Yasser Fakri Mustafa

University of Mosul · College of Pharmacy

The aim of this paper is to better understand the dynamics of crystallogenic and starting activity in biological fluids of patients throughout surgery and the late postoperative phase in alveococcosis. Samples of saliva from 22 individuals with alveococcosis were included in the research. Biological fluid samples were taken at the time of admission...

Nanoparticles (NPs) are insoluble particles with a diameter of fewer than 100 nanometers. Two main methods have been utilized in orthodontic therapy to avoid microbial adherence or enamel demineralization. Certain NPs are included in orthodontic adhesives or acrylic resins (fluorohydroxyapatite, fluorapatite, hydroxyapatite, SiO2, TiO2, silver, nan...

The seeds of two watermelon cultivars-allsweet and princess-were explored in this study as sources of potential biosafe natural antioxidant and anticancer agents. In the first algorithmic step, the acquired seeds were extracted using four solvents and three different extraction methodologies in each of the three modes. Second, the primary and secon...

Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays an important role in their medical action. Syn...

Article history: Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which have been instrumental in the...

Any solid, unprotected, and undefended surface in the aquatic environment will be fouled. Fouling, on the other hand, can affect a wide range of species that can tolerate some epibiosis. Several others, on the other hand, aggressively keep the epibionts off their body surface (antifouling). Antifouling defenses are built into marine plants like sea...

Article history: Background: The numerous additional valued substances present within plant biowaste products have a wide range of candidates regarding their recycling, promoting the idea of the circular economy. The bell pepper (BP, Capsicum annum L.) has high concentrations of various vitamins and minerals. Also, the biowastes of this plant, incl...

Modulatory signaling pathway such as T cell immunoreceptor with Ig and ITIM domains (TIGIT), Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4), P53 signaling and TIM (T-cell immunoglobin and mucin domain) are important in normal pregnancy and loss of their functions or dysregulation of related genes can lead to some disorders. Inflammation is a...

Altered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of...

Background Kidney stones (KSs), in fact, have been considered one of the most ancient and prevalent medical conditions that impact a significant number of human beings all around the world. Such stones can range greatly in size and can be detected in any part of the urinary system, including the kidneys, ureters, or bladder itself. The development...

Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed papers. Aim: The literature that has b...

Cancer is a complex genetic anomaly involving coding and non-coding transcript structural and expressive irregularities. A class of tiny non-coding RNAs known as microRNAs (miRNAs) regulates gene expression at the post-transcriptional level by binding only to messenger RNAs (mRNAs). Due to their capacity to target numerous genes, miRNAs have the po...

In this study, aluminium alloy 1050 strips were bonded together using the electrically assisted roll bonding process (EARB) atelectric current levels from 0 A up to 300 A. The effect of electric current level and plastic strain as the two main EARB parametershave been investigated on bonding strength by using the peel test. Results showed that by i...

During the last decades, the ever-increasing incidence of various diseases, like cancer, has led to a high rate of death worldwide. On the other hand, conventional modalities (such as chemotherapy and radiotherapy) have not indicated enough efficiency in the diagnosis and treatment of diseases. Thus, potential novel approaches should be taken into...

One of the best treatments for inflammatory diseases such as COVID -19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal mode...

The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become a subject of intense research in recent years. This oxysterol, derived from cholesterol, has been identified as a significant player in modulating immune responses and inflammation. Its involvement in autoimmune pathogenesis has drawn attention to its potential as a therap...

The production of harmful free radicals (H-FRs), especially those with oxygen or nitrogen atoms, depends on both internal and environmental causes. The negative effects of H-FRs are greatly alleviated by antioxidant protection. The harmful impact of oxidative stress, or OS, is brought on by a disparity between the defense mechanisms of the body and...

Aims This study aimed to summarize earlier randomized controlled trials on the effects of watermelon supplementation on blood pressure (BP) in adults. Methods A systematic search was performed in electronic databases including PubMed, Scopus, and ISI Web of Science up to May 2021. To compare the effects of watermelon with control, differences in w...

In this study using accumulative press bonding (APB) process, bimetal AA1060 and AA5083 have been fabricated. The aluminum bars were first press bonded and then this process continued up to five pressing steps. In the APB process, the composite samples were preheated at 320°C for 7 min before each pressing step. Mechanical-properties-of the-AA1060-...

MicroRNAs, as a major type of noncoding RNAs, have crucial roles in various functions during development. Available data have shown that miR-542-3p decreased in various types of cancers. MiR-542-3p is engaged in various cancer-related behaviors like glycolysis, metastasis, epithelial-to-mesenchymal transition (EMT), cell cycle, apoptosis, and proli...

