Yeon Soo Lee

Automatic segmentation of shoulder muscle MRI is challenging due to the high variation in muscle size, shape, texture, and spatial position of tears. Manual segmentation of tear and muscle portion is hard, time-consuming, and subjective to pathological expertise. This work proposes a new Region and Edge-based Deep Auto-Encoder (RE-DAE) for shoulder...

Background : Immuno-score, a prognostic measure for cancer, employed in determining tumour grade and type, is generated by counting the number of Tumour-Infiltrating Lymphocytes (TILs) in CD3 and CD8 stained histopathological tissue samples. Significant stain variations and heterogeneity in lymphocytes’ spatial distribution and density make automat...

Automatic segmentation of shoulder muscle MRI is challenging due to the high variation in muscle size, shape, texture, and spatial position of tears. Manual segmentation of tear and muscle portion is hard, time-consuming, and subjective to pathological expertise. This work proposes a new Region and Edge-based Deep Auto-Encoder (RE-DAE) for shoulder...

The new emerging COVID-19, declared a pandemic disease, has affected millions of human lives and caused a massive burden on healthcare centers. Therefore, a quick, accurate, and low-cost computer-based tool is required to timely detect and treat COVID-19 patients. In this work, two new deep learning frameworks: Deep Hybrid Learning (DHL) and Deep B...

COVID-19 is a global health problem. Consequently, early detection and analysis of the infection patterns are crucial for controlling infection spread as well as devising a treatment plan. This work proposes a two-stage deep Convolutional Neural Networks (CNNs) based framework for delineation of COVID-19 infected regions in Lung CT images. In the f...

Segmentation and detection of mitotic nuclei is a challenging task. To address this problem, a Transfer Learning based fast and accurate system is proposed. To give the classifier a balanced dataset, this work exploits the concept of Transfer Learning by first using a pre-trained convolutional neural network (CNN) for segmentation, and then another...

A churn prediction system guides telecom service providers to reduce revenue loss. Development of a churn prediction system for a telecom industry is a challenging task, mainly due to size of the data, high dimensional features, and imbalanced distribution of the data. In this paper, we focus on a novel solution to the inherent problems of churn pr...

The speckle noise commonly occurs in ultrasound imaging based applications. Due to the multiplicative nature, speckle noise deteriorates the visual quality of ultrasound images. This affects the performance of radiologists and practitioners for disease diagnosis and/or patient treatment. The current study proposes a bio-inspired multi-gene genetic...

Background Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed...

Different types of breast cancer are affecting lives of women across the world. Common types include Ductal carcinoma in situ (DCIS), Invasive ductal carcinoma (IDC), Tubular carcinoma, Medullary carci-noma, and Invasive lobular carcinoma (ILC). While detecting cancer, one important factor is mitotic count —showing how rapidly the cells are dividin...

Purpose Acromioclavicular (AC) joint dislocation is a common sports injury. Hook plate fixation is currently widely used to treat this injury, as it can promote the natural healing of the ligament with good clinical outcomes. However, subacromial erosion and impingement are frequently observed post-operatively. It was hypothesized that the morpholo...

Transosseous-equivalent (TOE) rotator cuff repair can increase contact area and contact pressure between the repaired cuff tendon and bony footprint and can show higher ultimate loads to failure and smaller gap formation compared with other repair techniques. However, it has been suggested that medial rotator cuff failure after TOE repair may resul...

This study aimed to quantify morphological characteristics of the posterior lumbar spinous process, which may affect stable implantation of screwless wire spring loops. Virtual implantations of a screwless wire spring loop onto pairs of lumbar spinous processes were performed for computed tomography (CT)-derived three-dimensional vertebral models o...

The present study assessed the changes in the length of the first metatarsal bone after performing proximal chevron metatarsal osteotomy (PCMO) or distal Chevron metatarsal osteotomy (DCMO) for patients with hallux valgus deformity. A total of 60 patients with moderate-to-severe hallux valgus deformity from July 2009 to July 2011 were randomly divi...

In this study, trigonelline, a niacin-related compound was incorporated into chitosan nanoparticles through ion-complex formation between anionic carboxylic acid group of trigonelline and cationic amine group of chitosan. Morphology of trigonelline-incorporated chitosan nanoparticles have spherical shape with less than 500 nm in size and thier size...

