Yang Liu

Zhengzhou University | zzu · Division of Material Science and Engineering

Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectively evaluated the relationship between dFLC (the difference between free light chain) reduction by Day 7 in Cyc...

Cyclic di-GMP (c-di-GMP) is a crucial secondary messenger in bacterial cells, profoundly impacting various physiological and biochemical processes. Numerous studies showed that c-di-GMP regulates specific bacterial pathways by interacting with related effectors, and modulating their functions at the transcriptional or post-transcriptional levels. H...

Sea cucumbers are predominant deposit feeders in benthic ecosystems, providing protective benefits to coral reefs by reducing disease prevalence. However, how they receive sufficient nutrition from seabed sediments remains poorly understood. Here, we investigate Holothuria leucospilota, an ecologically significant tropical sea cucumber, to elucidat...

Self-anthropomorphism in robots manifests itself through their display of human-like characteristics in dialogue, such as expressing preferences and emotions. Our study systematically analyzes self-anthropomorphic expression within various dialogue datasets, outlining the contrasts between self-anthropomorphic and non-self-anthropomorphic responses...

Nanoplastics (NPs) and microplastics (MPs) have emerged as pervasive environmental pollutants, and they ubiquitously distribute in ecosystems and accumulate within organisms, thereby posing a substantial threat to global ecology. Though the disruptive effects of NPs and MPs on physiology and behavior in some aquatic species have been extensively do...

Botulinum neurotoxin (BoNT), produced by Clostridium botulinum, is the most toxic protein known, capable of causing severe paralysis and posing a significant bioterrorism threat due to its extreme lethality even in minute quantities. Despite this, there are currently no FDA-approved vaccines for widespread public use. To address this urgent need, w...

The Apollo basin, located in the northeastern part of the South Pole-Aitken (SPA) basin, represents one of the Moon's most significant geological features, offering profound insights into the lunar interior structure, the effects of the SPA impact, and the history of lunar crust evolution. This study presents an in-depth geological analysis of the...

Mare domes (interpreted to be a type of shield volcano) represent one important endmember of a variety of volcanic edifices occurring across the volcanic plains on the Moon, whereas Ring‐Moat Dome Structures (RMDSs) are interpreted to reflect the thermodynamic behavior of plain‐forming mare flows during their emplacement and cooling. A comprehensiv...

The impressive performance of Large Language Models (LLMs) has consistently surpassed numerous human-designed benchmarks, presenting new challenges in assessing the shortcomings of LLMs. Designing tasks and finding LLMs' limitations are becoming increasingly important. In this paper, we investigate the question of whether an LLM can discover its ow...

Extracellular microRNA (miRNA) expression data generated by different laboratories exhibit heterogeneity, which poses challenges for biologists without bioinformatics expertise. To address this, we introduce ExomiRHub (http://www.biomedical-web.com/exomirhub/), a user-friendly database designed for biologists. This database incorporates 191 human e...

Background Solitary fibrous tumor (SFT) is a rare fibroblastic mesenchymal tumor that mostly involves the pleura and infrequently involves extra-pleural sites. De novo SFT of the kidney is uncommon, and malignant SFT is extremely rare. Case presentation We report a case of a 51-year-old man with a large malignant SFT in the left kidney. Pathologic...

This study reports a chromosome-level genome for Dracaena cambodiana, one of two typical dracaena species in China. This work will help to deepen the understanding of the dracaena species and the conservation and development of plant resources. The final assembly consisted of 54 scaffolds, spanning 1.08 Gb, with a scaffold N50 size of 52.29 Mb, enc...

Invasive tumors are difficult to be completely resected in clinical surgery due to the lack of clear resection margins, which greatly increases the risk of postoperative recurrence. However, chemotherapy and radiotherapy as the traditional means of postoperative adjuvant therapy, are limited in postoperative applications, such as multi-drug resista...

Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Gene editing technology repairs the conversion of the 6th base T to C in exon 7 of the paralogous SMN2 gene, compensating for the SMN protein expression and promoting the survival and function of motor neurons. Howeve...

Recent studies on the interplay between band topology and the layer degree of freedom provide an effective way to realize exotic topological phases. Here we systematically study the C6- and C3-symmetric higher-order topological phases in bilayer spinless tight-binding lattice models. For concreteness, we consider bilayer phononic crystals as the re...

Background: To improve the clinical evaluation of the prognosis of papillary renal cell carcinoma (PRCC), we screened a model to predict the survival of patients with mutations in related genes. Methods: We downloaded RNA sequencing information from all patients with PRCC in TCGA. We first analyzed the differences in genes and the enrichment of...

Myoblast proliferation and differentiation are essential for skeletal muscle development. In this study, we generated the expression profiles of mRNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs) in different developmental stages of chicken primary myoblasts (CPMs) using RNA sequencing (RNA-seq) technology. The dual luciferase reporter sy...

The ancient crop broomcorn millet (Panicum miliaceum L.) is an indispensable orphan crop in semi‐arid regions due to its short life cycle and excellent abiotic stress tolerance. These advantages make it an important alternative crop to increase food security and achieve the goal of zero hunger, particularly in light of the uncertainty of global cli...

Ge/SiGe heterostructure quantum well structures based on Ge two-dimensional hole gas have become one of the most promising research directions for preparing spin quantum bits due to their low disorder and high mobility. In this study, high-quality virtual substrates were epitaxially grown on 8-in silicon substrates using reduced pressure chemical v...

In this multicentre, real‐world study, we aimed to identify the clinical outcomes and safety of allogeneic haematopoietic stem cell transplantation (allo‐HSCT) in T‐lymphoblastic lymphoma (T‐LBL). A total of 130 Ann Arbor stage III or IV T‐LBL patients (>16 years) treated with allo‐HSCT across five transplant centres were enrolled. The 2‐year cumul...