Spinal cord injury (SCI) following trauma is a devastating neurological event that can lead to loss of sensory and motor functions. However, the most effective measures to prevent the spread of damage are treatment measures in the early stages. Currently, we investigated the combined effects of hyperbaric oxygen (HBO) along with epigallocatechin-3-...

This paper presents a highly effective approach aiming to produce derivatives of aromatic sulfoxides. The method utilizes environmentally friendly reaction conditions and offers improved efficiency in the synthesis process. The sodium bromide (NaBr) reagent has been used in a unique and chemo-selective way to electro-oxidize sulphides to sulfones....

Signal transducers and activators of transcription 3 (STAT 3) have been proposed to be responsible for breast cancer development. Moreover, evidence depicted that upregulation of STAT3 is responsible for angiogenesis, metastasis, and chemo-resistance of breast cancer. Tamoxifen (TAM) resistance is a major concern in breast cancer management which i...

The design and synthesis of new drugs are increasingly challenging in chemistry settings. The synthesis is itself lured by the properties of the product after synthesis, including solubility, hygroscopicity, intensive adverse effects, and biological inefficacy; hence, the creation of a new drug should be considered in light of the avoidance of thes...

Long non-coding RNAs (lncRNAs) are non-coding RNAs that were transcribed from the human genome and have become important regulators in a number of cellular activities, mostly via controlling gene expression. A growing body of evidence shows that lncRNAs regulate various factors to impact various biological activities that are related to tumorigenes...

This systematic review was conducted to estimate the pooled score of death anxiety during the COVID-19 pandemic. All eligible articles from January 2020 to May 2022 reporting the death anxiety score were included in the analysis b.y searching the Scopus, PubMed, Embase, and ISI databases. The standard score of death anxiety in the COVID-19 pandemic...

Most gas emissions by motor automobiles include unburned hydrocarbons, carbon monoxide, and other oxides (N x O y , SO x , etc.). There are many hydrocarbon compounds in car exhaust, such as benzopyran, formalde-hyde, butadiene, and so on. In this study, anatase titanium dioxide nano-particles (aTiO 2-NPs) filters are investigated to prevent the en...

Colorectal cancer (CRC) is comprised of transformed cells and non-malignant cells including cancer-associated fibroblasts (CAF), endothelial vasculature cells, and tumor-infiltrating cells. These nonmalignant cells, as well as soluble factors (e.g., cytokines), and the extracellular matrix (ECM), form the tumor microenvironment (TME). In general, t...

In this paper, ferromagnetic Fe2O3/Mn2O3 nanocomposites (Fe@Mn-1 and Fe@Mn-2) were synthesized and characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), a vibrating sample magnetometer (VSM), and transmission electron microscope (TEM). Fe@Mn-1 and Fe@Mn-2 nanocomposites were successfully synthesized and they...

The extracellular matrixes (ECM), as well as the microenvironmental signals, play an essential role in osteogenesis by regulating intercellular pathways. Recently, it has been demonstrated that a newly identified RNA, circular RNA, contributes to the osteogenesis process. Circular RNA (circRNA), the most recently identified RNA, is involved in the...

Background Previous studies have shown that physical appearance perfectionism could play an important role in social physique anxiety; however, the moderating role of body compassion has not been studied. The current study aims to explore the moderating role of body compassion in the relationship between physical appearance perfectionism and social...

Publication in the Iraqi Journal of Pharmacy (https://iphr.mosuljournals.com/) is free when a non-Iraqi author submits an article via official email, regardless of whether the list of authors includes Iraqi researchers.

Biofilm-related infections substantially contribute to bacterial illnesses, with estimates indicating that at least 80% of such diseases are linked to biofilms. Biofilms exhibit unique metabolic patterns that set them apart from their planktonic counterparts, resulting in significant metabolic reprogramming during biofilm formation. Differential gl...

Corrosion and scaling are among the problems that may arise when storing water in tanks. Several factors affect the corrosion and scaling of water, which include pH, temperature, alkalinity, Ca 2+ hardness, TDS, concentrations of Cl-, SO 4 2-, CO 3 2-, and HCO 3-. Also, several indices can be measured using these properties such as the Langelier sa...

Long non-coding RNAs (lncRNA) have been identified as essential components having considerable modulatory impacts on biological activities through altering gene transcription, epigenetic changes, and protein translation. Cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), a recently discovered lncRNA, was shown to be substantially el...