A novel 2-dimensional catalytic system was developed in which platinum nanoparticles (Pt NPs) were immobilized on exfoliated MgAl-layered double hydroxide (LDH) nanosheets through an electrostatic self-assembly between negatively charged Pt NPs and positively charged LDH nanosheets. The LDH nanosheets effectively provided the large double sides of...

Intramedullary screw fixation and bicortical screw fixation are widely used operation methods in the surgical treatment of Jones fractures. The purpose of this study is to evaluate of mechnical stability in two kind of Jones fracture. Using Mimics, three-dimensional models of the fifth metatarsal were reconstructed form computed tomography images o...

Mitochondrial protein of Plasmodium falciparum is an important target for anti-malarial drugs. Experimental approaches for detecting mitochondrial proteins are costly and time consuming. Therefore, MitProt-Pred is developed that utilizes Bi-profile Bayes, Pseudo Average Chemical Shift, Split Amino Acid Composition, and Pseudo Amino Acid Composition...

Churn prediction in telecom has recently gained substantial interest of stakeholders because of associated revenue losses. Predicting telecom churners, is a challenging problem due to the enormous nature of the telecom datasets. In this regard, we propose an intelligent churn prediction system for telecom by employing efficient feature extraction t...

The advent of non-thermal plasma brought a breakthrough in exploring its clinical applications in dermatology to bolster tissue generation in the domain of plasma medicine. This study aimed to investigate the effect of non-thermal plasma on the corneocyte of the skin cells, in treating superficial skin diseases via the process of corneocyte desquam...

The advances in electrotherapy to treat the diseased biological cell instigate its extension in gene therapy through the delivery of gene into the nucleus. The objective of this study is to investigate the application of moderate intensity alternating electric field, also known as tumor treating electric field on a carrier system consisting of a ch...

Background: Fiducial markers are objects placed in the field of view of an imaging system for use as a point of reference or a measure. There is no information regarding suitable markers for joint models. Objectives: We compared the fiducial markers commonly used in X-ray, CT, and MRI imaging modalities. Methods: The markers tested were plastic bal...

Purpose All-trans retinoic acid (RA)-incorporated nanoparticles were prepared using deoxycholic acid-conjugated dextran (DexDA). Anticancer activity of RA-incorporated DexDA nanoparticles were tested in vitro and in vivo. Methods RA-incorporated nanoparticles were prepared by dialysis. Antiproliferative and anti-invasive potential of RA-incorporat...

Background The first purpose of this study was to reveal the clinically important region-specific volumetric bone mineral density (vBMD) of the proximal humerus in patients with unilateral rotator cuff tear (RCT), and the second was to evaluate the relationship between vBMD of the proximal humerus and BMD of the hip and lumbar spine measured using...

Local distribution and quality of bone mineral density (BMD) in the proximal humerus are important for rotator cuff repair, internal fixations, and arthroplasty. The current study aimed to develop a volumetric BMD (vBMD) measurement technique that can specify the volumetric region of interest in an anatomically reproducible manner and ensures fair...

Churn prediction model guides the customer relationship management to retain the customers who are expected to quit. In recent times, a number of tree based ensemble classifiers are used to model the churn prediction in telecom. These models predict the churners quite satisfactorily; however, there is a considerable margin of improvement. In teleco...

Acetazolamide-challenged perfusion magnetic resonance imaging (MRI) has been shown as a method for assessment of cerebrovascular reserve (CVR) capacity in patients with atherosclerotic steno-occlusive disease of internal carotid artery. We have assessed the feasibility of the acetazolamide-challenged perfusion MRI for evaluating CVR in symptomatic...

Myolipoma is a rare benign tumor, composed of irregularly admixed adipose tissue and smooth muscle fibers. Few literature studies have described the radiologic appearance of myolipoma, especially in the soft tissue. No MRI findings in subcutaneous myolipoma of an extremity have been reported. Here, we report on the case of a 34-year-old woman with...

