Active and an eminent new researcher in the field of Pharmacology specially focusing on Gene knockin/knock out models.
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August 2013 - October 2018
Field of study
Methanolic extract of Morinda citrifolia unripe fruit (MMC) was tested against heroin addiction using a mouse modified runway model of drug-seeking. Habituation sessions were carried out for 10 min/d for 3 days. On day 0, the total run time of each mouse was noted (the start box to goal box) during the preconditioning test. This was followed by the...
ABSTRACT Introduction: Morinda citrifolia unripe fruit methanolic extract (MMC) was tested against heroin addiction using a modified mouse runway model. Methods: Habituation session was adopted for 10 min/d for 3 days. On day 0, the preconditioning test was conducted and the total run time of each mouse was noted (the start box to goal box). Then...
How to cite this article: Khan Y, Pandy V. Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm. J Res Pharm. 2020; 24(5): 632-639. ABSTRACT: In this study, we used methanolic extract of Morinda citrifolia Linn. fruit (MMC) in order to find its effect against ethanol seeking behavior in a modifi...
Phytotherapy is an emerging field successfully utilized to treat various chronic diseases including alcohol dependence. In the present study, we examined the effect of the standardized methanolic extract of Morinda citrifolia Linn. unripe fruit (MMC), on compulsive ethanol-seeking behavior using the mouse conditioned place preference (CPP) test. CP...
Morinda citrifolia L. commonly known as noni or Indian mulberry belongs to the family Rubiaceae. Noni fruit juice has recently become a very popular remedy for the treatment of several diseases, including psychiatric disorders. This study aimed to investigate the anticraving effect of Tahitian Noni® Juice (TNJ) against ethanol seeking behavior in I...
The present study established a novel mouse model of a runway drug self-administration in our laboratory. The operant runway apparatus consisted of three long runways arranged in a zig-zag manner. The methodology consisted of six distinct phases: habituation, preconditioning, conditioning, post-conditioning, extinction and reinstatement. The effect...
2015 Golden Helix Symposium - Next Generation Pharmacogenomics, Kuala Lumpur, Malaysia; 03/2015
Public Health Genomics 2015;18(suppl 1):1–51
The current study in our laboratory for a first time demonstrated the modified version of the oparent runway model of drug self-administration in mice permitted a more efficient long-term examination of runway operant behavior for IP drug reinforcement. The operant runway apparatus consisted of three long runways in a zig-zag manner. The operant ru...
Herbs have been used for several cardio vascular diseases, such as congestive heart failure, hypertension, angina pectoris, atherosclerosis, arrhythmia, cerebral and venous insufficiency. Atherosclerosis is the primary cause of heart disease and stroke. Hence blood lipid levels are probably the major determinant of the development of cardiovascular...
I hope you keeping well. I am Dr Yasmin Khan from Pakistan. I work at ICCBS (International Center for Chemical and Biological Sciences). "International Center for Chemical and Biological Sciences (ICCBS)" is a postgraduate UNESCO accredited research institute located in Karachi, Pakistan. It governs under the University of Karachi.
In Pakistan, no research center or university has a SPF level small laboratory animal facility. ICCBS institute has been given a task by Higher Education Commission, Pakistan to develop a national level SPF facility with the capacity to develop, and breed genetically modified mice for research purposes. This may also include the training of national researchers to acquire the required skills. Furthermore, this is also a need of time to properly manage the colonies of the genetically modified mice. For these reasons, we are looking for opportunities around the world institutions to build capacity building collaborations in this area of research. If you are interested in collaboration with ICCBS. Kindly let me know. I am waiting for your positive response.
I need accurate dose of Apomorphine for drug abuse as we know that apomorphine has biphasic effects.
I am going to analyse brain neurotransmitters and for that I want to know after brain sectioning how to store brain samples for one month under -80?
I am interested to analyse brain neurotransmitters (GABA, Glycine, Dopamine and Glutamic acid). I need to know how and by which method i can easily analyse neurotransmitters (ELIZA, HPLC. LCMS Or IHC) also I need to know by which samples (tissues or fluids).