Sludge from stone-cutting (SSC) factories and stone mines cannot be used as decorative stones, stone powder, etc. These substances are left in the environment and cause environmental problems. This study aim is to produce artificial stone composite (ASC) using sludge from stone cutting factories , cement, unsaturated resin, water, silicon carbide n...

Background The adverse health influences of polycyclic aromatic hydrocarbons (PAHs) exposures have been examined in several previous research. However, the evidence on the health influences of PAHs exposure during pregnancy and childhood is scarce, with no study on the infant's liver function. Therefore, in this study, the association of in-utero e...

During the radiotherapeutic treatment of pediatric oncology patients, they would be at a latent risk of developing ionizing radiation-induced ototoxicity when the cochlea or auditory nerve is located within the radiation field. Sensorineural hearing loss (SNHL) is an irreversible late complication of radiotherapy, and its incidence depends on vario...

Context: Arsenic has metallic and non-metallic properties. It is widely found in sulfide ores and belongs to the nitrogen family. Arsenic is used as an insecticide due to its high toxicity. Arsenic has caused many environmental concerns, including the widespread availability of arsenic in the environment, biological toxicity, and exploitation. Pote...

In this research, a facile and efficient protocol for the synthesis of rizatriptan analogues using natural deep eutectic solvents as an inexpensive, easily available, and environmentally friendly catalyst is developed. The reaction of various phenyl hydrazines (a–j) and 3,3-dimethoxy-N,N-dimethylpropan-1-amine (2) using natural deep eutectic solven...

Foodborne pathogenic bacteria exist in different forms in foodstuffs and pose a great threat to public health. Therefore, the rapid and touchy orientation of bacterial pollutants in food is urgently required to prevent the spread and emergence of foodborne illnesses. Thanks to the superiority of simple construction, rapidness, brilliant sensitivity...

Purpose: Ototoxicity is one of the major adverse effects of cisplatin therapy which restrict its clinical application. Alpha-lipoic acid administration may mitigate cisplatin-induced ototoxicity. In the present study, we reviewed the protective potentials of alpha-lipoic acid against the cisplatin-mediated ototoxic adverse effects. Methods: Based...

This work was aimed at synthesising and characterising five new conjugates of aspirin with aromatic amino acids and testing them in vitro as potential selective cyclooxygenase 2 (COX-2) inhibitors. The conjugates were synthesized by a 3-step approach and successfully characterized by analyzing their 1 H and 13 C NMR and optical spectra. The in vitr...

Parkinson’s disease (PD) as a prevalent neurodegenerative condition impairs motor function and is caused by the progressive deterioration of nigrostriatal dopaminergic (DAergic) neurons. The current therapy solutions for PD are ineffective because they could not inhibit the disease’s progression and they even have adverse effects. Natural polypheno...

Neurodegenerative diseases are age-related, multifactorial, and complicated conditions that affect the nervous system. In most cases, these diseases may begin with an accumulation of misfolded proteins rather than decay before they develop clinical symptoms. The progression of these diseases can be influenced by a number of internal and external fa...

Eighteen novel functionalized phenyl acetate derivatives of benzo[e]-bispyrone fused hybrids and their three precursors are developed in this study. The precursor acetic acid congeners of benzo[e]-bispyrone fused hybrids (Y1, Y8, and Y15) were created by combining acetone dicarboxylic acid and three resorcinol-based compounds. They were utilized in...

Purpose: Although chemotherapy and radiotherapy are effective in cancer treatment, different adverse effects induced by these therapeutic modalities (such as ototoxicity) restrict their clinical use. Co-treatment of melatonin may alleviate the chemotherapy/radiotherapy-induced ototoxicity. In the present study, the otoprotective potentials of mela...

Acute myocardial infarction (AMI) is a type of cardiac disease which is one of the main reasons for mortality worldwide. The fabrication of reliable diagnosis methods to predict heart attacks is difficult due to the low-level concentration of responsible biomarkers and limited time between the first symptoms and the heart attack. However, new advan...

Chemical sensors could pioneer great utilities in point-of-care diagnostic medical devices. Therefore, the interaction of the B24N24 and Al24N24 nano-clusters with phenytoin was theoretically studied to explore a potential chemical sensor. All calculations were performed using the B3LYP-D method in the gas and solution phases. The absorption energi...

Circular RNAs, as a type of non-coding RNAs, are identified in a various cell. Circular RNAs have stable structures , conserved sequence, and tissue and cell-specific level. High throughput technologies have proposed that circular RNAs act via various mechanisms like sponging microRNAs and proteins, regulating transcription factors , and scaffoldin...

