Yang Yang

• MD
• Medical Doctor at Zhejiang Cancer Hospital

We developed and validated a magnetic resonance imaging (MRI)-based radiomics model for the classification of high-grade glioma (HGG) and determined the optimal machine learning (ML) approach. This retrospective analysis included 184 patients (59 grade III lesions and 125 grade IV lesions). Radiomics features were extracted from MRI with T1-weighte...

Background Thoracic radiotherapy (TRT) has shown potential benefits in improving local control and overall survival (OS) in chemotherapy-responsive small-cell lung cancer (SCLC) cases. However, its role in the era of chemoimmunotherapy remains underexplored. In the current era of immunotherapy, this study evaluated the efficacy and safety of consol...

With the success of immunotherapy in advanced esophageal cancer, neoadjuvant chemo-immunotherapy (CIT) is being increasingly used for local staged esophageal cancer, especially in the context of clinical trials, which brings similar pCR with neoadjuvant chemoradiotherapy and shows promising results. However, there is still a part of potentially ope...

Background: The use of adjuvant first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC) remains controversial. Therefore, we performed a systematic review with meta-analysis to investigate the overall survival (OS) in patients with resected NSC...

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Circular RNAs (circRNAs) have been widely reported to play a role in the pathogenesis of various tumors. Nevertheless, the function of circ_0001955 in NSCLC progression has not been explored yet. This study aims to explore the functions of circ_0001955 in NSCLC...

Background: The impact of genomic factors on the response of patients with esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT), as well as how nCRT influences the genome and transcriptome of ESCC, remain largely unknown. Methods: 137 samples from 57 ESCC patients undergoing nCRT were collected and subjected to whole...

Objective Patients with small cell lung cancer (SCLC) have a high risk of developing brain metastases (BM). Prophylactic cranial irradiation (PCI) is a standard therapy for limited-stage SCLC (LS-SCLC) patients who achieved complete or partial response after thoracic chemoradiotherapy (Chemo-RT). Recent studies have indicated that a subgroup of pat...

Background Neoadjuvant chemoradiotherapy (nCRT) combined with surgery is still the standard treatment mode for esophageal cancer (EC), but the rate of distant metastasis and local recurrence of this triple mode is still high. Distant metastasis is the main recurrence pattern. Therefore, there is an urgent need to explore a new treatment model to im...

Water electrolysis is the most promising method to produce non-fossil fuel derived H2. The medium temperature (100–350 °C) water (steam) electrolysis is highly promising technology because it can not only reduce energy consumption but also utilize the low-grade waste heat. However, it is challenged by the proton conductive membrane performance. Her...

Background Small cell lung cancer (SCLC) is characterized by a high risk of brain metastasis and poor survival. This study aims to assess the prognostic role of lactate dehydrogenase (LDH) in limited-stage small cell lung cancer (LS-SCLC) treated with thoracic radiotherapy (TRT) and prophylactic cranial irradiation (PCI). Methods This study retros...

Objective: Radiation-induced lung injury (RILI) is a common complication of radiotherapy for thoracic tumors. This study investigated the alleviating effect of baicalin (BA) on RILI and its possible mechanism. Methods: RILI model was established by chest irradiation (IR) of C57BL/6 mice for 16 weeks. Different concentrations of BA were administe...

Objective: To identify genetic and clinicopathological factors that affect the response of patients with esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT), profile the genomic and transcriptomic alterations after nCRT and relate the alterations to patient’s prognosis. Methods: A total of 137 samples from 57 ESCC pati...

Objective: This study aims to investigate the protective effect of 3,3'-diindolylmethane (DIM) on the radiation-induced lung injury (RILI) model and to explore its possible mechanism. Methods: A mouse model of RILI was established by thoracic irradiation, and dexamethasone was used as a positive drug to investigate the effect of DIM on RILI mice....

Iodine (I2) capture over adsorbents has great potential for the treatment of radioactive nuclear wastes. Herein, we develop a direct synthesis of 2D structured pyrene-alkadiyne frameworks, poly(1,3,6,8-tetraethynylpyrene) (PTEP), through a facile and ultrarapid solid-phase thermal polymerization of 1,3,6,8-tetraethynylpyrene (TEP) monomers in air....

Objectives The proportion of elderly patients with esophageal cancer (EC) is increasing due to prolonged life expectancy and aging process. The aim of the study is to explore the optimal treatment strategy for elderly patients (aged ≥70 years) with locally advanced EC. Methods Eligible patients with cT2-4aNxM0 EC were identified in the Surveillanc...

Background Lactate dehydrogenase A (LDHA) is overexpressed and associated with poor prognosis in many kinds of cancer. In the current study, we evaluated the prognostic value of LDHA expression in non-small cell lung cancer (NSCLC), and tested whether LDHA inhibition might improve radiotherapy efficacy in NSCLC. Methods LDHA expression was investi...

