Yashpal S. Malik

Yashpal S. Malik
Guru Angad Dev Veterinary and Animal Sciences University | GADVASU · College of Animal Biotechnology

MVSc, PhD, PostDOC (USA)

About

388
Publications
399,226
Reads
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7,682
Citations
Introduction
20 years of Research Experience (Animal Disease Diagnosis & Control, 8 Projects), Guided 18 M.V.Sc./P.D. scholars, 213 Research/Review Papers, 5 Books, 27 Chapters, 582 NCBI GenBank submissions, 19 Popular/Technical publications. 5 Best Paper Awards. Member- 10 Professional Societies, Editor (AAVS), Editorial Board/Reviewer of 10 Int. journals. NAAS Associate (Young Scientist Recognition).
Additional affiliations
September 2008 - present
Indian Veterinary Research Institute
Position
  • ICAR National Fellow
September 2008 - present
Indian Veterinary Research Institute
Position
  • ICAR Nationa Fellow
Description
  • Postgraduate Courses in Virology discipline
May 2008 - August 2008
Jawaharlal Nehru Krishi Vishwavidyalaya
Position
  • Professor (Associate)
Description
  • Undergraduate and postgraduate courses in veterinary microbiology
Education
April 1999 - March 2000
August 1997 - March 2000
August 1995 - July 1997
CCS Haryana Agricultural University
Field of study
  • Veterinary Microbiology

Publications

Publications (388)
Article
Understanding the origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a highly debatable and unresolved issue for scientific communities all over the world. Understanding the mechanism of virus entry to the host cells is crucial to deciphering the susceptibility profiles of animal species to SARS-CoV-2. The interacti...
Article
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BT disease poses a constant risk to the livestock population around the world. A better understanding of the risk factors will enable a more accurate prediction of the place and time of high-risk events. Mapping the disease epizootics over a period in a particular geographic area will identify the spatial distribution of disease occurrence. A Geogr...
Article
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This review was focused on global data analysis and risk factors associated with morbidity and mortality of coronavirus disease 2019 from different countries, including Bangladesh, Brazil, China, Central Eastern Europe, Egypt, India, Iran, Pakistan, and South Asia, Africa, Turkey and UAE. Male showed higher confirmed and death cases compared to fem...
Preprint
Understanding the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a highly debatable and unsolved challenge for the scientific communities across the world. A key to dissect the susceptibility profiles of animal species to SARS-CoV-2 is to understand how virus enters into the cells. The interaction of SARS-CoV-2 liga...
Research
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Picobirnaviruses (PBVs) have been recognized as one of the important causal viral agents of gastroenteritis in several animal species especially in young immunocompro-mised hosts. In this study, we report the prevalence and molecular epidemiology of porcine PBVs from North Eastern Hilly region of India. A total of 457 fecal samples from piglets wer...
Article
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Purpose of Review There has been a high influx of publications on the SARS-CoV-2 and COVID-19 worldwide in the recent few months as very little was known about them. Nepal too had a substantial number of publications on the same, and there was a need to track the most relevant and impactful to the scientific community through bibliometric analysis....
Article
This communication summarizes the presentations given at the 1st international conference of the World Society for Virology (WSV) held virtually during 16–18 June 2021, under the theme of tackling global viral epidemics. The purpose of this biennial meeting is to foster international collaborations and address important viral epidemics in different...
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We provide a novel single restriction enzyme (RE) (BsaHI) digestion approach for detecting distinct pathotypes of the Newcastle disease virus (NDV). After scanning 4000 F gene nucleotide sequences in the NCBI database, a single RE (BsaHI) digesting site was discovered in the cleavage site. APMV-I “F gene” Class II specific primer-based reverse tran...
Article
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Coronavirus disease (COVID-19) caused by SARS-CoV-2 was notified from Wuhan city, Hubei province, China in the mid of December 2019. The disease is showing dynamic change in the pattern of COVID-19 confirmed cases and death toll in these low and middle-income countries (LMICs). In this study, exponential growth (EG) method was used to calculate the...
