Yaxiao Li

Yaxiao Li
University of Bath | UB · Department of Biology and Biochemistry

19.35
 · 
PhD

About

13
Publications
916
Reads
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92
Citations
Research Experience
January 2013 - October 2015
University of Bath
Position
  • PhD Student
September 2010 - December 2012
Shandong Agricultural University
Position
  • Master's Student
September 2006 - July 2010
Shandong Agricultural University
Position
  • Student

Publications

Publications (13)
Article
S‐acylation is a reversible posttranslational lipid modification in which a long chain fatty acid covalently attaches to specific cysteine(s) of proteins via a thioester bond. It enhances the hydrophobicity of proteins, contributes to their membrane association and plays roles in protein trafficking, stability and signalling. A family of Protein S‐...
Article
Seeds of Arabidopsis contain ~40% of triacylglycerol. It is converted to sugar to support post germination growth. We identified an Arabidopsis T-DNA knockout mutant that was sugar dependent during early seedling establishment. Our study showed that the β-oxidation process involved in catabolising the free fatty acids released from the seed triacyl...
Article
Full-text available
S-acylation, also known as S-palmitoylation or palmitoylation, is a reversible post-translational lipid modification in which long chain fatty acid, usually the 16-carbon palmitate, covalently attaches to a cysteine residue(s) throughout the protein via a thioester bond. It is involved in an array of important biological processes during growth and...
Article
Avermectin (AVM) has been widely used in agriculture and animal husbandry based on its broad spectrum of effective anthelmintic activity and specificity targets. However, AVM induction of cytotoxicity through DNA damage is still remains elusive. Here we investigate the cytotoxic effects of AVM in human non-target cells in vitro. We clarify that AVM...
Article
Full-text available
Eicosapentaenoic acid (EPA, 20:5Δ5,8,11,14,17) and Docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) are nutritionally beneficial to human health. Transgenic production of EPA and DHA in oilseed crops by transferring genes originating from lower eukaryotes, such as microalgae and fungi, has been attempted in recent years. However, the low yield of E...
Data
Prediction of frequency of codon usage of IgASE1 when expressed in Arabidopsis thaliana. The columns in red are the mostly rare codons used by Arabidopsis thaliana. The height of the column represents the frequency of codon usage. The 3 CGC codons at positions 10, 20 and 84 are marked in red arrows. (PPTX)
Data
Prediction of frequency of codon usage of PinD6 when expressed in S. cerevisiae. The height of the column represents the frequency of codon usage. The rarest 4 CGC codons at positions 9, 276, 376 and 433 are marked in red arrows and cluster of 2 codons with less than 30% usage are marked with red stars. (PPTX)
Article
Tebufenozide is considered an environmentally friendly pesticide due to its specificity on target insects, but the effects on human are well studied. Studies on the toxicity of tebufenozide at molecular and cellular level is poorly understood. The present study reveals non-selective cytotoxic effects of tebufenozide, and the apoptotic mechanism ind...
Article
Full-text available
The Asp-His-His-Cys cysteine rich domain (DHHC-CRD) containing Protein S-Acyl Transferases (PATs) are multi-pass transmembrane proteins that catalyze S-acylation (commonly known as S-palmitoylation), the reversible posttranslational lipid modification of proteins. Palmitoylation enhances the hydrophobicity of proteins, contributes to their membrane...
Article
Full-text available
IgASE1, a C18 Δ9-specific polyunsaturated fatty acid elongase from the marine microalga Isochrysis galbana, is able to convert linoleic acid and α-linolenic acid to eicosadienoic acid and eicosatrienoic acid in Arabidopsis. Eicosadienoic acid and eicosatrienoic acid are precursors of arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid...
Article
Full-text available
Multiple gene transfer (MGT) technology has become a powerful tool for basic and applied plant biology research in recent years. Despite some notable successes in obtaining plant lines harbouring multiple transgenes, these methods are still generally unwieldy and costly. We report here a straightforward and cost effective strategy, utilizing common...

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Cited By

Projects

Project (1)
Project
The Asp-His-His-Cys cysteine rich domain (DHHC-CRD) containing Protein S-Acyl Transferases (PATs) are multi-pass transmembrane proteins that catalyze S-acylation (commonly known as S-palmitoylation), the reversible posttranslational lipid modification ofproteins. Palmitoylation enhances the hydrophobicity of proteins, contributes to their membrane association and play roles in protein trafficking and signaling. We are working out the roles of different PATs in Arabidopsis.