Yasemin Yazan

• Anadolu University

Background Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there’s a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability. Aim and Objective The current research focuses on developing nanosized and non-t...

Development, in vitro and in vivo evaluation of dexketoprofen trometamol (DT)-loaded nanosized drug delivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe sonication. DT release from SLNs prepared and their kinetics were investigated. Structures of SLNs were elucidated by particle size and zeta...

Lithium is the principal and the most effective drug in the treatment of bipolar disorder since the middle of the previous century. However, narrow therapeutic range and side effect profile of lithium necessitate its careful and controlled use. Patient compliance is highly needed for commercially available lithium oral product administration. Takin...

Development and in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized and controlled release drug delivery system was aimed in this study. DT-loaded Eudragit® RL 100 polymeric nanoparticles were prepared using nano spray-dryer. Structures of DT-loaded polymeric nanoparticles were elucidated by particle size and zeta potential measur...

Purpose: To design, formulate and characterize sustained-release formulations of dexketoprofen trometamol (DT) nanoparticles (NPs) Methods: Dexketoprofen trometamol (DT)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs were produced by double emulsion-solvent evaporation method. The NPs were variously characterized for drug loading and release, part...

Development and in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized and controlled release drug delivery system was aimed in this study. DT-loaded Eudragit® RL 100 polymeric nanoparticles were prepared using nano spray-dryer. Structures of DT-loaded polymeric nanoparticles were elucidated by particle size and zeta potential measur...

A new, simple, rapid, precise, accurate and specific stability indicating reverse phase UPLC method developed for the determination of encapsulated olopatadine hydrochloride (OLO) in the polymeric nanoparticle formulations. Studies were carried out on a 2.1x50 mm, 1.8 μm Zorbax Eclipse Plus C18 column with an optimized mobile phase of methanol, wat...

Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency...

The primary purpose of this study was to extend the time of interaction of the carrier with the negatively charged ocular surface for enhanced penetration in order to improve ocular bioavailability. Moxifloxacin hydrochloride (MOX) was successfully incorporated into cationic Eudragit® RS 100 nanoparticles (NPs) by spray-drying process. Particle siz...

Carvedilol (CVL) has advantages over the first generation of β-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life leading to administration of high dosage and frequent dosing range. The need of design and producing a new prolonged-release dos...

Carvedilol (CVL) has advantages over the first generation of β-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life leading to administration of high dosage and frequent dosing range. The need of design and producing a new prolonged-release dos...

The pain situation has a very important effect on the biological, psychological, sociological and economic situation of the patient. Dexketoprofen trometamol (DT) has been developed as a water-soluble trometamine salt. DT is a rapidly acting analgesic agent in the treatment of painful musculoskeletal disorders such as back pain and osteoarthritis....

Hypertension (HT), which de nes systolic blood pressure as >140 mmHg or diastolic blood pressure >90 mmHg. There are now several drugs that are available in the market, including carvedilol (CVL) which is used for the management of cardiovascular disease and HT. CVL-containing PLGA nanoparticles (NPs) were prepared by nanoprecipitation method.

Skin fights constantly during the day to be saved from free radicals caused by UV rays and pollution. However, skin cells repair damage and restore complexion during sleep. Enhancement of repair and restoration can be achieved more effectively by the cosmetic products such as antioxidants applied during night. In this study, functional fabrics were...

Skin fights constantly during the day to be saved from free radicals caused by UV rays and pollution. However, skin cells repair damage and restore complexion during sleep. Enhancement of repair and restoration can be achieved more effectively by the cosmetic products such as antioxidants applied during night. In this study, functional fabrics were...

Development and in vivo/in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized, controlled release drug delivery system was aimed in this study. DT-loaded Kollidon® SR (KSR) and Eudragit® RS 100 (ERS) polymeric nanoparticles were prepared using Nano Spray-Dryer (B-90, Büchı Labortechnik AG, Flawil, Switzerland). Both delivery systems...

Acute and chronic pain occur as a result of tissue damage either accidentally because of an injury or in consequence of surgery. The treat of acute/chronic pain and inflammation is a crucial component of patient care. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most extensively used drugs worldwide owing to their efficacy in reducin...

