Yasir Qasim Almajidi

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• Assistant professor Dr in Pharmaceutics department/College of Pharmacy
• lecturer Dr at Nahrain University

Conventional ocular drug delivery forms (eye drops, eye ointments, and eye gels) possess poor bioavailability, less retention, and rapid precorneal discharge. In veterinary medicine, treating eye infections in animals like rabbits, dogs, and cats poses similar challenges. An in-situ gel drug delivery system (ISG-DDS) provides sustained action with...

ظهرت العلاجات القائمة على الحمض النووي الريبي (RNA) كواحدة من أقوى الخيارات العلاجية المستخدمة لتعديل التعبير الجيني / البروتيني وتحرير الجينات مع إمكانية علاج الأمراض التنكسية العصبية. ومع ذلك ، فإن توصيل الأحماض النووية إلى الجهاز العصبي المركزي (CNS) عن طريق المسار الجهازي ، لا يزال يمثل عقبة رئيسية. للتغلب على هذا المأزق ، تركز هذه المراجعة على...

Silymarin (SM), a natural polyphenolic flavonoid, shows antidiabetic and lipid-lowering characteristics with poor aqueous solubility and bioavailability. In the current investigation, SM-incorporated ethosomes (ETO) were designed and optimized using design expert version 8.0.7.1 to overcome these pitfalls. The SM-ETO were synthesized and subjected...

The goal of medical research across the world is to improve the health of patients. Nanotechnology is an emerging field that is now heavily concentrated in the realm of medicine continuous research in the sector has resulted in the emergence of a new discipline known as "nanomedicine," which attempts to provide new treatment options while also impr...

We developed a novel polylactic‐co‐glycolic acid (PLGA)‐polyamidoamine G4 (PAMAM G4)‐polycaprolactone (PCL) nanocarrier for efficient delivery of curcumin (Cur) to A549 lung cancer cells. The synthesized nanocarrier was characterized by applying analytical techniques, FT‐IR, DLS, TEM, and TGA. Successful synthesis, nano‐size diameter (40 to 80 nm),...

Field effect transistors (FETs)-based detection probes are powerful platforms for quantification in biological media due to their sensitivity, ease of miniaturization, and ability to function in biological media. Especially, FET-based platforms have been utilized as promising probes for label-free detections with the potential for use in real-time...

Peptic ulcer disease is a common gastrointestinal disorder. The current treatment for gastric ulcers (GUs) is pharmacological interventions including antacids, mucosal defensive agents, H2-receptor blockers, proton pump inhibitors (PPIs) as well as antibiotics targeting H. pylori infections. Additionally, there has been an increasing focus on the a...

Sperm cryopreservation is a common strategy for preserving male fertility; however, it may cause detrimental alterations in the structure and biological role of spermatozoa. The objective of this study is to mitigate the damages caused by cryopreservation through the use of canthaxanthin-loaded seminal exosomes (CAN-loaded EXO). To achieve this,...

Natural polymers are used more frequently in packaging as alternatives to synthetic plastics. Cornstarch is one of the cheapest carbohydrate biopolymers that form films with suitable properties and appearance but considerably larger hydrophilicity and low mechanical characteristics compared to synthetic films. Incorporating curcumin into cornstarch...

Nowadays, there is a wide range of deficiencies in treatment of diseases. These limitations are correlated with the inefficient ability of current modalities in the prognosis, diagnosis, and treatment of diseases. Therefore, there is a fundamental need for the development of novel approaches to overcome the mentioned restrictions. Chitosan (CS) nan...

Autophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor‐suppressive function through inducing apoptosis and remo...

Advanced therapeutic dressings are the current research interest that achieves rapid and complete wound healing. The healing of skin wounds demonstrates a remarkable cellular function process that is distinct in nature and involves the interaction of various cells, growth factors, and cytokines. In this study, nanofibrous scaffolds were prepared us...

The study focused on creating a novel and environmentally friendly nanocatalyst using cellulose (Cell), β-Cyclodextrin (BCD), graphene oxide (GO), Cu2O, and Fe3O4.The nanocatalyst was prepared by embedding GO and Cu2O into Cell-BCD hydrogel, followed by the in-situ preparation of Fe3O4 magnetic nanoparticles to magnetize the nanocomposite. The effe...

