Yeong Huei Desmond Chuah

• MB BCh BAO; MSc
• Medical doctor at University College Dublin

The attenuation of diabetic kidney disease (DKD) by metabolic surgery is enhanced by pharmacotherapy promoting renal fatty acid oxidation (FAO). Using the Zucker Diabetic Fatty and Zucker Diabetic Sprague Dawley rat models of DKD, we conducted studies to determine if these effects could be replicated with a non-invasive bariatric mimetic interventi...

Background Roux-en-Y gastric bypass surgery (RYGB) improves biochemical and histological parameters of diabetic kidney disease (DKD). Targeted adjunct medical therapy may enhance renoprotection following RYGB. Methods The effects of RYGB and RYGB plus fenofibrate, metformin, ramipril, and rosuvastatin (RYGB-FMRR) on metabolic control and histologi...

Introduction Impaired lipid metabolism in the renal tubule plays a prominent role in the progression of renal fibrosis following acute kidney injury (AKI) and in chronic kidney disease (CKD). Peroxisome proliferator-activated receptors (PPARs) are promising druggable targets to mitigate renal fibrosis by redirecting metabolism, including restoratio...

Investigation of renal tubular impact using NGAL as a biomarker in ZDSD rats with diabetic kidney disease following intensive medical therapy

Elevation of urinary NGAL is primarily associated with impaired prox- imal tubular reabsorption and distal nephron injury. This study ex- amined the effect of intensive medical therapy (IMT) on urinary excretion of NGAL in the Zucker Diabetic Sprague-Dawley (ZDSD) rat model of diabetic nephropathy (DN). Adult male ZDSD rats of 26 weeks of age were...