Partial articular surface of the rotator cuff tendon tears has been recognized as a source of treatable shoulder pain and a precursory pathology for full-thickness tendon tears. Arthroscopic rotator cuff repair is a possible surgical method of treatment. Recent data have shown that the treating partial-thickness rotator cuff repairs with transtendo...

The deintercalation of carbonate (CO32–) ions from MgAl-layered double hydroxides (LDHs) (Mg/Al = 2) both in monolayer films and powdered samples under atmospheric conditions in ethanol was investigated. A selenous acid precursor was incorporated into the interlayer gallery. Treatment with 0.5 M selenous acid (H2SeO3) for 30 min with powdered LDHs...

Internal cable fixation aims to provide stability of fractured bone to avoid movement which could result in loosening of the implant and a delay in healing, especially for periprosthetic bone fractures. The current study investigated the effect of the cable tightening loads on stability of fractured bone with internal cable fixation. A finite eleme...

The subtalar arthrodesis using screws has been performed to manage traumatic subtalar arthritis. Even though clinically there might not have been big difference between using single screw or double screws for subtalar arthrodesis, a double screw fixation is expected to bring a better initial stability in a mechanical view. This study aimed to asses...

In the total knee arthroplasty (TKA), kinematic benefits of the cruciate retaining (CR) mobile-bearing total knee arthroplasty are important. The current study aimed to assess how kinematic features of the anterior-posterior glide CR mobile-bearing TKA are different from those of normal knees or CR fixed-bearing TKA. Using a 3D/2D registration meth...

Mitochondria are all-important organelles of eukaryotic cells since they are involved in processes associated with cellular mortality and human diseases. Therefore, trustworthy techniques are highly required for the identification of new mitochondrial proteins. We propose Mito-GSAAC system for prediction of mitochondrial proteins. The aim of this w...

The ligamentum flavum may undergo various pathologic changes, including hypertrophy, calcification, ossification, and cyst formation. Ligamentum flavum hematoma (LFH) is a rare cause of spinal nerve root or cord compression and usually occurs in the lumbar spine. We report a 66-year-old woman with LFH occurring after an epidural block, mimicking ep...

Lumbar radiculopathies may occur in the course of many diseases but are rarely caused by abnormalities or pathologic changes in the epidural venous plexus. We describe a patient with lumbar radiculopathy attributable to a thrombolith of the epidural venous plexus, as diagnosed by computed tomography (CT) and magnetic resonance imaging (MRI), and wh...

We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 we...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Recently, due to problems arising from lattice mismatch in thin film growth in semiconductor manufacturing industry, researchers have shown great interest in modeling the physiochemical properties of cubic perovskite of types ABX3. They have put sizeable efforts to reduce error in the prediction of lattice constant (LC) of cubic perovskites. Howeve...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

The existing glenohumeral joint kinematic protocols are highly effective for studying in vivo shoulder kinematics but are not anatomically specific enough to address the asymmetric changes in glenohumeral joint kinematics and do not provide clear anatomic definitions for landmarks and directions. Therefore, the objective of this study was to develo...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Expanded polypropylene (EPP) foams have been widely used as protective materials in automotive bumpers, safety helmets, etc., but their dynamic behavior is not well defined. In the current study, quasi-static compression tests and dynamic tests using a split Hopkinson pressure bar were performed to investigate the effect of material density on the...

We propose a new multi-objective genetic algorithm (MOGA) based scheme for audio signal watermarking. By using this scheme, small size images can be embedded as a digital watermark for audio signal. Our proposed scheme automatically selects the intensity of watermark for embedding in audio signal during MOGA evolution cycle. The main benefit of thi...

High tibial osteotomy (HTO) for medial compartment knee osteoarthritis is preferred in the activity patient since it allows patients to return to sports and recreational activities similar to the preoperative level. The purpose of this study was to mathematically formulate medial and anteromedial opening gaps in the medial opening wedge HTO to achi...

Due to problems arising from lattice mismatch in thin film growth in semiconductor manufacturing industry, researchers have put sizeable efforts to reduce error in the prediction of lattice constant (LC) of cubic perovskites. However, linear prediction models were developed using linear regression techniques, which may not be able to find precisely...