Article
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Background: Rotaviruses are important cause of acute gastroenteritis. Group A and D rotavirus are the predominant enteric viruses groups in birds. Outbreaks of rotavirus may lead to significant economic losses in poultry industry. Rotavirus infection alters the function of the small intestinal epithelium, resulting in diarrhea. Methods: Poultry int...
Article
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Using a broad-range nested PCR assay targeting the DNA-dependent DNA polymerase (pol) gene, we detected adenoviruses in 17 (20.48%) out of 83 fecal samples from small Indian mongooses (Urva auropunctata) on the Caribbean island of St. Kitts. All 17 PCR amplicons were sequenced for the partial pol gene (~300 bp, hereafter referred to as Mon sequence...
Article
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Of the 1,415 human pathogens identified, 175 are responsible for causing emerging diseases, 132 are zoonotic and majority of the diseases are categorized as emerging or re-emerging. Emerging novel Coronavirus (COVID-19) is one of them, and it is responsible for causing social and economically critical disease in both humans and animals. This review...
Article
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Nested PCRs with circovirus/cyclovirus pan-rep (replicase gene) primers detected eukaryotic circular Rep-encoding single-stranded DNA (CRESS DNA) viruses in three (samples CN9E, CN16E and CN34) of 18 canine parvovirus-2-positive fecal samples from household dogs with hemorrhagic gastroenteritis on the Caribbean island of Nevis. The complete genomes...
Article
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The objective of this study was to assess the efficacy of a microencapsulated probiotic as an adjunct therapy in rotavirus-positive diarrhea of neonatal calves that received supportive treatment or supportive along with microencapsulated probiotic treatment, for 5 days. We examined whether microencapsulated Lactobacillus acidophilus NCDC15 probioti...
Article
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The present study reports the occurrence of rotavirus A (RVA), rotavirus D (RVD), rotavirus F (RVF), rotavirus G (RVG), and picobirnavirus (PBV) in fecal specimens of wild (n = 22), and exotic birds (n = 1) from different cities of Pará state. These animals were hospitalized at Veterinary Hospital of the Federal University of Pará, Brazil, in a per...
Article
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Bats have a primeval evolutionary origin and have adopted various survival methods. They have played a central role in the emergence of various viral diseases. The sustenance of a plethora of virus species inside them has been an earnest area of study. This review explains how the evolution of viruses in bats has been linked to their metabolic path...
Article
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Diagnosis of contagious caprine pleuropneumonia is imperative for timely detection and devising interventions that prevent disease spread and loss to farmers. Diagnosis of contagious caprine pleuropneumonia involves clinical signs, gross morphological lesions on postmortem, histopathology, culture and isolation, hematological, biochemical, serologi...
Article
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Fecal samples from 76 of 83 apparently healthy small Indian mongooses (Urva auropunctata) were PCR positive with circovirus/cyclovirus pan-rep (replicase gene) primers. In this case, 30 samples yielded high quality partial rep sequences (~400 bp), of which 26 sequences shared maximum homology with cycloviruses from an arthropod, bats, humans or a s...
Article
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Disinfectants and sanitizers are essential preventive agents against the coronavirus disease 2019 (COVID-19) pandemic; how16 ever, the pandemic crisis was marred by undue hype, which led to the indiscriminate use of disinfectants and sanitizers. Despite demonstrating a beneficial role in the control and prevention of COVID-19, there are crucial con...
Article
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Replication-associated protein (Rep)-encoding single-stranded DNA (CRESS DNA) viruses are a diverse group of viruses, and their persistence in the environment has been studied for over a decade. However, the persistence of CRESS DNA viruses in herds of domestic animals has, in some cases, serious economic consequence. In this study, we describe the...
Article
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To date, there is a dearth of information on canine parvovirus-2 (CPV-2) from the Caribbean region. During August–October 2020, the veterinary clinic on the Caribbean island of Nevis reported 64 household dogs with CPV-2-like clinical signs (hemorrhagic/non-hemorrhagic diarrhea and vomiting), of which 27 animals died. Rectal swabs/fecal samples wer...
