Yeboah Kwaku Opoku

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Verified

Yeboah verified their affiliation via an institutional email.

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• Ph.D
• Lecturer at University of Education, Winneba

Background: Schistosomiasis is considered one of the most devastating parasitic diseases globally, coming second only to malaria in terms of morbidity. The disease-causing parasite can inhabit the body for over a decade, leading to imbalances in the host’s metabolic systems. The flukes and their eggs can illicit various immunological and metabolic...

Introduction Tuberculosis is a global health problem that causes 1. 4 million deaths every year. It has been estimated that sputum smear-negative diagnosis but culture-positive pulmonary TB diagnosis contribute to 12.6% of pulmonary TB transmission. TB diagnosis by smear microscopy smear has a minimum detection limit (LOD) of 5,000 to 10,000 bacill...

Persistent diarrhoea and small bowel enteropathies are features of HIV infection. The coccidian parasites such as Microsporidium species, Cyclospora species, Cryptosporidium species, bacteria and cytomegaloviruses are implicated in HIV infections-associate diarrhoea. Determination of the prevalence of coccidian parasites and Microsporidium sp in HI...

Malaria kills an estimated 600,000 people each year, especially children under five years who reside in sub-Saharan Africa. Malaria fatalities are associated with severe forms such as cerebral malaria, acute respiratory failure, severe anaemia, renal failure, hypoglycaemia, and pulmonary oedema. Although the underlying pathogenic mechanisms in immu...

Objectives: Nrf2/ BACH1/ HO-1 proteins have been implicated in the development and progression of tumors. However, their clinical relevance in breast cancer remains unclear and understudied. This study evaluated Nrf2/ BACH1/ HO-1 protein expression and its relationship with age, tumor grade, tumor stage and TNM, ER, PR, HER2 and histologic type....

Rheumatoid arthritis (RA) is a common systemic autoimmune disease with global health importance. It is characterized by long-term complications, progressive disability, and high mortality tied to increased social-economic pressures. Rheumatic arthritis has an inflammatory microenvironment as one of the significant underlying factors and other compl...

Introduction Vulvovaginal candidiasis (VVC) is a public health problem with an estimated 138 million women globally experiencing recurrent VVC annually. The microscopic diagnosis of VVC has low sensitivity, but it remains an essential tool for diagnosis as the microbiological culture methods are limited to advanced clinical microbiology laboratorie...

Aims: To conduct a surveillance of antibiotic resistance patterns among Enterobacter species and Klebsiella pneumonia from clinical isolates between 2014 and 2020 at University of Cape Coast hospital Background:

Introduction Urgent surveillance is required to provide the needed information for the containment of multidrug resistant (MDR) Enterobacteriaceae . The objective was to examine the antibiotic-resistant patterns among the clinically isolated Enterobacter species and Klebsiella pneumonia from the outpatient department of the University of Cape Coast...

Rheumatoid arthritis (RA) is a common systemic autoimmune disease with a global health importance. It is characterized by long-term complications, progressive disability and high mortality tied to increased social-economic pressures. RA has an inflammatory microenvironment as one of the major underlying factors together with other complex proce...

Elevated levels of circulating fibroblast growth factor 21 (FGF21) have been reported in patients with hyperuricemia. However, the effect of FGF21 in hyperuricemic nephropathy (HN) remains unexplored. Here, we investigated the effect and mechanism of action of FGF21 on HN. HN model was induced with adenine and potassium oxysalt in wild‐type C57BL/6...

The evidence of rising numbers of multidrug-resistant organisms requires the implementation of effective stewardship programs. However, this should be informed by evidence-based knowledge of local antimicrobial resistance patterns. The current study aims to establish the prevalence of common pathogenic microbes including their antimicrobial suscept...

Background Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persists for longer than 1 h in patients with peripheral Plasmodium falciparum and no other explanation for encephalopathy. Significant r...