Background: The proportion of elderly patients with esophageal cancer (EC) is increasing due to prolonged life expectancy and aging process. However, the optimal treatment strategy for elderly patients (aged ≥70 years) with EC remains controversial. Methods: Eligible patients with cT1b-4aNxM0 EC were identified in the Surveillance, Epidemiology, an...

Lung squamous cell carcinoma (LUSC) is a prevalent subtype of nonsmall cell lung cancer (NSCLC). Dysregulated long noncoding RNAs (lncRNAs) are increasingly identified as pivotal modulators in cancer progression. NCK1 divergent transcript (NCK1-AS1) is a lncRNA that has been proven to be oncogenic in different types of human cancers. However, wheth...

Background LDHA is overexpressed in many kinds of cancer, and associated with poor prognosis. In the current study, we evaluated the prognostic value of LDHA expression in non-small cell lung cancer (NSCLC), and tested whether LDHA inhibition might improve radiotherapy efficacy in NSCLC. Methods LDHA mRNA expression was investigated in NSCLC patien...

Purpose: Radiation dose used in the neoadjuvant chemoradiotherapy (NCRT) for patients with locally advanced esophageal squamous cell carcinoma (ESCC) varies in different trials and clinical practice. Methods and Materials: Data from patients diagnosed with ESCC receiving NCRT followed by esophagectomy were retrospectively collected from February 20...

Background: Multimodality treatment is increasingly accepted and becoming the standard care for local advanced esophageal cancer (EC) patients. However, for early stage lymph node-negative EC patients, surgery alone is still the primary treatment approach, and the role of perioperative chemotherapy remains unclear. Methods: Patients with lymph n...

Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the pooled hazard risks were obtained...

The effects of dairy products on human health have been studied for years. However, the relationship between dairy products as well as calcium intake and the risk of lung cancer is still inconclusive. A total of 32 studies regarding this association were identified from the PubMed and Web of Science databases through April 1, 2015, including 12 coh...

Higher rate of glycolysis has been long observed in cancer cells, as a vital enzyme in glycolysis, lactate dehydrogenase A (LDH-A) has been shown with great potential as an anti-cancer target. Accumulating evidence indicates that inhibition of LDH-A induces apoptosis mediated by oxidative stress in cancer cells. To date, it's still unclear that whe...

The association between meat consumption and the risk of hepatocellular carcinoma (HCC) is still inconclusive. To conduct a systematic review and meta-analysis to quantitatively assess the relationship between meat intake and the risk of HCC. We searched the PubMed, Web of Science and EMBASE databases for relevant studies published before July 2013...

To evaluate the teratogenicity of the dental implant and provide a basis for safe applications of medical products. Chromosome aberration test, micronucleus test and the Ames test of the dental implant samples were performed. The results showed that samples of the dental implant did not cause chromosomal aberrations, nor induced the increase of bon...

Purpose: The objective of this study was to evaluate the teraogenic toxicity of central vein catheters after irradiation sterilization and provide basis for further application of medical apparatus in future. Methods: central vein catheters were sterilized by irradiation as ISO11137 standard, afterwards, a series of tests including chromosome aberr...

Objective:To evaluate the blood compatibility of a central venous catheter in order to provide evidence for the safety of medical devices. Methods:The indexes of coagulation including thrombin time(TT), prothrombin time(PT), activated partial thromboplastin time (APTT) and fibrinogen (Fg) concentration, as well as the indexes of platelet function p...

The aim of this study is to evaluate the blood compatibility of disposable burette transfusion apparatus and provide the basis for the clinical safety of medical products. Whole blood clotting time (WBCT), prothrombin time(PT),partial prothrombin time(PTT), hemolytic rate and bacterial endotoxin were measured. The results showed that there was no s...

Objective: To evaluate the histocompatibility and carcinogenic toxicity of silicone gel-filled breast implants after irradiation sterilization and promote the application of irradiation sterilization in the polymer biomaterials. Methods: The initial contaminating bacteria of silicone gel-breast implants were detected in accordance with ISO11737 sta...

To evaluate the blood and tissue compatibility of the dental implant samples, the whole blood clotting time, prothrombin time and partial prothrombin time, hemolytic rate and local implantation tests of the dental implant samples were determined, which will provide the basis for the clinical safety of such medical products. The WBCT, PT and PTT res...

The purpose of this study was to evaluate the genotoxicity of advanced composed material—silicone gel-filled breast implant after irradiation sterilization, which will provide basis for the safety of such medical material in clinical application. The irradiation dose for sterilization was set according to ISO11137-2 standard. Ames test, micronucleu...