Yasemen Adalı

Izmir University of Economics · Department of Pathology

Objective: Cyclin D1 is a protein that is involved in the regulation of the cell cycle and is encoded by the CCND1 gene. There are few studies on Cyclin D1 in the literature, and the results differ in the studies. In this study, the relationship between Cyclin D1 Expression and prognostic factors in bladder urothelial carcinomas was investigated. M...

Since obesity is a global health problem that can lead to life-threatening morbidity and mortality, we emphasize its importance in our medical curriculum. We would like to draw attention to its importance and multifaceted effects by reviewing the whole process from its molecular basis to systemic effects. Obesity cannot be evaluated from a single p...

In this study, it was aimed to examine the biochemical changes, hematological changes and cerebrospinal fluid (CSF) cytology and blood serum of cattle with head-eye form of Malignant Catarrhal Fever (MCF). For this pur- pose, 22 cattle diagnosed with "head-eye form" of MCF and clinically healthy 10 cattle were evaluated. Blood and cere- brospinal f...

Introduction: One of the most important factors influencing post-transplant success in kidney transplantation is preserving the viability of the organ from removal to transfer into the recipient. Aim: This study aimed to reduce the energy requirement with thiopental doses administered before organ transplantation, and to increase the organ viabi...

Objectives: This study aims to compare the newly created intravaginal endometritis model (IVM) with the intrauterine endometritis model (IUM). Methods: E. coli infusion was performed as intravaginally to the IVM and as intrauterinally to the IUM. The lives of all animals were terminated on the 7th day. Histopathological and biochemical analyses (GS...

Obesity and fatty liver is a widespread growing health problem in human with detrimental consequences that encouraged researchers to find ways to overcome it. In this study, gemfibrozil and L-carnitine were evaluated in prevention of obesity and hepatic lipidosis also the role of L-carnitine in avoiding side effects of gemfibrozil was investigated....

Background/Objective: Thyroid nodules are palpable, clinically undetectable lesions that can be found on ultrasound imaging. It is difficult to differentiate benign and malignant with ultrasound imaging. Fine needle aspiration is applied to these lesions for clinical, radiological and pathological examination to differentiate benign and malignant l...

T Obesity is on the increase in our country and around the world as a pandemic. In addition, the presence of the coronavirus disease-2019 (COVID-19) pandemic has made dealing with two pandemics at the same time challenging. Obesity is the leading cause of many diseases that can be prevented, particularly cardiovascular disorders. It has a negative...

Objectives: The aim of this study is to investigate the efficacy of sacubitril-valsartan treatment in the early period of Experimental Autoimmune Myocarditis (EAM) model, under the perspective of fibrosis and inflammatory cytokines. Methods: The study was performed using 18 rats in three groups of EAM (n=6), EAM treatment (n=6) and control (n=6). E...

Objective: Vitamin B12 deficiency can be seen in the cases with sleeve gastrectomy. Because the chief factor in vitamin B12 deficiency is gastric atrophy, we aimed to evaluate the effect of atrophy on postoperative vitamin B12 levels in patients who underwent sleeve gastrectomy. Material and methods: Sixty patients were included in this study. V...

The study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor group. Escherichia coli was a...

Background: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated. Methods: Forty adult female rats were used in...

Background The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene expressions, and the protective effects of melatonin in rat hearts administered with cisplatin.Methods and ResultsA total of 28 Wistar albino rats were divided into four groups. The vehicle was administered intraperitoneally (i.p.) to the...

Barret esophagus is considered as a precursor lesion for esophageal adenocarcinomas. Histopathological examination is required for the barret esophagus, where endoscopic examination takes an important place. Intestinal metaplasia is revealed with hematoxylin & eosin (H&E) and alcian blue (AB) in histopathological examinations. There are 2 different...

Aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia-induced pulmonary hypertension (PH)...

Background: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated. Methods and Results: Forty adult female rats...

One of the most common post-operative deficiencies after bariatric surgery is iron deficiency and one of the important determinants of post-operative iron deficiency is the preoperative condition. In this study, it was aimed to investigate the relationship between iron levels and histopathological findings observed in gastric tissue resected in sle...

