Yann Le Franc

Yann Le Franc
e-Science Data Factory

PhD

About

20
Publications
1,918
Reads
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233
Citations
Additional affiliations
July 2014 - present
e-Science Data Factory
Position
  • CEO and founder
October 2012 - December 2014
Le Franc consulting
Position
  • Researcher
September 2009 - June 2012
University of Antwerp
Position
  • Contractual researcher (postdoctoral fellow)
Education
October 2000 - December 2004
Université Victor Segalen Bordeaux 2
Field of study
  • PhD in Neuroscience and Pharmacology

Publications

Publications (20)
Conference Paper
Full-text available
A note in the margins of a book or a scientific paper, a comment on a manuscript or a reference to other related content: we are all using annotations to add information to existing physical documents. To offer a similar experience with digital content, we developed B2NOTE, a service that allows to associate additional information to a file in a co...
Article
Full-text available
The FAIR principles have been accepted globally as guidelines for improving data-driven science and data management practices, yet the incentives for researchers to change their practices are presently weak. In addition, data-driven science has been slow to embrace workflow technology despite clear evidence of recurring practices. To overcome these...
Conference Paper
Full-text available
The aggregation of multidisciplinary information is a challenge faced by large-scale data infrastructures serving scientific domains such as biodiversity , agronomy or ecology. This requires the integration of ontologies or thesauri from different domains. These semantic resources are often hosted within domain specific repositories which can be ha...
Article
Full-text available
The purpose of this document is to specify the basic data types required for storing electrophysiology and optical imaging data to facilitate computer-based neuroscience studies and data sharing. These requirements were developed within a working group of the Electrophysiology Task Force in the INCF Program on Standards for Data Sharing.
Conference Paper
Full-text available
Experiments in electrophysiology produce a lot of unstructured metadata collected in electrophysiology databases. The data are usually accessed through a web interface implemented on the top of data model respecting given data format. A lot of experiments are conducted outside the laboratory where access to these databases is not always available....
Article
We present a method to label and trace the lineage of multiple neural progenitors simultaneously in vertebrate animals via multiaddressable genome-integrative color (MAGIC) markers. We achieve permanent expression of combinatorial labels from new Brainbow transgenes introduced in embryonic neural progenitors with electroporation of transposon vecto...
Article
Full-text available
One of the major issues in Neurophysiology is the large diversity of data formats used to store both raw data and the associated metadata. The INCF Program on Standards for Data Sharing with the Task Force on electrophysiology (incf.org/programs/datasharing/electrophysiology-task-force) is concerned with developing data formats and metadata standar...
Conference Paper
Most data management systems include a database in the backend to store data and the associated metadata and a web-based user interface to access and modify the data/metadata. User interfaces are specifically tailored for representing a unique database structure and cannot be easily reused for other database structure. Furthermore the generated web...
Poster
Full-text available
Analysis of existing ontological resources reveals a lack of terms for accurately and unambiguously annotating electrophysiological data and metadata. With the development of different resources for describing and sharing this particular type of data, the community needs controlled vocabularies to describe the different types of electrophysiology r...
Article
Full-text available
Analysis of existing ontological resources reveals a lack of terms for accurately and unambiguously annotating electrophysiological data and metadata. With the development of different resources for describing and sharing this particular type of data, the community needs controlled vocabularies to describe the different types of electrophysiology r...
Article
Neural circuits of the brain are highly complex cellular architectures that assemble through a series of elaborate developmental processes. Mapping these architectures and tracing back their developmental history at the individual cell level are essential tasks for deciphering the building principles of neural circuits. Monochrome markers used so f...
Article
Full-text available
Deep dorsal horn relay neurons (dDHNs) of the spinal cord are known to exhibit multiple firing patterns under the control of local metabotropic neuromodulation: tonic firing, plateau potential, and spontaneous oscillations. This work investigates the role of interactions between voltage-gated channels and the occurrence of different firing patterns...
Chapter
Understanding the input–output transfer properties of NEURONs is a complex problem which requires detailed knowledge of the intrinsic properties of neurons, and how these intrinsic properties influence signal integration. More recently, it became clear that the transfer function of neurons also highly depends on the activity of the surrounding netw...
Article
Full-text available
First relay of peripheral sensory and nociceptive information, the dorsal horn network of the spinal cord is a dynamic integrator, rather than a simple relay. The aim of this work is to caracterize input/output transformation and to assess the effect of network parameters as cellular, synaptic and connectivity properties. We used a combined theoret...
Article
We use dynamic clamp to construct "hybrid" thalamic circuits by connecting a biological neuron in situ to silicon- or software-generated "neurons" through artificial synapses. The purpose is to explore cellular sensory gating mechanisms that regulate the transfer efficiency of signals during different sleep-wake states. Hybrid technology is applied...
Article
Full-text available
Premier relais des informations sensorielles et nociceptives périphériques, la moelle épinière est le siège de traitements dynamiques complexes. L'objectif de ce travail est de caractériser la transformation subie par le signal (sa fonction de transfert) et de quantifier l'impact des différents paramètres du réseau. Pour cela, nous avons utilisé un...

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