The aim of this study was to investigate the causes of the high revision rate of the hydroxyapatite-coated Anatomique Benoist Girard (ABG-I) prosthesis. We performed 204 total hip arthroplasties (THAs) at our hospital between March 1992 and December 1996. Of the 204 THA patients, 129 were followed up; the mean duration of follow-up was 12.2 years (...

In this study, we prepared adriamycin (ADR)-encapsulated core-shell type nanoparticles of a poly(DL-lactide-co-glycolide) (PLGA) grafted-dextran (DexLG) copolymer and evaluated its antitumor activity in vitro and in vivo. The particle size of ADR-encapsulated DexLG nanoparticles was around 50-200 nm and the morphology was spherical shapes at transm...

The current study assessed the effect of a bolt hole on tensile fatigue properties of CFRP laminates. Two specimens, i.e. [(0/90)3]S, [(0/45/90/–45)2]S, were analyzed using a finite element method and were experimentally tested for cases, both with and without a hole, whose diameter corresponded to 0.12 times the specimen width. Delamination positi...

An increased stress in the patella due to the implantation of a patellar button may also be another potential source of pain in total knee arthroplasty patients. This study assessed the location inside the patella having largest stress change after implantation of an ultra high molecular polyethylene patella button. Finite elements models of the pa...

This study aimed to assess the effect of posteromedial olecranon resection on the stability of the elbow joint, forearm kinematics, and strain in the anterior bundle of the medial ulnar collateral ligament. Seven elbows were tested after resecting all soft tissues except the capsuloligamentous structures. Varus-valgus angulation, forearm rotation,...

To understand why hydroxyapatite (HA)-coated acetabular cups did not produce satisfactory results, we measured the extent of bone ongrowth and HA absorption of the retrieved cups. Between March 1992 and June 1998, a total of 289 patients underwent total hip arthroplasty with an HA-coated ABG (Anatomical Benoist Giraud) prosthesis in our hospital. W...

Both CT and MRI are complementary to each other in that CT can produce a distinct contour of bones, and MRI can show the shape of both ligaments and bones. It will be ideal to build a CT-MRI combined model to take advantage of complementary information of each modality. This study evaluated the accuracy of the combined femoral model in terms of ana...

Various causes have been reported for cystic lesions arising from the cruciate ligaments. We present a case of synovial chondromatosis that involved the posterior cruciate ligament and was treated by an arthroscopic posterior-posterior triangulation method. We recommend that synovial chondromatosis be considered in the differential diagnosis of cys...

Lipase-catalyzed enantioselective transesterification has been performed to obtain chiral halogenated phenyl 2-hydroxypropanones, key intermediates of pharmaceuticals. Effects of organic solvents, reaction temperature, and substrate concentration were also investigated in Novozym 435-catalyzed transesterification of 1-(2,4-difluorophenyl)-2-hydroxy...

The aim of this study was to assess how much the digitizing error attributable to the thick soft tissues in the anterior pelvic area can affect the targeted acetabular socket alignment. The acetabular socket orientation angle was measured by using a synthetic pelvic model and an OrthoPilot total hip arthroplasty (Aesculap AG & Co KG, Tuttlingen, Ge...

The purpose of this study was to evaluate the effects of glenoid retroversion after total shoulder arthroplasty on glenohumeral joint contact pressures, contact areas, and forces. We studied 8 cadaveric shoulders with a custom shoulder testing system that permits anatomic loading of the rotator cuff and the humerothoracic muscles. Each shoulder was...

This study provides a robust measuring method of the femoral neck anteversion angle for use in a total hip replacement pre-planning program. The femora of 24 patients (69.3 ± 6.3 years old) were CT-scanned and converted into three-dimensionally volume-rendered models in ORTHODOC® (ISS Inc., CA, USA) which is the pre-planning software for ROBODOC su...

Enzymatic alcoholysis of rac-lactide for kinetic resolution was carried out in organic solvents. Effects of organic solvent, reaction temperature, and alcohol as a nucleophile were also investigated in Novozym 435-catalyzed alcoholysis of rac-lactide. Both alkyl (R)-lactate and alkyl (S,S)-O-lactyllactate were simultaneously obtained in high yields...