Abstract One of the most common post-operative deficiencies after bariatric surgery is iron deficiency and one of the important determinants of postoperative iron deficiency is the preoperative condition. In this study, it was aimed to investigate the relationship between iron levels and histopathological findings observed in gastric tissue resect...

Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters includ...

INTRODUCTION: Parathyroid neoplasms are tumors seen in about 0.1% of the population.Although parathyroid adenomas are the most common,carcinomas are also rarely seen.Our aim in this study is to evaluate the clinical, laboratory and histopathological characteristics of patients who underwent parathyroidectomy in our hospital in the last 5 years. MET...

Aims: Iron is an important metal ion as a biocatalyst on the other hand iron overload causes various diseases. Iron overload can result in fibrosis and hepatocellular carcinoma with various pathophysiological mechanisms, including oxidative damage in the liver. Therefore; in this study the effects of ozone and selenium -whose antioxidant propertie...

Amaç: Tiroid ince iğne aspirasyon sitolojisi (İİAS), tiroid nodüllerinin değerlendirilmesi için; hızlı, güvenilir, ekonomik bir yöntemdir. Bu yöntem hastaların ileri dönemde yönetimine katkı sağlamakta ve gereksiz cerrahi uygulamaları azaltmaktadır. Bu çalışmada İİAS sırasında, hasta başında yeterlilik değerlendirilmesinin, sitolojik yeterlilik ve...

Objetivo: O objetivo do presente estudo foi investigar o impacto bioquímico e histopatológico do tratamento de ozônio em modelo experimental de osteomielite em ratos. Métodos: Vinte e quatro ratos Sprague-Dawley machos adultos (3 meses de idade, pesando de 300 a 400 g) foram alocados randomicamente em três grupos. O grupo I (n = 8) serviu como cont...

Introduction: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic li...

Purpose This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2...

Özet Çeşitli kanserlerin tedavisinde yaygın olarak kullanılan platin içerikli kematerapötik ajan olan sisplatin (SP)' in klinik olarak kullanımını sınırlandıran potansiyel toksik etkileri bulunmaktadır. Bu çalışmanın temel odak noktası, sisplatin indüklü akciğer toksisitesinde oksidatif/nitrosatif stres ve antioksidan etkiler ile immunohistokimyasa...

Objective: Cold is a stress-inducing factor that can cause changes in bladder function in various ways. The present study is intended to investigate the effects of corticosteroid and antihistaminic treatment on acutely and chronically induced cold stress.Material and Methods: Forty-two female rats were randomly divided into seven groups as follows:...

Background: Alcoholic liver disease (ALD) is a worldwide health problem.Ozone and melatonin are agents that are widely used for their antioxidant properties in medical therapies.In this study, we aimed to evaluate the use of ozone and melatoninin ALD.Materials and Methods: Forty-eight rats were used and ethanol, melatonin, and ozone were administra...

Aim: Numerous methods are used to prevent the development of postoperative adhesion formation. There are few studies on the effects of ozone therapy on postoperative intraabdominal adhesions and ovarian functions. This study aimed to investigate the effects of ozone treatment on postoperative intraabdominal adhesions and ovarian roles in rats.Metho...

Introduction: Due to the well-known relationship between inflammatory processes and carcinogenesis, the diagnostic and prognostic value of systemic inflammatory markers are at the focus of research. This study aimed to investigate the predictive value of inflammatory cell data obtained from complete blood count in incidentally detected thyroid papi...

About many cytological, hametological and biochemically data in CSF, blood an sera in Malignant catarrhal fever...

Objective: The aim of our study was to investigate whether platelet indices were affected in patients with Hashimoto’s thyroiditis (HT). Method: 11 patients (10 female, 1 male) with HT and 26 subjects with nodular goiters (19 female, 7 male) selected as control group were included in the study. All cases were examined for complete blood count param...

Introduction: Feeding habits and environmental factors may rival genetic susceptibility as etiological factors related to various cancers. Humans are continuously exposed to many synthetic food additives, one of which is sodium nitrite (NaNO2). There is a direct correlation between increases in consumption of nitrite-treated products and incidence...