Uropathogenic Escherichia coli (E. coli) is an important urinary tract infection (UTI) that has been associated with both complicated and uncomplicated disease conditions. The global emergence of multiple drug-resistant (MDR) and extended-spectrum β-lactamase (ESBL) is of public health concern as the resistance limits the current treatment options....

The study sought to find out the impact of the use of internet on health-seeking-behavior among undergraduate students of University of Education, Winneba. The study employed the descriptive survey design using the quantitative research approach. A sample of 103 undergraduate students were conveniently selected from the five faculties in the Univer...

The study sought to find out the impact of the use of the internet on health-seeking behavior among undergraduate students of University of Education, Winneba. The study employed a descriptive survey design using the quantitative research approach. Samples of 515 undergraduate students were conveniently selected from the five faculties in the Unive...

Background The return of chloroquine-sensitive Plasmodium falciparum in sub-Saharan Africa countries offers the opportunity for the reintroduction of chloroquine (CQ) either in combination with other drugs or as a single therapy for the management of malaria. This study assesses the influence of individual study sites on the selection of CQ sensiti...

Chronic nonhealing wounds are painful with both psychological and financial cost to the affected patient tied to extensive economic repercussion on society. Here, we present a case of a 54-year-old man who has been living with a painful nonhealing septic ulcer wound for more than 30 years. Clinical examination revealed an extensive septic ulcerativ...

Currently, insulin is commonly used in the clinical management of canine diabetes. However, it must be injected preprandially causing much inconvenience to the owners. Therefore, the development of long-acting hypoglycemic agents has attracted much attention in the scientific community. This study aimed to investigate the long-acting hypoglycemic e...

Epidemiological investigations have shown an elevated expression of fibroblast growth factor 21 (FGF21) in the serum of patients with hyperuricemia. However, the effect of FGF21 on hyperuricemic nephropathy is still unknown. The purpose of this study, therefore, was to explore the effect and mechanism of action of FGF21 on hyperuricemic nephropathy...

Epidemiological investigations have shown an elevated expression of circulating fibroblast growth factor 21 (FGF21) of patients with hyperuricemia. However, the effect of FGF21 on hyperuricemic nephropathy (HN) is still unknown. The purpose of this study, therefore, was to explore the effect and mechanism of action of FGF21 on HN. The level of FGF2...

Pseudo-sclerodermas are neglected dermatological conditions associated with metabolic dysfunction of phenylalanine. Phenylalanine metabolic disorder is an autosomal genetic mutation in phenylalanine hydrolase (PAH). This mutation results in phenylalanine metabolism deficiency and subsequent accumulation of phenylalanine and phenylpyruvic acid in th...

Introduction The return of chloroquine-sensitive P. falciparum in sub-Saharan Africa countries offers the opportunity for reintroduction of chloroquine either in combination with other drugs or as a single therapy for the management of malaria. The reintroduction of chloroquine can serve as a stopgap to salvage the impending danger of complete fail...

Pseudo-sclerodermas are neglected dermatological conditions associated with metabolic dysfunction of phenylalanine. Phenylalanine metabolic disorder is an autosomal genetic mutation in phenylalanine hydrolase (PAH). This mutation results in phenylalanine metabolism deficiency and subsequent accumulation of phenylalanine and phenylpyruvic acid in th...

Background: Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has varied outcomes due to the kind of host cell and microorganism. The presence of autophagic compartments disrupt a significant number of pathogens and are further cleared by xenophagy in an autolysosome. Another...

Rheumatoid arthritis, a chronic degenerative autoimmune disease is hallmarked by tenacious inflammation of synovial membranes causing cartilage destruction and bone erosion. The search for effective therapies to mitigate its degenerative conditions remains partly elusive. Fibroblast growth factor 21 (FGF21) is known to modulate inflammation, playin...

Neurological dysfunction, one of the consequences of acute liver failure (ALF), and also referred to as hepatic encephalopathy (HE), contributes to mortality posing challenges for clinical management. FGF21 has been implicated in the inhibition of cognitive decline and fibrogenesis. However, the effects of FGF21 on the clinical and molecular presen...

