılının % 50-60 kadarını oluşturur, temel yapısı içten dışa keratin molekülünden başlayan ve mikrofibril, ve makrofibril yapılarını içeren sağlam bir yapı oluşturur (...

3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (β-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the β-TCP concentr...

From the past to the present, many biomaterials such as artificial heart and hip prostheses have been produced. Biomaterials must be biocompatible since they are in direct contact with the transported tissue. For this purpose, many biomaterials are produced in natural and synthetic structure. The bioceramics obtained by natural methods form a tight...

The development of innovative biomaterials, development of formulations and improvement of production processes are important for our country technology and economy. Congenital ear deprivation, called microtia, is a rare case. The ears are normally completed in the first 3 months of pregnancy. In light of the information obtained in the researches...

zet Küresel olarak her yıl 91 milyon tondan fazla balık ve kabuklu deniz hayvanı yakalanmaktadır. Gıda ve Tarım Örgütü (FAO), bu av miktarının yaklaşık % 50-60'ının insan tüketimi için kullanıldığını, geri kalanı ise atıldığını düşünmektedir. Aşırı tüketimi ve olumsuz çevresel etkileri azaltmaya katkıda bulunmak için ve yüksek katma değerli ürünler...

Rice is consumed as the main food product in Asian countries. In addition to white rice with the highest consumption, there are also red and black colored species. Due to the antioxidant properties of colored rice products, their use in various food production has been supported. Therefore, red rice is consumed in Japan in large quantities due to i...

Hydroxyapatite (HA), obtained from bovine bones, was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %, were sintered at various temperatures between 1000 and 1300°C, in air. Well-sintered samples were obtained after sintering at 1200 and 1300°C. The presence of h-BN contributed to dense...

Ceramics are inorganic, non-metallic, and compounds containing ionic and covalent bonds in various combinations. Ceramics designed and manufactured for use in damaged, diseased or worn parts of the body are called "bioceramics". In this study, inorganic bioceramics such as Hydroxyapatite (HA) and Tricalcium phosphate (TCP) were also synthesized by...

Aloe Vera (AV) reinforced polymeric wound healing hydrogel electrospinning. Nano biocomposites were produced from products obtained with all of the AV (10%) FDA (American Food and Drug Administration) approved polyvinyl alcohol (PVA) polymers at different ratios (1 ml, 5 ml, 8 ml). The cell is regenerative, wound and burn healing, antiseptic and ag...

Biomaterials are natural or synthetic materials used to support or support the functions of living tissues in the human body. In this study, bioceramic synthesis was done by chemical agitation method from egg shells. Nanocomposite matrums were obtained by electrospinning by adding various substances such as EGHA (HA from egg shell), Pumice, Niobiu...

Ceramics are inorganic, non-metallic, and compounds containing ionic and covalent bonds in various combinations. Ceramics designed and manufactured for use in damaged, diseased or worn parts of the body are called "bioceramics". In this study, inorganic bioceramics such as Hydroxyapatite (HA) and Tricalcium phosphate (TCP) were also synthesized by...

Aloe Vera (AV) reinforced polymeric wound healing hydrogel electrospinning. Nano biocomposites were produced from products obtained with all of the AV (10%) FDA (American Food and Drug Administration) approved polyvinyl alcohol (PVA) polymers at different ratios (1 ml, 5 ml, 8 ml). The cell is regenerative, wound and burn healing, antiseptic and ag...

Biomaterials are natural or synthetic materials used to support or support the functions of living tissues in the human body. In this study, bioceramic synthesis was done by chemical agitation method from egg shells. Nanocomposite matrums were obtained by electrospinning by adding various substances such as EGHA (HA from egg shell), Pumice, Niobiu...

In this study, a sea shell was converted into bioceramic phases at three different sintering temperatures (450oC, 850oC, 1000oC). Among the obtained bioceramic phases, a valuable β-TCP was produced via mechanochemical conversion method from sea snail Turritella terebra at 1000oC sintering temperature. For this reason, only the bioceramic sintered a...

zet Bu çalışmada, poliakrilonitril (PAN) ve poliakrilonitril (PAN)-hidroksiapatit (HA) nanoliflerin üretimi elektrospinning yöntemiyle sağlanmıştır. Üretilen HA katkılı PAN nanoliflerin, nanolif boyutları ve lif morfolojileri incelenerek, yaklaşık ortalama çapları 40-200 nm aralığında olduğu görülmüştür. FT-IR ile fonksiyonel grupların varlığı beli...

Black rice, which is rich in anthocyanins, vitamins and protein, has recently begun to be preferred. Black rice is an important source of special bone, nerve tissue, muscle work and heart health in the presence of more magnesium than white. Another difference of black rice is the high antioxidant value. Antioxidants strengthen the immune system and...

HA demonstrates greater hydrophobic property, and possesses lower resorption rate than TCP. There have been advantageous in pairing HA with TCP, as some designed parameters such as degradability and surface characteristics of the engineered scaffold have been improved [1]. By using a simple chemical method, it is possible to synthesize such biphasi...

Makine Mühendisliği Bölümü, Teknoloji Fakültesi, Fırat Üniversitesi, 23119 Elazığ, Türkiye. = erdibulus@arel.edu.tr ÖZET Biyouyumlu ve biyobozunur özelliklere sahip olan polikaprolakton (PCL), cerrahi amaçlı üretilen ipliklerde, ilaç salınım sistemi gibi biyolojik alanlar ve kolay şekillenebilir olmaları sebebiyle naylon katkılı malzemelerin içinde...

Electrospun Biocomposites As a novel alternative source of scaffold materials, a marine sourced bioceramic (MSB) was obtained by using a simple mechano-chemical conversion method. Different marine sourced calcium phosphate bioceramics [i.e. hydroxyapatite (HA), ß-tricalcium phosphate (ß-TCP), whitlockite, monetite and other phases], can be obtained...

Background: We evaluated the Bovine hydroxyapatite (BHA) structure. BHA powder was admixed with 5 and 10 wt% natural pumice (NP). Compression strength, Vickers micro hardness, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM) and X-ray diffraction studies were performed on the final NP-BHA composite products. The cells pr...

Nanotechnology has tremendous potential to revolutionize dentistry as a whole and can also introduce significant benefits to human society by improving health and presenting better use of natural resources. Nanomaterials and nanoparticles are likely to be cornerstones of innovative nanodental applications. It is believed that nanodentistry will imp...

Bioceramics is very important application for dental and orthopedic procedures. Beside all these normal procedures traffic accidents are requiring increasing number of graft, prostheses and orthosis applications. Bioceramics can be produced from local and natural sources with various methods. Those can be produced from various bone structures throu...

The biomedical applications of Poly (e-caprolactone) (PCL) have an extensive usage area such as tissue engineering, regenerative medicine, cartilage defects and biomedical implants. Because of the PCL’s high biocompatibility and excellent mechanical features some implants have been designed for getting remarkable results. Clinically approved fibers...

Calcium phosphates are very important biomaterials for orthopaedic and dental applications. Hydroxyapatite (HA) is one of the important phases used for grafting. Those are produced from synthetic and natural sources with various methods. Especially nano-bioceramics can be produced through calcitic and aragonitic structures (i.e. mussel shells, sea...

Bioceramics are commonly used biomaterials for orthopedic and dental applications. Among these bioceramics, hydroxyapatite (HA) and tricalcium phosphate (TCP) are of interest and are used in various biomedical applications. Production of bioceramics from natural materials such as bovine and sheep bones with calcination method, is possible. Lately,...