Yaser Peymanfar

Yaser Peymanfar
The Forsyth Institute

Doctor of Philosophy
Medical Scientist and Bone Biologist

About

13
Publications
1,940
Reads
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131
Citations
Citations since 2016
11 Research Items
131 Citations
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2016201720182019202020212022010203040
Introduction
Dr. Yaser Peymanfar is a medical researcher and bone biologist, passionate about bone, bone marrow, and cancer research.
Additional affiliations
September 2021 - August 2022
Harvard Medical School
Position
  • Post doctoral research fellow

Publications

Publications (13)
Article
Full-text available
Lysyl oxidases are multifunctional proteins derived from five lysyl oxidase paralogues (LOX) and lysyl oxidase-like 1 through lysyl oxidase-like 4 (LOXL1–LOXL4). All participate in the biosynthesis of and maturation of connective tissues by catalyzing the oxidative deamination of lysine residues in collagens and elastin, which ultimately results in...
Article
Full-text available
Intensive cancer chemotherapy is well known to cause bone vasculature disfunction and damage, but the mechanism is poorly understood and there is a lack of treatment. Using a rat model of methotrexate (MTX) chemotherapy (five once-daily dosses at 0.75 mg/kg), this study investigated the roles of the Notch2 signalling pathway in MTX chemotherapy-ind...
Article
Full-text available
Methotrexate (MTX) is a commonly used antimetabolite in cancer treatment. Its intensive use is linked with skeletal adverse effects such as reduced bone formation and bone loss, and yet little information is available on molecular mechanisms underlying MTX-induced impaired bone formation. This study investigated the effects of MTX treatment at a cl...
Article
Methotrexate (MTX) is a commonly used anti-metabolite in cancer treatment. Its intensive use is linked with skeletal adverse effects such as reduced bone formation and bone loss, and yet little information is available on molecular mechanisms underlying MTX-induced impaired bone formation. This study investigated the effects of MTX treatment at a c...
Article
Full-text available
Bone marrow stromal cells (BMSCs) are multipotent cells which can differentiate into chondrocytes, osteoblasts, and fat cells. Under pathological stress, reduced bone formation in favour of fat formation in the bone marrow has been observed through a switch in the differentiation of BMSCs. The bone/fat switch causes bone growth defects and disorder...
Article
Intensive use of methotrexate (MTX) and/or dexamethasone (DEX) for treating childhood malignancies is known to cause chondrocyte apoptosis and growth plate dysfunction leading to bone growth impairments. However, mechanisms remain vague and it is unclear whether MTX and DEX combination treatment could have additive effects in the growth plate defec...
Article
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however, their recovery potentials and mechanisms remain unclear. This study investigated the roles of the β‐catenin signaling pathway in bone and bone marrow recovery potentials in rats treated with antimetabolite methotrexate (MTX) (five once‐daily injecti...
Article
Full-text available
Opioids are widely administered to alleviate pain, including chronic pain in advanced cancer patients. Among opioids, morphine is one of the most clinically effective drugs for the palliative management of severe pain. In the last few decades, there has been a debate around the possible influence of opioids such as morphine on tumour growth and met...
Article
Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease spectrum and is defined by limb pain or impending limb loss because of compromised blood flow to the affected extremity. Current conventional therapies for CLI include amputation, bypass surgery, endovascular therapy, and pharmacological approaches. Although these conve...
Article
Wound healing is a complex but a fine‐tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose‐derive...
Article
Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin‑3 (NT-3) and its important roles as an osteogenic and angiogenic factor promoting the bony repair. The current study investigated its...
Article
Full-text available
Malaria is an infectious disease that in humans is caused by one of five species of the protozoan parasite Plasmodium and which is transmitted by mosquitoes of the genus Anopheles. Despite much investment over many years to eradicate or control the global incidence of malaria, infection remains a major cause of morbidity and mortality throughout th...
Article
Full-text available
Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic, and tumor antigens has been reported to trigger protective immunity. The use of plasmid DNA vaccinations against many diseases has produced promising results in animal and human clinical trials; however, safety concerns about the use of DNA vaccines exist, such as t...

Questions

Questions (2)
Question
Please help!!
As a part of my study I am very interested to know the effect of some drug on bone blood vessels. I need to use micro CT for bone blood vessel quantification but I am not sure if the drug damages or dilate blood vessels still I can use micro CT or not? and what is the must efficient way for injection of contrasting agent for rat blood vessel micro CT?
Question
Is it possible to use molecular and cellular and IHC methods for the same animal after micro CT quantification of bone blood vessels?

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Projects

Projects (5)
Project
Understanding the mechanisms of disease which lead to additional potential therapeutic approaches.
Project
To understand the molecular mechanism of methotrexate chemotherapy-induced bone marrow micro-vasculature damage.
Project
To study the molecular mechanism of methotrexate chemotherapy-induced bone damage and recovery