Fibroblast growth factor-21 (FGF21) is a member of the family of fibroblast growth factors (FGFs). FGF21 (synthesized by many organs) has been studied extensively for its role in the regulation of energy homeostasis. FGF21 came into the spotlight after its beneficial metabolic effects in reducing blood glucose, and weight in obesity were identified...

The protozoan parasites are evolutionarily divergent, unicellular eukaryotic pathogens representing one of the essential sources of parasitic diseases. These parasites significantly affect the economy and cause public health burdens globally. Protozoan parasites share many cellular features and pathways with their respective host cells. This includ...

Background. HIV infection is marked by the production of cytokines by infected cells and cells of the immune system. Variations in the levels of cytokine in HIV-infected individuals significantly impact the role of the immune system with the possibility to affect the course of HIV disease by either exacerbating or suppressing HIV replication. Aim....

Dipylidiasis is a zoonotic parasitosis caused by a canine and feline tapeworm, Dipylidium caninum which rarely infects humans, usually infants and young children. The accidental ingestion of cysticercoid infected flea Ctenocephalides felis is the cause of this cestode infection in humans. Here we report the first and a rare case of adult dipylidias...

Background : Cardiovascular diseases (CVD) continue to be a major cause of death among post-menopausal women. We sought to assess cardiovascular risk among pre- and post-menopausal women living within the Cape Coast Municipality by comparing the lipid profiles and other emerging biomarkers of CVD, i.e. the atherogenic index of plasma (AIP), viscera...

Artisanal small-scale mining is widely operated in various countries serving as a livelihood to many rural communities. However, it is a significant source of environmental mercury contamination which affects human health. Amalgamation and amalgam smelting, two significant steps in the artisanal small-scale mining operations generate lots of mercur...

Mild stresses cause adaptive response by enhancing the ability to resist other stresses. Some of the most ubiquitous causes of stress in animals are cold and starvation. It is well known that exercise improves both skeletal muscle and cardiac function in vertebrates. However, the effect of cold stress on endurance training, has not been studied tho...

Background: Hemoglobinopathies may have impact on the red cell indices, and these are critical to the diagnosis of thalassemias. The key components of the complete blood count have been used in the diagnosis of α+-thalassemia. That is the mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and red blood cell counts (RBC) could therefo...

Due to obesity many risk factors arise, such as Type 2 Diabetes, Impaired Glucose Tolerance dyslipidemia, hypertension and metabolic homeostasis and disorder. FGF21 is a key regulating endocrine, lipid metabolism, glucose metabolism. Fibroblast growth factor-21 improves glucose tolerance in obese mice, lowers serum free fatty acids (FFA) & results...

In recent decades, biological agents such as tumor necrosis factor-α (TNF-α) inhibitors, have revolutionized the treatment of psoriasis. However, inhibition of a single cytokine may not achieve satisfactory therapeutic results. It is against this background that this research was undertaken to investigate the anti-psoriatic effect of a novel fusion...

Objective: To identify the socio-behavioral risk factors associated with cryptosporidiosis among HIV/AIDS patients with chronic diarrhea symptoms visiting the HIV referral clinic at Cape Coast Teaching Hospital, Ghana. Methods: A cross-sectional study was conducted among 50 HIV/AIDS patients with recurrent diarrhea. Questionnaires were administere...

This study was undertaken to generate a novel dual targeting fusion protein (DTF), targeting tumor necrosis factor α (TNF-α) and interleukin 17A (IL-17A), and determine its anti-arthritis properties in vitro and in vivo. DTF consisted of an anti-IL-17A single chain variable fragment, a soluble TNF receptor 1, and an Fc fragment. Both clinical and h...

Objective: To investigate the role CD4+ levels play in controlling diarrhea conditions caused by intestinal coccidian infections among HIV/AIDS infected individuals visiting Tarkwa Municipal Hospital. Methods: Fifty HIV/AIDS infected subjects with diarrhea conditions were enrolled into the study. Stool and blood samples were collected from each in...