Evidence on prenatal exposure to polychlorinated biphenyls (PCBs) and its effects on newborns and potential biological mechanisms is not well defined yet. Therefore, this study aimed to examine whether PCBs are associated with lipid profile and non-invasive markers of hepatocyte injuries in samples of blood obtained from the umbilical cord. This st...

In contemporary times, nanotechnology has emerged as a notably sophisticated technological discipline. It possesses an interdisciplinary and multidisciplinary nature, spanning a wide array of domains including medical science, engi- neering, biology, physics, materials science, and chemistry. Utilization of nanotechnology offers a significant advan...

Magnesium has been a focal point of significant exploration in the biomedical engineering domain for many years due to its exceptional attributes, encompassing impressive specific strength, low density, excellent damping abilities, biodegradability, and the sought-after quality of biocompatibility. The primary drawback associated with magnesium-bas...

Background: Tazarotene (TZ) is a novel acetylenic class retinoid that selectively targets RARβ/γ. It is not particularly soluble or bioavailable, yet it is used to treat melanoma. Objective: To improve the tazarotene gel formula's transdermal distribution. Methods: TZ-incorporated binary ethosomes (TZ-BES) were developed for the current study. The...

The present study aimed to remove sulfonamide antibiotics from water samples using magnetic Fe3O4-bentonite nanocomposite (Fe3O4-Bt) as an adsorbent. The adsorbent has a surface area of 74.27 m2 g-1, a pore size of 87.53 nm, and a pore volume of 0.146 cm3 g-1. A central composite design (CCD) matrix was employed to model and optimize the process. T...

Wound dressing materials such as nanofiber (NF) mats have gained a lot of attention in recent years owing to their wonderful effect on accelerating the healing process and protection of wounds. In this regard, three different types of NF mats were fabricated using pure polyvinylpyrrolidone (PVP), PVP/κ-carrageenan (KG), and ursolic acid (UA) in the...

Background : Medicine’s success relies on solubility, which is the process of dissolving a solid substance in a fluid phase to create a uniform molecular dispersion. However, hydrophobic active medicinal components exhibit poor solubility in water, limiting their effectiveness and incorporation into medications. Aim : This review explores the poten...

Spinal cord injury (SCI) following trauma is a devastating neurological event that can lead to loss of sensory and motor functions. However, the most effective measures to prevent the spread of damage are treatment measures in the early stages. Currently, we investigated the combined effects of hyperbaric oxygen (HBO) along with epigallocatechin-3-...

Veterinary pharmaceuticals have been recently recognized as newly emerging environmental contaminants. Indeed, because of their uncontrolled or overused disposal, we are now facing undesirable amounts of these constituents in foodstuff and its related human health concerns. In this context, developing a well-organized environmental and foodstuff sc...

Oxidative stress is a physiological condition that occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the cell's antioxidant defense system. ROS are highly reactive molecules that can cause damage to cellular structures such as DNA, proteins, and lipids. the regulation of ROS levels and the antioxidant def...

In this research, a novel nanocomposite scaffold was developed based on a natural chitosan-gelatin (CS-Ge) hydrogel by incorporating synthetic polyvinyl alcohol (PVA) and MnFe layered double hydroxides (LDHs). The CS-Ge/PVP/MnFe LDH nanocomposite hydrogels was characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (X...

Correction for ‘Immobilized Ni on TMEDA@βSiO 2 @αSiO 2 @Fe 3 O 4 : as a novel magnetic nanocatalyst for preparation of pyrido[2,3- d :6,5- d ′]dipyrimidines’ by Yasir Qasim Almajidi et al. , RSC Adv. , 2023, 13 , 11393–11405, https://doi.org/10.1039/D3RA01720F.

Noncoding RNAs are a type of cellular RNA not having the ability to translate into proteins. As an important type of ncRNA with a length of about 22 nucleotides (nt), microRNAs were revealed to contribute to regulating the various cellular functions via regulating the protein translation of target genes. Among them, available studies proposed that...