Prostate carcinoma is a malignant situation that arises from genomic alterations in the prostate, leading to changes in tumorigenesis. The NF-κB pathway modulates various biological mechanisms, including inflammation and immune responses. Dysregulation of NF-κB promotes carcinogenesis, including increased proliferation, invasion, and therapy resist...

Significant health issues have lately been brought on by the dramatic increase in pathogenic microbes that are resistant to antibiotics. To manage or fight infections brought on by pathogens, investigators are looking for substitutes for currently used antimicrobial agents. Numerous approaches are being used to create effective antimicrobial agents...

Background: Recognizing and strengthening emotional intelligence is useful in all members of society, especially students. By recognizing emotional intelligence and applying it, students can achieve more success in their career. The aim of this study was to investigate the relationship between emotional intelligence and academic achievement among s...

In today's world, wound healing is a growing serious problem for clinical institutes. In this study, nanofi-brous scaffolds were prepared using polyurethane as a mat scaffold. Also, by immersing curcumin as an antibacterial component another scaffold was fabricated using the elec-trospinning technique. The obtained scaffolds were characterized by m...

This study aimed to investigate the potential of Coumarin C1 and C2 derivatives from apple seeds and Anpro supplementation to neutralize aflatoxin B1 in the quail diet., 3weeks -old quails were distributed into five-treatment each has 10 birds randomly. First treatment, negative control, in which the quails received not contaminated diet. Second tr...

This study was conducted in the laboratories of the Departments of Plant Protection and Animal Production at the College of Agriculture and Forestry / University of Mosul, and the Pharmacognosy laboratory of the College of Pharmacy / University of Mosul for the period from 3/9/2020 to 4/5/2022.The aims at identifying fungi contaminating local maize...

CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as SDF-1), which makes CXCL12/CXCR4 axis. CXCR4 interacts with its ligand, triggering downstream signaling pathways that influence cell proliferation chemotaxis, migration, and gene...

Liver cancer is the sixth most prevalent cancer and ranks third in cancer-related death, after lung and colorectal cancer. Various natural products have been discovered as alternatives to conventional cancer therapy strategies, including radiotherapy, chemotherapy, and surgery. Curcumin (CUR) with antiinflammatory, antioxidant, and antitumor activi...

Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with many adverse health outcomes. However, the evidence on such associations with the liver function was not reviewed systemically. Therefore in this study, we systemically reviewed the observational studies on exposure to PAHs and liver function. The MOOSE guidelines were app...

In an attempt to find versatile and readily accessible coumarin scaffolds with a broad spectrum of biomedical properties, seven bisimidazole–coumarin conjugates were synthesized through several steps starting from metacetamol and malonic acid. Spectroscopical techniques including FTIR, 1H-NMR, and 13C-NMR were employed to confirm the chemical backb...

Coumacine is a brand-new heterocyclic molecular nucleus that was discovered in 2018. In addition to the unique heterocycle known as coumacine, the designer has developed two variants known as coumacine I and II. Coumacine derivatives had been evaluated for their antibacterial effects in vitro against a variety of aerobic and anaerobic bacteria usin...

Due to its beneficial components, such as glycyrrhizin, licorice is regarded a medicinal and fragrant plant. This research was designed to investigate the efficacy of licorice essential oil as an alternative to chemical antibiotics on broiler production, carcass features, cellular and humoral safety, and numerous biochemical variables in broiler bl...

Background: Scientists have been paying attention to the life-giving properties of medicinal plants for many years. Among these plants is the eucalyptus plant. This plant has various compounds such as cineole and terpenes. It also contains compounds such as flavonoids, aliphatic aldehydes, sesquiterpene, quinotanen, catechins, salts, and vitamins....

Background: Phytic acid is a stored form of phosphorus in cereals so 65 to 70% of phosphorus in plant sources is phytate, and broilers are only able to use part of the phosphorus in plant sources. To meet the needs of chickens, it is necessary to use other artificial resources, which not only impose part of the cost of the breeding period, because...

The use of pesticides to eliminate pests and weeds has raised concerns about water pollution and adverse effects on aquatic organisms, so many efforts have been made to increase the resistance of fish to these pesticides by using a proper nutrition strategy. Therefore, the aim of this study is to investigate the growth performance, antioxidant, and...

Cancer is a virulent disease that is regarded as a black-hearted and evil-minded illness in many human civilizations because it develops silently and without warning until it reaches a life-threatening stage. In the management of cancer, chemotherapy represents the principal option but has significant toxic effects that negatively influence the pat...

Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no damage to normal cells in the process. Because of their specific features, such as, the ability to induce immunogenic cell death and to contain curative transgenes in their genomes, OVs have attracted attention as candidates to be utilized in cooperatio...