Chapter
There is an escalating necessity to augment our competences to diagnose infectious diseases early and precisely. The current methods of polymerase chain reaction (PCR) and antibody-based diagnostics offer quick and accurate results, but their widespread use/deployment is hindered by the need for sophisticated instrumentations and highly skilled tec...
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised o...
Article
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Pygmy hogs (Porcula salvania) are the smallest and rarest wild suid. It is categorized as a Critically Endangered species as per the Red List of the International Union for Conservation of Nature. This study reports the first detection of a single-stranded RNA virus species, Aichivirus C, belonging to the genus Kobuvirus (KobV) and the family Picor...
Preprint
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This study aimed to detect picobirnavirus (PBV) in the fecal samples of wild and domestic animals from 2014 to 2016 in the Amazon biome. For detection, Polyacrylamide Gel Electrophoresis (PAGE) and RdRp gene based Polymerase Chain Reaction (PCR) preceded by Reverse Transcription (RT) were used. Subsequently, statistical analyses were performed usin...
Article
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Introduction: Wild-type adult mice with intact interferon (IFN) system were neither susceptible to bluetongue virus (BTV) infection nor showed signs of morbidity/mortality. Establishment of immunologically competent wild-type adult mouse model with type I IFNs blockade is necessary to assess the pathogenesis, immune responses and testing of BTV vac...
Article
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Picobirnaviruses (PBVs) are bisegmented double-stranded RNA viruses that have been detected in a wide variety of animal species including invertebrates and in environmental samples. Since PBVs are ubiquitous in feces/gut contents of humans and other animals with or without diarrhea, they were considered as opportunistic enteric pathogens of mammals...
Article
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This study describes the spatial and temporal patterns of bluetongue (BT) outbreaks with environmental factors in Andhra Pradesh, India. Descriptive analysis of the reported BT outbreaks (n=2697) during the study period (2000‐2017) revealed a higher frequency of outbreaks during monsoon and post‐monsoon months. Correlation analysis of Normalized Di...
Chapter
Japanese encephalitis (JE), an important mosquito-transmitted viral encephalitis, is caused by Japanese encephalitis virus (JEV). Globally, JE is a foremost cause of encephalitis with about 70,000 human cases per year, leading to 10,000–15,000 deaths and causing psychiatric or neurological sequelae in around 30–50% of the survivors. The enzootic cy...
Chapter
Cryptosporidiosis is a highly contagious intestinal infection caused by Cryptosporidium, a protozoan parasite. Infections caused by Cryptosporidium baileyi, C. galli, C. meleagridis, and C. avium are regularly identified among pet and wild avian species. In our context, C. meleagridis is the most significant one, since it is the only Cryptosporidiu...
Chapter
Usutu virus (USUV) is an emerging arbovirus that has been attracting interest from the scientific community because of its prevalence in larger areas of Europe. USUV belongs to the genus Flavivirus and is maintained through an enzootic cycle encompassing birds and mosquitoes. USUV has adversely affected the avian population, causing high rates of m...
Chapter
Avian erysipelas is an economically important zoonotic disease of birds caused by the Gram positive, rod-shaped, facultatively anaerobic, bacterium, Erysipelothrix rhusiopathiae. Many species of wild and domestic birds are affected by the disease, though the disease is of much commercial relevance in farmed turkeys. Due to ubiquitous distribution a...
Chapter
Giardiasis is an important protozoan disease-causing diarrhea in both children and adults and transmitted mainly through fecal-oral route and distributed throughout the world. Giardia spp. also causes disease in pet and wild birds which may act as asymptomatic mechanical carriers of Giardia cysts to humans and other mammals. Among the six Giardia s...
Chapter
Migration of avian species is a special characteristic enabling them great mobility to cover distances over a relatively short period of time. Coupled with their abundance in almost everywhere on earth, birds serve as potential disseminators of pathogens, many of which affect humans causing zoonotic infections. Migration in birds takes forms rangin...
Chapter
Avian influenza (AI), informally known as “avian flu” or “bird flu,” causes devastating economic losses to poultry industries worldwide and is a well-recognized zoonotic threat to humans with pandemic potential. The causative agent of AI, the influenza A virus, is an eight-segmented single-stranded RNA virus fitting to the family Orthomyxoviridae....
