Yasir Sharif

University of the Punjab | PU · Institute of Biochemistry and Biotechnology

Background: Trace elements are the essential elements that are involved in systematic development and proper functioning of the human body. In beta thalas-semia patients, variations of their concentration that eventually lead to the death of erythrocytes and hence worsen the disorder, have been reported. Objective: The purpose of the current study...

The reason of high mortality rate in the patients of beta-thalassemia major is iron overload because it leads to many secondary complications. Condition of iron overload is known as hemochromatosis (HC). HC causes distorted formation of HFE protein that disturbs the whole pathway of HAMP protein synthesis which results in unbounded form of ferropor...

Background: Trace elements are the essential elements that are involved in systematic development and proper functioning of the human body. In beta thalassemia patients, variations of their concentration that eventually lead to the death of erythrocytes and hence worsen the disorder, have been reported. Objective: The purpose of the current study w...

Objectives: To evaluate any association between the frequency of hereditary hemochromatosis (HFE) gene mutation (H63D and C282Y) and iron overload in beta-thalassemia major (BTM) patients. Methods: The case-control study was conducted from June 2016 to February 2018. Blood samples from 204 BTM patients and 204 normal controls were taken from the...

A stability-indicating reversed-phase high-performance liquid chromatographic method has been developed for analysis of gemifloxacin in tablet formulations. When the drug was subjected to forced degradation under acidic, basic, thermal, oxidative, and photolytic conditions, the degradation products produced were successfully separated on a 250 mm x...