Polymeric nanoparticles based on biocompatible and biodegradable polymers are preferred for drug delivery owing to their property of being adsorbed intact in the gastrointestinal tract after oral administration. Stability of polymeric nanoparticles are generally described as physical, chemical, long-term "pharmaceutical" and colloidal stabilities....

In this study, an economic, easy, basic, quick, sensitive and error-free reverse phase high performance liquid chromatography (RP-HPLC) modified method was developed for the determination of dexketoprofen trometamol. NUCLEODUR C18 (5.0 μ, 250 mm × 4.6 mm) was used as the stationary phase while acetonitrile-methanol (25:75 v/v) mixture was the mobil...

Cervical cancer is one of the most life threatening type of cancer among women and is generally resistant to chemotherapy. The objective of this study was to prepare a vaginal suppository containing a chemotherapeutic agent and a genetic material that can be applied locally for cervical cancer. Paclitaxel was selected as the chemotherapeutic agent...

Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, nontoxic and biocompatible polymeric nanoparticles, and investigating their effectiveness in epilepsy. For this purpose, GABA conjugated N,N-dimethylacrylamide based pegylated nanoparticles were designed and...

HPLC analysis of gamma-aminobutyric acid (GABA) and its relevant application to the unique polymeric nanoparticles (PNP) is described in this study. GABA is a major inhibitor neurotransmitter which is widely distributed in the central nervous system. Changes in GABA metabolism may play an important role in the origin and spread of seizure activity...

In the present study, levofloxacin hemihydrate (Levo-h) was successfully incorporated into cationic Eudragit®RL 100 (ERL) nanoparticles by spray-drying method aiming oral application. Particle size and zeta potential measurements, entrapment efficiency, morphological, thermal, FTIR and NMR analyses and Levo-h quantification by UV analyses were perf...

The objectives of the present work was to design and characterize the rabeprazole sodium (RAB) loaded halloysite nanotubes (HNTs) to overcome acidic degradation of RAB and provide an alternative non-toxic and biocompatible drug delivery for the currently available marketed enteric coated drug formulations. Incorporation of RAB into nanotubes was pe...

Due to the recent advances in molecular biology, there are promising gene therapy studies for prevention and treatment of cancer, genetic and infectious diseases. Many technologies in molecular biology and biotechnology were developed, and among those technologies, ‘antisense technology’ has become prominent in recent years. In this study, non-vira...

The aim of this study was to modify the release and thus enhance the bioavailability of a calcium antagonist cinnarizine whose aqueouse solubility is low and half-life is short. For this purpose, solid dispersion system was chosen as the delivery system since it is a simple method at laboratory conditions and it is belived to increase the dissoluti...

Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there is a need for developing efficient modern drug delivery systems. Main attempt in this study was to extend the interaction of the carrier with negatively charged ocular surfaces for enhanced penetration from both corneal and n...

In the present study chitosan based gel formulations containing Egg Yolk Oil (EYO) and Epidermal Growth Factor (EGF) were formulated successfully aiming at enhanced topical treatment of dermal burns the combination of traditional approaches with modern drug delivery systems. Physicochemical properties of the formulations were analyzed and efficacy...

The aim of this study was to prepare and evaluate stable cationic solid lipid nanoparticles (SLNs) as colloidal carriers for gene therapy. SLNs were mainly composed of three different biocompatible and biodegradable matrix lipids called tripalmitin, glyceryl dibehenate, and triglyceride, all containing the cationic lipid N -(1-(2,3-dioleoyloxy)prop...

Gamma aminobutyric acid (GABA) is a key neuro transmitter which is widely distributed in the central nervous system, where it usually inhibits impulse transmission. A number of study is being performed on epilepsy, inhibition of γ-amino butyric acid (GABA) synthesis, blockage of release or postsynaptic reaction were determined to provoke convulsion...

Abstract In the present study, cyclosporine A (CsA) was successfully incorporated into cationic chitosan nanoparticles by spray-drying method aiming ocular application. Physicochemical characterisation of particles was performed in detail. Among the particles prepared using three types of chitosan with different molecular weights, particles contain...