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Background: Several physical factors such as photon beam energy, electron beam energy, and dose rate may affect the dosimetric properties of polymer gel dosimeters. The photon beam energy and dose rate dependence of PASSAG gel dosimeter were previously evaluated. Objective: This study aims to assess the dosimetric properties of the optimized PAS...

In this study, an eco-friendly procedure was established by vortex-assisted liquid phase microextraction based on deep eutectic solvent (VA−LPME−DES) combined with graphite furnace atomic absorption spectroscopy (GFAAS). The performance of this method was demonstrated by the extraction and analysis of lead (Pb), cadmium (Cd) and mercury (Hg) in fis...

Non-healing wounds impose a huge annual cost on the survival of different countries and large populations in the world. Wound healing is a complex and multi-step process, the speed and quality of which can be changed by various factors. To promote wound healing, compounds such as platelet-rich plasma, growth factors, platelet lysate, scaffolds, mat...

Nanomedicine is a field that combines biology and engineering to improve disease treatment, particularly in cancer therapy. One of the promising techniques utilized in this area is the use of micelles, which are nanoscale delivery systems that are known for their simple preparation, high biocompatibility, small particle size, and the ability to be...

In the current body of research, a very quick and effectual procedure for the synthesis of pyrido[2,3-d:6,5-d']dipyrimidines has been developed. This method is accomplished through the one-pot multi-component reaction of 2-thiobarbituric acid, NH4OAc and aldehydes utilizing Ni-TMEDA@βSiO2@αSiO2@Fe3O4 as a novel mesoporous nanomagnetic catalyst at r...

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Nanomedicine is a field that combines biology and engineering to improve disease treatment, particularly in cancer therapy. One of the promising techniques utilized in this area is the use of micelles, which are nanoscale delivery systems that are known for their simple preparation, high biocompatibility, small particle size, and the ability to be...

In atherosclerosis, the gradual buildup of lipid particles into the sub-endothelium of damaged arteries leads to numerous lipid alterations. The absorption of these modified lipids by monocyte-derived macrophages in the arterial wall leads to cholesterol accumulation and increases the likelihood of foam cell formation and fatty streak, which is an...

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In the present work, the adsorption mechanism and capacity of MWCNTs/CoFe2O4 nanocomposite as an adsorbent were investigated. Levofloxacin (LFX), a widely used antibiotic, was selected as a hazardous model contaminant in aqueous solutions. The surface and inner characterization of MWCNTs/CoFe2O4 was obtained via SEM/TEM, XRD, BET/BJH, and pHPZC. Th...

Oro slippery tablets (OSTs) is a technique used to improve swallowing of tablets for patients with dysphagia. The aim of this study was to formulate irbesartan and hydrochlorothiazide as Oroslippery tablets (OST) containing 150 mg irbesartan and 25 mg hydrochlorothiazide for dysphagia patients. A simple and rapid method of analysis was developed an...

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Background: Vemurafenib (VEM) was a licensed drug for the treatment of skin melanoma and is available only in the market as oral tablets prescribed in huge doses (1920 mg/day). One reason for the high dose is vemurafenib's low oral bioavailability. Methods: VEM-lipid complex (DLC) was predicted based on Conquest and Mercury programs and prepared us...

Background: Vemurafenib (VEM) was a licensed drug for the treatment of skin melanoma and is available only in the market as oral tablets prescribed in huge doses (1920 mg/day). One reason for the high dose is vemurafenib's low oral bioavailability. Methods: VEM-lipid complex (DLC) was predicted based on Conquest and Mercury programs and prepared us...

Background: Vemurafenib (VEM) was a licensed drug for the treatment of skin melanoma and is available only in the market as oral tablets prescribed in huge doses (1920 mg/day). One reason for the high dose is vemurafenib's low oral bioavailability. Methods: VEM-lipid complex (DLC) was predicted based on Conquest and Mercury programs and prepared us...

Background: Vemurafenib (VEM) was a licensed drug for the treatment of skin melanoma and is available only in the market as oral tablets prescribed in huge doses (1920 mg/day). One reason for the high dose is vemurafenib's low oral bioavailability. Methods: VEM-lipid complex (DLC) was predicted based on Conquest and Mercury programs and prepared us...