The following consecutive phases made up the synthetic strategy that was used in this study to reach the target: Acetone dicarboxylic acid was initially created by combining citric acid with sulfuric acid. Then, using two entries based on the Pechmann reaction, resorcinol and its substitutes were combined with acetone dicarboxylic acid to create no...

Schiff base-inorganic complexes have significantly contributed to the development of modern drug design due to their significance in a number of multi-discipline study fields. This nearly exhaustive review examines every aspect and characteristic of these complexes, with a focus on a few key biomedical traits. Schiff base, the organic component of...

Background: Coumarins and their derivatives excel in chemical diversity, coupled with a wide variety of biological potentials, and tend to be beneficial to the health of the human body. One of these derivatives that has sparked the attention of medicinal chemistry specialists in recent decades is benzo-fused coumarins, which have demonstrated their...

Synthesis of high viscosity, ecofriendly, and low melting point poly(ionic liquid)s (LMP-PIL) with network structure has been introduced by the reaction of 1,1′,1′′‑(1,3,5‑triazine‑2,4,6‑triyl) tris(3‑methyl‑1H‑imidazol‑3‑ium) iodide ionic liquid (TAIm[I] IL) monomer with disodium salts of various open-chain carboxylic acids as well as sulfonic aci...

In atherosclerosis, the gradual buildup of lipid particles into the sub-endothelium of damaged arteries leads to numerous lipid alterations. The absorption of these modified lipids by monocyte-derived macrophages in the arterial wall leads to cholesterol accumulation and increases the likelihood of foam cell formation and fatty streak, which is an...

In today’s world, the stability and affordability of food colorants have caused to attracted considerable attention in the food industry. Food dyes attract the appearance of food by increasing color of that while the harmful effect of these dyes on living organs is undeniable. Synthetic food colors are becoming more common than natural ones via foo...

Hydroxycoumarins and their based conjugates revealed a wide-ranged biological activity providing potential scaffolds to serve better in therapy. This work aims to synthesize six new azo-coumarinic conjugates termed SY1-SY6 and investigate their potentials as antitumor and antibacterial applicants. The synthesis of these conjugates started from cant...

Background: Urtica dioica (UD), as a natural antioxidant, has positive effects on oocyte maturation. This study aimed to investigate the effects of hydro-alcoholic UD extract and retinoic acid on follicular development in an in vitro fertilization (IVF) condition. Methods: A total of 40 female Wistar rats were randomly divided into 5 groups: group...

Using notch geometry in the metallic glass (MG) samples, it is possible to improve the homogeneous plasticity and mechanical properties. In this work, the molecular dynamics (MD) simulation was performed to indicate how the alloying composition of MGs can tune the mechanical properties of notched samples. For this purpose, CuZr MGs were constructed...

Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified...

Using molecular dynamics (MD) simulation, the pressure bonding of Cu54Zr46 metallic glass (MG) was performed under the introduction of an oxygen layer at the interface with different thicknesses. The results indicated that the evolution of the oxide layer in the joint zone was consistent with the inverse logarithmic law, which meant that the oxide...

Objective(s): Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties. Materials and Methods: The MTT assay was used to assess the cytotoxic activity of corosolic acid on MDA-MB-231 and MCF7 cell lines. To determine the apoptotic cells, the...

Background: Although radiotherapy is one of the main cancer treatment modalities, exposing healthy organs/tissues to ionizing radiation during treatment can lead to different adverse effects. In this regard, it has been shown that the use of radioprotective agents may alleviate the ionizing radiation-induced toxicities. Objective: The present stud...

To find a potential sensor for the carbamazepine (CBZ) drug, pure and doped Zn12O12 nanoclusters were utilized to adsorption CBZ using the density functional theory (DFT) calculation. After adsorption of CBZ on the Zn12O12, AlZn11O12, and GaZn11O12 nanoclusters, the adsorption energies were calculated at −104.31, −142.51, and −94.89 kJ mol−1, respe...

Nowadays, our societies are entangled with numerous problems more and more. One of them is food safety, which has a direct relationship with public health. Indeed, food contaminations have been categorized as some important groups including bacteria, viruses, heavy metals, toxins, pesticides, food colorants and so forth. Over the last two decades,...

The reproductive system is extremely vulnerable to chemotherapy drugs, ionizing radiation, toxic heavy metals, chemicals, and so on. These harmful stimuli are able to induce oxidative damage, apoptosis, inflammation, and other mechanisms in the reproductive organs, leading to different adverse reproductive effects. It was shown that using medicinal...