Introduction: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recent formulations. Chitosan sta...

An efficient sunscreen formulation shows good absorption in the relevant UV range. Efficacy also means that the UV absorber must be easily incorporated in any kind of formulation. In this study, a chemical absorber, octocrylene, and one of the most important physical blockers, zinc oxide, could be successfully incorporated into Solid Lipid Nanopart...

The Millennium Summit in 2000 established the Millennium Development Goals (MDGs), which were agreed upon by 193 countries and 23 international organizations to combat extreme poverty and other pressing global priorities for human development. In the December 2011 issue of CPPM, Borda-Rodriguez and Huzair present an analysis of the close ties and s...

In the present study, cyclosporine A (CsA) was incorporated successfully into cationic Eudragit RS 100 nanoparticles (EPNs) aiming ocular application. Physicochemical characterization of the EPNs prepared was performed during the storage period of 6 months. Following in vitro release tests, sheep were used in in vivo studies where 100 microL of for...

UV filters are traditionally classified as chemical absorbers and physical blockers depending on their mechanism of action. In this study, one of the most important chemical UVB absorber, octocrylene, was incorporated into Solid Lipid Nanoparticle (SLN) systems which themselves have UV blocking potential similar to physical blockers. Determination...

In this study, topically applicable o/w microemulsion (ME), o/w simple emulsion (SE) and solid lipid nanoparticle (SLN) cosmetic delivery systems were prepared containing vitamin E. Characterization of the systems was performed by various techniques, particle size and zeta potential measurement, X-ray diffraction, NMR, vitamin E quantification by v...

In the present study, Cyclosporine A (CsA) was successfully incorporated into cationic solid lipid nanoparticles (SLN) for ocular application. Physicochemical characterizations of SLNs were analysed in detail during the storage period of 6 months. Due to the better characteristics like smaller particle size (248.00 +/- 0.33 nm) with narrow size dis...

Among the visible changes frequently seen in aged skin are roughness in skin surface, widening of pores, sagging with wrinkling, excess skin on eyelids, downward mouth, double chin, color changes such as paling, darkening and brown spots and telangiectacy, or "broken vens". As a result of recent research, changes in cell nucleus were suggested to t...

The bioavailabilities of single 100-mg oral and rectal doses of diphenylhydantoin sodium were studied in five healthy volunteers. The rectal form used was prepared at laboratory conditions and the oral form was a commercial preparation. Blood samples were analysed over a 72-hr period. Evaluation of the AUC, tmax and Cmax values have shown that the...

Abstract The nasal route has been shown to be effective for the administration of numerous drugs in order to improve drug bioavailability. A nasal gel of verapamil hydrochloride was formulated and evaluated pharmacodynamically in humans, using electrocardiographic results, with comparison to oral and IV routes. Seven volunteers were involved in the...

The purpose of the study was to see the effect of two antiaging agents in one stable multiple emulsion prepared using natural oil. Vitamin C, which is a very unstable ingredient and is decomposed in the presence of oxygen, active as an antioxidant, was entrapped in the inner aqueous phase of w/o/w multiple emulsion. In this way, slow release can be...

Specificity to target molecule, high selectivity and sensitivity to release and targeting were achieved using molecularly imprinted polymer (MIP) systems. In this study, propranolol HCl (PHCL) imprinted methacryloylamidohistidine-Co/ PHCL (MAH-Co/PHCL) microspheres were prepared by suspension polymerization. Differences in pH, concentration and tim...

Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the micropartic...

In this study, titanium dioxide (TiO2) was incorporated into solid lipid nanoparticle (SLN) formulations using both classical and novel preparation methods. The SLNs were investigated by evaluating their stabilities and physicochemical characteristics. UV-protection abilities of formulations were investigated using in vitro TransporeTM and Sun To S...

The aim of this study was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare solid binary systems. Differential scanning calorimetry, X-ray diffractometry, and particle size analysis were used to ch...