Chapter
New castle disease (ND) (also “pseudofowl pest” and “avian pneumoencephalitis”) is an OIE-listed disease caused by the virulent strains of avian avulavirus 1 (formerly avian paramyxovirus-1) of genus Avulavirus (formerly Paramyxovirus) of the family Paramyxoviridae. It is an economically devastating viral disease of poultry industry which often led...
Chapter
West Nile is a neurotropic problem caused by West Nile virus (WNV), a neurotropic arbovirus. The natural reservoir and biological vector of the WNV are birds and Culex sp. mosquito, respectively. WNV is naturally maintained in the bird–mosquito–bird transmission cycle. Horses and humans acquire the infection from mosquitoes, are incidental hosts wi...
Chapter
Avian salmonellosis is an infectious disease affecting many species of domestic and wild birds causing heavy economic losses in commercial poultry. The disease is caused by various serovars of Salmonella spp., which are Gram negative, non-spore-forming, rod-shaped bacteria. Avian salmonellosis is reported from all over the world. Infected hosts she...
Chapter
We here discuss some of the sporadic fungal infections of birds, viz., Dermatophytosis (caused by Microsporum and Trichophyton), Dactylariosis (caused by Dactylaria gallopava), Histoplasmosis (Histoplasma capsulatum), Cryptococcosis (caused by Cryptococcus neoformans), Candidiasis (caused by Candida spp.), Rhodotoruliasis (caused by Rhodotorula spp...
Chapter
Avian campylobacteriosis is an important bacterial zoonotic infection of birds that affect both farmed and wild birds. The disease is caused by Gram-negative, microaerophilic bacteria of the genus Campylobacter—mostly C. jejuni and C. coli. Birds are considered natural and largest reservoir of C. jejuni. The infection is transmitted by contaminated...
Chapter
We here discuss some of the miscellaneous viral zoonoses involving birds either as reservoirs/natural/amplifying/carrier hosts. Western equine encephalomyelitis (WEE), Eastern equine encephalitis (EEE), Mayaro fever (MF), and sindbis fever (SF) are mosquito-transmitted viral zoonotic diseases caused by Alphavirus of Togaviridae family. St. Louis en...
Chapter
Avian mycoplasmosis is an economically important disease of birds including farmed and wild species. Among a number of pathogenic mycoplasmas, Mycoplasma gallisepticum and M. synoviae are most important causative agents of avian mycoplasmosis. Unlike other bacteria, mycoplasmas lack cell wall, lack rigidity, and appear pleomorphic. The infection sp...
Chapter
Ticks are considered as the second most potential source of vector-borne diseases to humans. Migratory birds are long-distance transporters of ticks and have been accounted for carrying different human pathogens such as tick-borne encephalitis virus, Crimean Congo Hemorrhagic Fever (CCHF) virus, Anaplasma marginale, Babesia divergens, Anaplasma pha...
Chapter
Avian chlamydiosis, also known as Psittacosis or Ornithosis, is a zoonotic disease of birds caused by members of the genus Chlamydia. The organisms causing chlamydiosis are obligate intracellular pathogens with a biphasic developmental cycle characterized by the infectious form known as elementary body and the metabolically active form known as ret...
Chapter
Avian botulism is a neuroparalytic disease caused by antigenically distinct toxins produced by Clostridium botulinum. The disease affects domestic fowls as well as wild birds for which botulism is most significant cause of mass mortality. The disease has been reported from many parts of the world. Birds usually contract the disease through consumpt...
Chapter
Fungal diseases are consistently ignored throughout the years regardless of their disturbing effect on human well-being. It is evaluated those fungal contaminations kill more than 1.5 million individuals each year. Recent global estimates have found 3,000,000 cases of chronic pulmonary aspergillosis in a year. Aspergillosis is among the most vital...
Chapter
Avian tuberculosis also known as avian mycobacteriosis is a chronic disease affecting wild and domestic birds including captive and pet birds. The disease is primarily caused by acid fast mycobacterial species Mycobacterium avium and M. genavense. Avian tuberculosis is worldwide in distribution. Various species of wild and captive birds are affecte...