This study provides a robust measuring method of the femoral neck anteversion angle for use in a total hip replacement pre-planning program. The femora of 24 patients (69.3 +/- 6.3 years old) were CT-scanned and converted into three-dimensionally volume-rendered models in ORTHODOC (ISS Inc., CA, USA) which is the pre-planning software for ROBODOC s...

Overhead-throwing athletes have increased external and diminished internal glenohumeral rotation that may alter glenohumeral kinematics. To quantify the kinematic changes present in a cadaveric model of a thrower's shoulder. Controlled laboratory study. In 8 fresh-frozen cadaveric shoulders, the rotator cuff and overlying muscles were removed, and...

In this study, we investigate the feasibility of in-situ crack propagation by using a double cleavage drilled compression (DCDC) specimen showing a slow crack velocity down to 0.03 mm/s under 0.01 mm/s of displacement control. Finite element analysis predicted that the DCDC specimens would show at least 4.3 fold delayed crack initiation time than...

Spontaneous bilateral rupture of the quadriceps tendons without a significant history of trauma is an uncommon disease. It is generally associated with chronic metabolic disorders such as chronic renal failure and secondary hyperparathyroidism. Here, we report a case of spontaneous bilateral tendon rupture in a patient on chronic hemodialysis for t...

The patellar component of a total knee replacement (TKR) is the most frequent source of non-septic complications after total knee arthroplasty. Fracture of patellar pegs in all polyethylene patellar components is a very rare occurrence. We report such a case of a patellar polyethylene fracture in a 72-year-old female patient 10 years after TKR. Due...

We present the case of a symptomatic anterior elbow cyst supposedly due to repeated (exertional) trauma. Instead of the usual open excision, arthroscopic excision was performed using a Wissinger rod through an additional anterolateral portal for distraction. Histopathology confirmed the lesion to be a ganglion. MRI 12 months postoperatively showed...

We repaired full-thickness rotator cuff tears in human cadaveric shoulder specimens. The purpose of this study was to determine whether a repaired supraspinatus will result in a change in joint forces, contact pressures and area, and position of the humerus relative to the glenoid compared with the pathologic and simulated complete-tear specimens....

By using Candida antarctica lipase B under mild conditions, the highly enantioselective acylation of alkyl (R)-lactate from racemic mixture with vinyl alkanoate has been accomplished. In this research effects of the organic solvent, the alkyl chain length of the alkyl lactates and of the vinyl alkanoates, and the reaction temperature on the enantio...

This paper considers the problem of recursive estimation in linear discrete-time systems. We derive an optimal combination of arbitrary number correlated estimates. In particular, for two estimates this combination represents the well-known Millman and Bar-Shalom-Campo formulae for uncorrelated and correlated estimation errors, respectively. This n...

Horseradish peroxidase-catalyzed polymerization of cardanol in aqueous organic solvent was investigated in the presence of a redox mediator. Cardanol is a phenol derivative from a renewable resource mainly having a C15 unsaturated hydrocarbon chain with mostly 1-3 double bonds at a meta position. Unlike soybean peroxidase (SBP), it has been shown t...

The mean square optimal adaptive filtering problem for wide class of the nonlinear continuous-discrete stochastic systems is solved. The state vector of a system is determined by the Ito stochastic differential equation and the observation described by stochastic difference equations depend on unknown vector parameters. Equations for conditional de...

The continuous-discrete filtering problem for different types of observations is considered. In the work of Cho and Oh, the suboptimal continuous and discrete filters for this type of observations were developed. In this paper, we present a generalization of these filters to mixed continuous-discrete systems. The new suboptimal filter allows fully...

In [1], we developed a new suboptimal filtering methods for a class of linear and nonlinear continuous dynamic systems with multidimensional observation vector. The methods are based on the decomposition of Kalman filtering and extended Kalman filtering equations by observation vector. In this paper, we present a generalization of these filtering m...

This paper presents suboptimal linear and nonlinear filtering methods based on observation vector partition. The usual Kalman filter and extended Kalman filter are decomposed into separate local filters by observation vector partition method. The proposed filtering methods allow parallel processing of information and reduce both off-line and on-lin...