The purpose of the study was to prepare a stable multiple emulsion system containing two skin antiaging agents using a natural oil vitamin C, known to be a very unstable ingredient and is decomposed in the presence of oxygen, was entrapped in the internal aqueous phase of w/o/w multiple emulsion. In this way, vitamin C is expected to exhibit slow r...

Bioavailability of acalcium antagonist cinnarizine, known to have a low aqueous solubility, islow or variable. Enhancement of the dissolution behavior of such a drug material can improve its oral bioavailability. For the improvement of the dissolution rate, solid dispersions were prepared by fusion method dur to the complete dispersion ability of t...

Pyridostigmine bromide (PB) is an anticholinesterase agent whose aqueous solubility is high and which has a short elimination half-life. Its dosage rate in the treatment of myastenia gravis is frequent due to the short half-life and it exhibits side effects. Microparticles designed to deliver a pharmaceutical active ingredient efficiently at the mi...

Modification of the dissolution rate and, thus, the enhancement of the bioavailability of a dopaminergic drug, piribedil, which has a low aqueous solubility and short elimination half-life have been the aim in this study. Preparations of micron and submicron particles using solid lipid carriers have been performed for this purpose. For the avoidanc...

Piribedil is a dopamin agonist with vasodilator activity and whose aqueous solubility is low and elimination half-life is short. It is widely used in cerebral ageing and in Parkinson's disease. Literature on physico-chemical and pharmacological properties, analysis methods, bioavailability and pharmacokinetics of piribedil has been reviewed in this...

Synopsis Stable multiple emulsions that contain different lipophilic surfactants in the internal aqueous phase have been formulated. The multiple systems were assessed by evaluating several parameters such as macroscopic aspect, droplet size, percent release and accelerated stability under centrifugation or elevated temperature. The effect of polym...

Colloidal drug delivery systems are one of the subjects investigated intensively in the pharmaceutical field, in recent years. Those systems include microspheres, polymeric nanoparticles, liposomes and fat emulsions. An ideal colloidal system has to carry the active ingredient contained to the site of action and must be able to release it an approp...

The features of topically applied suncream films depend on the applied quantities and could be modified by water immersion and air drying. The aim of this study was to investigate the effects of the aforementioned factors on physical sunscreen films and to establish the correlation between the in vitro determined Sun Protection Factor (SPF) and the...

Salbutamol sulphate is a sympathomimetic amine having a rather short plasma half-life. Aiming to achieve sustained release of this drug through microencapsulation, the coacervation method with a 1:1 core-shell ratio was used. In vitro release rate experiments were performed on the microcapsules prepared using ethyl cellulose as the coating agent an...

A modified and simple HPLC procedure has been developed for verapamil in plasma. Plasma samples have been vortex-mixed and centrifuged without any need of extraction. The analysis has been performed on a C20 reversed-phase column with fluorometric detection using 5,6-benzoquinoline as an internal standard. Standard curve has been found to be linear...

An improvement in the dissolution of theophylline with β-cyclodextrin was achieved by subjecting them to co-grinding and freeze-drying methods. The products obtained were examined by the phase solubility methad, differential scanning calorimetry and X-ray diffractometry. The products thus prepared were evaluated with respect to their dissolution be...

The purpose of this review is to update the information on multiple emulsions known to be promising delivery systems for both pharmaceuticals and cosmetic materials. The possibility of encapsulating active substances within liquid membranes may lead to interesting opportunities in both fields. Thus the formulation, manufacturing, stabilization, ana...

The direct current polarographic behaviour of dipyridamole, a coronary vasodilator, in the supporting electrolyte consisting of 0.2 M KCl, 20 % (v/v) ethanol and buffer solutions is described in this study. Morphologically well-defined DC polarographic curves have appeared within the pH range of 7–8 and the optimum polarographic conditions found we...

The main purpose of our study is to achieve the release at a slower rate and the prolonged action of dextropropoxyphene hydrochloride through microencapsulation. Besides this, microencaosulation of this active agent can prevent the incomnatibility in the presence of aspirin, and the local anesthetic effecton the tongue. Microcapsules o f dextroprop...