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9
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Introduction
Current institution
Additional affiliations
November 2010 - August 2015
Position
- PhD Student
Description
- PhD thesis: Towards novel antibacterial development - from peptidoglycan to lipoprotein biogenesis
Publications
Publications (9)
Antibacterial photodynamic therapy (APDT) has drawn increasing attention from the scientific society for its potential to effectively kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance that bacteria can rapidly develop against traditional antibiotic therapy. The review summarizes the mechanism of action...
In the Author Contributions section, Tamimount Mohammadi (TM) should be listed as one of the persons who conceptualized and supervised the study. © 2018 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, prov...
As an integral membrane protein, purification and characterization of phospho-N- acetylmuramyl- pentapeptide translocase MraY have proven difficult. Low yield and concerns of retaining stability and activity after detergent solubilization have hampered the structure-function analysis. The recently developed detergent-free styrene-maleic acid (SMA)...
DNS-UDP-MurNAc-pentapeptide on TLC.
The left plate shows the fluorescence. The right plate is a reverted image. The right lane on each plate is the final purified compound after HPLC purification.
(TIF)
Free SMA does not inhibit LysC activity.
DDM-MraY (lane 1) digestion by LysC at molar ratio protein:protease = 1:50 (lane 2) or 1:100 (lane 3). DDM-MraY digestion by LysC in presence of 0.03% free Xiran SZ30010 SMA polymer at molar ratio protein:protease = 1:50 (lane 4) or 1:100 (lane 5).
(TIF)
A method for the enumeration and quantification of osteosarcoma (OS) circulating tumor cells (CTCs) is currently not available. A correlation between the number of CTCs and progression-free survival (PFS) has been established for other cancers, but not for OS CTCs. A method was therefore developed for CTC quantification in OS and validated in a pro...
Peptidoglycan is the major component of the cell envelope of virtually all bacteria. It has structural roles and acts as a selective sieve for molecules from the outer environment. Peptidoglycan synthesis is therefore one of the most important biogenesis pathways in bacteria and has been studied extensively over the last twenty years. The pathway s...
Phospho-MurNAc-pentapeptide translocase (MraY) catalyzes the synthesis of Lipid I, a bacterial peptidoglycan precursor. As
such, MraY is essential for bacterial survival and therefore is an ideal target for developing novel antibiotics. However
the understanding of its catalytic mechanism, despite the recently determined crystal structure, remains...