Our aim was to investigate the protective role of ozone treatment against gentamicin-induced nephrotoxicity in an experimental rat model. In this study, a total of 30 rats were allocated in 5 groups (n=6 in each group). The control group (Group 1) received isotonic saline only, while Groups 2 and 3 received gentamicin at doses of 15 mg/kg/day and 5...

BACKGROUND/AIM: Alcoholic liver disease is an important health problem which is reversible during early stages of liver damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression of the toxic effects of alcohol. In our study, we investigated the efficiency of ozone and seleni...

Purpose: To evaluate the effect of amniotic fluid in liver preservation in organ transplantation, and compare it with standard preservation solutions. Methods: The groups consisted of Group 1: Ringer Lactate (RL) group, Group 2: HTK group, Group 3: UW group, Group 4: AF group. The livers of rats from Group 1, 2, 3, and 4 were perfused and placed...

Introduction: In this study, the authors aimed to research the histopathologic effects of intraurethral use of dexpanthenol for hypospadias repair. Dexpanthenol is a derivative of pantothenic acid, a B complex vitamin. Pantothenic acid is a molecule contributing in the structure of coenzyme A. It decreases the release of myeloperoxidase from granu...

Background: Malignant tumors are important causes of mortality and morbidity in the world. It is known that the incidence of tumors- in which a large number of etiologic agents are identified and continued to be investigated- varies according to age, gender and geographical location. This study aimed to determine the prevalence and localization dis...

The effect of ozone treatment in experimental rat gout arthritis was investigated. Twenty adult albino male rats were divided into 4 groups: Group 1 (Control) was followed without any medication, Group 2 (Gout control) was injected with a single dose of 0.2 mL (10 mg) monosodium urate (MSU) intraarticulary to 1st metatarsophalangeal joint to create...

Background: Hydatidiform mole (HM) is the most frequently encountered disease among gestational trophoblastic diseases. HM can invade myometrium and result in hysterectomy and because of the absence of any predictive method, the disease can be lately diagnosed in the periphery. Author aimed to evaluate predictive value of the inflammatory cell coun...

Objective For treatment of obesity, which is one of the important health problems of the present time, lifestyle modification, pharmacotherapy, behavioral treatment methods, and surgical procedures are commonly used. Sleeve gastrectomy is widely used among surgical procedures. We aimed to investigate the relationship between histopathologic finding...

Objective(s) The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia,...

Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast...

It is a very wide market, from herbal products to slimming medicines, to blends sold in transit. Many herbal products have been used for years and are known to be useful. However, some herbal products can cause serious side effects on the users. Traders say that most of these herbal products are natural. Unlike medicines, herbal products are not te...

Arsenic is a natural element and is present in trace amounts in all living materials that live in water, on rocks, in plants and in animals. Worldwide chronic arsenic poisoning has become a threat to human health. Arsenic exposure is most often transmitted from contaminated water and food. It is the most harmful substance in drinking water and it i...

This study was conducted to investigate the effects of branched chain amino acids (BCAAs) consumption on myocardium and coronary arteries, in rats subjected to regular and intense exercise. Eight-week old, 30 male rats were randomly divided into experimental- and controlgroups. For a total of 8 weeks, every other day, both groups were subjected to...

Objective: The aim of the present study was to investigate the biochemical and histopathological impact of ozone treatment in an experimental model of osteomyelitis in rats. Methods: A total of 24 adult male Sprague-Dawley rats (3 months old, each weighing 300 to 400 g) were randomly allocated into three groups. Group I (n=8) served as a control a...

ABSTRACT Pesticides are one of the most hazardous pollutants for human and environmental health due to their toxic effects and accumulation. In this review, it was aimed to summarize the literature which can be a source for future studies by evaluating the data about histological and genotoxic effects of neonicotinoids, one of the insecticide grou...

Patolojik inceleme sonucu bir merkezde DKİS, bir merkezde atipik papilloma ve atipik hiperplazi tanısı alan olguyu tedavi ve izlem konusunda yaşanılan karmaşa nedeni ile sunmak istiyoruz. Olgu 24 yaşında kadın hastada 21 yaşından beri memede kitle şikayeti bulunmaktadır. Yapılan fizik muayenede sol memede düzensiz sınırlı kitle saptanmıştır. Radyo...