Background In China, real‐world data on surgical challenges and postoperative complications after neoadjuvant immunotherapy of lung cancer are limited. Methods Patients were retrospectively enrolled from January 2018 to January 2023, and their clinical and pathological characters were subsequently analyzed. Surgical difficulty was categorized into...

Pseudomonas aeruginosa is a widespread nosocomial pathogen with a significant capacity to cause both severe acute infections and biofilm-related chronic infections. Small RNAs (sRNAs) are noncoding regulatory molecules that are stabilized by the RNA chaperone Hfq, triggering various signaling pathways. Here, we identified an Hfq-binding sRNA in P....

Neoadjuvant immunotherapy has evolved as an effective option to treat non-small cell lung cancer (NSCLC). B cells play essential roles in the immune system as well as cancer progression. However, the repertoire of B cells and its association with clinical outcomes remains unclear in NSCLC patients receiving neoadjuvant immunotherapy. Single-cell RN...

Droplet microfluidics has revolutionized single-cell analysis, allowing for ultra-high-throughput sorting of droplets to meet the demands of single-cell sorting. However, accurately and efficiently dispensing target droplets into specific containers for downstream analysis has remained a challenge. Here, we present an integrated microfluidic drople...

Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the survival motor neuron 1 ( SMN1 ) gene. Gene editing technology repairs the conversion of the 6th base T to C in exon 7 of the paralogous SMN2 gene, compensating for the SMN protein expression and promoting the survival and function of motor neurons. Howe...

The oxide abundances of the lunar regolith are fundamental for understanding the geological evolution of the Moon both regionally and globally. Several models have been constructed to estimate the oxide contents of lunar regolith from the visible and near-infrared (VNIR) spectra based on Apollo and Luna samples. In recent years, China's successful...

Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 and pyruvate oxidase (POx)‐co‐loaded Cu‐NS single‐atom nanozyme (Cu‐NS@UK@POx), that not only trigger pyroptosis through cascade biocat...

Dragon's blood, the red resin derived from the wounded Dracaena, is a precious traditional medicine used by different culture. Dracaena cochinchinensis is one of the main species of Dracaena, and is the endangered medicinal plants in China. The vulnerable status severely limits the medicinal value and wide application of dragon’s blood. Therefore,...

Context.— Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) rarely exhibits a predominant tubulocystic architecture with few other components. RCC with pure tubules and cysts lined by eosinophilic tumor cells with prominent nucleoli would raise the diagnosis of tubulocystic RCC. It is important to differentiate the 2 entities because the...

Delayed re‐epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large‐scale acute or chronic wounds. However, effective strategies for targeting these two aspects concurrently are still lacking. Herein, an antioxidative active‐shrinkage hydrogel (AHF@AS Gel) is constructed that can integratedly prom...

Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is an extremely rare kidney tumor seen mainly in patients with end-stage renal disease. Currently, there are few reports on this type of tumor. We describe the case of a 58-year-old man who had been receiving peritoneal dialysis for more than nine years due to chronic renal insuffici...

Due to the openness of the wireless propagation environment, wireless networks are highly susceptible to malicious jamming, which significantly impacts their legitimate communication performance. This study investigates a reconfigurable intelligent surface (RIS) assisted anti-jamming communication system. Specifically, the objective is to enhance t...

Background Radiomics is increasingly utilized to distinguish pulmonary nodules between lung adenocarcinoma (LUAD) and tuberculosis (TB). However, it remains unclear whether different segmentation criteria, such as the inclusion or exclusion of the cavity region within nodules, affect the results. Methods A total of 525 patients from two medical ce...

Graphene, a promising material with excellent properties, suffers from a major limitation in electronics due to its zero bandgap. The gas molecules adsorption has proven to be an effective approach for band regulation, which usually requires a harsh environment. Here, O2⁻ ions produced with triboelectric plasma are used for in situ regulation of gr...

Background. Pigmented microcystic chromophobe renal cell carcinoma (RCC) is a subtype of chromophobe RCC. Its distinct histopathologic features are microcystic and microtubular pattern, pigmentation, and microcalcifications. Pigmented microcystic chromophobe RCC has ultrastructure, immunophenotypic structure, and molecular results similar to chromo...

This paper introduces the Ninth Dialog System Technology Challenge (DSTC-9). This edition of the DSTC focuses on applying end-to-end dialog technologies for four distinct tasks in dialog systems, namely, 1. Task-oriented dialog Modeling with Unstructured Knowledge Access, 2. Multi-domain task-oriented dialog, 3. Interactive evaluation of dialog and...

The Internet of Things (IoT) positioning technology has expanded the distribution space through information transmission between devices, thereby finding extensive application in diverse domains such as intelligent perception, intelligent recognition, intelligent management, etc. In recent years, scholars have been researching the optimal selection...

Renal cell carcinoma with fibromyomatous stroma (RCC FMS), defined as an “emerging entity” in the 2016 WHO classification and recommended to be a novel entity by GUPS, is represented by tumor cells with clear to mildly eosinophilic cytoplasm displaying elongated and branching tubules and papillae. A fibromyomatous stroma could be observed in these...

Background In China, real-world data on surgical challenges and postoperative complications after neoadjuvant immunotherapy of lung cancer is limited. Methods Patients were retrospectively enrolled from January 2018 to January 2023, whose clinical and pathological characters were subsequently analyzed. Surgical difficulty was categorized into a bi...

(1) Background: To evaluate the predictive value of Holter monitoring for overall survival (OS) of patients with light chain amyloidosis (AL amyloidosis). (2) Methods: 137 patients with newly diagnosed AL amyloidosis who underwent Holter monitoring within 6 months of diagnosis were included. The primary outcome was OS. Landmark analysis was conduct...