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Yasuhiko Deguchi

Yasuhiko Deguchi
Osaka Metropolitan University · Neuropsychiatry

MD.,PhD.

About

35
Publications
2,890
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244
Citations

Publications

Publications (35)
Article
Full-text available
Background The number of patients living with depression continues to increase in Japan. The economic effects of depression include loss of productivity due to both absenteeism and presenteeism. Gender differences have been reported in prevalence, onset pathways and subjective symptoms of depression. Aims To understand how workers with major depre...
Article
Full-text available
Objective: Our previous metabolomics study showed that the plasma nervonic acid levels were higher in patients with major depressive disorder (MDD) than those in healthy controls and patients with bipolar disorder (BD). To examine whether the nervonic acid levels differ in the central nervous system, we investigated the levels in the cerebrospinal...
Article
Full-text available
The severity of major depressive disorder (MDD), which is related to the depressive symptoms , is a predictor of clinical outcomes and may be used to determine the appropriate treatment. However, there is a lack of systematic research on the relationship between early depressive symptoms and MDD severity. This study aimed to clarify the association...
Article
Background Patients with bipolar disorder (BD) have increased plasma IL-6 levels, which are higher in depressed BD (dBD) than remitted BD (rBD). However, the mechanism that differentiates the cytokine levels between dBD and rBD is not understood. First, we determined whether brain-derived mtDNA can be detected in plasma using neuron-specific mutant...
Article
Full-text available
This study aims to clarify the effect of occupational stress and changes in the work environment on non-healthcare workers’ (HCWs) mental health during the third wave of the COVID-19 pandemic in Japan. A web-based, cross-sectional survey was conducted from 16 to 17 December 2020. Data from 807 non-HCWs were included. We evaluated occupational stres...
Article
Full-text available
Background: Antipsychotics with dopamine (D2) receptor antagonism can be effective for emesis in cancer patients. Extrapyramidal symptoms (EPS) induced by typical antipsychotics can be exacerbated by other D2 receptor antagonists. We describe a case of persistent EPS induced by long-term, intermittent administration of low-dose olanzapine along wi...
Article
Sickness absences are a significant public health and economic problem worldwide. However, sickness absence diagnoses and trends have not been reported in much detail in Japan. This study was a retrospective cohort study. We examined data on certified diagnoses and the durations of sickness absence lasting over 90 days (long-term sickness absence)...
Article
Background: The work required to assist individuals in improving their mental health is stressful and known to be associated with burnout. In Japanese companies, non-medical occupational health (OH) staff often take the role of maintaining and improving workers' mental health. However, few studies have examined burnout in this population. Aims:...
Article
Full-text available
Background: Stigma related to mental illness can be an obstacle affecting the quality of life of people with mental illness. Although mental illness in the workplace is a public problem globally, few studies have investigated the effect of stigma on job-related problems such as burnout. Aim: This study aimed to clarify the association between me...
Article
Background: Teaching is one of the most stressful occupations. Over the last decade, about 5000 Japanese public school teachers per year have taken sick leave due to a mental illness. School principals and vice principals also face occupational stress, although few studies have examined occupational stress in these groups. Aims: To clarify the r...
Article
Full-text available
Most teachers have a high risk of work-related stress and mental disorders. Drunken driving and hazardous alcohol consumption (HAC) among teachers are social problems. Gender differences among teachers in burnout, occupational stress, self-efficacy and job satisfaction were reported. This study aimed to clarify gender differences in the relationshi...
Data
NIOSH-GJSQ score calculation. (PDF)
Data
Questionnaire in Japanese. (PDF)
Article
Background: Work-related stressors are associated with low sleep quality. However, few studies have reported an association between role stressors and sleep quality. Aims: To elucidate the association between role stressors (including role conflict and ambiguity) and sleep quality. Methods: Cross-sectional study of daytime workers whose sleep...
Article
Background: Diagnostic biomarkers of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) are urgently needed because none are currently available. Methods: We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with MDD (n = 9), BD (n = 6), SZ (n = 17), and matched healthy controls (...
Article
Full-text available
After workers take long-term sickness absence due to mental disorders (LTSA-MD), the occupational stress of the coworkers in the same work unit might be affected. The aims of this study were to evaluate the effect of the incident of LTSA-MD on the coworkers' occupational stress. A retrospective cohort study of 16,032 public servants was conducted....
Article
Full-text available
Background: Although inflammatory cytokines are established biomarkers of mood disorders, their molecular mechanism is not known. We hypothesized that circulating mitochondrial DNA (mtDNA) contributes to inflammation and could be used as biomarkers. We investigated if circulating mtDNA level is associated with inflammatory cytokines and can be use...
Article
Full-text available
Insomnia among workers reduces the quality of life, contributes toward the economic burden of healthcare costs and losses in work performance. The relationship between occupational stress and insomnia has been reported in previous studies, but there has been little attention to temperament in occupational safety and health research. The aim of this...
Data
GJSQ scores, Temperaments and AIS scores by position classification (XLSX)
Data
GJSQ scores, Temperaments and AIS scores by gender (XLSX)
Data
GJSQ scores, Temperaments and AIS scores by type of employment (XLSX)
Data
GJSQ scores, Temperaments and AIS scores by occupation (XLSX)
Article
Full-text available
Aims: There is an urgent need for diagnostic biomarkers of bipolar disorder (BD) and schizophrenia (SZ); however, confounding effects of medication on hamper biomarker discovery. In this study, we conducted metabolome analyses to identify novel plasma biomarkers in drug-free patients with BD and SZ. Methods: We comprehensively analyzed plasma me...
Article
Full-text available
The relationship between temperaments and mental disorders has been reported in previous studies, but there has been little attention to temperaments in the occupational safety and health research. The aim of this study was to clarify the effects of temperaments on occupational stress among local government employees. The subjects were 145 Japanese...
Article
Full-text available
Japanese teachers are mentally and physically burdened with various work stressors. This cross-sectional study examined the relationship between depressive symptoms and perceived individual level occupational stress including role problems among Japanese schoolteachers. This study included 1,006 teachers working in public schools in a Japanese city...
Article
BACKGROUND: Aggression in the workplace is increasingly recognized as a serious problem, but there are few studies about worker aggression toward outsiders in the workplace. We investigated the association between aggression and occupational stress among teachers.
Article
Full-text available
The traditional Japanese personality "shinkeishitsu" has become almost outdated even in modern Japanese psychiatry, yet the shinkeishitsu trait can still be found among the Japanese population. Shinkeishitsu relates phobic anxiety disorders, panic disorder, generalized anxiety disorder, obsessive-compulsive disorder, and somatoform disorder. Howeve...
Article
Full-text available
The relationships between occupational stress and depressive symptoms in prison officers have rarely been studied in Japan. Thus, we analyzed the associations between occupational stress factors and depressive symptoms among Japanese prison officers. This was a cross-sectional study involving 426 male prison officers (20-60-year-old). Depressive sy...

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