Chapter
Migration in birds is a fascinating biological phenomenon. Migration denotes the annual predictable return movements among breeding and nonbreeding populations of birds. Over millennia, the migration in birds evolved with and by various adaptive mechanisms enabling them to survive in the harshest of the conditions. Migration helps in population dif...
Book
Zoonotic diseases pose a serious threat to global health and economy. Domestic and wild birds play crucial roles in transmission and spread of important zoonotic pathogens, with significant implications on human and avian health. Although zoonotic diseases have been extensively studied, information on various aspects of avian zoonotic pathogens hav...
Chapter
Avian colibacillosis caused by Escherichia coli is an economically important disease of birds especially the commercially farmed species. The disease is reported worldwide from many species of wild birds also. The disease is mainly transmitted through contaminated feed and water which are polluted by organisms shed via fecal droppings of the birds....
Article
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COVID-19 caused by the virus SARS-CoV-2 has gripped essentially all countries in the world, and has infected millions and killed hundreds of thousands of people. Several innovative approaches are in development to restrain the spread of SARS-CoV-2. In particular, BCG, a vaccine against tuberculosis (TB), is being considered as an alternative therap...
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Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported to strengthen its binding affinity to mammalian ACE2. The N501T mutation in SARS-CoV-2-CTD furnishes better support to hotspot 353 in comparison with SARS-CoV and shows...
Article
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Rotavirus A (RVA) causes viral gastroenteritis in humans and animals, including calves, piglets, and foals. The current study reports the genetic characterization of the full-length enterotoxin gene, NSP4, from caprine and ovine species. Upon characterizing eight full-length NSP4 genes by sequencing, it was found that the four caprine and three ovi...
Article
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The newly emerged COVID-19 caused by SARS-CoV-2 is rapidly spreading around the globe. Until date, we have relied on prevention of the disease through isolation, quarantine, and clinical care of affected individuals. However, studies on the crucial roles of asymptomatic and mildly infected patients in disease transmission, specific antiviral drugs,...
Article
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This Special Focus ‘SARS-CoV-2 / COVID-19: Advances in Developing Vaccines and Immunotherapeutics’ consists of 20 peer-reviewed articles (Research Articles, Mini-Reviews, Commentaries) covering various developments, trends, and advances in discovering effective vaccines and immunotherapies for SARS-CoV-2/COVID-19 along with presenting the current s...
Article
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The novel coronavirus (CoV), earlier named 2019-nCoV, and later as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has now created havoc and panic across the globe by its severe ongoing pandemic. This virus has to date as of 13 th November 2020, killed nearly 1.3 million persons out of more than 53 million confirmed positive cases, whi...
Article
The SARS-CoV-2/ COVID-19 pandemic has spread across the globe and affected millions of individuals as of the efficient virus transmission potential mediated via multiple virus shedding routes. The presence of SARS-CoV-2 in the stool samples and its prolonged shedding in environmental compartments like sewage and wastewater signifies a potential thr...
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The clinical severity, rapid transmission and human losses due to coronavirus disease 2019 (Covid‐19) have led the World Health Organization to declare it a pandemic. Traditional epidemiological tools are being significantly complemented by recent innovations especially using artificial intelligence (AI) and machine learning. AI‐based model systems...
Article
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SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), is suspected to have been first contracted via animal-–human interactions; it has further spread across the world by efficient human-to-human transmission. Recent reports of COVID-19 in companion animals (dogs and cats) and wild carnivores such as tigers have created a dilemma regarding...
Article
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The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of millions of infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those over 60 years old are affected more severely. Moreover, pre-existing co...
Article
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The COVID-19 pandemic, caused by a novel zoonotic coronavirus (CoV), SARS-CoV-2, has infected 46,182 million people, resulting in 1,197,026 deaths (as of 1 November 2020), with devastating and far-reaching impacts on economies and societies worldwide. The complex origin, extended human-to-human transmission, pathogenesis, host immune responses, and...